• KSCE Journal of Civil and Environmental Engineering Research
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• v.40 no.5
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• pp.521-526
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• 2020

Airfield pavements, such as runways and taxiways, are essential for smooth take-off and landing of fixed-wing aircraft and are the most important installation for the military to carry out air operations during wartime. Therefore, in wartime, it is necessary to reduce the damage to these installations and repair them in the shortest possible time. Recently, the pattern of attack is changing from the use of conventional high explosive which is to create large craters to the use of multiple warheads weapon system which is to effectively attack enemy's airfields but unrelated to accuracy. Hence in this study, through identifying the specification and composition of multiple warheads weapon system, we checked the protection performance and damage patterns of the pavement when explosion occurred on the installed military runway and taxiway by the multiple warheads weapon system. And The multiple warheads weapon systems is able to cause extensive damage but the destructive power of each warhead is not as great, so I would like to propose an airfield pavement design plan for minimal protection against such attacks.

• Bulletin of the Korean Chemical Society
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• v.35 no.12
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• pp.3571-3575
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• 2014

Proteasome, a multicatalytic protease complex, has been validated as a promising therapeutic target in oncology. Carfilzomib (Kyprolis$^{(R)}$), a tetrapeptide epoxyketone, irreversibly inhibits the chymotrypsin-like (CT-L) activity of the proteasome and has been recently approved for multiple myeloma treatment by FDA. A chemistry effort was initiated to discover the compounds that are reversibly inhibit the proteasome by replacing the epoxyketone moiety of carfilzomib with a variety of ketones as reversible and covalent warheads at the C-terminus. The newly synthesized compounds exhibited significant inhibitory activity against CT-L activity of the human 20S proteasome. When the compounds were tested for cancer cell viability, 14-8 was found to be most potent in inhibiting Molt-4 acute lymphoblastic leukemia cell line with a $GI_{50}$ of $4.4{\mu}M$. Cytotoxic effects of 14-8 were further evaluated by cell cycle analysis and Western blotting, demonstrating activation of apoptotic pathways.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.4
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• pp.43-52
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• 2021

In weapon assignment studies to defend against threats such as ballistic missiles and long range artillery, threat assessment was partially lacking in analysis of various threat attributes, and considering the threat characteristics of warheads, which are difficult to judge in the early flight stages, it is very important to apply more reliable optimal solutions than approximate solution using LP model, Meta heuristics Genetic Algorithm, Tabu search and Particle swarm optimization etc. Our studies suggest Generic Rule based threat evaluation and weapon assignment algorithm in the basis of various attributes of threats. First job of studies analyzes information on Various attributes such as the type of target, Flight trajectory and flight time, range and intercept altitude of the intercept system, etc. Second job of studies propose Rule based threat evaluation and weapon assignment algorithm were applied to obtain a more reliable solution by reflection the importance of the interception system. It analyzes ballistic missiles and long-range artillery was assigned to multiple intercept system by real time threat assessment reflecting various threat information. The results of this study are provided reliable solution for Weapon Assignment problem as well as considered to be applicable to establishing a missile and long range artillery defense system.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.46 no.4
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• pp.218-228
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• 2023

Maintaining sea superiority through successful mission accomplishments of warships is being proved to be an important factor of winning a war, as in the Ukraine-Russia war. in order to ensure the ability of a warship to perform its duties, the survivability of the warship must be strengthened. In particular, among the survivability factors, vulnerability is closely related to a damage assessment, and these vulnerability data are used as basic data to measure the mission capability. The warship's mission capability is usually measured using a wargame model, but only the operational effects of a macroscopic view are measured with a theater level resolution. In order to analyze the effectiveness and efficiency of a weapon system in the context of advanced weapon systems and equipments, a warship's mission capability must be measured at the engagement level resolution. To this end, not the relationship between the displacement tonnage and the weight of warheads applied in the theater level model, but an engagement level resolution vulnerability assessment method that can specify physical and functional damage at the hit position should be applied. This study proposes a method of measuring a warship's mission capability by applying the warship vulnerability assessment method to the naval engagement level analysis model. The result can be used as basic data in developing engagement algorithms for effective and efficient operation tactics to be implemented from a single unit weapon system to multiple warships.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.6
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• pp.761-768
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• 2013

New warheads are designed and developed to be highly lethal when used as part of ballistic missile payloads. There are many trades associated with the design of a central warhead core, mainly dealing with the projectiles or penetrators. Obviously, a payload-type configuration is very susceptible to kills from one projectile because of the high impacts required for bomblet or submunition payloads. Based on these requirements, the optimum kill vehicle configuration will have the smallest mass and relative velocity that will kill all the submunitions. The designs of the penetrator shape and size are directly related to the space and weight of the warhead. The shape, size, L/D, penetrator material, and manner in which they are inserted inside the surrounding explosive segments are critical in achieving successful penetrator design. The AUTODYN-3D code was used to study the effect of penetrator penetration. The objective of numerical analysis was to determine the penetration characteristics of the penetrator produced by hypervelocity impacts under different initial conditions such as initial velocity, shape, and L/D of the penetrator.