• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.28 no.2
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• pp.155-160
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• 2002

Oral squamous cell carcinoma (OSCC), the most common head and neck cancer, shows poor prognosis as a result of frequent local invasion and lymph node metastasis that is mediated by multiple proteolytic enzymes and angiogenesis. In recent reports, angiogenesis is known to play an important role in tumor invasion and metastasis. The purpose of this study was to determine the role of angiogenesis in OSCCs, particularly with respect to the invasive and the metastatic potential. The microvessel density (CD31) in 34 human OSCC cases were investigated by immunohistochemistry, and reviewed with respect to the invasiveness and the presence of lymph node metastasis and following results were obtained. The blood vessel density $(28.8{\pm}7.9)$ in the strong invasive cases were significantly higher than those $(23.3{\pm}6.9)$ in the weak invasive cases. (p<0.05) In the 14 cases with lymph node metastasis, the average blood vessel density was $28.5{\pm}9.6$. On the other hand, in the 20 cases without lymph node metastasis, the blood vessel density was $25.2{\pm}6.4$. The blood vessel density was not statistically related to lymph node metastasis. (p>0.05) These results suggest that angiogenesis may be related to the local invasion of OSCC and further research will be needed to investigate the possibility that antiangiogenic agent can be used as an anticancer agent for OSCC.

• Journal of the Korea Society of Computer and Information
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• v.16 no.7
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• pp.49-58
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• 2011

Augmented Reality(AR) assists human's cognitive ability through the information visualization by substantiating information about virtual situation. This technology is studied in a variety of ways including education, design, industry, and so on, by various supply of information devices equipped with cameras and display monitors. Since the most of the AR system depends on limited interaction that responds to the order from user, it can not reflect diverse real world situation. In this study, we suggest a knowledge based augmented reality system, which is composed of context awareness agent that provides recognized context information, along with knowledge based component that provides intelligent capability by utilizing domain knowledges. With this capability, the augmented object can generate dynamic model intelligently by reflecting context information, and can make the interaction possible among the multiple objects. We developed rule based context awareness system along with 3D model generation, and tested interaction among the augmented objects. And we suggest a framework that can provide a convenient way of developing augmented reality system for user.

• The Journal of Advanced Prosthodontics
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• v.5 no.2
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• pp.104-109
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• 2013

PURPOSE. Among the surface treatment methods suggested to enhance the adhesion of resin cement to fiberreinforced composite posts, conflicting results have been obtained with silanization. In this study, the effects of silanization, heat activation after silanization, on the bond strength between fiber-reinforced composite post and resin cement were determined. MATERIALS AND METHODS. Six groups (n=7) were established to evaluate two types of fiber post (FRC Postec Plus, D.T. Light Post) and three surface treatments (no treatment; air drying; drying at $38^{\circ}C$). Every specimen were bonded with dual-curing resin cement (Variolink N) and stored in distilled water for 24 hours at $37^{\circ}C$. Shear-bond strength (MPa) between the fiber post and the resin cement were measured using universal testing device. The data were analyzed with 1-way ANOVA and by multiple comparisons according to Tukey's HSD (${\alpha}$=0.05). The effect of surface treatment, fiber post type, and the interactions between these two factors were analyzed using 2-way ANOVA and independent sample T-tests. RESULTS. Silanization of the FRC Postec Plus significantly increased bond strength compared with the respective non-treated control, whereas no effect was determined for the D.T. Light Post. Heat drying the silane coupling agent on to the fiberreinforced post did not significantly improve bond strength compared to air-syringe drying. CONCLUSION. The bond strength between the fiber-reinforced post and the resin cement was significantly increased with silanization in regards to the FRC Postec Plus post. Bond strength was not significantly improved by heat activation of the silane coupling agent.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.4
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• pp.411-422
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• 2002

Recently, there have been active researches about the VPCS (Virtual Parallel Computing System) based on multiple agents. The PVCS uses personal computers or workstations that are dispersed all over the internet, rather than a high-cost supercomputer, to solve complex problems that require a huge number of calculations. It can be made up with either homogeneous or heterogeneous computers, depending on resources available on the internet. In this paper, we propose a new method in order to distribute worker agents and work packages efficiently on the VPCS based on the IBM Aglets. The previous methods use mainly the master-slave pattern for distributing worker agents and work packages. However, in these methods the workload increases dramatically at the central master as the number of agents increases. As a solution to this problem, our method appoints worker agents to distribute worker agents and workload packages. The proposed method is evaluated in several ways on the VPCS, and its results are improved to be worthy of close attention as compared with the previous ones.

• The KIPS Transactions:PartB
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• v.11B no.2
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• pp.207-212
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• 2004

This paper presents a reinforcement learning framework for stock trading systems. Trading system parameters are optimized by Q-learning algorithm and neural networks are adopted for value approximation. In this framework, cooperative multiple agents are used to efficiently integrate global trend prediction and local trading strategy for obtaining better trading performance. Agents Communicate With Others Sharing training episodes and learned policies, while keeping the overall scheme of conventional Q-learning. Experimental results on KOSPI 200 show that a trading system based on the proposed framework outperforms the market average and makes appreciable profits. Furthermore, in view of risk management, the system is superior to a system trained by supervised learning.

• The KIPS Transactions:PartC
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• v.9C no.1
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• pp.79-88
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• 2002

Transcoding proxy strategy has been widely used as a means to reduce the delay in retrieving Web pages over wireless mobile data service networks. However, this strategy has the serious drawbacks of being a potential point of failure or a bottleneck of the service. We developed a distributed proxy server system in which multiple proxy servers are installed at geographically dispersed locations and share the workloads among them by serving mobile hosts only within assigned regions. A new handoff message protocol to enable handoffs between proxies as the mobile hosts move between regions is proposed. According to the proxy server handoff protocol, a client agent at the mobile horst requests a proxy server to start handoff processing by which two proxy servers synchronize distilled data belonging to a HTTP session that must be maintained across the handoff. Also, we introduce the architecture of the proxy server and the client agent that handles the proxy server handoff. Finally, we evaluate the proposed system through performance test.

• The Korean Journal of Mycology
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• v.42 no.4
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• pp.333-340
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• 2014

The aim of this study was to isolate a potential multifunctional biocontrol agent from bacteria for control of multiple plant diseases as an alternative to fungicides. A total of 201 strains were isolated from soil undamaged by repeated cultivation in Sunchang and their ability to produce antibiotics, siderophores and extracellular enzymes such as protease, cellulase and amylase was investigated. Selected strain SCS3 produced cellulose, protease and amylase. This strain also produced siderophores and showed excellent antifungal activity against various phytopathogens. SCS3 was identified as Bacillus subtilis using 16S rRNA sequencing, and named Bacillus subtilis SCS3. Finally, physiological and biochemical characteristics of B. subtilis SCS3 were examined. From the results, B. subtilis SCS3 was found to be a useful multifunctional biocontrol agent against various phytopathogens.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.5
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• pp.333-339
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• 2016

In this paper, a fundamental experiment regarding the formation of porous 3D structures for personal safety products using 3D PPP (Porous Polymer Printing) was introduced for the first time. The filament was manufactured by mixing PP (Polypropylene) and CBA (Chemical Blowing Agent) with polymer extruder, and the diameter of the filament was approximately 1.75mm. The proposed 3D PPP method, combined with the conventional FDM (Fused Deposition Modeling) procedure, was influenced by process parameters, such as the nozzle temperature, printing speed and CBA density. In order to verify the best processing conditions, the depositing parameters were experimentally investigated for the porous polymer structure. These results provide parameters under which to form a multiple of 3D porous polymer structures, as well as various other 3D structures, and help to improve the mechanical shock absorption for personal safety products.

• Journal of Korea Society of Industrial Information Systems
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• v.29 no.4
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• pp.67-76
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• 2024

In this study, we address the problem of target detection using multiple agents. Specifically, the detection problem involving mobile agents necessitates additional strategies for path planning. The objective is to maximize the total utility derived from the detection process over a specific period. This detection problem incorporates realistic utility values by considering a stochastic process based on the Poisson process, which accounts for the changing probability of target event occurrence over time. The objective function is nonlinear and is classified as an NP-hard problem. To identify an effective solution within an efficient computation time, this study demonstrates that the objective function possesses the characteristic of submodularity. Using this property, we propose a heuristic algorithm designed to obtain a reasonable strategy with relatively low computational time. The proposed algorithm shows solution performance and the ability to generate solutions within an appropriate computation time through theoretical and experimental results.

• Journal of Digestive Cancer Research
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• v.12 no.2
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• pp.72-81
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• 2024

Esophageal squamous cell carcinomas constitute a major proportion of esophageal cancers in Korea. Conventional chemotherapy and radiation therapy are the options for treating advanced/metastatic esophageal cancer, but the prognosis remains poor. Immunotherapy has significantly improved the prognosis of several advanced/metastatic cancers including esophageal squamous cell carcinoma. In Korea, immunotherapy is used to treat advanced/metastatic esophageal squamous cell carcinoma, and treatment results are expected to further improve. Immunotherapy is a term used to describe a treatment modality involving a biological/targeted agent that aims to enhance and restore the ability of the immune system to detect and destroy cancer cells by modifying or blocking co-stimulating signals. Immune checkpoint inhibitors have revolutionized cancer treatment with the administration of a single agent (monotherapy) or combinations of multiple agents, with the three approved agents being anti-PD-1 (programmed death 1), anti-PD-L1 (programmed cell death ligand 1), and anti-CTLA4 (cytotoxic T-lymphocyte-associated protein 4) monoclonal antibodies. Anti-PD-1 drugs including nivolumab and pembrolizumab have been mainly investigated for treating advanced/metastatic esophageal squamous cell cancer. Studies on their effectiveness in a neoadjuvant setting, a curative adjuvant setting, or as the first-line treatment for advanced or metastatic setting are ongoing. This review describes the principle of action, summary of existing clinical studies, and prospects for immune checkpoint inhibitors used in the treatment of advanced/metastatic esophageal squamous cell cancer.