• Interaction and multiscale mechanics
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• 제3권3호
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• pp.235-255
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• 2010

This paper investigates the heat equation for domains subjected to an internal source with a sharp spatial gradient. The solution is first approximated using linear finite elements, and sufficiently small time-step sizes to yield stable simulations. The main area of interest is then in the ability to approximate the solution using Generalized Finite Elements, and again explore the time-step limitations required for stable simulations. Both high order elements, as well as elements with special enrichments are used to generate solutions. When compared to linear finite elements, the high order elements deliver better accuracy at a given level of mesh refinement, but do not offer an increase in critical time-step size. When special enrichment functions are used, the solution can be approximated accurately on very coarse meshes, while yielding solutions which are both accurate and computationally efficient. The major conclusion of interest is that the significantly larger element size yields larger allowable time-step sizes while still maintaining stability of the time-stepping algorithm.

• 한국정밀공학회지
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• 제20권10호
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• pp.183-190
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• 2003

Major device failures such as die cracking, interfacial delamination and warpage in flip chip packages are due to excessive heat and thermal gradients- There have been significant researches toward understanding the thermal performance of electronic packages, but the majority of these studies do not take into account the combined effects of thermo-mechanical interactions of the different package constituents. This paper investigates the thermo-mechanical performance of flip chip package constituents based on the finite element method with thermo-mechanically coupled elements. Delaminations with different lengths between the silicon die and underfill resin interfaces were introduced to simulate the defects induced during the assembly processes. The temperature gradient fields and the corresponding stress distributions were analyzed and the results were compared with isothermal case. Parametric studies have been conducted with varying thermal conductivities of the package components, substrate board configurations. Compared with the uniform temperature distribution model, the model considering the temperature gradients provided more accurate stress profiles in the solder interconnections and underfill fillet. The packages with prescribed delaminations resulted in significant changes in stress in the solder. From the parametric study, the coefficients of thermal expansion and the package configurations played significant roles in determining the stress level over the entire package, although they showed little influence on stresses profile within the individual components. These observations have been implemented to the multi-board layer chip scale packages (CSP), and its results are discussed.

• 천문학회보
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• 제43권1호
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• pp.62.1-62.1
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• 2018

Galaxies in the cluster environment interact with the intracluster medium (ICM), losing the interstellar medium (ISM) and alternating their evolution. Observational evidences of the extraplanar ISM stripped by the ICM's ram pressure are prevalent in HI imaging studies of cluster galaxies. However, current theoretical understanding of the ram pressure stripping (or ICM-ISM interaction in general) is still limited mainly due to the lack of numerical resolution at ISM scales in large-scale simulations. Especially, self-consistent modeling of the turbulent, multiphase ISM is critical to understand star formation in galaxies interacting with the ICM. To achieve this goal, we utilize the TIGRESS simulation suite, simulating a local patch of galactic disks with high resolution to resolve key physical processes in the ISM, including cooling/heating, self-gravity, MHD, star formation, and supernova feedback. We then expose the ISM disk to ICM flows and investigate the evolution of star formation rate and the properties of the ISM. By exploring ICM parameter space, we discuss an implication of the simple ram pressure stripping condition (so called the Gunn-Gott condition) to the realistic ISM.

• 천문학회보
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• 제41권1호
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• pp.33.2-33.2
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• 2016

Since the serendipitous discovery of a large-scale atomic hydrogen ($H_I$) ring discovered in the Leo I galaxy group, its origin has been under debate till today, whether it is the leftover after group formation or stripped gas structure during the galaxy-galaxy interaction. Intriguingly a number of $H_I$ clumps have been identified along the gas ring, some of which turn out to be associated with optically catalogued dwarf galaxies. The formation history based on detailed optical and $H_I$ gas properties of those dwarf galaxies will enable us to verify the origin of the Leo ring. In this work, we first probe the redshift and multi-color properties of those dwarf galaxies, using deep photometric and spectroscopic data from CFHT, Gemini and Magellan telescope.

• Steel and Composite Structures
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• 제27권2호
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• pp.229-242
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• 2018

High strength steel is widely used in industrial applications to improve the load-bearing capacity and reduce the overall weight and cost. To take advantage of the benefits of this type of steel in construction, an innovative hybrid fabricated member consisting of high strength steel tubes welded to mild steel plates has recently been developed. Component-scale uniaxial and multiaxial cyclic experiments have been conducted with simultaneous constant or varying axial compression loads using a multi-axial substructure testing facility. The structural interaction of high strength steel tubes with mild steel plates is investigated in terms of member capacity, strength and stiffness deterioration and the development of plastic hinges. The deterioration parameters of hybrid specimens are calibrated and compared against those of conventional steel specimens. Effect of varying axial force and loading direction on the hysteretic deterioration model, failure modes and axial shortening is also studied. Plate and tube elements in hybrid members interact such that the high strength steel is kept within its ultimate strain range to prevent sudden fracture due to its low ultimate to yield strain ratio while the ductile performance of plate governs the global failure mechanism. High strength material also significantly reduces the axial shortening in columns which prevents undesirable frame deformations.

• Ocean Systems Engineering
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• 제7권2호
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• pp.107-120
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• 2017

Spud-can is used for fixing jack-up rig on seabed. It needs to be inserted up to the required depth during the installation process to secure enough soil reaction and prevent overturning accidents. On the other hand, it should be extracted from seabed soils as fast as possible during the extraction process to minimize the corresponding operational cost. To achieve such goals, spud-can may be equipped with water-jetting system including monitoring and control. To develop such a smart spud-can, a reliable numerical simulation tool is essential and it has also to be validated against physical model tests. In this regard, authors developed a numerical simulation tool by using a commercial program ANSYS with extended Drucker-Prager (EDP) formula. Authors also conducted small-scale (1/100) physical model tests for verification and calibration purpose. By using the numerical model, a systematic parametric study is conducted both for sand and K(kaolin)-clay with varying important soil parameters and the best estimated soil properties of the physical test are deduced. Then, by using the selected soil properties, the numerical and experimental results for a sand/K-clay multi-layer case are cross-checked to show reasonably good agreement. The validated numerical model will be useful in the next-stage study which includes controllable water-jetting.

• BioChip Journal
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• 제12권4호
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• pp.268-279
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• 2018

Flower-shaped organic-inorganic hybrid nanostructures, termed nanoflowers, have received considerable recent attention as they possess greatly enhanced activity, stability, durability, and even selectivity of entrapped organic biomolecules, which are much better than those from the conventional methods. They can be synthesized simply via co-incubation of organic and inorganic components in aqueous buffer at room temperature and yield hierarchical nanostructures with large surface-to-volume ratios, allowing for low-cost production by easy scale-up, as well as the high loading capacity of biomolecules without severe mass transfer limitations. Since a pioneering study reported on hybrid nanoflowers prepared with protein and copper sulfate, many other organic and inorganic components, which endow nanoflowers with diverse functionalities, have been employed. Thanks to these features, they have been applied in a diverse range of areas, including biosensors and biocatalysis. To highlight the progress of research on organic-inorganic hybrid nanoflowers, this review discusses their synthetic methods and mechanisms, structural and biological characteristics, as well as recent representative applications. Current challenges and future directions toward the design and development of multi-functional nanoflowers for their widespread utilization in biotechnology are also discussed.

• BMB Reports
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• 제55권9호
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• pp.417-428
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• 2022

Herbal medicine, a multi-component treatment, has been extensively practiced for treating various symptoms and diseases. However, its molecular mechanism of action on the human body is unknown, which impedes the development and application of herbal medicine. To address this, recent studies are increasingly adopting systems pharmacology, which interprets pharmacological effects of drugs from consequences of the interaction networks that drugs might have. Most conventional network-based approaches collect associations of herb-compound, compound-target, and target-disease from individual databases, respectively, and construct an integrated network of herb-compound-target-disease to study the complex mechanisms underlying herbal treatment. More recently, rapid advances in high-throughput omics technology have led numerous studies to exploring gene expression profiles induced by herbal treatments to elicit information on direct associations between herbs and genes at the genome-wide scale. In this review, we summarize key databases and computational methods utilized in systems pharmacology for studying herbal medicine. We also highlight recent studies that identify modes of action or novel indications of herbal medicine by harnessing drug-induced transcriptome data.

• Asian-Australasian Journal of Animal Sciences
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• 제12권2호
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• pp.305-327
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• 1999

In the paper insight is given in the legislation policy to restrain environmental pollution by pig husbandry, focused on The Netherlands (Mineral Accounting System). Besides, nutritional measures are presented to reduce environmental pollution by lowering excretion of N and P, emphasizing (multi) phase feeding, the use of low protein, synthetic amino acids supplemented diets, phytase and its effect on phosphorus and calcium digestibility, its interaction with phytic acid and proteins, and the environmental impact of the use of phytase in pig diets. Also, nutritional means are indicated to reduce ammonia volatilization from pig operations. It is concluded that nutrition management can substantially contribute to reduction of N and P excretion by pigs, mainly by lowering dietary protein levels, (multi) phase feeding and the use of microbial phytase, and that the use of phytase on a large scale in The Netherlands has a tremendous environmental impact. In 20 years the excretion of P in growing-finishing pigs has more than halved. Ammonia emission from manure of pigs can be reduced substantially by lowering dietary protein content, but also by including additional non-starch polysaccharides in the diet. A very promising method to reduce ammonia emission is to manipulate dietary cation-anion difference, e.g. by adding acidifying salts to the diet, which will lower pH of urine substantially. Further research is desirable. This also applies to determining dietary factors influencing the odour release from manure. Finally, some speculation on the future of pig farming from an environmental viewpoint is presented.

• Journal of Oral Medicine and Pain
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• 제45권3호
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• pp.56-64
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• 2020

Purpose: Temporomandibular disorders (TMD) is a mosaic of clinical signs and symptoms that can be regarded as a set of phenotypes that are affected by various factors including pain sensitivity, pain disability, sleep and psychological functioning. The aims of this study were to evaluate association of pain experience, sleep quality and psychological distress with different phenotypes of TMD patients. Methods: This retrospective study included a cohort (n=1,858; 63.8% for female, mean age=34.9±15.9 years) of patients with TMD. A set of self-administered questionnaires concerning pain interference (Brief Pain Inventory), pain disability (Graded Chronic Pain Scale), sleep quality (Pittsburg Sleep Questionnaire Index), psychological distress (Symptom Checklist-90 revised), and pain catastrophizing (Pain Catastrophizing Scale) were administered to all participants at the first consultation. All TMD patients were classified into four groups including TMD with internal derangement without pain (TMD_ID, n=370), TMD with joint pain (TMD_J, n=571), TMD with muscle pain (TMD_M, n=541) and TMD with muscle-joint combined pain (TMD_MJ, n=376). Results: The female ratio was particularly high in the group with TMD_MJ (p=0.001). The patients with muscle pain and both muscle and joint pain had longer symptom duration (p=0.004) and presented significantly higher scores in pain experience (p<0.001), subjective sleep quality (p<0.001), pain catastrophizing (p<0.001) and psychological distress (p<0.05) except for paranoid-ideation than the groups with only joint problems. Conclusions: The results of this study highlight the importance of multi-dimensional approach that consider pain disability, sleep quality, and psychological functioning in the management of TMD with muscle component. This study would contribute to a better understanding of interaction between heterogeneous TMD and multiple risk factors in order to build tailored treatment based on different phenotypes.