• Journal of Pharmaceutical Investigation
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• 제19권2호
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• pp.87-92
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• 1989

The multilayered monolithic type transdermal delivery device has been designed and analyzed by a numerical analysis. The device consists of three layered polymer matrices which posess the different diffusion parameters, respectively. The purpose of this study was to design an ideal transdermal drug delivery device which is capable of initial burst and zero order release later on. Numerical modelings were simulated for a dispersed and a dissolved multilayered monolithic system. The results showed that the dispersed multilayered monolithic system could meet the requirements for an ideal transdermal delivery device.

• Biomaterials and Biomechanics in Bioengineering
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• 제1권1호
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• pp.1-12
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• 2014

Polymer multilayered hydrogels were prepared on a titanium alloy (Ti) substrate using a layer-by-layer (LBL) process to load a cell growth factor. Two water-soluble polymers were used to fabricate the multilayered hydrogels, a phospholipid polymer with both N, N-dimethylaminoethyl methacrylate (DMAEMA) units and 4-vinylphenylboronic acid (VPBA) units [poly(MPC-co-DMAEMA-co-VPBA) (PMDV)], and the polysaccharide alginate (ALG). PMDV interacted with ALG through a selective reaction between the VPBA units in PMDV and the hydroxyl groups in ALG and through electrostatic interactions between the DMAEMA units in PMDA and the anionic carboxyl groups in ALG. First, the Ti substrate was covered with photoreactive poly vinyl alcohol, and then the Ti alloy was alternately immersed in the respective polymer solutions to form the PMDV/ALG multilayered hydrogels. In this multilayered hydrogel, vascular endothelial growth factor (VEGF) was introduced in different layers during the LbL process under mild conditions. Release of VEGF from the multilayered hydrogels was dependent on the location; however, release continued for 2 weeks. Endothelial cells adhered to the hydrogel and proliferated, and these corresponded to the VEGF release profile from the hydrogel. We concluded that multilayered hydrogels composed of PMDV and ALG could be loaded with cell growth factors that have high activity and can control cell functions. Therefore, this system provides a cell function controllable substrate based on the controlled release of biologically active proteins.

• Interaction and multiscale mechanics
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• 제5권4호
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• pp.369-383
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• 2012

In this paper, soil-structure interaction analysis has been presented for beams resting on multilayered geosynthetic-reinforced granular fill-soft soil system. The soft soil and geosynthetic reinforcements are idealized as nonlinear springs and elastic membranes, respectively. The governing differential equations are solved by finite difference technique and the results are presented in non-dimensional form. It is observed from the study that use of geosynthetic reinforcement is not very effective for maximum settlement reduction in case of very rigid beam. Similarly the reinforcements are not effective for shear force reduction if the granular fill has very high shear modulus value. However, multilayered reinforced system is very effective for bending moment and differential settlement reduction.

• Environmental Engineering Research
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• 제9권5호
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• pp.193-200
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• 2004

A study of the treatment of piggery wastes using a multilayered metal-activated carbon system followed by carbon bed filtration was carried out at bench scale. From the physicochemical properties obtained from samples treated with aqueous solutions containing metallic ions such as Ag$^+$, Cu$^{2+}$, Na$^{-}$, K$^+$ and Mn$^{2+}$, main inspections are subjected to isothem shape, pore distribution with micropore, SEM and EDX. Multilayered metal-activated carbons were contacted to waste water to inwestigate the simultaneous catalytic effect for the COD, BOD, T-N and T-P removal. From these removal performance was achieved. The high efficiency of the multilayered metal-activated carbon bed, satisfactory removal performance was achieved. The high efficiency of the multilayered metal-activated carbon bed was derermined by the properties of this material for trapping, catalytic effect and adsorption of organic solid particles.

• 정보저장시스템학회논문집
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• 제7권2호
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• pp.53-59
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• 2011

We have developed a compact and high-power mode-locked fiber laser for multilayered optical memory. Fiber lasers have the potential to be compact and stable light sources that can replace bulk solid-state lasers. To generate high-power pulses, we used stretched-pulse mode locking. The average power and pulse width of the output pulse from the fiber laser that we developed were 109 mW and 2.1 ps, respectively. The dispersion of the output pulse was compensated with an external single-mode fiber of 2.5 m length. The pulse was compressed from 2.1 ps to 93 fs by dispersion compensation. The fiber laser we have developed is possible to use as a light source of multilayered optical memory. We also present a fiber confocal microscope as an alignment-free readout system of multilayered optical memories. The fiber confocal microscope does not require fine pinhole position alignment because the fiber core is used as the point light source and the pinhole, and both of which are always located at the conjugated point. The configuration reduces the required accuracy of pinhole position alignment. With these techniques we can present an all-fiber recording and readout system for multilayered memories.

• 한국음향학회지
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• 제9권2호
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• pp.5-13
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• 1990

본 연구에서는 수 파장 이상의 깊이에 존재하는 결함을 탐상하기 위하여 50MHz의 중심주파수에서 동작하는 small aperture형 초음파현미경을 구성하였고 다층구조 샘플에 대한 영상을 연구분석하였다. 다층구조물에서의 출력특성을 음향감쇠, 수차, 렌즈형태, 샘플의 특성에 영향을 받으며 이것은 다층구조 I.C.와 bonding층 탐상에 이용할 수 있다. 실험결과, small aperture형 초음파현미경은 large aperture형 시스템에 비하여 두꺼운 샘플의 탐상에 유리하며 타 도구에서 관찰이 어려운 다층구조의 층별 탐상과 내부구조의 변형상태등을 2차원 영상으로 탐상할 수 있는 유용한 도구임을 확인하였다.

• Journal of Magnetics
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• 제17권2호
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• pp.78-82
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• 2012

CoNiFe(CNF)/$BaTiO_3(BTO)$/CoNiFe(CNF) multilayered thin films were deposited on Pt/Ti/$SiO_2$/Si substrates by using pulsed laser deposition (PLD) system. We fabricated three different thin films of BTO, BTO/CNF and CNF/BTO/CNF for magneto-capacitor and studied their crystalline structure, surface and interface morphology, and magnetic and electrical properties. When three different structures of multilayered thin film were compared, magnetization of CNF/BTO/CNF thin films was decreased by magnetic and dielectric interaction. Also we confirmed that capacitance of CNF/BTO/CNF multilayered thin film was enhanced as being near tetragonal structure with increasing of c/a ratio because of atomic bonding at interface between BTO dielectric and CNF magnetic materials. Finally, we studied the change of the capacitance of CNF/BTO/CNF multilayered thin film with magnetic field for emergence of magnetocapacitance and suggested a possibility of enhanced capacitance.

• Geomechanics and Engineering
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• 제23권3호
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• pp.275-287
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• 2020

Rectangular barrettes have been increasingly used as foundations for many infrastructure projects, but the vertical vibration of a barrette has been rarely addressed theoretically. This paper presents an analysis method of dynamic response for a rectangular barrette subjected to a time-harmonic vertical force with the aid of a modified Vlasov foundation model in multilayered viscoelastic soil. The barrette-soil system is modeled as a continuum, the vertical continuous displacement model for the barrette and soil is proposed. The governing equations of the barrette-soil system and the boundary conditions are obtained and the vertical shaft resistance of barrette is established by employing Hamilton's principle for the system and thin layer element, respectively. The physical meaning of the governing equations and shaft resistance is interpreted. The iterative solution algorithm flow is proposed to obtain the dynamic response of barrette. Good agreement of the analysis and comparison confirms the correctness of the present solution. A parametric study is further used to demonstrate the effects of cross section aspect ratio of barrettes, depth of soil column, and module ratio of substratum to the upper soil layers on the complex barrette-head stiffness and the resistance stiffness.

• Carbon letters
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• 제7권3호
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• pp.180-187
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• 2006

The treatment of piggery wastes was carried out at pilot scale using a multilayered metal-activated carbon system followed by carbon bed filtration. The physicochemical properties were obtained from treated samples with aqueous solutions containing metallic ions such as $Ag^+$, $Cu^{2+}$, $Na^+$, $K^+$ and $Mn^{2+}$, which main obsevations are subjected to inspect surface properties, color removal properties by Uv/Vis and EDX. Multilayered metal-activated carbons were contacted with waste water to investigation of the simultaneous catalytic effect for the COD, BOD, T-N and T-P removal. The removal results for the piggery waste using multilayered metal-activated carbon bed was achieved the satisfactory removal performance under permitted values of Ministry of Environment of Korea. The high efficiency of the multilayered metal-activated carbon bed was determined by the performance of this material for trapping, catalytic effect and adsorption of organic solid particles.

• Smart Structures and Systems
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• 제9권2호
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• pp.105-125
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• 2012

A modified Pagano method is developed for the three-dimensional (3D) free vibration analysis of simply-supported, multilayered functionally graded material (FGM) circular hollow cylinders with a constant rotational speed with respect to the meridional direction of the cylinders. The material properties of each FGM layer constituting the cylinders are regarded as heterogeneous through the thickness coordinate, and then specified to obey a power-law distribution of the volume fractions of the constituents, and the effects of centrifugal and Coriolis accelerations, as well as the initial hoop stress due to rotation, are considered. The Pagano method, which was developed for the static and dynamic analyses of multilayered composite plates, is modified in that a displacement-based formulation is replaced by a mixed formulation, the complex-valued solutions of the system equations are transferred to the real-valued solutions, a successive approximation method is adopted to extend its application to FGM cylinders, and a propagator matrix method is developed to reduce the time needed for its implementation. These modifications make the Pagano method feasible for multilayered FGM cylinders, and the computation in the implementation is independent of the total number of the layers, thus becoming less time-consuming than usual.