• Journal of Korean Neurosurgical Society
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• v.43 no.5
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• pp.237-238
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• 2008

Myoclonus is a rare side effect of gabapentin (GBP) and has been reported in patients with preexisting myoclonus, mental retardation, chronic static encephalopathy, diffuse brain damage, impaired renal function, or end stage renal disease. We report a case of myoclonus in a patient with normal renal function and no previous disorders. A 69-year-old female underwent diskectomy and foraminotomy at the left L4-L5 level. Post-operatively, she complained of paresthesia in her left leg, which was thought to be due to root manipulation during surgery. To relieve the paresthesia, she was given tramadol, an oral opioid agonist, and GBP. One week after GBP was increased to 900 mg per day, myoclonus developed, which severely impaired her normal activity. Her symptoms resolved 2 days after discontinuation of GBP. The coadministration of tramadol and GBP may mutually enhance the myoclonic potential of each drug. The causal relationship between GBP and myoclonus was suggested by cessation of myoclonus after GBP discontinuation despite continued therapy with tramadol.

• Annals of Clinical Neurophysiology
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• v.7 no.1
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• pp.20-21
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• 2005

Myoclonus may originate from the cerebral cortex, subcortical structures, brainstem, spinal cord or peripheral nerve. But unilateral upper limb myoclonus related to cortical infarct is an unusual clinical picture. We report a 67-year-old man presented with myoclonus, associated with primary motor cortex infarction.

• Journal of The Korean Society of Clinical Toxicology
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• v.4 no.2
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• pp.155-157
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• 2006

Myoclonus is manifested in a variety of situations including metabolic derangements, brain lesions, epilepsy, and drugs toxicity. We reported a rare case of amitriptyline-induced myoclonus. A 64-year-old man with a tension-type headache was administered amitriptyline at 15 mg/day. Eight days after initiation of amitriptyline, multifocal myoclonus developed, involving the face and upper extremities. Two hours after the administration of clonazepam at 1 mg, myoclonus resolved completely.

• Annals of Clinical Neurophysiology
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• v.19 no.1
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• pp.71-73
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• 2017

The spinal segmental myoclonus by viral radiculitis has been rarely reported and the pathophysiology remains to be elucidated. However, the hyperactivity of contiguous anterior horn neurons induced by viral irritation has been suggested to be a possible patho-mechanism. In general, spinal segmental myoclonus is not well-controlled by medication and the patient suffers from continuous involuntary movement. We recently experienced a case of spinal segmental myoclonus induced by herpes zoster radiculitis, and which was successfully relieved by epidural injections.

• Journal of Yeungnam Medical Science
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• v.35 no.2
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• pp.240-243
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• 2018

Negative myoclonus (NM) is a jerky, shock-like involuntary movement caused by a sudden, brief interruption of muscle contraction. An 80-year-old man presented with multifocal NM and confusion. Two days before the onset of NM, he commenced the intake of pregabalin at a dose of 150 mg/day for neuropathic pain. His NM resolved completely and mental status improved gradually after the administration of lorazepam intravenously and the discontinuation of pregabalin. Our study suggests that pregabalin can cause NM even in patients without a history of seizures.

• Annals of Clinical Neurophysiology
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• v.9 no.2
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• pp.85-88
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• 2007

Hashimoto's encephalopathy has been described as a steroid-responsive syndrome of encephalopathy associated with high serum concentration of anti-thyroid antibodies. We report a 67-year-old woman who presented with myoclonus involving both upper extremities. Brain MRI and EEG showed no diagnostic abnormalities. Thyroid functions were normal, but anti-thyroid antibodies were elevated both in serum and in CSF. Hashimoto's encephalopathy can present with myoclonus even without outstanding encephalopathic feature, therefore anti-thyroid antibody test should be included in diagnostic test in patient with myoclonus.

• Journal of Yeungnam Medical Science
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• v.37 no.4
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• pp.329-331
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• 2020

Negative myoclonus (NM) is a shock-like jerky involuntary movement caused by a sudden, brief interruption of tonic muscle contraction. NM is observed in patients diagnosed with epilepsy, metabolic encephalopathy, and drug toxicity and in patients with brain lesions. A 55-year-old man presented with NM in both his arms and neck. He has taken medications containing tramadol at a dose of 80-140 mg/day for 5 days due to common cold. He had no history of seizures. Acute lesions were not observed during magnetic resonance imaging, and abnormal findings in his laboratory tests were not noted. His NM resolved completely after the discontinuation of tramadol and the oral administration of clonazepam. Our case report suggests that tramadol can cause NM in patients without seizure history or metabolic disorders, even within its therapeutic dose.

• The Korean Journal of Pain
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• v.24 no.3
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• pp.169-171
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• 2011

Postherpetic neuralgia is the most frequent complication of herpes zoster. Treatment of this neuropathic pain syndrome is difficult and often disappointing. Although postherpetic neuralgia is generally a self-limited condition, it can last indefinitely. Continuous epidural blockade for patients with acute zoster can shorten the duration of treatment. However, continuous epidural block has some complications such as infection, dural puncture, and total spinal and nerve damages. We report a case of myoclonus during continuous epidural block with ropivacaine, morphine, and ketamine in an acute zoster patient.

• Annals of Clinical Neurophysiology
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• v.19 no.2
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• pp.136-140
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• 2017

A 77-year-old male with amyotrophic lateral sclerosis had a hypoxic event. After resuscitation, generalized myoclonus appeared and resolved after two days. Five days after the hypoxic event, myoclonic seizures re-emerged right after performing a somatosensory evoked potential and persisted for ten days. Electroencephalogram revealed frequent bi-hemispheric synchronous spike and waves in the central areas. We suggest that somatosensory evoked potential testing may trigger myoclonic status epilepticus. Underlying cortical degeneration associated with amyotrophic lateral sclerosis could attribute to this phenomenon.

• Korean Journal of Biological Psychiatry
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• v.8 no.1
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• pp.167-174
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• 2001

A 54-year old male patient who was suffering from bipolar I disorder for 19 years and was admitted to the National Bugok Mental Hospital due to a depressive episode, was referred to the Kosin University Gospel Hospital. On arrival at the emergency room, he had confused mentality with disorientation, memory impairment, hypomania, marked anxiety and hyperirritability. The change of neuromuscular activity such as ataxia, gait disturbance, tremor, shivering, myoclonus and epileptic seizures was also shown. In addition, the symptoms and signs of autonomic instability including diaphoresis, tachycardia, hypotension, fever and facial flushing were noticed. The above symptoms developed after the administration of sertraline successive to the discontinuation of fluoxetine without any washout period. The degree of severity seemed to be severe because he had epileptic seizures, fever and hypotension. He was recovered from the severe serotonin syndrome by the supportive symptomatic treatment with sodium valproate, clonazepam, lorazepam and cyproheptadine after cessation of the selective serotonin reuptake inhibitors during hospitalization. Therefore, this rare case of severe serotonin syndrome was reported and related literatures were also reviewed.