• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3065-3071
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• 2012

Aim: The present investigation was to evaluate the effects of essential oils of Wedelia chinensis (Osbeck) on free radicals and in vivo antioxidant properties. Methods: Essential oils were extracted using hydro-distillation and compound analysis was performed by GC-MS analysis. Screening for inhibitory activity was conducted by DPPH and OH-scavenging assays. In addition an in vivo study was carried out in cell line implanted cancer bearing mice with assessment of levels of catalase, superoxide dismutase, glutathione peroxidase, lipid peroxidation, nitric oxide and reduced glutathione. Finally, lungs were dissected out for histopathology study of metastasis. Results: GC-MS analysis revealed the presence of carvocrol and trans-caryophyllene as the major compounds with 96% comparison with the Wilily and NBS libraries. The essential oil exhibited significant inhibition in DPPH free radical formation. Whereas reducing power and hydroxyl radical scavenging activity are dose dependent. When compared with the standard, it was found that the essential oil has more or less equal activity in scavenging free radicals produced. In the animal studies, the level of antioxidant enzymes catalase, superoxide dismutase and glutathione peroxidase, as well as glutathione, were found to be increased in treated groups whereas lipid peroxidation and nitric oxide were reduced. Histopathology report also shows that the essential oil has a significant combating effect against cancer development. Conclusion: In all the in vitro assays, a significant correlation existed between the concentrations of the essential oil and percentage inhibition of free radicals. The in vivo studies also has shown a very good antioxidant property for the essential oil during cancer development. From, these results the essential oil can be recommended for treating disease related to free radicals and to prevent cancer development.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.3A
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• pp.217-224
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• 2010

In this paper, we propose a hard handover algorithm for a base station's self-optimization, one of the automatic operational technologies for the 3GPP LTE systems. The proposed algorithm simultaneously considers a mixed target sell selection method for optimal selection and a multiple parameter based active hysteresis method with the received signal strength from adjacent cells and the cell load information of the candidate target cells from information exchanges between eNBs through X2 interface. The active hysteresis method chooses optimal handover hysteresis value considering the costs of the various environmental parameters effect to handover performance. The algorithm works on the optimal target cell and the hysteresis value selections for a base station's automatic operational optimization of the LTE system with the gathered informaton effects to the handover performance. The simulation results show distinguished handover performances in terms of the most important performance indexes of handover, handover failure rate and load balancing.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.2 no.1
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• pp.23-35
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• 2008

Mobile IP (MIP) is the solution supporting the mobility of Mobile Nodes (MNs), however, it is known to lack the support for NEtwork MObility (NEMO). NEMO manages situations when an entire network, composed of one or more subnets, dynamically changes its point of attachment to the Internet. NEMO Basic Support (NBS) protocol ensures session continuity for all the nodes in a mobile network, however, there exists a serious pinball routing problem. To overcome this weakness, there are many Route Optimization (RO) solutions such as Bi-directional Tunneling (BT) mechanism, Aggregation and Surrogate (A&S) mechanism, Recursive Approach, etc. The A&S RO mechanism is known to outperform the other RO mechanisms, except for the Binding Update (BU) cost. Although Improved Prefix Delegation (IPD) reduces the cost problem of Prefix Delegation (PD), a well-known A&S protocol, the BU cost problem still presents, especially when a large number of Mobile Routers (MRs) and MNs exist in the environment such as train, bus, ship, or aircraft. In this paper, a solution to reduce the cost of delivering the BU messages is proposed using a multicast mechanism instead of unicasting such as the traditional BU of the RO. The performance of the proposed multicast-based BU scheme is examined with an analytical model which shows that the BU cost enhancement is up to 32.9% over IPDbased, hence, it is feasible to predict that the proposed scheme could benefit in other NEMO RO protocols.

• Korean Journal of Pharmacognosy
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• v.39 no.1
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• pp.7-18
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• 2008

The chemical composition of the volatile constituents from the leaves, stems, and roots of Acanthopanax sessiliforus growing wild in Mt. Deok-Yu was determined by GC and GC-MS spectrometric analysis with the aid of NBS, Wiley Library and RI indice searches. The major constituents identified were ${\delta}-3-carene$ (7.24%), limonene (8.10%), ${\beta}-thujene$ (17.85%), trans-bicyclic hydrocarbon (13.35%) and ${\delta}-cadinene$ (4.28%) in the leaves from one year-grown plants, tricyclene (7.21%), ${\beta}-myrcene$ (7.62%), limonene (10.23%), ${\beta}-thujene$ (15.61%) and dihydroedulan I (6.12%) in the leaves from three years-grown plants, ${\delta}-3-carene$ (4.96%), limonene (5.93%), ${\beta}-phellandrene$ (17.31%) and naphthalene (7.79%) in the stems from one year-grown plants, ${\alpha}-pinene$ (5.21%), limonene (5.12%) and ${\beta}-phellandrene$ (9.82%) in the stems from three years-grown plants, ${\alpha}-pinene$ (12.73%), ${\beta}-pinene$ (11.16%), ${\delta}-3-carene$ (6.16%) and ${\gamma}-cadinene$ (23.39%) in the roots from one year-grown plants, and ${\alpha}-pinene$ (17.25%), ${\beta}-pinene$ (9.35%), ${\delta}-3-carene$ (7.26%) and ${\gamma}-cadinene$ (17.95%) in the roots from three years-grown plants.

• The Plant Pathology Journal
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• v.23 no.4
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• pp.281-286
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• 2007

Interactions between viral proteins and host proteins are essential for virus replication. Especially, translation of viral genes completely depends on the host machinery. In potyviruses, interactions of genome-linked viral protein (VPg) with host translation factors including eIF4E, eIF(iso)4E, and poly(A)-binding protein (PABP) has previously been characterized. In this study, we investigated interactions between Soybean mosaic virus (SMV) viral proteins and host translation factors by yeast two-hybrid system. SMV VPg interacted with eIF4E, eIF(iso)4E, and PABP in yeast two-hybrid system, while SMV helper component proteinase (HC-pro) interacted with neither of those proteins. The interaction between SMV NIb and PABP was also detected. These results are consistent with those reported previously in other potyviruses. Interestingly, we found reproducible and specific interactions between SMV coat protein (CP) and PABP. Deletion analysis showed that the region of CP comprising amino acids 116 to 206 and the region of PABP comprising amino acids 520 to 580 are involved in CP/PABP interactions. Soybean library screening with SMV NIb by yeast two-hybrid assay also identified several soybean proteins including chlorophyll a/b binding preprotein, photo-system I-N subunit, ribulose 1,5-biphosphate carboxylase, ST-LSI protein, translation initiation factor 1, TIR-NBS type R protein, RNA binding protein, ubiquitin, and LRR protein kinase. Altogether, these results suggest that potyviral replicase may comprise a multi-protein complex with PABP, CP, and other host factors.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2018.06a
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• pp.126-126
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• 2018

최근 차세대 디스플레이인 flexible 하고 transparent 한 디스플레이 개발이 진행 중 이며, 이러한 디스플레이가 개발 되기 위해 백 플레인으로 사용되는 Thin Film Transistor (TFT) 또한 차세대 디스플레이 못지 않게 연구가 진행 되고 있다. 기존의 무기물을 기반으로 하고 Rigid한 TFT는 현재 많은 곳에 적용이 되어 사람들이 사용 하고 있다. 하지만 이미 시장은 포화상태이며 차세대 디스플레이 컨셉인 flexible 하고 투명한 것과 맞지 않는다. 그래서 유연하며 투명한 특성을 가진 TFT에 대한 연구가 활발히 진행 되고 있으며 많은 성과를 이루었다. 이러한 소자를 이용하여 훗날 Electronic-skin(e-skin)이라 부르는 전자 피부를 활용하여 실시간 모니터링 할 수 있는 헬스 케어 분야 등에 활용 가치 또한 높다. 현재 유연하며 투명한 기판 및 물질 개발에 많은 연구 개발이 진행 되고 있다. 하지만 유연한 기판을 사용하여 TFT를 제작한 후 stress나 bending에 대한 내구성과 안정성, 신뢰성 등이 무기물을 기반으로 한 TFT에 비해 좋지 않은 실정이다. 따라서 유연하며 투명한 기판을 사용한 TFT에 대한 안정성, 신뢰성 등을 확보하여야 한다. 본 연구 에서는 유연한 기판을 사용하여 TFT를 제작 한 후, TFT특성과 안정성을 확보하는 것을 목표로 실험을 진행하였다. 우리는 Mo전극과 Parylene 기판을 사용하여 유연한 TFT소자를 탑 게이트 구조로 제작 하였고 Rigid한 Glass기판 위에 Floating Process를 진행하기 위해 PVA층을 코팅 후 그 위에 Parylene을 CVD로 증착 하고 IGZO를 Sputter를 사용해 증착했다. Parylene은 DI Water 70도에서 Floating 공정을 통해 Rigid 기판에서 탈착 시켰다. 유연한 기판 위에 TFT를 제작 후 bending에 대한 특성 변화 및 안정성에 대한 측정을 실시하였다. Bending에 대한 특성 변화는 우수한 결과가 나왔지만 안정성 측정 중 Negative Bias Stress(NBS) 상에서 비정상적인 On Current Drop 현상이 발생 되었다. Parylene과 Channel층 사이 interface roughness로 인해 charge trap이 되고 이로 인해 On Current Drop 이라는 현상으로 나타났다. 그래서 우리는 Parylene 기판과 Channel 층간의 surface roughness를 개선하기 위한 방법으로 UV Treatment를 사용하였고 시간을 다르게 하여 surface 개선을 진행했다. Treatment 시간을 증가 시킴에 따라 Surface roughness가 많이 좋아 졌으며, Surface를 개선하고자 비정상적인 On Current Drop 현상이 없어졌으며 위 실험으로 Polymer의 surface roughness에 따라 TFT에 대한 안정성에 대한 신뢰성이 확보 될 수 있는 것을 확인 하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.11
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• pp.5301-5323
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• 2017

Small cell deployment offers a low-cost solution for the boosted traffic demand in heterogeneous cellular networks (HCNs). Besides improved spatial spectrum efficiency and energy efficiency, future HCNs are also featured with the trend of network architecture convergence and feasibility for flexible mobile applications. To achieve these goals, dual connectivity (DC) is playing a more and more important role to support control/user-plane splitting, which enables maintaining fixed control channel connections for reliability. In this paper, we develop a tractable framework for the downlink SINR analysis of DC assisted HCN. Based on stochastic geometry model, the data-control joint coverage probabilities under multi-frequency and single-frequency tiering are derived, which involve quick integrals and admit simple closed-forms in special cases. Monte Carlo simulations confirm the accuracy of the expressions. It is observed that the increase in mobility robustness of DC is at the price of control channel SINR degradation. This degradation severely worsens the joint coverage performance under single-frequency tiering, proving multi-frequency tiering a more feasible networking scheme to utilize the advantage of DC effectively. Moreover, the joint coverage probability can be maximized by adjusting the density ratio of small cell and macro cell eNBs under multi-frequency tiering, though changing cell association bias has little impact on the level of the maximal coverage performance.

• Journal of Korea Society of Industrial Information Systems
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• v.16 no.2
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• pp.171-190
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• 2011

As competition has deepened between business institutions, it has been difficult to predict and respond quickly to business environment. Most business firms have started to introduce Enterprise Resource Planning (ERP) in order to improve their business environment. However, it increases the probability of failure to implement the systems without considering the structural characterisitcs of the organizations. The paper studies what influence the characteristic variables of organizational structure and management system have on the performance of the ERP systems of small and medium-sized enterprises. Also, since it is important to compare the level of information system of Korea and China in the midst of the rapid growth of Chinese economy, the paper&nbs p;compares the ERP performance of Chinese and Korean small and medium sized enterprises that implemented ERP system.

• 한국균학회소식:학술대회논문집
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• 2015.11a
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• pp.26-26
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• 2015

Phytophthora infestans is the causal agent of potato and tomato late blight, one of the most devastating plant diseases. P. infestans secretes effector proteins that are both modulators and targets of host plant immunity. Among these are the so-called RXLR effectors that function inside plant cells and are characterized by a conserved motif following the N-terminal signal peptide. In contrast, the effector activity is encoded by the C terminal region that follows the RXLR domain. Recently, I performed in planta functional profiling of different RXLR effector alleles. These genes were amplified from a variety of P. infestans isolates and cloned into a Potato virus X (PVX) vector for transient in planta expression. I assayed for R-gene specific induction of hypersensitive cell death. The findings included the discovery of new effector with avirulence activity towards the Solanum bulbocastanum Rpi-blb2 resistance gene. The Rpi-blb2 encodes a protein with a putative CC-NBS-LRR (a coiled-coil-nucleotide binding site and leucine-rich repeat) motif that confers Phytophthora late blight disease resistance. We examined the components required for Rpi-blb2-mediated resistance to P. infestans in Nicotiana benthamiana. Virus-induced gene silencing was used to repress candidate genes in N. benthamiana and to assay against P. infestans infections. NbSGT1 was required for disease resistance to P. infestans and hypersensitive responses (HRs) triggered by co-expression of AVRblb2 and Rpi-blb2 in N. benthamiana. RAR1 and HSP90 did not affect disease resistance or HRs in Rpi-blb2-transgenic plants. To elucidate the role of salicylic acid (SA) in Rpi-blb2-mediated resistance, we analyzed the response of NahG-transgenic plants following P. infestans infection. The increased susceptibility of Rpi-blb2-transgenic plants in the NahG background correlated with reduced SA and SA glucoside levels. Furthermore, Rpi-blb2-mediated HR cell death was associated with $H_2O_2$, but not SA, accumulation. SA affects basal defense and Rpi-blb2-mediated resistance against P. infestans. These findings provide evidence about the roles of SGT1 and SA signaling in Rpi-blb2-mediated resistance against P. infestans.

• Proceedings of the SAREK Conference
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• 2008.06a
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• pp.748-753
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• 2008

In modern buildings, the air-tightness and insulation for energy saving resulted in degradation of Indoor Air Quality(IAQ). It has brought out new diseases such as New Building Syndrome(NBS) and Sick Building Syndrome(SBS) to the tenants of such buildings. As a result, researches on the Dynamic Breathing Building(DBB) are being undertaken to minimize energy loss as well as to improve IAQ. DBB is a state-of-the-art technology to build channels inside the wall so that air migrates between indoor and outdoor, which improves insulation performance and IAQ. This study attempts to evaluate the improvement of DBB employed in real buildings. As analyzing tools, IAQ improvement and particle degradation while were evaluated while the required indoor ventilation rate was satisfied. DBB were installed in the twin test cells at Korea Institute of Energy Research(KIER). From the test, IAQ was compared with outdoor air base on the concentration of particle matter(PM10). As a results, the concentration of particle dust (PM10) within the breathing walls was reduced by 80% at 0.7 ACH, 67% at 2 ACH, 63% at 3 ACH respectively. As ACH is higher, Dnamic Isulation(DI) and normal wall permit more PM10 particles being infiltrated.