• 한국임상수의학회지
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• 제38권1호
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• pp.36-40
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• 2021

A 12-year-old dog was referred due to multiple superficial lymphadenopathy. On cytology, each lymph node showed different cell populations where some of them consisted of intermediate to large lymphocytes with frequent Mott cells. Presence of Mott cells along with immature lymphocytes made the cytological diagnosis challenging, and therefore, supplementary diagnostic tests including PCR for Antigen Receptor Rearrangement (PARR) assay and flow cytometry were performed. This case report illustrates the value of flow cytometry in the diagnosis of lymphadenopathy with ambiguous cytologic findings.

• 대한두경부종양학회지
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• 제31권1호
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• pp.14-17
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• 2015

Castleman's disease is an uncommon lymphoproliferative disorder. The disorder can be classified based on histological subtype, such as hyaline vascular type, plasma cell type, and mixed type, and can also be clinically divided into either unicentric or multicentric type. Its exact pathophysiology is not clearly identified. The unicentric type is able to be treated by surgical resection. However, there is no standard treatment modlity for the multicentric type. Treatment of multicentric type includes anti-cancer chemotherapy and radiation therapy. Recently, authors have experienced a rare case of unicentric type of Castleman's disease accompanying a mucoepidermoid carcinoma of parotid gland and report a case which is discussed with references.

• 한국임상수의학회지
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• 제26권3호
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• pp.263-267
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• 2009

A 9-year-old, female, Maltese Dog(2.15 kg of body weight) was referred to the Veterinary Medical Teaching Hospital, Chungnam National University with cervical masses, abdominal masses and petechia. Physical examination showed masses in mandibular, prescapular, inguinal, popliteal lymph node and abdominal subcutaneous hemorrhage. This case was diagnosed as the multicentric lymphoma by physical examination, laboratory examination, radiography, ultrasonography, CT, fine needle aspiration and histopathologic examination. This dog was treated by low-budget protocol with lomustine and prednisolone. The dog show that response duration and survival time is 143days and 263 days, respectively.

• Investigative Magnetic Resonance Imaging
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• 제12권2호
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• pp.161-169
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• 2008

목적 : 유방 절제 생검 후 유방암이 진단된 환자에서 잔류종양과 추가 병변을 진단하는데 있어 자기공명영상의 유용성을 알아보고자 하였다. 대상 및 방법 : 2005년 3월부터 2007년 8월까지 유방 절제 생검으로 유방암이 진단되고 수술 전 자기공명영상을 시행한 16명의 환자를 대상으로 하였다. 생검 후 생긴 공동 주위로 두껍고 불규칙한 조영증강 테두리를 보이거나 공동에 연하여 조영증강되는 종괴가 있는 경우를 잔류종양이 있다고 보았다. 또한 공동과 분리된 다초점성, 다발성, 혹은 반대측 유방 병변 등의 추가 병변을 확인하였다. 수술 후 조직학적 소견을 비교하여 자기공명영상의 정확성을 평가하였고 자기 공명영상소견에 따라 향후 치료에 변화가 있었는지를 알아보았다. 결과 : 공동주위 조영증강 소견으로 잔류종양을 평가하는 자기공명영상의 민감도와 특이도는 각각 85.7%(6/7)와 55.6%(5/9)이었다. 자기공명영상으로 6명의 환자에서 다초점성(multifocal), 다발성(multicentric), 혹은 반대측 유방에 추가 병변을 발견하였다. 자기공명 영상의 결과에 따라 7명의 환자에서 치료 범위가 변화되었다. 결론 : 절제 생검 후 자기공명영상에서 보인 소견 중 공동주위 조영증강 소견만으로 잔류종양 유무를 감별하기 어렵다. 그러나 유방 자기공명영상은 다초점성 및 다발성 혹은 반대측 병변을 포함한 추가병변을 발견하는 데 도움을 주어 수술적 치료에도 유용한 정보를 제공한다.

• Journal of Chest Surgery
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• 제20권2호
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• pp.348-352
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• 1987

A 51 year-old male was admitted with the chief complaints of swallowing difficulty and pain on neck and upper chest for 2 months prior to admission: He was taken biopsy under esophagoscopy, and the result was squamous cell carcinoma. Preoperatively we studied the esophagogram and chest CT. On these, we found the main appreciable mass at midesophagus easily. But, we missed the upper cervical unexpected mass. So we performed the esophagectomy and lymph node dissection from upper clavicle level to the esophagogastric junction by thoracic approach as wide as possible, and cervical esophagostomy and feeding gastrostomy also. At that evening we reviewed the studied films in detail, and we found another mass lesion at C4-C6 level of cervical esophagus. We performed the 2nd operation e.g. cervical esophagectomy on next morning without hesitation. Between these two masses, there was almostly normally looking skip area grossly. The squamous cell carcinoma of the esophagus could be multicentric in character and may have skip area. But, we heard little reports until now. The two masses could be different in origin or be same probably by submucosal spreading. Anyway, it was an alarming case to the surgeon not to neglect the another possible lesions in squamous cell type. Postoperative course was uneventful, he took G-tube feeding with no problems on 7th postoperative day. Now he took the postoperative irradiation at out patient department.

• 대한수의학회지
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• 제57권1호
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• pp.59-61
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• 2017

A 15-year-old castrated mixed breed dog presented due to a 5-month history of cough and difficulty in ambulation. Necropsy showed multiple periosteal and intramedullary infiltrative masses in the appendicular skeleton. In addition, single and multiple neoplastic nodules were observed in several organs, including the lungs, liver, kidney, and heart. Microscopically, several skeletal neoplastic masses and nodules in the parenchymal organs revealed similar changes. The neoplastic cells were spindle- to polygonal-shaped with prominent osteoid production and occasional cartilaginous and bone formation. Based on the gross findings and histopathology results, the case was diagnosed as multicentric osteosarcoma with systemic metastases.

• 대한영상의학회지
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• 제85권1호
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• pp.240-246
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• 2024

상피상 혈관육종은 혈관에 생기는 육종 중 드문 변이이다. 이 종양은 대개 연부조직에서 발생하고, 뼈에서 발생하는 경우는 특히 드물다. 다발성으로 발생한 경우 이 종양은 이차성 골전이와 혼동될 수 있으며, 매우 치명적인 임상 진행을 보일 수 있다. 우리는 61세의 남성에서 다발성으로 발생한 상피상 혈관육종의 증례를 보고하고자 한다. 이 종양은 혈관성 파종으로 인해 발생한 것으로 추정된다. 엑스선 단순 촬영, CT 및 MRI에서 양쪽 하지 장골에 여러 개의 골융해성 병변이 관찰되었다. 이 중 일부는 골피질을 파괴하면서 연조직성 병변도 동반되었다. 초기 영상의학적 검사 결과로는 전이성 암종이 의심되어, PET-CT를 촬영하였다. 흥미롭게도, PET-CT에서는 이러한 병변들이 양쪽 하지 뼈의 반골, 장골, 경골을 따라 분포하고 있어, 혈관을 따라 파종할 가능성이 있는 혈관육종의 가능성도 확인되었다. 병리학적 소견에서 또한 처음에는 전이성 암종의 가능성을 고려하여 추가적인 면역 화학 염색 검사를 시행하였다. 그러나, 혈관성 표지자인 CD31, ERG 등의 검사 결과 강한 양성 소견을 보여 최종적으로 이 병변은 상피상 혈관육종으로 진단되었다. 이번 증례를 통해 뼈에 일차성으로 발생한 상피상 혈관육종에 대한 임상적, 영상의학적 특징을 정리하여, 진단적 혼동을 줄이고 더 나은 치료 방법을 제공하는데 도움이 될 것이다.

• 대한치과의사협회지
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• 제42권12호통권427호
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• pp.873-881
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• 2004

• Annals of Clinical Neurophysiology
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• 제19권1호
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• pp.74-76
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• 2017

Muscle specific tyrosine kinase (MuSK) myasthenia gravis (MG) is a rare subtype of MG, which is immunologically distinct and differential therapeutic response. Though MG is often associated with other autoimmune disorders or malignancy, concurrence of other disease and MuSK MG has been infrequently reported. We present a patient of MuSK MG associated with multicentric Castelman disease.

• 한국임상수의학회지
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• 제3권2호
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• pp.309-316
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• 1986

One six-year-old male Cocker spaniel with chief complaints of mandibular swelling and anorexia was referred. This dog was diagnosed into lymphosarcoma by the results of the examination with peripheral blood and fluid of the lymph nodes and bone marrow aspirated. This patient was multicentric form clinically and was cytomorphologically identified into lymphoblastic form of lymphosarcoma.