• Title/Summary/Keyword: N.D.C method

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The Crystal and Molecular Structures of Sulfametrole

  • Koo Chung Hoe;Chung Yong Je;Shin Hyun So;Suh Jung Sun
    • Bulletin of the Korean Chemical Society
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    • v.3 no.1
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    • pp.9-13
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    • 1982
  • Sulfametrole, $C_9H_{10}N_4O_3S_2$, crystallizes in the monoclinic system, space group $P2_1/n$ , with a = 8.145(2), b = 16.505(4), c = 9.637(1)${\AA},{\beta}=103.72(1)^{\circ},D_m=1.52gcm^{-3}$,Z=4.Intensities for 3594(2143 observed) unique reflections were measured on a four-circle diffractometer with Mo $K{\alpha}$ radiation $({\lambda}=0.71069{\AA})$. The structure was solved by direct method and refined by full-matrix least squares to a final R of 0.070. The geometrical features of the thiadiazole ring indicate some ${pi}$-electron delocalization inside the ring. The least squares planes defined by the benzene and thiadiazole rings are nearly perpendicular to each other(dihedral angle; $93.9^{\circ}$ ). All the potential hydrogen-bond donor atoms in the molecule, N(1) and N(2), are included in the hydrogen bonding. The molecules through hydrogen bonding form three dimensional network.

Expert Supervisory Control for Robustness of D.C. Servo Motor Control (직류 서보 전동기 제어의 강인성을 위한 전문가 관리 제어)

  • Oh, Hun;Park, Wal-Seo
    • The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.9 no.6
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    • pp.78-82
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    • 1995
  • It is needed to robust control for D.C. servo motor according to industrial automation. However, when a motor has an effect of disturbance and variable load, it is very difficult to guarantee the robustness of the system. as a compensation way of solving this problem, in this paper, a expert supervisory control method for motor control system is presented. Expert supervisory controller is designed by error and error change, and nth control input is decided by the addition of (n-1)th control input and inference amount of increase or decrease. Control input of expert supervisory control is transmitted to input, and the disturbance effect decrease remarkable by control input. The robustness of D.C. servo motor using expert supervisory control is demonstrated by the computer simulation.

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Glucosamine Hydrochloride and N-Acetylglucosamine Influence the Response of Bovine Chondrocytes to TGF-β3 and IGF in Monolayer and Three-Dimensional Tissue Culture

  • Pizzolatti, Andre Luiz A.;Gaudig, Florian;Seitz, Daniel;Roesler, Carlos R.M.;Salmoria, Gean Vitor
    • Tissue Engineering and Regenerative Medicine
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    • v.15 no.6
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    • pp.781-791
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    • 2018
  • BACKGROUND: Glucosamine hydrochloride (GlcN HCl) has been shown to inhibit cell growth and matrix synthesis, but not with N-acetyl-glucosamine (GlcNAc) supplementation. This effect might be related to an inhibition of critical growth factors (GF), or to a different metabolization of the two glucosamine derivatives. The aim of the present study was to evaluate the synergy between GlcN HCl, GlcNAc, and GF on proliferation and cartilage matrix synthesis. METHOD: Bovine chondrocytes were cultivated in monolayers for 48 h and in three-dimensional (3D) chitosan scaffolds for 30 days in perfusion bioreactors. Serum-free (SF) medium was supplemented with either growth factors (GF) $TGF-{\beta}$ ($5ng\;mL^{-1}$) and IGF-I ($10ng\;mL^{-1}$), GlcN HCl or GlcNAc at 1mM each or both. Six groups were compared according to medium supplementation: (a) SF control; (b) SF + GlcN HCl; (c) SF + GlcNAc; (d) SF + GF; (e) SF + GF + GlcN HCl; and (f) SF + GF + GlcNAc. Cell proliferation, proteoglycan, collagen I (COL1), and collagen II (COL2) synthesis were evaluated. RESULTS: The two glucosamines showed opposite effects in monolayer culture: GlcN HCl significantly reduced proliferation and GlcNAc significantly augmented cellular metabolism. In the 30 days 3D culture, the GlcN HCl added to GF stimulated cell proliferation more than when compared to GF only, but the proteoglycan synthesis was smaller than GF. However, GlcNAc added to GF improved the cell proliferation and proteoglycan synthesis more than when compared to GF and GF/GlcN HCl. The synthesis of COL1 and COL2 was observed in all groups containing GF. CONCLUSION: GlcN HCl and GlcNAc increased cell growth and stimulated COL2 synthesis in long-time 3D culture. However, only GlcNAc added to GF improved proteoglycan synthesis.

A multimodal adaptive evolution of the N1 method for assessment and design of r.c. framed structures

  • Lenza, Pietro;Ghersi, Aurelio;Marino, Edoardo M.;Pellecchia, Marcello
    • Earthquakes and Structures
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    • v.12 no.3
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    • pp.271-284
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    • 2017
  • This paper presents a multimodal adaptive nonlinear static method of analysis that, differently from the nonlinear static methods suggested in seismic codes, does not require the definition of the equivalent Single-Degree-Of-Freedom (SDOF) system to evaluate the seismic response of structures. First, the proposed method is formulated for the assessment of r.c. plane frames and then it is extended to 3D framed structures. Furthermore, the proposed nonlinear static approach is re-elaborated as a displacement-based design method that does not require the use of the behaviour factor and takes into account explicitly the plastic deformation capacity of the structure. Numerical applications to r.c. plane frames and to a 3D framed structure with inplan irregularity are carried out to illustrate the attractive features as well as the limitations of the proposed method. Furthermore, the numerical applications evidence the uncertainty about the suitability of the displacement demand prediction obtained by the nonlinear static methods commonly adopted.

Decomposition of leaf litter of some evergreen broadleaf trees in Korea

  • Lee, Kyung Eui;Cha, Sangsub;Lee, Sang Hoon;Shim, Jae Kuk
    • Journal of Ecology and Environment
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    • v.38 no.4
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    • pp.517-528
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    • 2015
  • Litter decomposition is an important process in terrestrial ecosystem. However, studies on decomposition are rare, especially in evergreen broadleaf trees. We collected the leaf litter of five evergreen broadleaf trees (Daphniphyllum macropodum, Dendropanax morbifera, Castanopsis cuspidata var. thunbergii, Machilus thunbergii and Quercus acuta), and carried out a decomposition experiment using the litterbag method in Ju-do, Wando-gun, Korea for 731 days from December 25, 2011 to December 25, 2013. Among the five experimental tree species, C. cuspidata var. thunbergii distribution was limited in Jeju Island, and D. macropodum was distributed at the highest latitude at Mt. Baekyang (N 35°40′). About 2% of the initial litter mass of D. macropodum and D. morbifera remained, while 20.9% remained for C. cuspidata var. thunbergii, 30.4% for M. thunbergii, and 31.6% for Q. acuta. D. macropodum litter decayed four times faster (k = 2.02 yr-1) than the litter of Q. acuta (k = 0.58 yr-1). The decomposition of litter was positively influenced by thermal climate such as accumulated mean daily air temperature (year day index) and precipitation, as well as by physical characteristics such as thickness (R2=0.939, P = 0.007) and specific leaf area (SLA) (R2 = 0.964, P = 0.003). The characteristics of chemical composition such as lignin (R2 = 0.939, P = 0.007) and water-soluble materials (R2 = 0.898, P = 0.014) showed significant correlations with litter decomposition. However, the nutrients in litter showed complicated species-specific trends. The litter of D. macropodum and D. morbifera had fast decomposition despite their low nitrogen concentration and high C/N ratio. This means that the litter decomposition was more strongly affected by physical characteristics than chemical composition and nutrient content. On the other hand, the litter of Q. acuta which had the slowest decay rate had a high amount of N and low C/N ratio. Thus, the decomposition of Q. acuta litter was more affected by the P content of the litter than the N content, although all litter had similar physical characteristics.

A study on the fabrication of PI thin films by VDP method (증착중합법에 의한 폴리이미드 박막의 작성에 관한 연구)

  • Kim, H.G.;Han, S.O.;Kim, J.S.;Park, K.H.;Jin, K.S.;Lee, D.C.
    • Proceedings of the KIEE Conference
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    • 1994.07b
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    • pp.1394-1396
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    • 1994
  • Polyimide thin films were fabricated an using vapor deposition polymerization apportus, and their FT-IR and TGA characteristics were investigated. The peaks of $720cm^{-1}$ and $1380cm^{-1}$ show C=O stretch mode and C-N stretch mode, and that of the cured polyimide at $350^{\circ}C$ were sturated. $T_d$(Depolymerization temperature) was showed at $405^{\circ}C$ from research of thermal resistivity characteristics by TGA It was possible to fabrication of polyimide thin film by VDPM.

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A Study on the Effect of the Compaction Density on the Stability of Earth Dam (흙댐의 다짐밀도가 안정도에 미치는 영향에 관한 연구)

  • 윤충섭;김시원
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.31 no.1
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    • pp.82-95
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    • 1989
  • This study was carried out for the stability analysis of earth dam by the variation of compaction density. The test samples were taken from five kinds of soil used for banking material and the degree of compaction for this samples were chosen 100, 95, 90, 85, and 80 percent. The stability problems were analysed by the settlement and camber( extra banking) of dam, strength parameter and dam slope, and coefficient of permeability and seapage flow through dam body. The results of the stability analysis of earth dam are as follows. 1. The more the fine particle increases and lower the compaction degree becomes, the lower the preconsolidation load becomes but the compression index becomes higher. 2. Sixty to eighty percent of settlement of dam occurs during the construction period and the settlement ratio after completion of dam is inversly proportional to the degree of compaction. 3. The camber of dam has heigher value in condition that it has more fine particle(N) and heigher dam height(H) with the relation of H= e(aN-bH-e). 4. The cohesion(C) decreases in proportion to compaction degree(D) and fine particle(N) with the relation of C= aD+ bN-c, but the internal friction angle is almost constant regardless of change of degree of compaction. 5. In fine soil, strength parameter from triaxial compression test is smaller than that from direct shear test but, they are almost same in coarse soil regardless of the test method. 6. The safety factor of the dam slope generally decreases in proportion to cohesion and degree of compaction but, in case of coarse soil, it is less related to the degree of compaction and is mainly afected by internal friction angle. 7. Soil permeability(K) decreases by the increases of the degree of compaction and fine particle with relation of K=e(a-bl)-cN) 8. The more compaction thickness is, the less vertical permeability (Kv) is but the more h6rzontal permeability (KH) is, and ratio of Kv versus KH is largest in range from 85 to 90 percent of degree of corn paction. 9. With the compaction more than 85 percent and coefficient of permeability less than ${\alpha}$X 10-$^3$cm/sec, the earth dam is generally safe from the piping action.

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Anti-influenza Compounds Isolated from Descurainia sophia Seeds

  • Woo Seung Yang;Choong Je Ma
    • Natural Product Sciences
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    • v.29 no.2
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    • pp.113-119
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    • 2023
  • Descurainia sophia seeds methanol extract showed significant anti-influenza activity and we tried to isolate anti-influenza compounds from the D. sophia extract. D. sophia seeds were extracted with 80% methanol and fractionated with n-hexane, ethyl acetate, CHCl3 and n-butanol. The anti-influenza activity of each fraction was assessed using sulforhodamine B (SRB) method in A549 cells, human-derived lung cancer cells. The ethyl acetate and CHCl3 fractions showed the most potent anti-influenza activity. Seven compounds were isolated from CHCl3 fraction and identified 1-decanol (1), 2-(3,4-dihydroxy-2-methylenebutoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (2), daucosterol (3), isorhamnetin (4), quercetin (5), sinapic acid (6), and helveticoside (7) by spectroscopic data such as UV, IR, 1H-NMR, 13C-NMR and mass spectroscopy. Anti-influenza activities of isolated compounds were evaluated using SRB method in A549 cells. Compounds 3, 4 and 7 had significant anti-influenza activity in a dose-dependent manner.