• Journal of Acupuncture Research
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• 제20권3호
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• pp.1-14
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• 2003

Objective : The aim of the study was to investigate the preventive effect of Acanthopanax senticosus(AS) aqua-acupuncture into Sinsu(BL23) of the multiple low-does strepozotocin(STZ)-induced diabetic rats. Methods : The experimental animals were divided into 4 groups : normal group of rats, control group of multiple low-does STZ-induced diabetic rats, NSAA group with 0.4ml normal saline(NS) aqua-acupunctured subcutaneously into Sinsu in multiple low-does STZ-induced diabetic rats, and ASAA group with 0.4ml of 20% AS aqua-acupunctured subcutaneously into Sinsu in multiple low-does STZ-induced diabetic rats. Each of AS and NS aqua-acupuncture was done subcutaneously into both loci of Sinsu taking turns everyday for 3 weeks. Thereafter the levels of serum glucose, body weight, index of kidney hypertrophy, urine glucose, urinary albumin excretion, creatinine clearance, mesangial cell and TGF-${\beta}1$ expression in glomeruli and tubular cells were measured on the determined day. Conclusions : 1. Both ASAA and NSAA groups decreased the serum glucose levels in multiple low-dose STZ-induced diabetic rats as compared to the cintrol group, and ASAA group showed more significant decreases than NSAA group. 2. Both ASAA and NSAA groups prevented the development of diabetes in multiple low-dose STZ-induced diabetic rats as compared to the control group, and ASAA group prevented more markedly the development of diabetes than NSAA group. 3. Both ASAA and NSAA groups prevented the reduction of body weight in multiple low-dose STZ-induced diabetic rats as compared to the control group, and ASAA group showed the same as the normal group. 4. Both ASAA and NSAA groups did not show any changes of the creatinine clearance in multiple low-does STZ-induced diabetic rats. 5. Both ASAA and NSAA groups prevented the excretion of urinary glucose and albumin in multiple low-dose STZ-induced diabetic rats as compared to the cintrol group, and ASAA group showed more significant prevention than NSAA group. 6. Both ASAA and NSAA groups prevented the expansion of glomerular cells and the protein expression of transforming growth factor-${\beta}1$ in multiple low-dose STZ-induced diabetic rats as compared to the cintrol group, and ASAA group prevented more significantly than NSAA group.

• Journal of Korean Neurosurgical Society
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• 제62권6호
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• pp.700-711
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• 2019

Objective : The treatment of multiple thoracolumbar spine fractures according to fracture continuity has rarely been reported. Herein we evaluate the clinical features and outcomes of multiple thoracolumbar fractures depending on continuous or noncontinuous status. Methods : From January 2010 to January 2016, 48 patients with acute thoracic and lumbar multiple fractures who underwent posterior fusion surgery were evaluated. Patients were divided into two groups (group A : continuous; group B : noncontinuous). We investigated the causes of the injuries, the locations of the injuries, the range of fusion levels, and the functional outcomes based on the patients' general characteristics. Results : A total of 48 patients were enrolled (group A : 25 patients; group B : 23 patients). Both groups had similar pre-surgical clinical and radiologic features. The fusion level included three segments (group A : 4; group B : 5) or four segments (group A : 19; group B : 5). Group B required more instrumented segments than did group A. Group A scored 23.5 and group B scored 33.4 on the Korean Oswestry Disability Index (KODI) at the time of last follow-up. In both groups, longer fusion was associated with worse KODI score. Conclusion : In this study, due to the assumption of similar initial clinical and radiologic features in both group, the mechanism of multiple fractures is presumed to be the same between continuous and noncontinuous fractures. The noncontinuous fracture group had worse KODI scores in long-term follow-up, thought to be due to long fusion level. Therefore, we recommend minimizing the number of segments that are fused in multiple thoracolumbar and lumbar fractures when decompression is not necessary.

• 대한지구과학교육학회지
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• 제3권1호
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• pp.76-85
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• 2010

The purpose of this study is to examine the effect of higher grades in elementary the science process skill and scientific attitudes by multiple-intelligence. To verify research problem, the subject of this study were sixth-grade students selected from two classes of an elementary school located in U1san : the search group is composed of twenty-nine students who were participated in multiple-Intelligence situation, and the other is composed of thirty-two students(comparison group) who were participated in teacher map based learning situation. During six weeks, the multiple-Intelligence was executed in th search group while the teacher map based instruction in comparison group Post-test showed following results: First, the search group showed a significant improvement in the science process skill compared th the comparison group. Second, the search group did not showed a significant improvement in the scientific attitudes compared th the comparison group. In conclusion, multiple-Intelligence teaching model was more effective than the teacher map based teaching model on science process skill. However, since the study has a limit on an object of the study and the applied curriculum, the additional studies need to be conducted with an extended comparative group and curriculum.

• 대한한의학회지
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• 제16권1호통권29호
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• pp.379-402
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• 1995

This study was performed to investigate the comparative effects of Apitoxin(0.1% bee venom 0.1cc) & Acupuncture therapy on the knee joint arthritis induced by 0.1% carrageenin solution at Rt. knee joint in rats. After carrageenin injection, the apitoxin was injected for two times (Experimental group I : 1 & 24hours later, Experimental group II : 48 & 72hours later) into the corresponding loci to Rt. $ST_{35}$(Group 3) & $EX-LE_4$(group 4) of the human body in rats. Acupuncture therapy was done same as above. And then the comparative effects of apitoxin and acupuncture therapy on the knee joint arthritis were estimated by the WBC count, RBC count, hemoglobin level, hematocrit level and ASO titer in serum. The results were summerized as follows : 1. The effects of apitoxin & acupuncture on WBC count showed remarkable decrease at group 3 & group 4 as compared with the control group in both experimental group I & experimental group II. There were not any statistical difference from apitoxin and acupuncture therapy by Duncan's multiple range test. 2. The effect of apitoxin on RBC count showed noticeable decrease at group 3 & group 4 as compared with the control group in both experimental group I & experimental group II. The acupuncture was not showed decrease at group 3 & group 4 as compared with the control group in both experimental group I & experimental group II. There were not any statistical difference from apitoxin and acupuncture therapy by Duncan's multiple range test. 3. The effects of apitoxin & acupuncture on hemoglobin level showed noticeable decrease at group 3 & group 4 as compared with the control group in both experimental group I & experimental group II. There were not any statistical difference from apitoxin and acupuncture therapy by Duncan's multiple range test. 4. The effect of apitoxin on hematocrit level showed noticeable decrease at group 3 & group 4 as compared with the control group in both experimental group I & experimental group II. The acupuncture was not showed decrease at group 3 & group 4 as compared with the control group in both experimental group I & experimental group II. There were not any statistical difference from apitoxin and acupuncture therapy by Duncan's multiple range test. 5. The effect of apitoxin on ASO titer showed noticeable decrease at group 3 & group 4 as compared with the control group only in experimental group I. The apitoxin & acupuncture showed decrease at group 3 & group 4 as compared with the control group in experimental group II. There were significantly statistical difference from apitoxin and acupuncture therapy by Duncan's multiple range test. The effect of apitoxin showed slightly decrease as compared with the acupuncture therapy by Duncan's multiple range test.

• Clinical and Experimental Reproductive Medicine
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• 제29권4호
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• pp.259-267
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• 2002

Objective: This study was performed to compare the clinical outcomes of GnRH antagonist (Cetrorelix) single dose and multiple dose protocols for controlled ovarian hyperstimulation with GnRH agonist long protocol. Materials and Method: From September 2001 to March 2002, 48 patients (55 cycles) were performed controlled ovarian hyperstimulation for ART using by either GnRH antagonist and GnRH agonist. Single dose of 3 mg GnRH antagonist was administered in 15 patients (17 cycles, single dose group) at MCD #8 and multiple dose of 0.25 mg of GnRH antagonist was administered in 15 patients (18 cycles, multiple dose group) from MCD #7 to hCG injection day. GnRH agonist was administered in 18 patients (20 cycles, control group) by conventional GnRH agonist long protocol. We compared the implantation rate, number of embryos, and clinical pregnancy rate among three groups. Student-t test and Chi-square were used to determine statistical significance. Statistical significance was defined as p<0.05. Results: There were no significant differences in ampules of used gonadotropins, number of mature oocytes, obtained embryos between single and multiple dose group, but compared with control group, ampules of used gonadotropins, number of mature oocytes, obtained embryos were decreased significantly in both groups. Clinical pregnancy rate and implantation rate were not different in three groups. There were no premature LH surge and ovarian hyperstimulation syndrome in three groups. Multiple pregnancy were occurred 1 case in multiple dose group and 2 case in control group. Conclusions: GnRH antagonist is a safe, effective, and alternative method in the controlled ovarian hyperstimulation compared with GnRH agonist. Clinical outcomes and efficacy of both single and multiple dose protocol are similar between two groups.

• Journal of Korean Neurosurgical Society
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• 제52권4호
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• pp.334-338
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• 2012

Objective : We compared the survival time between patients with multiple gamma knife radiosurgery (GKRS) and patients with a single GKRS plus whole brain radiation therapy (WBRT), in patients with multiple metachronous brain metastases from lung cancer. Methods : From May 2006 to July 2010, we analyzed 31 patients out of 112 patients who showed multiple metachronous brain metastases. 20 out of 31 patients underwent multiple GKRS (group A) and 11 patients underwent a single GKRS plus WBRT (group B). We compared the survival time between group A and B. Kaplan-Meier method and Cox proportional hazards were used to analyze relationship between survival and 1) the number of lesions in each patient, 2) the average volume of lesions in each patient, 3) the number of repeated GKRS, and 4) the interval of development of new lesions, respectively. Results : Median survival time was 18 months (range 6-50 months) in group A and 6 months (range 3-18 months) in group B. Only the average volume of individual lesion (over 10 cc) was negatively related with survival time according to Kaplan-Meier method. Cox-proportional hazard ratio of each variable was 1.1559 for the number of lesions, 1.0005 for the average volume of lesions, 0.0894 for the numbers of repeated GKRS, and 0.5970 for the interval of development of new lesions. Conclusion : This study showed extended survival time in group A compared with group B. Our result supports that multiple GKRS is of value in extending the survival time in patients with multiple metachronous brain metastases, and that the number of the lesions and the frequency of development of new lesions are not an obstacle in treating patients with GKRS.

• Genomics & Informatics
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• 제14권4호
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• pp.187-195
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• 2016

In genetic association studies with high-dimensional genomic data, multiple group testing procedures are often required in order to identify disease/trait-related genes or genetic regions, where multiple genetic sites or variants are located within the same gene or genetic region. However, statistical testing procedures based on an individual test suffer from multiple testing issues such as the control of family-wise error rate and dependent tests. Moreover, detecting only a few of genes associated with a phenotype outcome among tens of thousands of genes is of main interest in genetic association studies. In this reason regularization procedures, where a phenotype outcome regresses on all genomic markers and then regression coefficients are estimated based on a penalized likelihood, have been considered as a good alternative approach to analysis of high-dimensional genomic data. But, selection performance of regularization procedures has been rarely compared with that of statistical group testing procedures. In this article, we performed extensive simulation studies where commonly used group testing procedures such as principal component analysis, Hotelling's $T^2$ test, and permutation test are compared with group lasso (least absolute selection and shrinkage operator) in terms of true positive selection. Also, we applied all methods considered in simulation studies to identify genes associated with ovarian cancer from over 20,000 genetic sites generated from Illumina Infinium HumanMethylation27K Beadchip. We found a big discrepancy of selected genes between multiple group testing procedures and group lasso.

• 대한화학회지
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• 제56권6호
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• pp.759-767
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• 2012

이 연구의 목적은 탐구적 과학 글쓰기(SWH) 프로그램이 학생들의 글쓰기에서 나타난 다중 표상에 미치는 영향 및 다중 표상에 대한 학생들의 인식을 알아보기 위한 것이다. 이 연구는 광역시에 위치한 남녀공학 중학교 1학년 학생들을 대상으로 3개 학급 94명의 학생을 실험집단으로, 2개 학급 64명의 학생을 비교집단으로 선정하여 수행하였다. 실험집단은 총 8개 주제의 탐구적 과학 글쓰기 프로그램을 수행하였고, 비교집단은 같은 기간 동안 전통적인 실험수업을 수행하였다. 학생들이 작성한 요약 글쓰기에서 나타난 다중 표상을 분석한 결과, 실험집단의 평균이 비교집단에 비해 통계적으로 유의미하게 높은 것으로 나타났다. 프로그램에 참여한 학생들의 다중 표상에 대한 인식 조사에서 모든 학생들이 개념에 대한 자신의 생각을 표현 하는데 있어서 다중 표상의 필요성과 효과를 인지하고 있었다. 그러나 실제 다중 표상을 사용하는 수준에는 차이가 있으며 이는 다중 표상 사용에 대한 이해와 연관이 있는 것으로 나타났다.

• Journal of electromagnetic engineering and science
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• 제15권2호
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• pp.76-81
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• 2015

This paper presents a design of a transmission line negative group delay (NGD) circuit with multiple pole characteristics. By inserting an additional transmission line into a conventional NGD circuit, the proposed circuit provides further design parameters to obtain wideband group delay (GD) and to help reduce signal attenuation. As a result, the number of gain compensating amplifiers can be reduced, which can contribute to stable operation when integrated into RF systems. The multiple pole characteristics can provide wider NGD bandwidth and can be obtained by connecting resonators with slightly different center frequencies separated by quarter-wavelength transmission lines. For experimental validation, an NGD circuit with two poles GD characteristic is designed, simulated, and measured.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제21권5호
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• pp.387-392
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• 2015

맵리듀스(MapReduce)는 대용량의 데이터를 다수의 컴퓨터로 병렬 처리하기 위해 사용되는 프레임워크이다. Group-by 질의는 데이터를 지정된 애트리뷰트들의 값에 따라 그룹화하고, 각 그룹에 대해 지정된 집계 함수 값을 구하는 질의이다. 본 논문에서는 둘 이상의 group-by 질의가 동시에 요청되었을 때, 이들을 맵리듀스를 사용하여 효율적으로 처리하는 기법을 제안한다. 제안 기법은 각 group-by 질의를 독립적으로 계산하는 대신, 총 수행비용을 줄이기 위해 하나 이상의 맵리듀스 잡을 통해 단계적으로 계산한다. 성능 평가 실험을 통해, 제안 기법이 각 group-by 질의를 독립적으로 계산하는 단순 방법에 비해 좋은 성능을 가짐을 보인다.