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A neonate with Joubert syndrome presenting with symptoms of Horner syndrome

  • Lee, Narae;Nam, Sang-Ook;Kim, Young Mi;Lee, Yun-Jin
    • Clinical and Experimental Pediatrics
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    • v.59 no.sup1
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    • pp.32-36
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    • 2016
  • Joubert syndrome (JS) is characterized by the "molar tooth sign" (MTS) with cerebellar vermis agenesis, episodic hyperpnea, abnormal eye movements, and hypotonia. Ocular and oculomotor abnormalities have been observed; however, Horner syndrome (HS) has not been documented in children with JS. We present the case of a 2-month-old boy having ocular abnormalities with bilateral nystagmus, left-dominant bilateral ptosis, and unilateral miosis and enophthalmos of the left eye, which were compatible with HS. Brain magnetic resonance imaging (MRI) revealed the presence of the MTS. Neck MRI showed no definite lesion or mass around the cervical sympathetic chain. His global development was delayed. He underwent ophthalmologic surgery, and showed some improvement in his ptosis. To the best of our knowledge, the association of HS with JS has not yet been described. We suggest that early neuroimaging should be considered for neonates or young infants with diverse eye abnormalities to evaluate the underlying etiology.

The Effectiveness of Lumbar Cerebrospinal Fluid Drainage to Reduce the Cerebral Vasospasm after Surgical Clipping for Aneurysmal Subarachnoid Hemorrhage

  • Park, Soojeong;Yang, Narae;Seo, Euikyo
    • Journal of Korean Neurosurgical Society
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    • v.57 no.3
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    • pp.167-173
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    • 2015
  • Objective : Removal of blood from subarachnoid space with a lumbar drainage (LD) may decrease development of cerebral vasospasm. We evaluated the effectiveness of a LD for a clinical vasospasm and outcomes after clipping of aneurysmal subarachnoid hemorrhage (SAH). Methods : Between July 2008 and July 2013, 234 patients were included in this study. The LD group consisted of 126 patients, 108 patients in the non LD group. We investigated outcomes as follow : 1) clinical vasospasm, 2) angioplasty, 3) cerebral infarction, 4) Glasgow outcome scale (GOS) score at discharge, 5) GOS score at 6-month follow-up, and 6) mortality. Results : Clinical vasospasm occurred in 19% of the LD group and 42% of the non LD group (p<0.001). Angioplasty was performed in 17% of the LD group and 38% of the non LD group (p=0.001). Cerebral infarctions were detected in 29% and 54% of each group respectively (p<0.001). The proportion of GOS score 5 at 6 month follow-up in the LD group was 69%, and it was 58% in the non LD group (p=0.001). Mortality rate showed 5% and 10% in each group respectively. But, there was no difference in shunt between the two groups. Conclusion : LD after aneurysmal SAH shows marked reduction of clinical vasospasm and need for angioplasty. With this technique we have shown favorable GOS score at 6 month follow-up.

Congenital Internal Hernia Presented with Life Threatening Extensive Small Bowel Strangulation

  • Lee, Narae;Kim, Su-Gon;Lee, Yeoun Joo;Park, Jae-Hong;Son, Seung-Kook;Kim, Soo-Hong;Hwang, Jae-Yeon
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.16 no.3
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    • pp.190-194
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    • 2013
  • Internal hernia (IH) is a rare cause of small bowel obstruction occurs when there is protrusion of an internal organ into a retroperitoneal fossa or a foramen in the abdominal cavity. IH can be presented with acute or chronic abdominal symptom and discovered by accident in operation field. However, various kinds of imaging modalities often do not provide the assistance to diagnose IH preoperatively, but computed tomography (CT) scan has a high diagnostic accuracy. We report a case of congenital IH in a 6-year-old boy who experienced life threatening shock. CT scan showed large amount of ascites, bowel wall thickening with poor or absent enhancement of the strangulated bowel segment. Surgical exploration was performed immediately and had to undergo over two meters excision of strangulated small bowel. To prevent the delay in the diagnosis of IH, we should early use of the CT scan and take urgent operation.

Isolation of Genes Specifically Expressed in Different Developmental Stages of Pleurotus ostreatus Using Macroarray Analysis

  • Lee, Seung-Ho;Joh, Joong-Ho;Lee, Jin-Sung;Lim, Jong-Hyun;Kim, Kyung-Yun;Yoo, Young-Bok;Lee, Chang-Soo;Kim, Beom-Gi
    • Mycobiology
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    • v.37 no.3
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    • pp.230-237
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    • 2009
  • The oyster mushroom (Pleurotus ostreatus) is one of the most important edible mushrooms worldwide. The mechanism of P. ostreatus fruiting body development has been of interest both for the basic understanding of the phenotypic change of the mycelium-fruiting body and to improve breeding of the mushrooms. Based on our previous publication of P. ostreatus expressed sequence tag database, 1,528 unigene clones were used in macroarray analysis of mycelium, fruiting body and basidiospore developmental stages of P. ostreatus. Gene expression profile databases generated by evaluating expression levels showed that 33, 10, and 94 genes were abundantly expressed in mycelium, fruiting body and basidiospore developmental stages, respectively. Among them, the genes specifically expressed in the fruiting body stage were further analyzed by reverse transcription-polymerase chain reaction and Northern blot to investigate temporal and spatial expression patterns. These results provide useful information for future studies of edible mushroom development.

Functional significance of rSK2 N-terminal region revealed by electrophysiology and Preliminary Structural Studies

  • Narae Shin;Kang, Gil-boo;Eom, Soo-Hyun;Park, Chul-Seung
    • Proceedings of the Korean Biophysical Society Conference
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    • 2003.06a
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    • pp.41-41
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    • 2003
  • Small conductance calcium-activated potassium channels (or SKCa channels) are potassium selective, voltage-independent, and activated by intracellular calcium concentration. These channels play important roles in excitable cells such as neuron in the central nervous system (Vergara et al., 1998). The activity of SKCa channels underlies the slow afterhyperpolarization that inhibits neuronal cell firing (Hille, 1991; Vergara et al.,1998). Until now, N-terminal region of rSK2 isn't characterized. To study the role of N-terminus, we constructed the N-terminal deletion mutant and characterized by electrophysiological means. Interestingly, N-terminal deletion mutant be trafficked to membrane couldn't evoke any ionic currents. Thus, N-terminal region has a role in functional rSK2 channel formation. To elucidate the function of N-terminal region, (His)6-conjugated protein was purified and filtrated by affinity column chromatography. Surprisingly, N-terminal region was shown in tetramer size that was supported by cross-linking result. Thus, we predicted that N-terminal region might be involved in the tetramerization of rSK2.

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New records of ferns in the flora of Laos (1) (라오스 미기록 양치식물 (1))

  • Hwang, In Chun;Moon, Myung-Ok;Bounphanmy, Somchanh;Yoon, Narae;Sun, Byung-Yun
    • Korean Journal of Plant Taxonomy
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    • v.45 no.2
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    • pp.109-113
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    • 2015
  • Fieldwork in Lao PDR during 2007-2008 resulted in the discovery of 15 unrecorded fern species among the flora of Lao PDR. All have been identified in other countries in southeastern Asia, as well as from other tropical areas. The species are as follows: Asplenicaceae (Asplenium delavayi, A. rockier), Athyriaceae (Anisocampium cuspidatum), Dennstaedtiaceae (Microlepia hookeriana, Pteridium revolutum), Dryopteridaceae (Didymochlaena truncatula, Dryopteris cochleata, Polystichum biaristatum, P. lindsaefolium), Gleicheniaceae (Dicranopteris curranii), Hypodematiaceae (Hypodematium crenatum), Lindsaeaceae (Lindsaea heterophylla), Pteridaceae (Pteris decrescens), Polypodiaceae (Pyrrosia nummularifolia) and Thelypteridaceae (Cyclosorus dentatus).

A Mechanism of IPP's(Coal Fired) Optimal Power Generation According to Introduction of RPS(Renewable Portfolio Standard) (RPS제도 도입에 따른 민간 석탄 발전소의 최적 발전량 결정 메커니즘 연구)

  • Ha, Sun-Woo;Lee, Sang-Joong
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.65 no.7
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    • pp.1135-1143
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    • 2016
  • A private company's 1,000 MW coal-fired power plant will be the first coal-fired power plant that was included in the 5th 'Basic Plan on Electricity Demand and Supply' (2010). Now it is facing the task to abide by the RPS(Renewable Portfolio Standard) policy after commercial operation. If they fail to supply the necessary REC (Renewable Energy Certificate) mandated by the RPS policy, they are subject to be fined by the government and forced to modify the cost function to reflect the burden. Eventually the company's coal-fired power plant will be forced to reduce generation to maximize profit because the amount of electricity generated by the power plant and the REC obligation is positively correlated. This paper analyzed the change of cost function of private coal-fired power plant according to the introduction of RPS policy from the viewpoint of private company, and finally proposed the optimal generation to maximize the profit of private coal-fired power plant under the current RPS policy.

Identification of Fungi Isolated from Cheongdo-Banshi (flat persimmon) Stored in a Refrigerator (냉장 저장 중인 청도반시에 발생한 곰팡이의 동정)

  • Bang, Narae;Ha, Sango;Kim, Dae-Ho;Kim, Seon-Hwa;Hong, Seung-Beom
    • The Korean Journal of Mycology
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    • v.42 no.4
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    • pp.276-281
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    • 2014
  • Nine strains of fungi which showed different colonies were isolated from Cheongdo-Banshi (flat persimmon) stored in a refrigerator. Based on morphological and molecular characteristics, they were identified as Botrytis cinerea (n=4), Penicillium expansum (n=2), and Rhizopus delemar (n=1). Of these, B. cinerea and P. expansum occurred frequently but R. delemar occurred rarely. This report of P. expansum and R. delemar on persimmon is the first time in Korea.

The herd-level prevalence of antibodies against Mycobacterium avium subspecies paratuberculosis in the Gyeonggi and Chungbuk of Korea, as detected by bulk tank milk ELISA

  • Jang, Yunho;Lee, Haet-Nim;Kim, Narae;Ok, Yu Sin;Kim, Tae-woon;Jung, Suk Chan;Kim, Jae-Myung
    • Korean Journal of Veterinary Service
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    • v.39 no.4
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    • pp.227-230
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    • 2016
  • Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease (JD) in ruminants. This is the first large scale report to estimate the herd-level prevalence of antibodies against MAP by using an ELISA to detect antibodies in bulk tank milk (BTM) samples. The samples were collected from January 2011 to November 2011, from 636 herds of the dairy farms in the Gyeonggi and Chungbuk areas of Korea. The overall apparent prevalence of MAP antibody-positive herds was 8.5%, and regional prevalence were 32/440 (7.3%) and 22/196 (11.2%) of dairy farms in the Gyeonggi and Chungbuk areas, respectively. The results did not differ significantly by region. While we have determined the prevalence rate of MAP in the Gyenoggi and Chungbuk areas in this study, there is a continuing need for well-designed studies to calculate the prevalence of MAP in dairy herds based on culture and molecular findings.

A Study on Decision making Method of Hydrological Survey Based on Meteorological data (기상자료 기반(Weather-Based)의 수문조사 의사결정 방안 연구)

  • Kang, Narae;Choi, Jaemyeong;Noh, Huiseong
    • Proceedings of the Korea Water Resources Association Conference
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    • 2019.05a
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    • pp.269-269
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    • 2019
  • 첨단장비 및 기술의 도입으로 수문조사 측정기술 수준은 일정수준에 도달하였으나, 여전히 수문조사 시 많은 인력과 시간이 요구되고 있다. 수문조사 업무 규모와 범위에 비해 현재 수문조사에 투입되는 인력은 지극히 제한적이기 때문에 측정기술 자체보다는 운영 인프라 및 환경적 개선이 필요하다고 할 수 있다. 또한 유량 측정시 정확한 첨두유량 발생시각을 포착하기 어려울 뿐만아니라, 때로는 위험이 수반되기 때문에 업무의 비효율성 및 관측 자료의 정확도가 저하되는 문제가 발생하고 있다. 본 연구에서는 비교적 높은 시간 정확도를 가지는 레이더 자료와 예측자료를 이용하여 실시간(또는 시간단위)으로 제공되는 기상정보(호우 예상지점, 도달시간 등)를 활용하여 현 조사원의 위치, 조사원의 구역 내에서 측정 우선 지점(주요 예보 지점), 측정 지점까지의 이동시간 등을 고려하여 유량 측정 순서, 최적 경로를 탐색하고자 한다. 실시간(또는 시간단위) 기상상황과 이에 따른 조사원의 이동 순서, 경로를 디지털화하여 표출(시스템, 모바일 App. 등)하여 제공함으로써 조사수행 인력의 이동을 최소화하고 효율적인 수문조사를 위한 정보 제공할 수 있을 것으로 사료되며 또한 관리자 입장에서 표출시스템의 정보를 통해 실시간 현장 정보 파악함으로써 가변하는 기상상황과 현장의 환경적 변화 사이에서 유연한 대처 및 유동적인 지원을 가능케 할 수 있을 것으로 판단된다.

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