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http://dx.doi.org/10.7314/APJCP.2012.13.11.5375

Current Evidence on the Relationship Between Two Polymorphisms in the NBS1 Gene and Breast Cancer Risk: a Meta-analysis  

Zhang, Zhi-Hua (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University)
Yang, Lin-Sheng (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University)
Huang, Fen (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University)
Hao, Jia-Hu (Department of Maternal and Child Health, School of Public Health, Anhui Medical University)
Su, Pu-Yu (Department of Maternal and Child Health, School of Public Health, Anhui Medical University)
Sun, Ye-Huan (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.11, 2012 , pp. 5375-5379 More about this Journal
Abstract
Introduction: Published studies on the association between Nijmegen breakage syndrome 1(NBS1) gene polymorphisms and breast cancer risk have been inconclusive, and a meta-analysis was therefore performed for clarification. Methods: Eligible articles were identified by a search of MEDLINE and EMBASE bibliographic databases for the period up to March 2012. The presence of between-study heterogeneity was investigated using the chi-square-based Cochran's Q statistic test. When there was statistical heterogeneity, the random effects model was chosen; otherwise, fixed effects estimates were reported as an alternative approach. Results: A total of 11 eligible articles (14 case-control studies) were identified, nine case-control studies were for the 657del5 mutation (7,534 breast cancer cases, 14,034 controls) and five case-control studies were for the I171V mutation (3,273 breast cancer cases, 4,004 controls). Our analysis results indicated that the 657del5 mutation was associated with breast cancer risk (carriers vs. non-carriers: pooled OR =2.63, 95% CI: 1.76-3.93), whereas the I171V mutation was not (carriers vs. non-carriers: pooled OR =1.52, 95% CI: 0.70-3.28). Conclusion: The present meta-analysis suggests that the 657del5 gene mutation in the NBS1 gene plays a role in breast cancer risk, while the I171V mutation does not exert a significant influence.
Keywords
NBS1 gene; 657del5 mutation; I171V mutation; polymorphism; cancer risk; breast cancer; meta-analysis;
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