• Title/Summary/Keyword: Multicenter

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A randomized, double-dummy, multicenter non-inferiority clinical trials to evaluate the efficacy and the safety of Joins(SKI 306X) compared to diclofenac in patients with osteoarthritis of the knee (양측 눈가림, 무작위배정, 다기관공동 제 3 상 임상시험 결과 : 퇴행성 관절염에 대한 조인스(SKI 306X)정과 Diclofenac과의 비열등성 임상시험)

  • Jung Kui-Oak;Jung Young-Bok;Seong Sang-Cheol;Ahn Jin-Hwan;Roh Kwon-Jae;Kim Jung-Man;Park Byung-Joo
    • 대한예방의학회:학술대회논문집
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    • 2001.10a
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    • pp.302-304
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    • 2001
  • PDF

A Phase II, double-blinded, randomized, multicenter clinical trial for evaluation of efficacy and safety of rhEGF in patients with diabetic foot ulcer (제 2 상, 이중맹검, 무작위배정, 다기관 공동임상시험의 결과 : 당뇨병성 족부궤양에 대한 표피 성장인자(Epidermal Growth Factor, EGF)의 치료 효과를 평가)

  • Choi Ji-Hyeon;Jung Kui-Oak;Sohn Ho-Young;Kim Young-Sul;Lee Hong-Gyu;Lee Kui-Up;Lee Hyun-Chul;Lee Byung-Doo;Park Byung-Joo
    • 대한예방의학회:학술대회논문집
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    • 2001.10a
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    • pp.305-307
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    • 2001
  • PDF

Fecal Retention in Overactive Bladder (OAB) in Children: Perspective of a Pediatric Gastroenterologist

  • Jeong, Su Jin
    • Childhood Kidney Diseases
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    • v.19 no.1
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    • pp.1-7
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    • 2015
  • Coexisting voiding and bowel dysfunction in children are common in the clinic. The idea that overactive bladder (OAB) and constipation arise from one single pathophysiology has been reinforced in many studies. In Korea, a nationwide multicenter study conducted in 2009 showed that overall prevalence of OAB in children, 5-13 years of age, was 16.59% and this number has increased more recently. The initial step to manage coexisting fecal retention and OAB in children is to characterize their bowel and bladder habits and to treat constipation if present. Although diagnosing constipation in children is difficult, careful history-taking using the Bristol Stool Form Scale, and a scoring system of plain abdominal radiography, can help to estimate fecal retention more easily and promptly. Non-pharmacological approaches to manage functional constipation include increasing fluids, fiber intake, and physical activity. Several osmotic laxatives are also effective in improving OAB symptoms and fecal retention. Additionally, correction and education in relation to toilet training is the most important measure in treating OAB with fecal retention.

History of Minimally Invasive Surgery for Gastric Cancer in Korea

  • Kim, Young-Woo;Yoon, Hong-Man;Eom, Bang-Wool;Park, Ji-Yeon
    • Journal of Gastric Cancer
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    • v.12 no.1
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    • pp.13-17
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    • 2012
  • Laparoscopic gastrectomy was begun in 1995 in Korea. But, there was 4 years gap to reactivate in 1999. High incidence of gastric cancer and increasing proportion of early cancer through national screening program along with huge effort and enthusiasm of laparoscopic gastric surgeon, and active academic exchange with Japanese doctors contributed development of laparoscopic gastrectomy in Korea. Study group activity of Korean Laparoscopic Gastrointestinal Surgery Study (KLASS) group and Collaborative Action for Gastric Cancer (COACT) group were paramount to evoke large scale multicenter clinical study and various well performed clinical studies. This review encompasses mainly international publications about this area so far in Korea.

High-flow nasal cannula oxygen therapy in children: a clinical review

  • Kwon, Ji-Won
    • Clinical and Experimental Pediatrics
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    • v.63 no.1
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    • pp.3-7
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    • 2020
  • High-flow nasal cannula (HFNC) is a relatively safe and effective noninvasive ventilation method that was recently accepted as a treatment option for acute respiratory support before endotracheal intubation or invasive ventilation. The action mechanism of HFNC includes a decrease in nasopharyngeal resistance, washout of dead space, reduction in inflow of ambient air, and an increase in airway pressure. In preterm infants, HFNC can be used to prevent reintubation and initial noninvasive respiratory support after birth. In children, flow level adjustments are crucial considering their maximal efficacy and complications. Randomized controlled studies suggest that HFNC can be used in cases of moderate to severe bronchiolitis upon initial low-flow oxygen failure. HFNC can also reduce intubation and mechanical ventilation in children with respiratory failure. Several observational studies have shown that HFNC can be beneficial in acute asthma and other respiratory distress. Multicenter randomized studies are warranted to determine the feasibility and adherence of HFNC and continuous positive airway pressure in pediatric intensive care units. The development of clinical guidelines for HFNC, including flow settings, indications, and contraindications, device management, efficacy identification, and safety issues are needed, particularly in children.

A Density Peak Clustering Algorithm Based on Information Bottleneck

  • Yongli Liu;Congcong Zhao;Hao Chao
    • Journal of Information Processing Systems
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    • v.19 no.6
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    • pp.778-790
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    • 2023
  • Although density peak clustering can often easily yield excellent results, there is still room for improvement when dealing with complex, high-dimensional datasets. One of the main limitations of this algorithm is its reliance on geometric distance as the sole similarity measurement. To address this limitation, we draw inspiration from the information bottleneck theory, and propose a novel density peak clustering algorithm that incorporates this theory as a similarity measure. Specifically, our algorithm utilizes the joint probability distribution between data objects and feature information, and employs the loss of mutual information as the measurement standard. This approach not only eliminates the potential for subjective error in selecting similarity method, but also enhances performance on datasets with multiple centers and high dimensionality. To evaluate the effectiveness of our algorithm, we conducted experiments using ten carefully selected datasets and compared the results with three other algorithms. The experimental results demonstrate that our information bottleneck-based density peaks clustering (IBDPC) algorithm consistently achieves high levels of accuracy, highlighting its potential as a valuable tool for data clustering tasks.

Factors Associated with Gastric and Duodenal Neuroendocrine Tumor Development

  • Kwangwoo Nam;Su Youn Nam
    • Journal of Digestive Cancer Research
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    • v.12 no.1
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    • pp.1-5
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    • 2024
  • The incidence and prevalence of upper gastrointestinal neuroendocrine tumors (NETs), including gastric NETs (GNETs) and duodenal NETs (DNETs), have been gradually increasing. These trends may be associated with the increased use of health checkups, which includes upper endoscopy, in conjunction with better disease recognition. However, the clinical factors associated with GNETs and DNETs remain unknown; previous studies revealed discrepancies. Recently, metabolic disorders have been indicated as potential factors that are associated with GNETs and DNETs. This review summarizes the results of previous studies and briefly introduces the results of a recent Korean multicenter study on the factors associated with GNETs and DNETs.