• Child Health Nursing Research
• /
• 제13권4호
• /
• pp.436-443
• /
• 2007

Purpose: An exploratory study was done to examine the validity of the new Ballard scale with extended scoring system(eNBS) in estimating gestational age(AG) in full-term newborns. Method: The eNBS scoring system was extended to include all numbers of total score of NBS and GA to allow a 3-days variation in GA estimatio compared to the original scale which has a 2-week variation due to the application of a 5-score interval for the total NBS score and only even numbers for GA. GA by eNBS(GA-eNBS) was compared with GA by LMP(GA-LMP) and GA by standard NBS(GA-sNBS) in 133 full-term newborns. Difference between GA-LMP and GA-eNBS was analyzed for each GA. Results: Positive correlations were observed in GA-sNBS and GA-eNBS with GA-LMP. There was no difference between GA-LMP and GA-eNBS at 39GA and 40GA. At 37GA and 38GA, GA-eNBS overestimated GA-LMP up to 1 week, while underestimating up to 1 week at 41GA. Conclusions: The accuracy of eNBS was validated within 3 days of variation in GA estimation at 39-40GA. Overestimation by eNBS suggests the possible acceleration of fetal maturity in premature newborns, while underestimation, of the deceleration of fetal maturity in postterm newborns.

• 한국조리학회지
• /
• 제9권3호
• /
• pp.102-113
• /
• 2003

This study was conducted to investigate Korean soy sauces and Japanese soy sauces for their flavor and taste when they are used for Teriyaki sauce preparation. The results showed the followings; 1. The panelists liked more naturally brewed soy sauce (NBS) than mixed (NBS + acid-hydrolyzed) soy sauces, especially S company's NBS, 501S and Japanese K company's koikuchi NBS were preferred sauces. 2. The preference of Chicken Teriyaki preparation were also appeared to be the highest with S company's NBS, 501S and Japanese K company's koikuchi NBS. Both of them are naturally brewed soy sauces. 3. Chicken Teriyaki Sauce's preference were also high that made from the highly preferred soy sauces, therefore, it would be the better selection with the highly preferred soy sauces for the Chicken Teriyaki preparation. 4. There were no significant difference in preferences between imported NBS and domestic NBS, so it would be good to use Korean NBS for Chicken Teriyaki preparation.

• Archives of Pharmacal Research
• /
• 제8권1호
• /
• pp.39-41
• /
• 1985

Bromocycloetherification of a series of 3-and 4-olefinic alcohols using NBS-acetonitrile gave corresponding bromo-tetrahydrofuran with high regio and steroselectivity.

• BMB Reports
• /
• 제52권3호
• /
• pp.208-213
• /
• 2019

Chemoresistance is the primary obstacle in the treatment of locally advanced and metastatic nasopharyngeal carcinoma (NPC). Recent evidence suggests that the transcription factor forkhead box M1 (FoxM1) is involved in chemoresistance. Our group previously confirmed that FoxM1 is overexpressed in NPC. In this study, we investigated the role of FoxM1 in cisplatin resistance of the cell lines 5-8F and HONE-1 and explored its possible mechanism. Our results showed that FoxM1 and NBS1 were both overexpressed in NPC tissues based on data from the GSE cohort (GSE12452). Then, we measured FoxM1 levels in NPC cells and found FoxM1 was overexpressed in NPC cell lines and could be stimulated by cisplatin. MTT and clonogenic assays, flow cytometry, ${\gamma}H2AX$ immunofluorescence, qRT-PCR, and western blotting revealed that downregulation of FoxM1 sensitized NPC cells to cisplatin and reduced the repair of cisplatin-induced DNA double-strand breaks via inhibition of the MRN (MRE11-RAD50-NBS1)-ATM axis, which might be related to the ability of FoxM1 to regulate NBS1. Subsequently, we demonstrated that enhanced sensitivity of FoxM1 knockdown cells could be reduced by overexpression of NBS1. Taken together, our data demonstrate that downregulation of FoxM1 could improve the sensitivity of NPC cells to cisplatin through inhibition of MRN-ATM-mediated DNA repair, which could be related to FoxM1-dependent regulation of NBS1.

• International Journal of Naval Architecture and Ocean Engineering
• /
• 제5권1호
• /
• pp.81-100
• /
• 2013

During the final quarter of the last century considerable efforts have been spent to reduce the hull pressure fluctuations caused by unsteady propeller cavitation. This has resulted in further changes in propeller design characteristics including increased skew, tip unloading and introduction of "New Blade Sections" (NBS) designed on the basis of the so-called Eppler code. An experimental study was carried out to investigate flow characteristics of alternative two-dimensional (2-D) blade sections of rectangular planform, one of which was the New Blade Section (NBS) developed in Newcastle University and other was based on the well-known National Advisory Committee for Aeronautics (NACA) section. The experiments comprised the cavitation observations and the measurements of the local velocity distribution around the blade sections by using a 2-D Laser Doppler Anemometry (LDA) system. Analysis of the cavitation tests demonstrated that the two blade sections presented very similar bucket shapes with virtually no width at the bottom but relatively favourable buckets arms at the suction and pressure sides for the NACA section. Similarly, pressure analysis of the sections displayed a slightly larger value for the NBS pressure peak. The comparative overall pressure distributions around the sections suggested that the NBS might be more susceptible to cavitation than the NACA section. This can be closely related to the fundamental shape of the NBS with very fine leading edge. Therefore a further investigation into the modification of the leading edge should be considered to improve the cavitation behaviour of the NBS.

• 여성건강간호학회지
• /
• 제29권1호
• /
• pp.20-31
• /
• 2023

Purpose: As more newborns have received expanded newborn screening (NBS) for metabolic disorders, the overall number of false-positive results has increased. The purpose of this study was to explore the psychological impacts experienced by mothers related to the NBS process. Methods: An online parenting community in Korea was selected, and questions regarding NBS were collected using web crawling for the period from October 2018 to August 2021. In total, 634 posts were analyzed. The collected unstructured text data were preprocessed, and keyword analysis, topic modeling, and visualization were performed. Results: Of 1,057 words extracted from posts, the top keyword based on 'term frequency-inverse document frequency' values was "hypothyroidism," followed by "discharge," "close examination," "thyroid-stimulating hormone levels," and "jaundice." The top keyword based on the simple frequency of appearance was "XXX hospital," followed by "close examination," "discharge," "breastfeeding," "hypothyroidism," and "professor." As a result of LDA topic modeling, posts related to inborn errors of metabolism (IEMs) were classified into four main themes: "confirmatory tests of IEMs," "mother and newborn with thyroid function problems," "retests of IEMs," and "feeding related to IEMs." Mothers experienced substantial frustration, stress, and anxiety when they received positive NBS results. Conclusion: The online parenting community played an important role in acquiring and sharing information, as well as psychological support related to NBS in newborn mothers. Nurses can use this study's findings to develop timely and evidence-based information for parents whose children receive positive NBS results to reduce the negative psychological impact.

• Elastomers and Composites
• /
• 제48권3호
• /
• pp.225-231
• /
• 2013

본 연구에서는 carboxylated SBR latex와 zinc oxide가 SBS 복합재의 내마모성과 debris 특성 개선에 미치는 영향을 관찰하였다. 실리카를 첨가한 SBS 복합재는 실리카 입자간의 수소 결합에 의한 강한 filler-filler interaction으로 인한 낮은 분산성 때문에 기계적 강도, NBS 내마모성, debris 특성이 전체적으로 감소하는 것으로 나타났다. carboxylated SBR latex를 첨가한 SBS 복합재는 carboxyl group과 실리카의 silanol group간의 결합을 통하여 filler-filler interaction이 감소하고 실리카의 분산성이 증가하기 때문에 기계적 강도, NBS 내마모성, debris 특성이 향상되는 것을 확인 하였다. carboxylated SBR latex와 zinc oxide를 동시에 첨가한 경우, carboxyl group에 의한 실리카의 분산성 향상과 더불어 zinc ion과 carboxyl group간의 ion cluster 형성을 통하여 물성이 크게 증가하였다. Zinc ion과 carboxyl group간의 ion cluster 형성은 $1550{\sim}1650cm^{-1}$의 zinc carboxylate group stretch 피크의 FT-IR 분석 결과로 확인하였다. carboxylated SBR latex와 zinc oxide를 첨가한(SC-4) 복합재의 경우, 인장강도 $156kgf/cm^2$, 신장율 936%, 인열강도 59.4kgf/cm의 우수한 기계적 강도를 나타내었으며, NBS 내마모성은 338%로 가장 우수한 특성을 나타내었다. 또한, 표면 마찰 시에 debris 발생 역시 크게 감소하며, 표면 마찰 저항의 증가로 파도 형태의 마모 특성을 나타내었다.

• 한국정보통신학회:학술대회논문집
• /
• 한국정보통신학회 2014년도 추계학술대회
• /
• pp.769-772
• /
• 2014

비정질 InGaZnO 박막트랜지스터의 Gate Overlap 길이에 따른 NBS(Negative Bias Stress) 및 hot carrier 스트레스 후 시간별 문턱전압의 변화에 의한 소자신뢰도를 분석하였다. 측정에 사용된 소자는 비정질 InGaZnO TFT이며 채널 폭 $W=104{\mu}m$, 게이트 길이 $L=10{\mu}m$이며 Gate Overlap 길이는 $0,1,2,3{\mu}m$를 사용하였다. 소자 신뢰도는 전류-전압을 측정하여 분석하였다. 측정 결과, hot carrier 스트레스 후 Gate Overlap 길이가 증가할수록 문턱전압의 변화가 증가하였다. 또한, NBS 후에는 Gate Overlap 길이가 증가할수록 문턱전압의 변화가 감소하였고 장시간 스트레스 후에 hump가 발생하였다.

• Archives of Pharmacal Research
• /
• 제15권4호
• /
• pp.333-335
• /
• 1992

Hofmann rearrangement of a series of primary aliphatic and aromatic carboxamides 1a-1m with HgO-NBS (or dibromantin)R'OH-DMF gives corresponding carbamates 2a-2m in excellent yields.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권11호
• /
• pp.5375-5379
• /
• 2012

Introduction: Published studies on the association between Nijmegen breakage syndrome 1(NBS1) gene polymorphisms and breast cancer risk have been inconclusive, and a meta-analysis was therefore performed for clarification. Methods: Eligible articles were identified by a search of MEDLINE and EMBASE bibliographic databases for the period up to March 2012. The presence of between-study heterogeneity was investigated using the chi-square-based Cochran's Q statistic test. When there was statistical heterogeneity, the random effects model was chosen; otherwise, fixed effects estimates were reported as an alternative approach. Results: A total of 11 eligible articles (14 case-control studies) were identified, nine case-control studies were for the 657del5 mutation (7,534 breast cancer cases, 14,034 controls) and five case-control studies were for the I171V mutation (3,273 breast cancer cases, 4,004 controls). Our analysis results indicated that the 657del5 mutation was associated with breast cancer risk (carriers vs. non-carriers: pooled OR =2.63, 95% CI: 1.76-3.93), whereas the I171V mutation was not (carriers vs. non-carriers: pooled OR =1.52, 95% CI: 0.70-3.28). Conclusion: The present meta-analysis suggests that the 657del5 gene mutation in the NBS1 gene plays a role in breast cancer risk, while the I171V mutation does not exert a significant influence.