• 턱관절균형의학회지
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• 제1권1호
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• pp.13-18
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• 2011

Objectives: We investigated muscle force from the upper limb lifting resistance test to conform the objectivity in manual muscle test. Methods: We made standard method in upper limb lifting resistance test to compare with experiment method switching the lower limb position left & right. And resistance forces of upper limb of subject were checked to inspector with closing eyes. Results: 1. The lifting resistance of right upper limb was stronger when the lower limb of right and left were abducted. 2. The lifting resistance of right upper limb was weaken when the lower limb of right and left were adducted. 3. The lifting resistance of right upper limb was weaken when the lower limb of right and left were elevated. Conclusions: As the above results, the deltoid muscle force checked in the upper limb lifting resistance test is affected by the location of lower limbs, it suggested that the muscle force of some part in the body will be affected by the other parts. It will be useful to understand the symmetry principle of body in muscle function.

• BMB Reports
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• 제56권8호
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• pp.426-438
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• 2023

Muscle wasting in end-stage renal disease (ESRD) is an escalating issue due to the increasing global prevalence of ESRD and its significant clinical impact, including a close association with elevated mortality risk. The phenomenon of muscle wasting in ESRD, which exceeds the rate of muscle loss observed in the normal aging process, arises from multifactorial processes. This review paper aims to provide a comprehensive understanding of muscle wasting in ESRD, covering its epidemiology, underlying molecular mechanisms, and current and emerging therapeutic interventions. It delves into the assessment techniques for muscle mass and function, before exploring the intricate metabolic and molecular pathways that lead to muscle atrophy in ESRD patients. We further discuss various strategies to mitigate muscle wasting, including nutritional, pharmacological, exercise, and physical modalities intervention. This review seeks to provide a solid foundation for future research in this area, fostering a deeper understanding of muscle wasting in ESRD, and paving the way for the development of novel strategies to improve patient outcomes.

• 생명과학회지
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• 제22권6호
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• pp.713-722
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• 2012

Landrace와 Berkshire의 longissimus dorsi muscle으로부터 단백질 발현양상의 차이를 보기 위하여 2-DE실험을 통하여 분석한 결과 Landrace 에서 특이적으로 발현 양이 증가한 단백질들은 serum albumin precursor, troponin T (TnT; slow skeletal muscle), myoglobin였다. Berkshire에서 특이적으로 발현 양이 증가한 단백질들은 heat shock 27 kDa protein 1, troponin T (fast skeletal muscle), muscle creatine kinase, phosphoglucomutase 1, triosephosphate isomerase (Tpi 1), adenylate kinase isoenzyme 1 (AK1)였다. Landrace의 longissimus dorsi muscle에서는 slow skeletal muscle과 연관된 단백질들이 발현된 반면에 Berkshire에서는 fast skeletal muscle, 물질대사경로, 에너지 생산과 관련된 단백질들이 발현되었다. Berkshire를 이용하여 성장단계별로 단백질 발현을 분석해 본 결과 growing Berkshire에서 발현이 증가한 단백질은 aldehyde dehydrogenase 1 family, member L1 (ALDHL1)와 muscle creatine kinase이고 finishing Berkshire에서 발현이 증가한 단백질은 heat shock 27 kDa protein 1, TnT (slow skeletal muscle), TnT (fast skeletal muscle), serum albumin precursor, PGM 1, AK 1, Tpi 1였다. 이 결과는 Finishing Berkshire의 등심에서는 growing Berkshire에 비교하여 골격근육, 에너지물질대사, 세포골격 등이 보다 활성화된 것으로 사료된다.

• 대한물리의학회지
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• 제8권1호
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• pp.117-125
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• 2013

PURPOSE: The purpose of this study was to investigate the effect of trunk muscle strengthening exercises on balance performance of sitting posture and upper extremity function, targeting the children with spastic diplegic cerebral palsy. METHODS: 20 children with spastic diplegic cerebral palsy were sampled at random and the tests were conducted for 6 weeks, 3 times per week. For experimental groups, basic physical therapy and trunk muscle strengthening exercises were conducted and for control groups, only basic physical therapy was conducted. BPM(Balance Performance Monitor) was used to measure balance performance and QUEST(quality of upper extremity skills test) was used to measure the upper extremity function. RESULTS: The comparison of changes in sitting balance performance in between experimental groups and control groups show significant difference (p<.05), the changes of the upper extremity function in experimental groups and control groups show significant difference (p<.05). CONCLUSION: Trunk muscle strengthening exercises are effective in improving balance performance and the upper extremity function for the children with spastic diplegic cerebral palsy.

• 대한물리치료과학회지
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• 제19권3호
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• pp.1-7
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• 2012

Purpose : The purpose of present study was to investigate pulmonary function among smokers and non-smokers, and effect on respiratory muscle training in smoker. Methods : Twenty participants were allocated into smokers group(n = 10) and non-smokers group(n = 10). Pulmonary function was measured by spirometry(Pony FX, COSMED Inc., Italy). The smoker group was compared pulmonary function before and after respiratory muscle training. Results : The results were as follows; There was significant difference on PEF, FEV1/FVC%, FEF25~75%, MEF75% and MEF50% among smoker and non-smokers(p<.05). But, there was not significantly difference after intervention in smokers. Conclusion : The present study found that smoker decreased pulmonary function than non-smokers.

• 척추신경추나의학회지
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• 제6권1호
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• pp.97-104
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• 2011

Objectives : The purpose of this study is to compare the effect of superficial acupuncture to deep acupuncture on normal muscle function. Methods : In Group A, 12 healthy subjects had been treated by deep acupuncture(10mm). In Group B, 12-healthful subjects had been treated by superficial acupuncture(5mm). Each session took 10 minutes. Before and after the treatment, outcomes were assessed by Algometer for muscle tenderness, dynamometer for grasping power and Meridian-Electromyograph(MEMG) for extensor muscles. Results : The Contraction power of finger extensor muscles assessed by MEMG had decreased significantly in both groups. The muscle fatigue of finger extensor muscles assessed by MEMG had increased significantly in Deep acupuncture group. Grasping power assessed by dynamometer had no significant change in both groups. Conclusions : According to above results, superficial acupuncture is more effective on reducing muscle fatigue.

• PNF and Movement
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• 제8권3호
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• pp.9-16
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• 2010

Purpose : The purpose of this study was to investigate effects of kinesio taping of thigh muscle on isokinetic muscular function during closed kinetic chain exercise of lower extremity. Methods : Twenty healthy males were participated in this study. The isokinetic muscular function of closed kinetic chain were measured for peak torque, peak torque % body weight, average power, max rep tot work before and after application of kinesio taping on thigh muscles. Results : At $60^{\circ}/s$ peak force and peak force % body weight were significant increased in both extension(p<0.01) and flexion(p<0.001) after applying kinesio taping. At $180^{\circ}/s$ average power was significant increased in both extension and flexion after applying taping(p<0.001). At $240^{\circ}/s$ max rep tot work was significant increased in both extension(p<0.001) and flexion(p<0.05). Conclusion : This study suggests that application of kinesio taping on thigh muscle was more effective to improve isokinetic muscular function in closed kinetic chain exercise of lower extremity.

• 대한전자공학회논문지
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• 제25권3호
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• pp.335-342
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• 1988

In this paper, we proposed a new algorithm for EMG low frequency analysis. Through the power spectrum analysis of Gaussian's, Gamma's and Erlang's PDF(probability density function) based on the proposed algorithm, the proper PDF of IPI (inter pulse interval) representing the firing rate of muscle was suggested. In order to verify the proposed algorithm EMG signals of masseter and biceps muscle were detected by surface electrode and its power spectrum analysis was performed. The experimental results are compared with the computer simulaiton. As a result, the masseter muscle's IPI was fitted by Gamma PDF, having a 10Hz fundamental frequency including n(1+\ulcornerfp high harmnic frequency on 10% MVC(maximum voluntary contaraction). And the biceps muscle's IPI was fitted by Gaussian PDF, also it have a 14Hz fundamental frequency.

• The Korean Journal of Physiology and Pharmacology
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• 제21권6호
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• pp.567-577
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• 2017

Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all associated with mitochondrial dysfunction in skeletal muscle. Mitochondria are dynamic organelles that regulate cellular metabolism and bioenergetics, including ATP production via oxidative phosphorylation. Due to these critical roles of mitochondria, mitochondrial dysfunction results in various diseases such as obesity and type 2 diabetes. Obesity is associated with impairment of mitochondrial function (e.g., decrease in $O_2$ respiration and increase in oxidative stress) in skeletal muscle. The balance between mitochondrial fusion and fission is critical to maintain mitochondrial homeostasis in skeletal muscle. Obesity impairs mitochondrial dynamics, leading to an unbalance between fusion and fission by favorably shifting fission or reducing fusion proteins. Mitophagy is the catabolic process of damaged or unnecessary mitochondria. Obesity reduces mitochondrial biogenesis in skeletal muscle and increases accumulation of dysfunctional cellular organelles, suggesting that mitophagy does not work properly in obesity. Mitochondrial dysfunction and oxidative stress are reported to trigger apoptosis, and mitochondrial apoptosis is induced by obesity in skeletal muscle. It is well known that exercise is the most effective intervention to protect against obesity. Although the cellular and molecular mechanisms by which exercise protects against obesity-induced mitochondrial dysfunction in skeletal muscle are not clearly elucidated, exercise training attenuates mitochondrial dysfunction, allows mitochondria to maintain the balance between mitochondrial dynamics and mitophagy, and reduces apoptotic signaling in obese skeletal muscle.

• Perspectives in Nursing Science
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• 제2권1호
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• pp.19-36
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• 2005

Muscle atrophy is defined as a decrease in muscle mass, cross-sectional area, and myofibrillar protein content. Causes inducing muscle atrophy may be inactivity, denervation, undernutrition and steroid. Inactivity may decrease protein synthesis and increase protein breakdown of skeletal muscle. The muscle atrophy due to inactivity was induced by bed rest, hindlimb suspension, cast, total hip replacement arthroplasty, anterior cruciate ligament reconstruction. Denervated atrophy may be induced by the loss of innervation from lower motor neuron. The atrophy was apparent in the lower limb of hemiplegic patients following ischemic stroke and in the hindlimb of ischemic stroke rats. Protein breakdown of skeletal muscle in the undernourished state results in muscle atrophy. The atrophy due to undernutrition was evident in cancer and leukemia patients and in the undernourished rats. Steroids have been used to treat allergies, inflammatory diseases, autoimmune diseases and to inhibit immune function following transplantation. Steroids may induce muscle atrophy by protein breakdown of skeletal muscle. Muscle Physiology Laboratoryat College of Nursing, Seoul National University proved that dexamethasone may induce hindlimb muscle atrophy in rats and exercise and DHEA may attenuate hindlimb muscle atrophy induced by the steroid in rats. Nurses working with patients undergoing steroid treatment need to be cognizant of steroid induced muscle atrophy. They need to assess whether muscle atrophy is being occurred during and after the steroid treatment. Moreover, they need to apply exercise and DHEA to the patients undergoing steroid treatment in order to attenuate the steroid induced muscle atrophy.