• Journal of Korean Society of Industrial and Systems Engineering
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• v.35 no.4
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• pp.110-117
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• 2012

The demand for facility used in producing multi-products is changed dynamically for discrete and finite time periods. The excess or the shortage for facility is occurred according to difference of the facility capacity size and demand for facility through given time periods. The shortage facility is met through the outsourcing production. The excess facility cost is considered for the periods that the facility capacity is greater than the demand for the facility, and the outsourcing production cost is considered for the periods that the demand for facility is greater than the facility capacity. This paper addresses to determine the facility capacity size, outsourcing production products and amount that minimizes the sum of the facility capacity cost, the excess facility cost and the outsourcing production cost. The characteristics of the optimal solution are analyzed, and an algorithm applying them is developed. A numerical example is shown to explain the problem.

• Journal of Pharmaceutical Investigation
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• v.39 no.4
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• pp.263-267
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• 2009

The purpose of this study is to evaluate the efficacy of stipulated cleaning process, and the prohibition of cross-contamination and microbiological contamination, which inadequate cleaning in multi-production could occur, through cleaning validation of multi-purpose facility used to produce five biopharmaceutical products as sterile injection. After production of five biopharmaceutical products such as hGH, rhGCSF, rhEPO, rhFSH and rhIFN using vial filling machine, the cleaning validation such as residual analysis of active ingredients or human serum albumin, measurement of total organic carbon (TOC), residual analysis of detergent and microbiological contamination were carried out. In the case of rhGH and rhGCSF clean validations, drug residues were not detected. Furthermore, in the case of rhEPO, rhFSH and rhIFN clean validations, human serum albumin residues were not detected. At TOC (total organic carbon) analysis, all clean validations gave the TOC of about average 137.93%, not more than 150% of acceptance criteria. At sodium analysis for the checking of residues of cleaning agent, sodium residues were not detected. In sterility test, they showed no microbiological contamination of bacteria and fungi. Thus, this cleaning validation was determined as successful in protection of cross-contamination and induction of safety in multi-purpose facility.

• Journal of Korean Institute of Industrial Engineers
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• v.31 no.3
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• pp.240-247
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• 2005

Today's hightech society requires thousands of different products which ultimately result in billions of tons of materials discarded, most of which end up in landfills. Therefore industrial circles could not help thinking about environmental problems by regulations of government or pressures of consumer. Generally, the related research subjects are classified into both of environmentally conscious manufacturing and product recovery, where product recovery aims to minimize the amount of waste sent to landfills by recovering materials and parts from old or outdated products by means of recycling and remanufacturing (including reuse of parts and products). In this research, we constructed a model for remanufacturing various goods using a single facility and developed a dynamic programing(DP) algorithm based upon the optimal solution characterization. We showed the efficiency of the developed DP algorithm with a numerical example.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.49-55
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• 2017

Most motor cases adopt deep drawing products, which are excellent in waterproof functions, concentricity, right angle, and quality. In addition, the blower motor and seat motor, which are installed in the car interior and do not require waterproof function, adopts a multi-forming manufacturing method. The deep drawing process requires an expensive transfer press that can digest approximately 12 processes, such as drawing, trimming and piercing. On the other hand, products can be produced with low investment because the multi-forming method is composed of one multi-forming machine or one multi-forming machine and one press. The multi-forming machine is a high-priced facility that is mostly imported and a bending / shearing process multi-foaming machine, which was developed by domestic small and medium-sized enterprises, is not enough to reduce the production cost. An integral multi - forming machine is used as a limited working method for thin material and small products. A large product and thick material has a high shear load. A large product and thick material has a high shear load and uses a single crank press. After blanking, the worker manually feeds the material to a multi-forming machine. When the bending operation is performed in the multi-forming machine, it is transferred to the press again to calibrate the dimensions. This variance in work processes has resulted in lower cost competitiveness due to the lower productivity, quality issues, and excessive operator input. The aim of this study was to establish a stable and cost - effective production system through bending / shearing process separation and facility automation.

• IE interfaces
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• v.13 no.2
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• pp.217-224
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• 2000

This paper analyzes the effects of setup cost reduction in a dynamic lot-sizing model for a single-facility multi-product problem. In the model, demands for each product are known, no backlogging is allowed, and a single resource is employed. Also, setup cost is defined as a function of capital expenditure to invest in setup cost reduction. Furthermore, in each production period the facility (or plant) produces many products, each representing a fixed part of the involved production activity (or input resource quantity). In this paper, the structure of the optimal solution is characterized and an efficient algorithm is proposed for simultaneously determining the optimal lot size with reduced setup cost and the optimal investment in setup cost reduction. Also, the proposed algorithm is illustrated by a numerical example with a linear and an exponential setup reduction functions.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.26 no.1
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• pp.85-94
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• 2003

In this paper, a mathematical model is developed for economic design of multi-stage distribution system that consists of factory, central distribution centers, local distribution centers and retailers. The retailers are supplied products from different stage suppliers according to order size. The retailers are supplied products from factory if demand amount is large, central distribution center if medium, local distribution center if small. The economic design is to determine the economic size of facility factors that consist of distribution system. The cost factors are transportation cost from supply places to demand places, handling cost at distribution centers and inventory holding cost at retailers. It is to determine the transportation route of each retailer, the size and number of the vehicle at factory and distribution centers, the handling amount at distribution centers in order to minimize the total costs. The mathematical model is represented, the solution procedure is developed, and a numerical example is shown.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.23 no.6
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• pp.406-412
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• 2011

This paper describes the analysis on freeze and refrigeration capacity of cold storage facilities for fisheries products during the last 15 years. And based on the analysis results, we prospect the number and scale of cold storage facilities in the near future. The main analysis results are summarized by the followings; Under the present conditions, the number and scale of our facilities is 879 and 3,586,824 ton, respectively. In comparison of the present and last 15 years ago, the business number increases about 22%, the accommodation capacity increases approximately 80%. In the reported update reference with the related data during the last 15 years, the capacity of cold storage facilities in 2011 expects to reach up to 4,600,000 ton. The newlyestablished facility in 2011 has the function of a multi-purpose distribution center as well as the existing cold storage, but this facilities converges in the capital area. Therefore, in this paper, we provided the basic reference data for the present situation and prediction of our cold storage facilities. But it is necessary to investigate and analyse widely our cold storage facilities for fisheries products in the near future.

• IE interfaces
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• v.16 no.3
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• pp.280-290
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• 2003

Many firms are trying to optimize their production and distribution functions separately, but possible savings by this approach may be limited. Nowadays, it is more important to analyze these two functions simultaneously by trading off the costs associated with the whole. In this paper, I treat a production and distribution planning problem for single-period inventory products comprised of a single production facility and multiple customers, with the aim of optimally coordinating important and interrelated decisions of production sequencing and vehicle routing. Then, I propose a hybrid genetic algorithm incorporating several local optimization techniques, HGAP, for integrated production-distribution planning. Computational results on test problems show that HGAP is effective and generates substantial cost savings over Hurter and Buer's decoupled planning approach in which vehicle routing is first developed and a production sequence is consequently derived. Especially, HGAP performs better on the problems where customers are dispersed with multi-item demand than on the problems where customers are divided into several zones based on single-item demand.

• Journal of Korean Institute of Industrial Engineers
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• v.19 no.2
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• pp.65-74
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• 1993

In this paper, a two-echelon production-inventory model is developed which integrates the production scheduling problem of the multi-products produced on a single facility and the inventory problem of the related raw materials. The setup costs of the final products are assumed to be dependent on the production sequence. The aim is to determine simultaneously the production cycle time and the production sequence of the final products, and the procurement cycle times of the raw materials. For the model developed, a solution algorithm is suggested and illustrated with a numerical example. And the result is compared with those obtained by two separate subproblems.

• IE interfaces
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• v.22 no.2
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• pp.153-164
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• 2009

An effective management for reverse flows of products such as reuse, repair and disposal, has become an important issue for every aspect of business. In this paper, we study the Location-Routing Problem (LRP) in the multi-stage closed-loop supply chain network. The closed-loop supply chain in this study integrated both forward and reverse flows. In forward flow, a factory, Distribution Center (DC) and retailer are considered as usual. Additionally in reverse flow, we consider the Central Returns collection Center (CRC) and disposal facility. We propose a mixed integer programming model for the design of closed-loop supply chain integrating both forward and reverse flows. Since the LRP belongs to an NP-hard problem, we suggest a heuristic algorithm based on genetic algorithm. For some test problems, we found the optimal locations and routes by changing the numbers of retailers and facility candidates. Furthermore, we compare the efficiencies between open-loop and closed-loop supply chain networks. The results show that the closed-loop design is better than the open one in respect to the total routing distance and cost. This phenomenon enlarges the cut down effect on cost as an experimental space become larger.