• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7575-7581
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• 2015

Corticotropin-releasing factor(CRF), one of the stress driven neuropeptides, was widely proposed to influence hair loss and re-growth. For the development of receptor antagonists, the screening system based on intracellular calcium signal process was developed and optimized. The aequorin parental cells were transfected with CRF1 receptor and alpha 16 promiscuous G protein cDNA to establish HEK293a16/hCRF1, a stable cell line for the human CRF1 receptor. In HEK293a16/hCRF1 cells, the range of sauvagine dose response was 12-fold higher($EC_{50}:15.21{\pm}1.83nM$) than in the transiently expressed cells, hence essential conditions for the antagonist screening experiments such as the robust signals and high solvent tolerance were secured. The standard antagonists for the CRF1 receptor, antalarmin and CP154526, resulted $IC_{50}$ values of $414.1{\pm}5.5$ and $290.7{\pm}1.9nM$, respectively. Similar results were presented with frozen HEK293a16/hCRF1 cells. Finally, our HEK293a16/hCRF1 cells with the aequorin based cellular functional assay can be a model system for the development of functional cosmetics and modulators that can have a clinical efficacy on hair re-growth.

• Journal of the Korea institute for structural maintenance and inspection
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• v.26 no.1
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• pp.49-57
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• 2022

In order to efficiently analysis the stability of a slope, measuring the shear strength of soil is needed. The Standard Penetration Test (SPT) is not appropriate for a slope inspection due to cost and weights. One of the ways to effectively measure the N-value is the Dynamic Cone Penetration Test (DCPT). This study was performed to develop a minimized multi-function sensors that can easily estimate CPT values and Volumetric Water Content. N value with multi-fuction sensor DCPT showed -2.5 ~ +3.9% error compared with the SPT N value (reference value) in the field tests. Also, the developed multi-fuction sensor system was tested the correlation between the CPT test and the portable tester with indoor test. The test result showed 0.85 R2 value in soil, 0.83 in weathered soil, and 0.98 in mixed soil. As a result of the field test, the multi-function sensor shows the excellent field applicability of the proposed sensor system. After further research, it is expected that the portable multi-function sensor will be useful for general slope inspection.

• Journal of Animal Environmental Science
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• v.11 no.3
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• pp.153-160
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• 2005

This study was conducted to determine the effect of floor type of finishing building and increasing market weight of finishing Pigs on Performance, carcass traits and pork quality. Four hundred and forty-four finishing pigs were confined and administered with different floor type(concrete slat and bedded with sawdust) and increasing market weight(110kg to 130kg) of finishing building. The result obtained from this study were summarized as follows; 1. There was no significant difference between the floor type of finishing building in the body weight gain, feed intake and gain per feed. And also increasing market weight of finishing pigs was not affected the performance of finishing pigs. 2. Increasing market weight of finishing pigs affect the carcass yield. The market weight at 130kg showed more amount of each cut of carcass, especially the belly portion was higher, but backfat thickness was not different. 3. Carcass traits did not show any significant difference due to the difference of market weight of finishing pig and floor type of finishing building. 4. There was no significant difference in the chemical compositions and meat color of pork loin between the floor type of finishing building and increasing market weight of finishing pigs.

• Journal of the korean academy of Pediatric Dentistry
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• v.31 no.4
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• pp.685-695
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• 2004

The aim of this study was to evaluate the resistance to degradation and to compare the wear resistance characteristics of four composite resins in an alkaline solution. The resistance to degradation was evaluated on the basis of mass loss(%), degradation depth(${\mu}m$), Si loss(ppm) and wear depth. The brands studied were Heliomolar flow, Filtek supreme, Point4, Tetric flow. The results were as follows: 1. The sequence of the mass loss was in descending order by Heliomolar flow, Filtek supreme, Point4, Tetric flow. There was significant differences among the materials except Heliomolar flow and Filtek supreme. 2. The sequence of the degree of degradation layer depth was in descending order by Filtek supreme, Heliomolar flow, Tetric flow, Point4. There were significant differences among the materials except Heliomolar flow and Tetric flow. 3. The sequence of Si loss was in descending order by Filtek supreme, Heliomolar flow, Point4, Tetric flow. There were significant differences among the materials except Point 4 and Tetric flow. 4. The sequence of maximum wear depth was in descending order by Heliomolar flow, Point4, Fillet supreme, Tetric flow and there was increasing wear depth on soaking in 0.1N NaOH solution. 5. When observed with SEM, destruction of bonding between matrix and filler was observed and when observed with CLSM, the depth of degradation layer of specimen surface was observed. There results indicate that wear and hydrolytic degradation could be considered to be evaluation factors of composite resins.

• Journal of the Korean GEO-environmental Society
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• v.13 no.1
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• pp.53-61
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• 2012

In this study, the research on MC anchor has been developed as composite type has done. MC anchor exerts bearing pressure on pre-bored hole where the end fixing device is expanded. Therefore, the uplift capacity is to be increased and it has the characteristics that the anchor body is not eliminated from the ground even if the grouting is not carried out properly. Furthermore, it reduces the loss of tension and raises the construction availability by inserting the reinforced bar as well as the anchor cable, while it can improve the long-term stability because the nail is expected to play the role when the loss of the anchor cable is occurred in a long-term. However, because the resistance mechanism of the compound anchor such as MC anchor is different from friction anchor, the estimation method of the uplift capacity by the frictional force of the ground and the grout is not proper. Particularly, in domestic cases, the problem to overestimate or underestimate the uplift capacity is expected because the design method considering the soil characteristics about the compound anchor has not been developed. Therefore, in this study, in order to evaluate the characteristics of MC anchor and a kind of compound anchor, we measured the uplift, the tension and the creep by nine anchors tests in shale ground that the fluctuation of the strength is great. In addition, we analyzed the test result comparing to the result of the general friction anchor and evaluated the characteristics of MC anchor movement to gather the results. As a result of the test, we found the effect that the uplift capacity is increased in shale ground comparing to the general friction anchor.

• Journal of the Korean GEO-environmental Society
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• v.13 no.1
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• pp.21-29
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• 2012

Ground failure by liquefaction can occur not only during shaking but also as the result of the post-liquefaction process after an earthquake. During the process of ground deformation and failure, excess pore water pressure in soil is redistributed, which can then lead to changes in the effective stress of soils. Therefore, in order to provide a further understanding of the phenomenon, we have to estimate the properties of effective stress during the recompression process in post-liquefaction as well, not only the total amount of pore water drained. The primary objectives of this study are to determine and compare the recompression properties in the post-liquefaction process in terms of the relationship between volumetric strains and mean effective stresses under the various conditions of relative density and shear stress history. In all experimental cases, the volumetric strains increase greatly in the low effective stress level, almost to the zero zone, and granite soil, which has fine grains, undergoes gradual changes in the relationship between volumetric strains and mean effective stresses compared with fine sand. And, we can also find that recompression properties in the post-liquefaction process by cyclic loading depend highly on the dissipation energy and maximum shear strain, and this fact can be obtained in all cases regardless of the existence of fine content, relative density, and loading history. Especially, granite soil having fine grains can be defined uniformly in the relationship between dissipation energy and maximum volumetric strain, while fine sand cannot be so uniformly defined.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.4
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• pp.369-374
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• 2015

In this paper, an EM sensing based prestressing force estimation method is proposed, in which it can estimate tensile force of PS tendon for PSC girder. The PSC girder has more improved performance than the general concrete girder by introducing the prestressing to the concrete. Thus the PSC girder bridge is widely constructed due to its high performance and low cost. However, the prestressing force has not been managed nevertheless it is major factor for the maintenance of the PSC girder bridge. The prestressing force was just measured during construction using jacking device and after that, it can not be managed. For this reason, this paper proposes a tensile force estimation method of PS tendon based on EM sensor. The permeability of ferroelectric material is changed according to the induced stress to the material, in which it can be measured using EM sensor. To measure the permeability of PS tendon, the EM sensor was fabricated and verified by performing the MTS test. The test was performed using 7-wire steel tendon under the 0, 40, 80, 120, 160, 200 KN of tensile force. The permeability of PS tendon was gradually decreased according to the increasement of tensile force. The regression method was used to find the relation between permeability and stress. As a result, the permeability has linear relation with the tensile force of PS tendon and the pre-stressing force can be estimated by the derived estimation equation.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.3
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• pp.530-539
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• 2003

The aim of this study was to evaluate the resistance to degradation of four commercial composite resins in an alkaline solution. The brands studied were Charisma, Filtek P 60, Palpique Estelite, and Spectrum. Preweighed discs of each brand were exposed to 0.1N NaOH solution at $60^{\circ}C$. After 2 weeks they were removed, neutralized with HCl, washed with water and dried. Resistance to degradation was evaluated on the basis of following parameters: (a) mass loss(%) - determined from pre-and post-exposed specimen weights; (b) Si loss(ppm) - obtained from ICP-AE analysis of solution exposed to specimens; and (c) degradation depth(${\mu}m$) - measured SEM and CLSM from polished circular sections of exposed specimens. The results were as follows: 1. The sequence of mass loss was in descending order by Palpique Estelite, Filtek P 60, Charisma, and Spectrum. 2. The sequence of the degree of degradation layer depth was in descending order by Filtek P 60, Charisma, Palpique Estelita, and Spectrum. 3. The sequence of the Si loss was in descending order by Chrisma, Spectrum, Palpique Estelite, and Filtek P 60. 4. The correlation coefficient between mass loss and degradation layer depth was relatively high(r=0.704, p<0.05). 5. When observed with SEM, destruction of bonding was observed between resin matrix and filler. 6. When observed with CLSM, degradation layer depth of composite resin surface was observed.

• Journal of the Korean Ceramic Society
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• v.41 no.8
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• pp.618-622
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• 2004

Excitation spectra of the 1.6 rm emission originating from $Ho^{3＋}$：$^{5}$ I$_{5}$ \longrightarrow$^{5}$ I$_{7}$ transition in fluoride, sulfide, and selenide glasses were measured at wavelengths around 900nm where the fluorescing $^{5}$ I$_{5}$ level is located. In specific energy range where the frequency upconversion populating $^{5}$ F$_{1}$ state happens, the excitation efficiency of the 1.6 fm emission was deteriorated in fluoride and sulfide hosts. In selenide however spectral line shapes of the excitation spectrum and the '$^{5}$ I$_{8}$ \longrightarrow$^{5}$ I$_{5}$ absorption spectrum looked seemingly identical to each other. Differences in optical nonlinearity as well as electronic band gap energy of the host glasses used are responsible for the experimental observations. On the other hand, codoping of rare earths such as Tb$^{3+}$, Dy$^{3+}$, Eu$^{3+}$, and Nd$^{3+}$ was effective in decreasint the terminating $^{5}$ I$_{7}$ level lifetime. However, at the same time, some of the codopants increased unnecessary absorption at the 1.6 $\mu$m wavelengths via their ground state absorption. Though the lifetime quenching effect of Eu$^{3+}$ was moderate, it exhibited no additional extrinsic absorption at the 1.6 $\mu$m band.EX>m band.

• Journal of Sensor Science and Technology
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• v.11 no.4
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• pp.209-217
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• 2002

The developing of buried fiber optic sensor with high sensitivity and broad-area detecting intruders is carried out using fiber optic ROTDR(Rayleigh Optical Time Domain Reflectometry). The sensing part was designed to be able to broad-area detect intrusion effect per optical fiber length under ground. The bending light losses in optical fibers are investigated by commercial mini ROTDR with wavelength $1.55{\mu}m$, distance range 5km, pulse width 20ns, SNR=5.7. The sensing fibers are selected as the common telecommunication fibers are the 1.5mm, 3.5 mm outer diameter, 4km each length fiber products. Experiments were investigate the characteristics of signal sensitivity according to applied intrusion weight. The relation between the applied weight and the bending loss was almost linear, and broad-area detect intrusion effects are the 2m resolution and $1.3m^2$ per optical fiber length respectively. The light loss by the applied weight on fiber was 0.17 dB/kg. that the sensitivity of the optical fiber sensor was sufficient to detect intruders passing over the buried optical fiber.