• Steel and Composite Structures
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• 제34권3호
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• pp.321-332
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• 2020

The loss of composite action at the hogging moment zone for a continuous composite girder reduces the girder stiffness and strength. This paper presents an experimental investigation of the use of an ultra-high performance concrete (UHPC) slab at the hogging moment zone and a normal concrete (NC) slab at the sagging moment zone. The testing was conducted to verify the level of loading at which composite action is maintained at the hogging moment zone. Four two-span continuous composite girders were tested. The thickness of the UHPC varied between a half and a full depth of slab. The degree of shear connection at the hogging moment zone varied between full and partial. The experimental results confirmed the effectiveness of the UHPC slab to enhance the girder stiffness and maintain the composite action at the hogging moment zone at a load level much higher than the upper service load limit. To a lesser degree enhanced performance was also noted for the smaller thickness of the UHPC slab and partial shear connection at the hogging moment zone. Plastic analysis was conducted to evaluate the ultimate capacity of the girder which yielded a conservative estimation. Finite element (FE) modeling evaluated the girder performance numerically and yielded satisfactory results. The results indicated that composite action at the hogging moment zone is maintained for the degree of shear connection taken as 50% of the full composite action and use of UHPC as half depth of slab thickness.

• 산업공학
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• 제11권1호
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• pp.199-205
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• 1998

This paper describes the development of on-the-machine measuring(OMM) system which can directly measure the two and three dimensional machined accuracy using a scanning probe in milling machine. Two algorithms, NC program based continuous path(CP) measurement and CAD data assisted point to point(PTP) measurement, are developed for three dimensional measurements, with consideration of the characteristics of the scanning probe. The algorithms are used to develop an auto measuring system. The delveloped system is compared with the CMM (Coordinate Measuring Machine) in terms of accuracy and repeatability. The OMM system is expected to realize measurement time reduction and hence result in high productivity.

• The Korean Journal of Physiology and Pharmacology
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• 제5권1호
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• pp.79-86
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• 2001

Recent clinical studies have shown that a high proportion of patients with acute promyelocytic leukemia (APL) achieve complete remission after treatment with all-trans retinoic acid (ATRA). However, most patients who receive continuous treatment with ATRA relapse and develop ATRA-resistant leukemia. Dendritic cells (DCs) are important antigen-presenting cells in the development of antileukemic T-cell responses. In this study, we investigated the strategies to overcome ATRA resistance of APL cells by inducing the differentiation of DCs from human leukemic cell lines for the developtment of adoptive immunotherapy. CD83 was used as a mature DC marker in this study and the expression of CD83 mRNA was determined by RT-PCR method. The promyelocytic leukemic cell line HL-60, B lymphoblast cell lines RPMI 7666 and NC-37 could be induced to dendritic cells in vitro. Treatment of HL-60 with phorbol 12-myristate 13-acetate (PMA) resulted in the expression of myeloid-related DC phenotypes, while treatment of RPMI 7666 with fms-like tyrosine kinase 3 ligand (Flt3-ligand, FL) and treatment of NC-37 with PMA and FL led to the expression of lymphoid-related DC phenotypes. In conclusion, myeloid-related DC phenotypes and lymphoid-related DC phenotypes could be generated from HL-60, NC-37 and RPMI 7666 cell lines, respectively. These DC phenotypes can potentially be used to generate antileukemic T cells in vitro for adoptive immunotherapy.

• 한국생산제조학회지
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• 제8권1호
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• pp.74-80
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• 1999

Recently, manufacturing work has been transformed to small scale production form with various types to act up to user's expectation from mass production with a little items required in the past. Then FMS using NC type machinaries has been applied actively also in domestic manufacturing line to meet thus tendency, but there are many machining troubles occured during work process not be settled yet. Nowdays high efficiently has been required no less than high precision in grinding work for the improvement of productivity. In this study, to represent more advance FMS can be adapted to thus situation In-process type monitoring method using AE and Current sensors is suggested to investigate the machining condition in grinding process. As results form this experimental study, it is recognized well that grinding conditions and dressing point of in time cab be estimated effectively using monitoring method suggested. Furthermore, surface shape of grinding wheel on voluntary point of in time can be predicted indirectly through the observation and comparison of AE signal waveform obtained as performance of continuous dressing work.

• 한국기계가공학회지
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• 제10권2호
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• pp.1-8
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• 2011

5-axis NC machining has a good advantage of the accessibility of tool motion by adding two rotary axes. It offers numerous advantages such as expanding machining fields in parts of turbo machineries like impeller, propeller, turbine blade and rotor, reasonable tool employment and great reduction of the set-up process. However, as adding two rotary axes, it is difficult to choose suitable machining conditions in terms of cutter path and cutter posture at a cutter contact point. Therefore in this paper, it is proposed to decide suitable machining condition through an experimental method such as adopting various cutter paths, cutter postures types. Also, in order to increase the efficiency of 5-axis machining, it is necessary to minimize the cutter posture changes and create a continuous cutter path while avoiding interference. This study, by using an MC-space algorithm for interference avoidance and an MB-spline algorithm for continuous control, is intended to create a 5-axis machining cutter path with excellent surface quality and economic feasibility. finally, this study will verify the effectiveness of the suggested method through verification processing.

• 한국CDE학회논문집
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• 제9권2호
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• pp.143-147
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• 2004

To design parts satisfying physical property in the continuous region, we do it in the discrete rectangular mesh points. Then we obtain points data from parts design and usually construct the surface using least squares method. In such case, that surface has an oscillation in the ineffective region which is inadequate for physical phenomena or NC machining. To solve both problems simultaneously, we extend the surface smoothly to have small curvature in the extended region. Up to now, we use the least squares method for the parts design in Color Picture Tube or Color Display Tube but in this paper, we use functions which is easily controllable. This surface has no error within the effective region compared to the least squares method.

• 대한의용생체공학회:의공학회지
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• 제31권1호
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• pp.27-32
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• 2010

Noninvasive detection of patients with probable Alzheimer's disease (AD) is of great importance for assisting a medical doctor's decision for early treatment of AD patients. In the present study, we have extracted quantitative electroencephalogram (qEEG) variables, which can be potentially used to diagnose AD, from resting eyes-closed continuous EEGs of 22 AD patients and 27 age-matched normal control (NC) subjects. We have extracted qEEG variables from mean phase coherence (MPC) and EEG coherence, evaluated for all possible combinations of electrode pairs. Preliminary trials to discriminate the two groups with the extracted qEEG variables demonstrated that the use of MPC as a supplementary or alternative measure for the EEG coherence may enhance the accuracy of noninvasive diagnosis of AD.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제50권11호
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• pp.546-555
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• 2001

ln this paper, the optimum design of electrical apparatus using design variable parametrization is presented. For analysis and design, the finite element method and the design sensitivity method is used, respectively. By applying the parametrization of the design variables, the obtained designed shape is continuous and smooth. For the parametrization the Bezier spline is used. The designed shape with parametrization is characterized by the control points. By delivering control points to the commercial CAD packages or NC machines, the exact designed shape can be realized in the manufacturing the electrical apparatus. The designed results with and without parametrization are compared and the validity of the parametrization is verified.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1994년도 추계학술대회 논문집
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• pp.125-130
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• 1994

Recently,manufacturing work been transformed to small acale production from with various items to act up to user's expectation from mass production with a little items required in the past. The FMS using NC type mother machinaries has been applied actively also in domestic manufacturing line to meet thus tendancy, but there are many machining troubles occured in work process not be settled yet. Nowdays high efficiency has been required no less than high precision in grinding work for the improvement of productivity. In this study, to represent more advanced FMS can be adapted to thus situation In-process type monitoring method using AE and Current sensors is suggested to investigatethe machining condition in grinding process. As results from this experimental study, is is recoqnized well that grinding conditions and dressing point of in time can be estimated effectively using monitoring method suggested. Furthermore, surface shape of grinding wheel on voluntary point of in time can be predicted indirectly through the observation and comparison of AE signal waveform obtained as performance of continuous dressing work.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 1997년도 가을 학술발표회 프로그램
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• pp.1.1-32
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• 1997

Atmospheric monitoring capabilities were established in 1988 by the University of Florida at Duke forest, near Durham. NC: Cary forest, near Gainesville, FL: and Austin forest, near Nacogdoches, TX. Continuous (hourly averaged) measurements of air quality (ozone, nitrogen oxides and sulfur dioxide) and meteorological variables were made at these three low elevation (< 200 meters), rural locations in the southeastern U.S. for more than three years. During the same period at these sites wet and dry acid deposition samples were collected and analyzed on an event and weekly basis, respectively The monitoring locations were selected to determine actual atmospheric exposure indices for southern pine species in support of on-site surrogate exposure chamber studies conducted by Southern Commercial Forest Research Cooperative (SCFRC) investigators. Daily and quarterly averaged ozone maxima were higher (55 ppb) at the northernmost site in the network (Duke forest) in the second and third quarters (spring and summer seasons) and lower (35 ppb) in the first and fourth quarters (winter and fall seasons), when compared to ozone levels at the two southernmost sites (Cary and Austin forests). Seasonal ozone levels at the latter two sites were similar Nitrogen oxieds and sulfur dioxide levels were insignificant (< 5 ppb) most of the time at all sites, although soil emissions of NO at two sites were found to influence nighttime ozone concentrations. Typical maximum quarterly and annual aggregate ozone exposure indices were significantly higher at Duke forest (92.5/259 ppm-hr) than those values observed at the two southern sites (65.6/210 ppm-hr). Acid deposition (wet and dry) components concentrations and deposition fluxes observed at the Duke forest, NC piedmont site, were generally greater, dependent on site and season, than corresponding variables measured at either of the two southern coastal plain sites (Cary and Austin forests). Acid deposition variables observed at the latter two sites were remarkably similar, both qualitatively and quantitatively, although the sites were located 1300 km apart. A comparison of deposition fluxes of elemental nitrogen (NO3, NH4') and sulfur (5042-, SO3) components in wet and dry forms indicated that wet deposition accounts for approximately 70% of the total nitrogen and 73% of the total sulfur input on an annual equivalent basis at all sites.