• The Mathematical Education
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• v.60 no.4
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• pp.431-449
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• 2021

Elementary mathematics textbooks present contents for enhancing problem solving competency. Still, teachers find teaching problem solving to be challenging. To understand the supports textbooks are suggesting, this study examined tasks from the challenging/thinking and inquiry mathematics. We analyzed 288 mathematical activities based on an analytic framework from the 2015 revised mathematics curriculum. Then, we employed latent class analysis to classify 83 mathematical tasks as a new approach to categorize tasks. As a result, execution of the problem solving process was emphasized across grade levels but understanding of problems was varied by grade levels. In addition, higher grade levels had more opportunities to be engaged in collaborative problem solving and problem posing. We identified three task profiles: 'execution focus', 'collaborative-solution focus', 'multifaceted-solution focus'. In Grade 3, about 80% of tasks were categorized as the execution profile. The multifaceted-solution was about 40% in the thinking/challenging mathematics and the execution profile was about 70% in Inquiry mathematics. The implications for developing mathematics textbooks and designing mathematical tasks are discussed.

• Genomics & Informatics
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• v.21 no.2
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• pp.23.1-23.9
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• 2023

The mammalian sirtuin family, consisting of SIRT1-SIRT7, plays a vital role in various biological processes, including cancer, diabetes, neurodegeneration, cardiovascular disease, cellular metabolism, and cellular homeostasis maintenance. Due to their involvement in these biological processes, modulating sirtuin activity seems promising to impact immuneand aging-related diseases, as well as cancer pathways. However, more understanding is required regarding the safety and efficacy of sirtuin-targeted therapies due to the complex regulatory mechanisms that govern their activity, particularly in the context of multiple targets. In this study, the interaction landscape of the sirtuin family was analyzed using a systems biology approach. A sirtuin protein-protein interaction network was built using the Cytoscape platform and analyzed using the NetworkAnalyzer and stringApp plugins. The result revealed the sirtuin family's association with numerous proteins that play diverse roles, suggesting a complex interplay between sirtuins and other proteins. Based on network topological and functional analysis, SIRT1 was identified as the most prominent among sirtuin family members, demonstrating that 25 of its protein partners are involved in cancer, 22 in innate immune response, and 29 in aging, with some being linked to a combination of two or more pathways. This study lays the foundation for the development of novel therapies that can target sirtuins with precision and efficacy. By illustrating the various interactions among the proteins in the sirtuin family, we have revealed the multifaceted roles of SIRT1 and provided a framework for their possible roles to be precisely understood, manipulated, and translated into therapeutics in the future.

• Clinical and Experimental Pediatrics
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• v.63 no.8
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• pp.291-300
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• 2020

Advances in autoimmune encephalitis studies in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder. The disorder or syndrome has been linked to a wide variety of pathologic processes associated with the neuron-specific autoantibodies targeting intracellular and plasma membrane antigens. However, current criteria for autoimmune encephalitis are quite dependent on antibody testing and responses to immunotherapy, which might delay the diagnosis. This form of encephalitis can involve the multifaceted presentation of seizures and unexpected behavioral changes. The spectrum of neuropsychiatric symptoms in children is less definitive than that in adults, and the incorporation of clinical, immunological, electrophysiological, and neuroradiological results is critical to the diagnostic approach. In this review, we document the clinical and immunologic characteristics of autoimmune encephalitis known to date, with the goal of helping clinicians in differential diagnosis and to provide prompt and effective treatment.

• Management & Information Systems Review
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• v.17
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• pp.381-399
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• 2005

During the past decade a great deal of attention has focused on the impact of IT investment. However, many related studies have frequently generated controversial or inconsistent results. These results imply that the relationship between IT investment and performance is complex and multifaceted. And empirical studies with new analytical techniques are badly needed to examine the way IT investment interacts with various organizational and environmental elements to influence corporate performance. Accordingly a study of IT investment needs to make a contingency approach to determining the level of IT investment based on the competitive strategy in a macro perspective. The basic purpose of this research is to analyse the relationship between IT investment and IT effectiveness and to identify the moderating effect of competitive strategy in the relationship. The results showed that there is no relationship between IT investment and IT effectiveness, and the competitive strategy can be considered as a significant moderating variable between IT investment and IT effectiveness.

• Korean System Dynamics Review
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• v.16 no.1
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• pp.75-91
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• 2015

The price-volume in land by land categories is evaluated with dynamic approaches in the era of aging society This research tries to investigate in the respect of major factors such as real estate, macro-economics, and population that is simulated by land categories. The system dynamics approaches on price-volume in land are forecasted until 2020 using the data in the period of 2000-2014. In regard to methodologies, this research adopted system dynamics to evaluate the relationships between price-volume in land and aging society. The meaningful results have been found during the last over 10 year's analysis as the dynamic relations with major factors. Regarding land categories, this research tries to overcome former research limitations. As an implication from the price-volume in land, it confirmed that the multifaceted aspects show that system dynamics approach effectively simulated them by price-volume in land with the population of aging society.

• Journal of the Korean Operations Research and Management Science Society
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• v.16 no.2
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• pp.109-109
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• 1991

We have recognized that an organization should be viewed from a multifaceted perspective necessitating a sophisticated analytical and systematic approach to monitor and improve organizational performance. Although some performance measurement systems have been proposed and are currently being used in many organizations, no performance measurement system has presented a mechanism for integrating all of the information of performance measures in a way that considers relationships between them. This paper introduces the implementation of the performance information integration method(PIIM) which synthesizes all useful information of performance measures with consideration of the relationship and generates a single, global, organizational performance score. The PIIM was empirically validated by implementing in one of Missouri Veterans Homes

• Physical Therapy Korea
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• v.10 no.1
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• pp.97-108
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• 2003

Slipping during various kinds of movement often leads to potentially dangerous incidents of falling. The purpose of this paper was to review some of the research performed in the field including such topics as rating scales for balance, kinematics and kinetics of slipping, adaptation to slippery conditions, postural and balance control, and protective movement during falling. Controlling slipping and fall injuries requires a multifaceted approach. Environmental conditions (state of floor surface, tidiness, lighting, etc), work task (walking, carrying, pushing, lifting, etc), and human behavior (anticipation of hazards, adaptation to risks, risk taking, etc) must be accounted for in the assessment of slip and fall-related risks. Future directions of research must deal with modeling of basic tribophysical, biomechanical, and postural control process involved in slipping and falling.

• Journal of dental hygiene science
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• v.17 no.3
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• pp.257-266
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• 2017

This study investigated factors affecting the subjective experience of oral symptoms among 2,285 elementary school students in the fourth and sixth grades using the Korean survey on the Health of Youth and Children in 2010. After conducting chi-square and Mann-Whitney U tests, we performed multiple logistic regression analysis to determine the factors affecting children's experience of oral symptoms. We found that the factors most frequently associated with the subjective experience of more oral symptoms were lower tooth brushing frequency, greater intake of foods that cause dental caries, higher stress levels, and lower levels of support from friends. In conclusion, determinants of children's oral health, such as children's oral health behaviors and psychological factors must be considered in a multifaceted approach to developing programs to promote oral health among children.

• International Journal of Advanced Culture Technology
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• v.11 no.3
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• pp.231-235
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• 2023

Currently, China's urban landscape is undergoing a gradual shift from incremental development to stock renovation. Furthermore, the planning and development objectives of urban communities have evolved from solely focusing on physical space construction to promoting sustainable development within a humanistic society. The current approach to community planning and construction, which emphasizes a singular dimension of residential life, overlooks the multifaceted aspects of community life and production. This oversight leads to a lack of attention to interpersonal relationships within the community, difficulties in establishing a connection between people and their environment, and numerous other issues. Consequently, this paper seeks to redefine the concept of sociality within community spaces by considering the continuum of time and space within communities. It aims to delineate the roles of "power" and "rights" within the community context, with a particular focus on everyday life, in order to reevaluate strategies and methods for fostering dynamic community development.

• Quality Improvement in Health Care
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• v.29 no.2
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• pp.85-93
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• 2023

Purpose: The predominant approach for mitigating inadequate sampling rates has primarily involved bolstering the volume of education. This study aimed to curtail inadequate sampling rates through the implementation of continuous quality improvement (CQI) activities, tailoring effective methods to the unique needs of each institution. Methods: We developed a sample handling guidebook and implemented QI activities to address this issue. Results: These measures resulted in a 4.7% decrease in inadequate sampling rates, concurrently improving knowledge of sample handling and overall nurse satisfaction. We addressed the root causes of inadequate sampling before laboratory pre-processing by: 1) focusing on systematic rather than erratic errors through CQI activities, 2) revising the sample handling guide, and 3) delivering face-to-face education based on the specific needs of the nursing department. These changes resulted in an additional 0.6% decrease in the inadequate sampling rate. Conclusion: This study demonstrates that the implementation of CQI activities based on evidence derived from a multifaceted causal analysis significantly reduced the inadequate sampling rate compared to previous studies.