• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.347-350
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• 2012

TP53 is the mostly commonly mutated gene in many cancers and the P53 tumor suppressor protein is involved in multiple cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control and apoptosis. A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine. TP53 Arg 72 is more active than TP53 Pro 72 in inducing apoptosis. The aim of this study was to understand the association of the 72 codon polymorphism with acute leukemia development and prognosis. A total of 288 acute leukemia cases comprising 147 acute lymphocytic leukemia (ALL) and 141 acute myeloid leukemia (AML), as well as 245 controls were recruited for analysis of the TP53 72 polymorphism using PCR-RFLP method. Significant association of homozygous arginine genotype with AML was observed (${\chi}^2$- 133.53; df-2, p < 0.001. When data were analyzed with respect to clinical variables, elevation in mean WBC, blast %, LDH levels and slight reduction in DFS in ALL cases with the arginine genotype was observed. In contrast, AML patients with Pro/Pro had elevated WBC, Blast%, LDH levels with slightly reduced DFS. Our study indicates that Arg/Arg genotype might confer increased risk to development of acute myeloid leukemia.

• Research in Community and Public Health Nursing
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• v.21 no.4
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• pp.458-467
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• 2010

Purpose: This study was conducted in order to identify factors related to the health behavior in elementary school children at a late school age and to provide basic data to develop more concrete and practical applications for health promotion and disease prevention. Methods: The participants were 2,775 4th, 5th and 6th graders sampled from 10 elementary schools in Busan Metropolitan City and data were collected from 15th May to 30th June, 2010. The collected data were analyzed by mean, percentile, t-test, ANOVA, Pearson s correlation coefficient, and stepwise multiple regression using the SPSS/WIN 17.0 program. Results: The average percentiles for self-rated health, body satisfaction, stress, parent attachment, self-esteem, and health behavior were 82.8, 69.5, 40.9 79.3, 75.9 and 75.9, respectively. There was significant relationship among the levels of self-rated health, body satisfaction, stress, parent attachment, self-esteem, and health behavior. Body satisfaction was the most powerful factor to the health behavior of elementary school children at a late school age, and was followed by parent attachment, self-rated health, self-esteem, and grade in order. These variables explained 26.6% of the total variance in health behavior. Conclusion: Health promotion behavior programs including body satisfaction and self-esteem elevation programs should be applied to children at home and in school and community. To achieve this, institutional and economic support should be continued.

• Journal of Preventive Medicine and Public Health
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• v.43 no.2
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• pp.125-130
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• 2010

Objectives: The current study was performed to assess the distribution of intraocular pressure (IOP) and its association with metabolic syndrome (MS) in a community. Methods: We measured IOP and MS components from 446 adults, age 20 or more years old, who reside in a community in Kyunggi Province, South Korea. We compared the level of IOP according to the number of metabolic abnormalities and between normal and abnormal metabolic components. Linear regression analyses were used to determine the relationship between IOP and metabolic components. Results: No significant difference in IOP (mean${\pm}$SE) was found between men ($12.24{\pm}2.42$) and women ($12.55{\pm}2.41$ mmHg, p > 0.1), while IOP of men tended to decrease as age increased (p for trend < 0.01). After adjusting for age, IOP of subjects with abdominal obesity in men and high blood pressure in women were significantly higher than those without abdominal obesity or high blood pressure (p < 0.05). Female subjects with MS showed significantly higher IOP than those without MS. Participants with more metabolic disturbances tended to have a greater IOP elevation with a linear trend after adjusting for age and sex. In the univariate regression analysis, age and waist circumference were significantly associated with IOP in men, but systolic and diastolic blood pressure were associated with IOP in women. In final multiple regression model, age, systolic blood pressure, and triglyceride were associated with IOP in women, and age in men. Conclusions: These findings suggest that MS and its components may be important determinants of elevated IOP.

• Journal of the Korean Institute of Landscape Architecture
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• v.35 no.1 s.120
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• pp.79-87
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• 2007

The objective of this study was to delineate forest patches in the cities around the Geum-buk mountains at the north of the Geum River using multiplesatellite remote sensing data. Landsat visible and near-infrared satellite images obtained at multiple dates in the growing season were used to create a forest distribution map. Fragstats 3.3 was used to get the landscape indices delineating the distribution of forest patches. Additional ground truth data was used to assess the accuracy of the classification. Factor analysis was used to get the 26 landscape indices clustered into 4 factors. Factor I was labeled as' size of forest patches', factor II as 'fragmentation of forest patches', factor III as 'shape of forest patches', and factor IV as 'complexity of forest patches'. Factor I described large patches and their core area, while others did small patches and their shape and complexity. Cities including Cheonan, Gongju, Cheongyang, and Boryeong near the main ridge of the Geumbuk Mtns. had a small number of large-sized forest patches. However, cities including Taean, Seosan, Dangjin, Hongseong near the ridge of the western Geumbuk Mtns. had a large number of small-sized forest patches. Finally, this study showed that the region near the coast line in Chung-nam province has various types of forest patches having an irregular forest edge due to the elevation and slope lower than the one of the region far from the coast line which is near the ridge of the Geum-buk Mountains. Remote sensing data were useful to understand the distribution of forest patches, and landscape indices could be keys to delineate the relationship between forest patches. And the factor analysis, which simplified 26 landscape indices into 4 landscape patterns allowed us to understand the distribution and relationship of forest patches in an easy way.

• Journal of Korea Water Resources Association
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• v.53 no.2
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• pp.121-129
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• 2020

The increase of impervious surface and development along the river due to urbanization not only causes an increase in the number of associated flood risk factors but also exacerbates flood damage, leading to difficulties in flood management. Flood control measures should be prioritized based on various geographical information in urban areas. In this study, a probabilistic flood hazard assessment was applied to flood-prone areas near an urban river. Flood hazard maps were alternatively considered and used to describe the expected inundation areas for a given set of predictors such as elevation, slope, runoff curve number, and distance to river. This study proposes a Bayesian logistic regression-based flood risk model that aims to provide a probabilistic risk metric such as population-at-risk (PAR). Finally, the logistic regression model demonstrates the probabilistic flood hazard maps for the entire area.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.26 no.6
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• pp.652-657
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• 2000

The kidneys play a vital role in the maintenance of normal body fluid volumes and in the composition of the extracellular fluid compartments. There are normally more than 2 million functioning glomeruli that regulate total body water and solute concentrations. As renal failure progresses, there is a decrease in the number of functioning nephrons. Chronic renal failure(CRF) is the consequence of a multitude of diseases that cause permanent destruction of the nephron. Azotemia is an elevation in blood urea nitrogen(BUN) and serum creatinine levels subsequent to a decreased glomerular filtration rate(GFR), which results in uremia. This loss of renal function can cause functional and metabolic abnomalities of body. For this problem, oral & maxillofacial surgeons have demanded to routinely treat patients with CRF. However, there has not been a reported case of orthognathic surgery by bilateral sagittal split ramus osteotomy(BSSRO) in patients with CRF, which can cause multiple complications in healthy patients. We report developmental mechanism of complication associated with CRF and preop. and postop. care of orthognathic surgery by BSSRO in Cl III patient with severe chronic renal failure.

• Journal of Korea Water Resources Association
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• v.42 no.7
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• pp.559-569
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• 2009

Due to environmental, economical and the other limitations, it has been more difficult to construct new large hydraulic structure such as dam. For this reason, it has been tried to use small hydraulic structure such as washland as alternative of hydraulic facility. Because the flood control effect of small hydraulic structure are affected by runoff volume, hydrograph, storage capacity and weir crest elevation, and design frequency must be predetermined for the design of the hydraulic structure. Multiple washlands will be required to satisfy enough peak reduction effect so that considering washlands as a network, rather than individually, are critical to analysis of flood reduction effect. In this study, new index for determination of optimal location for washlands is presented and the existing model for this determination is modified by adopting the new index. Developed new model is applied to Ansung river basin for examination and the new model shows its' applicability as a decision making criteria for the determination of optimal location for washlands.

• Journal of Korean Society of Forest Science
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• v.96 no.3
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• pp.251-258
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• 2007

Airborne Lidar (light detection and ranging) can be an effective alternative in forest inventory to overcome the limitations of conventional field survey and aerial photo interpretation. In this study, we attempt to develop methodologies to identify individual trees and to estimate tree height from airborne Lidar data. Initially, digital elevation model (DEM) data representing the exact ground surface were generated by removing non-ground returns from the multiple-return laser point clouds, obtained over the coniferous forest site of rugged terrain. Based on the canopy height model (CHM) data representing non-ground layer, individual tree heights are extracted through pseudo-grid method and moving window filtering algorithm. Comparing with field survey data and aerial photo interpretation on sample plots, the number of trees extracted from Lidar data show over 90% accuracy and tree heights were underestimated within 1.1m in average at two plantation stands of pine (Pinus koraiensis) and larch (Larix leptolepis).

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.32 no.6
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• pp.625-635
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• 2014

Multiple strips are required for large area mapping using ALS (Airborne Laser Scanner) system. LiDAR (Light Detection And Ranging) data collected from the ALS system has discrepancies between strips due to systematic errors of on-board laser scanner and GPS/INS, inaccurate processing of the system calibration as well as boresight misalignments. Such discrepancies deteriorate the overall geometric quality of the end products such as DEM (Digital Elevation Model), building models, and digital maps. Therefore, strip adjustment for minimizing discrepancies between overlapping strips is one of the most essential tasks to create seamless point cloud data. This study implemented area-based matching (ABM) to determine conjugate features for computing 3D transformation parameters. ABM is a well-known method and easily implemented for this purpose. It is obvious that the exact same LiDAR points do not exist in the overlapping strips. Therefore, the term "conjugate point" means that the location of occurring maximum similarity within the overlapping strips. Coordinates of the conjugate locations were determined with sub-pixel accuracy. The major drawbacks of the ABM are sensitive to scale change and rotation. However, there is almost no scale change and the rotation angles are quite small between adjacent strips to apply AMB. Experimental results from this study using both simulated and real datasets demonstrate validity of the proposed scheme.

• Journal of Korea Water Resources Association
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• v.34 no.3
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• pp.241-251
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• 2001

A flow determination algorithm is proposed for the distributed hydrologic model. The advantages of a single flow direction scheme and multiple flow direction schemes are selectively considered to address the drawbacks of existing algorithms. A spatially varied flow apportioning factor is introduced in order to accommodate the accumulated area from upslope cells. The channel initiation threshold area(CIT) concept is expanded and integrated into the spatially distributed flow apportioning algorithm in order to delineate a realistic channel network. An application of a field example suggests that the linearly distributed flow apportioning scheme provides some advantages over existing approaches, such as the relaxation of over-dissipation problems near channel cells, the connectivity feature of river cells, the continuity of saturated areas and the negligence of the optimization of few parameters in existing algorithms. The effects of grid sizes are explored spatially as well as statistically.