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Immune-Enhancing Effect of Nanometric Lactobacillus plantarum nF1 (nLp-nF1) in a Mouse Model of Cyclophosphamide-Induced Immunosuppression

  • Choi, Dae-Woon;Jung, Sun Young;Kang, Jisu;Nam, Young-Do;Lim, Seong-Il;Kim, Ki Tae;Shin, Hee Soon
    • Journal of Microbiology and Biotechnology
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    • v.28 no.2
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    • pp.218-226
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    • 2018
  • Nanometric Lactobacillus plantarum nF1 (nLp-nF1) is a biogenics consisting of dead L. plantarum cells pretreated with heat and a nanodispersion process. In this study, we investigated the immune-enhancing effects of nLp-nF1 in vivo and in vitro. To evaluate the immunostimulatory effects of nLp-nF1, mice immunosuppressed by cyclophosphamide (CPP) treatment were administered with nLp-nF1. As expected, CPP restricted the immune response of mice, whereas oral administration of nLp-nF1 significantly increased the total IgG in the serum, and cytokine production (interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-${\alpha}$)) in bone marrow cells. Furthermore, nLp-nF1 enhanced the production of splenic cytokines such as IL-12, TNF-${\alpha}$, and interferon gamma (IFN-${\gamma}$). In vitro, nLp-nF1 stimulated the immune response by enhancing the production of cytokines such as IL-12, TNF-${\alpha}$, and IFN-${\gamma}$. Moreover, nLp-nF1 given a food additive enhanced the immune responses when combined with various food materials in vitro. These results suggest that nLp-nF1 could be used to strengthen the immune system and recover normal immunity in people with a weak immune system, such as children, the elderly, and patients.

The Properties of GaN Grown by BVPE Method on the Si(111) Substrate with Pre-deposited Al Layer (Al 박막이 증착 된 Si(111) 기판 위에 HVPE 방법으로 성장한 GaN의 특성)

  • Shin Dae Hyun;Baek Shin Young;Lee Chang Min;Yi Sam Nyung;Kang Nam Lyong;Park Seoung Hwan
    • Journal of the Korean Vacuum Society
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    • v.14 no.4
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    • pp.201-206
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    • 2005
  • In this work, we tried to improve the fabrication process in HVPE (Hydride Vapor Phase Epitaxy) system by using Si(111) substrate with pre-deposited Al layer. PL measurements was done for samples with and without pre-deposited Al on Si and it was also examined the dependence of the optical characteristic properties on AlN buffer thickness for GaN/AIN/Al/Si. A sample with thin Al nucleation layer on Si substrate reveals a better optical property than the other. And it suggests that the thickness for AlN buffer layer with thin Al nucleation layer on Si(111) substrate is most proper about $260{\AA}$ to grow GaN in HVPE system. The surface morphology of GaN clearly shows the hexagonal crystallization. The XRD pattern showed strong peak at GaN{0001} direction.

Effect of irradiation on the oxidation kinetics of TODGA-based extraction mixtures at atmospheric pressure

  • Skvortsov, I.V.;Belova, E.V.;Yudintsev, S.V.
    • Nuclear Engineering and Technology
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    • v.52 no.9
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    • pp.2034-2040
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    • 2020
  • The gas evolution from mixtures consisting of 0.2 M solution of N,N,N',N'-tetra-n-octyldiglycolamide (TODGA) in n-alcohol (n-decanol or n-nonanol) with Isopar-M diluent was investigated during thermal oxidation. The effect of ionizing radiation on their thermal stability has been studied. It has been determined that the volume of gaseous thermolysis products increases by 260% in the case of n-nonanol and 80% in the case of n-decanol compared to non-irradiated solutions. It has been shown that the gas evolution rate and gas volume increase when the irradiated mixture saturated with nitric acid is heated. However, there are no prerequisites for the development of autocatalytic oxidation.

Effect of Sesbania Incorporation as Nitrogen Source on Growth and Yield of Whole Crop Barley and Reduction of N Fertilizer in Saemangeum Reclaimed Tidal Land

  • Lee, Su-Hwan;Bae, Hui-Su;Oh, Yang-Yeol;Lee, Sang-Hun;Kim, Yeong-Joo;Kim, Sun;Ryu, Jin-Hee;Jung, Kang-Ho;Lee, Choong-Geun;Kim, Jae-Hyeon;Kim, Yeong-Doo;Choi, Weon-Young;Cho, Jae-Yeong;Lee, Kyoung-Bo;Lee, Keon-Hui;Park, Ki-Do
    • Korean Journal of Soil Science and Fertilizer
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    • v.49 no.6
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    • pp.751-759
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    • 2016
  • It is known that the poor soil fertility of newly reclaimed saline soils is due to the lack of organic matter and available mineral nutrients for crop production. The effect of green manuring with Sesbania aculeata in combination with five rates of urea-N treatments (N0. N25, N50, N75, N100) on the productivity of a subsequent whole-crop barley and the fertility of the reclaimed saline soil in Saemangeum was evaluated in the field during 2013-2014 growing season. Sesbania was grown during summer season (June to October). The amount of Sesbania incorporated was $16.2Mg\;ha^{-1}$. Sesbania contributed to $393kg\;N\;ha^{-1}$ to the soils when ploughed down and incorporated before whole-crop barley cultivated. The performances of whole-crop barley following sesbania incorporation were significantly affected by a combination of Sesbania manuring and different N rates. The N fertilizer equivalence without N fertilizer following Sesbania was 42.6% ($63.9kg\;N\;ha^{-1}$), compared with N100 ($150kg\;N\;ha^{-1}$) in fallow soils. The whole-crop barley yield responded to N fertilizer rates in both sesbania-amended and fallow soil. The yield response to nitrogen rates in fallow soil was linear (Y=0.0586X+3.3011, $R^2=0.9534$), whereas that in sesbania-amended soils was quadratic (Y= -0.001X2+0.1322X+5.7143, $R^2=0.9576$). The yield of whole-crop barley in sesbania-amended with increasing N rates was increased up to SN75 (115 kgN) $10.3Mg\;ha^{-1}$. Apparent N recovery (ANR) of whole-crop barely showed decreased with sesbania plus increasing rates of N fertilizer. Despite higher yield with sesbania manuring plus increasing N rates, the contributions of N from Sesbania with increasing N rates to whole-crop barley were decreased, whereas those from fertilizer increment due to excessively mineralized Nitrogen. Considering yield, ANR, N contribution from Sesbania and nitrogen fertilizer, the optimum N rate was N50 rate following sesbania incorporation.

Double Layer Anti-reflection Coating for Crystalline Si Solar Cell (결정질 실리콘 태양전지를 위한 이층 반사방지막 구조)

  • Park, Je Jun;Jeong, Myeong Sang;Kim, Jin Kuk;Lee, Hi-Deok;Kang, Min Gu;Song, Hee-eun
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.26 no.1
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    • pp.73-79
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    • 2013
  • Crystalline silicon solar cells with $SiN_x/SiN_x$ and $SiN_x/SiO_x$ double layer anti-reflection coatings(ARC) were studied in this paper. Optimizing passivation effect and optical properties of $SiN_x$ and $SiO_x$ layer deposited by PECVD was performed prior to double layer application. When the refractive index (n) of silicon nitride was varied in range of 1.9~2.3, silicon wafer deposited with silicon nitride layer of 80 nm thickness and n= 2.2 showed the effective lifetime of $1,370{\mu}m$. Silicon nitride with n= 1.9 had the smallest extinction coefficient among these conditions. Silicon oxide layer with 110 nm thickness and n= 1.46 showed the extinction coefficient spectrum near to zero in the 300~1,100 nm region, similar to silicon nitride with n= 1.9. Thus silicon nitride with n= 1.9 and silicon oxide with n= 1.46 would be proper as the upper ARC layer with low extinction coefficient, and silicon nitride with n=2.2 as the lower layer with good passivation effect. As a result, the double layer AR coated silicon wafer showed lower surface reflection and so more light absorption, compared with $SiN_x$ single layer. With the completed solar cell with $SiN_x/SiN_x$ of n= 2.2/1.9 and $SiN_x/SiO_x$ of n= 2.2/1.46, the electrical characteristics was improved as ${\Delta}V_{oc}$= 3.7 mV, ${\Delta}_{sc}=0.11mA/cm^2$ and ${\Delta}V_{oc}$=5.2 mV, ${\Delta}J_{sc}=0.23mA/cm^2$, respectively. It led to the efficiency improvement as 0.1% and 0.23%.

Course and Distribution of Facial Nerve of the Korean Native Goat (한국재래산양 두부의 안면신경 분포에 관한 해부학적 연구)

  • Lee, Heung-shik;Lee, In-se;Kim, Dae-joong
    • Korean Journal of Veterinary Research
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    • v.26 no.1
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    • pp.1-9
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    • 1986
  • This study was carried out to investigate the branch and distribution of Nervus facialis of the Korean native goat. The observation was made by dissection of embalmed cadavers of ten Korean native goats. The results were as follows; 1. N. facialis arose from the ventrolateral surface of the medulla oblongata. 2. In the facial canal, N. facialis gave off N. petrosus major, N. stapedius and Chorda tympani. 1) N. petrosus major arose from Ganglion geniculi, passed through the pterygoid canal and terminated in Ganglion pterygopalatinum. 2) Chorda tympani joined N. lingualis at the lateral surface of the internal pterygoid muscle. 3. At the exit of the stylomastoid foramen, N. facialis gave off N. caudalis auricularis, Ramus auricularis internus, Ramus stylohyoideus and Ramus digastricus. 1) N. caudalis auricularis arose by two branches in 6 cases and by a single branch in 4 cases. N. caudalis auricularis gave off branches to the caudoauricuIar muscles and the internal surface of the conchal cavity. 2) Ramus auricularis internus arose by a single branch except in 2 cases in which it arose in common with N. caudalis auricularis. It penetrated the caudolateral surface of the tragus and distributed in the skin of the scapha. 3) Ramus stylohyoideus and Ramus digastricus arose separately from N. facialis. 4. In the deep surface of the parotid gland, N. facialis divided into N. auriculopalpebralis, Ramus buccalis dorsalis and Ramus buccalis ventralis. In 6 cases, N. facialis gave off Ramus buccalis ventralis and then divided into N. auriculopalpebralis and Ramus buccalis dorsalis. In 3 cases, N. facialis trifurcated into Ramus buccalis ventralis, Ramus buccalis dorsalis and N. auriculopalpebralis. In one case, N. facialis gave off N. auriculopalpebralis and then divided into Ramus buccalis dorsalis and Ramus buccalis ventralis. 1) Ramus buccalis ventralis ran along the ventral border of the masseter muscle and distributed to the buccinator and depressor labii inferioris muscles. Ramus buccalis ventralis communicated with a branch of Ramus buccalis dorsalis and N. buccalis. In 2 cases, it also communicated with N. mylohyoideus. 2) Ramus buccalis dorsalis communicated with Ramus transverses faciei, N. buccalis, N. infraorbitalis and a branch of Ramus buccalis ventralis. Ramus buccalis dorsalis distributed to the orbicularis oris, caninus, depressor labii inferioris, levator labii superioris, buccinator, malaris, nasolabialis and zygomaticus muscles. 3) N. auriculopalpebralis gave off Rami auriculares rostrales, which supplied the zygomaticoauricularis muscle, the frontoscutularis muscle and the skin of the base of the ear. N. auriculopalpebralis then continued as Ramus zygomaticus, which innervated the frontal muscle, the lateral surface of the base of the horn, the orbicularis oculi muscle and the adjacent skin of the orbit. N. auriculopalpebralis communicated with Nn. auriculares rostrales and Ramus zygomaticotemporalis. In 7 cases, it also communicated with N. infratrochlearis.

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Estimation of Soybean N Fraction Derived from N Sources by $^{15}N$ in Soybean Cultivation with Rye as Green Manure (호밀녹비 이용 시 중질소($^{15}N$)를 이용한 질소원 유래별 콩의 집적질소 분획추정)

  • Seo, Jong-Ho;Lee, Seong-Hee;Cho, Young-Son;Lee, Jae-Eun;Lee, Chung-Keun;Kwon, Young-Up
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.53 no.1
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    • pp.50-57
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    • 2008
  • Winter season cultivation of rye as green manure for soybean have been a favorite with farmer because it could remove a risk of injury by continuous cropping and increase N uptake and yield of soybean. Effects of rye green manure on soybean N uptake, $N_2$ fixation and yield were investigated with $^{15}N$ as pot experiment in greenhouse in 2004 and field in 2005, respectively. The N derived from N fertilizer ($^{15}N$) in rye green manure increased with increasing of N fertilizer rate compared to N derived from soil. N uptake and DM yield of soybean at the pot with paddy soil was higher than those at the pot with upland soil mainly due to the increase of N uptake from paddy soil. Total $^{15}N$ recovery in soil was higher at rye green manure than no green manure because $^{15}N$ applied to rye plant was remained highly as soil organic N compared to chemical N fertilizer. $^{15}N$ recovery in soybean plant increased in proportion to amounts of N fertilizer applied to rye. The N fractions from $N_2$ fixation of soybean plant at the pot experiment in 2004 ranged from 92% to 95%, on the other hand those in field experiment in 2005 ranged from 82% to 84%. Estimation of amount of $N_2$ fixation was not different between Difference method and $^{15}N$ method in 2004 and 2005.

ON THE DIFFERENCE EQUATION $x_{n+1}\;=\;{\alpha}\;+\;{\frac {x^p_n}{x^p_{n-1}}}$

  • Aloqeili, Marwan
    • Journal of applied mathematics & informatics
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    • v.25 no.1_2
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    • pp.375-382
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    • 2007
  • We Study, firstly, the dynamics of the difference equation $x_{n+1}\;=\;{\alpha}\;+\;{\frac{x^p_n}{x^p_{n-1}}}$, with $p\;{\in}\;(0,\;1)\;and\;{\alpha}\;{\in}\;[0,\;{\infty})$. Then, we generalize our results to the (k + 1)th order difference equation $x_{n+1}\;=\;{\alpha}\;+\;{\frac{x^p_n}{nx^p_{n-k}}$, $k\;=\;2,\;3,\;{\cdots}$ with positive initial conditions.

OSCILLATION CRITERIA FOR SECOND-ORDER NONLINEAR DIFFERENCE EQUATIONS WITH 'SUMMATION SMALL' COEFFICIENT

  • KANG, GUOLIAN
    • Bulletin of the Korean Mathematical Society
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    • v.42 no.2
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    • pp.245-256
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    • 2005
  • We consider the second-order nonlinear difference equation (1) $$\Delta(a_nh(x_{n+1}){\Delta}x_n)+p_{n+1}f(x_{n+1})=0,\;n{\geq}n_0$$ where ${a_n},\;{p_n}$ are sequences of integers with $a_n\;>\;0,\;\{P_n\}$ is a real sequence without any restriction on its sign. hand fare real-valued functions. We obtain some necessary conditions for (1) existing nonoscillatory solutions and sufficient conditions for (1) being oscillatory.

Reaction of Ru(tpy)$Cl_3$ with N,N,C-Terdentates, 3,2'-Annulated-6-(2"-pyridyl)-2-phenylpyridines

  • 장영동;박재규
    • Bulletin of the Korean Chemical Society
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    • v.20 no.10
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    • pp.1200-1204
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    • 1999
  • The reactions of Ru(tpy)Cl3 (tpy = 2,2';6',2"-terpyridine) with new N,N,C-terdentate ligands, 3,2'-annulated-6-(2"-pyridyl)-2-phenylpyridines (1, HL) and the properties of their Ru(II) complexes are described. The distribution ratio of the two possible Ru(II) complexes, a pentaaza-coordinated complex [Ru(tpy)(1-N,N')Cl]+ and a cycloruthenated complex [Ru(tpy)(La-N,N',C)]+ are highly dependent on the length of the polymethylene unit. The trimethylene bridge of the N,N,C-terdentate in pentaaza-coordinated complex is rigid enough to induce an asymmetry in the complex.