• Korean Journal of Community Nutrition
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• v.10 no.5
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• pp.668-676
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• 2005

The purpose of this study was to determine the relationship between the students' levels of involvement in school lunch service and their satisfaction levels with the service. A survey was conducted with $5^{th}\;and\;6^{th}$ grade elementary students eating school lunches. Out of 1,680 questionnaires distributed to the students from 14 schools, 1,254 complete questionnaires $(74.6\%)$ were analyzed. The questionnaire included two 5-point multi-item scales for measuring levels of involvement in and satisfaction with school lunch service, respectively. A factor analysis grouped 20 items measuring school lunch satisfaction into three factors: 'food satisfaction', 'nutrition & sanitation satisfaction', and 'service & environment satisfaction'. As a result of multiple regression analyses controlling the influence of such variables as students' grades, gender, school location, years and places of eating school lunches, students' levels of involvement in school lunch service was proven to be positively associated with levels of school lunch satisfaction overall, as well as satisfaction levels in regard to 'food', 'nutrition & sanitation', and 'service & environment', respectively. It was suggested that efforts such as nutrition education to increase students' levels of involvement in school lunches could be a useful strategy to improve students' satisfaction with school lunch service.

• Fire Science and Engineering
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• v.29 no.5
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• pp.14-22
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• 2015

This thesis is based on the study of necessity of an addressable emergency broadcasting system to improve evacuation performance in order to minimize human casualty by avoiding the initial evacuation after fires such as the multi-unit dwelling fire in Euijeongbu in 2015. To minimize the damage from fire generated in a complex internal structure such as modern buildings, introduction of adaptable emergency broadcasting system, could increase the efficiency of evacuation by preventing of initial mistaken evacuation directions by alerting the accurate location of fire to the occupants, is needed. As such, this study designed and fabricated the addressable emergency broadcasting system using the existing addressable system. Its performance was compared with a conventional emergency broadcasting system to confirm the necessity of the addressable emergency broadcasting system to improve evacuation performance. The test result showed that the addressable emergency broadcasting system decreased the evacuation time by up to 30.3% in a small-scale model evacuation performance experiment, up to 54.6% in a hallway evacuation performance experiment compared to the conventional emergency broadcasting system.

• Journal of the Korea institute for structural maintenance and inspection
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• v.8 no.2
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• pp.137-145
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• 2004

The paper provides a methodology of identifying a substructure model when sectional and material properties of the structure are not the a priori information. In defining a substructure model, it is required that structural responses be consistent with the actual behavior of the part of the structure. Substructure model is identified by estimating boundary spring constants and stiffness properties of the substructure. Static and modal system identification methods have been applied using responses measured at limited locations within the substructure. Simulation studies for static and dynamic responses have been carried. The results and associated problems are discussed in the paper. The procedure has been also applied to an actual multi-span plate-girder Gerber-type bridge with dynamic responses obtained from a moving truck test and construction blasting vibrations.

• Biomolecules & Therapeutics
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• v.26 no.6
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• pp.599-607
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• 2018

Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical trials, unexpected liver toxicity resulted in premature termination of its development. Here, we investigated whether TAK-875 directly inflicts toxicity on hepatocytes and explored its underlying mechanism of toxicity. TAK-875 decreased viability of 2D and 3D cultures of HepG2, a human hepatocarcinoma cell line, in concentration-(>$50{\mu}M$) and time-dependent manners, both of which corresponded with ROS generation. An antioxidant, N-acetylcysteine, attenuated TAK-875-mediated hepatotoxicity, which confirmed the role of ROS generation. Of note, knockdown of GPR40 using siRNA abolished the hepatotoxicity of TAK-875 and attenuated ROS generation. In contrast, TAK-875 induced no cytotoxicity in fibroblasts up to $500{\mu}M$. Supporting the hepatotoxic potential of TAK-875, exposure to TAK-875 resulted in increased mortality of zebrafish larvae at$25{\mu}M$. Histopathological examination of zebrafish exposed to TAK-875 revealed severe hepatotoxicity as manifested by degenerated hypertrophic hepatocytes with cytoplasmic vacuolation and acentric nuclei, confirming that TAK-875 may induce direct hepatotoxicity and that ROS generation may be involved in a GPR40-dependent manner.

• BMB Reports
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• v.39 no.3
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• pp.329-334
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• 2006

RNAi (RNA interference) has become a popular means of knocking down a specific gene in vivo. The most common approach involves the use of chemically synthesized short interfering RNAs (siRNAs), which are relatively easy and fast to use, but which are costly and have only transient effects. These limitations can be overcome by using short hairpin RNA (shRNA) expression vectors. However, current methods of generating shRNA expression vectors require either the synthesis of long (50-70 nt) costly oligonucleotides or multi-step processes. To overcome this drawback, we have developed a one-step short-oligonucleotides-based method with preparation costs of only 15% of those of the conventional methods used to obtain essentially the same DNA fragment encoding shRNA. Sequences containing 19 bases homologous to target genes were synthesized as 17- and 31-nt DNA oligonucleotides and used to construct shRNA expression vectors. Using these plasmids, we were able to effectively silence target genes. Because our method relies on the onestep ligation of short oligonucleotides, it is simple, less error-prone, and economical.

• The Transactions of the Korea Information Processing Society
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• v.4 no.1
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• pp.255-269
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• 1997

In this paper, we describe the implementation of C cross-compiler for the ES-C2340 DSP2 processor by using the GNU compiler. For the rapid and efficient developing of the compiler and other parts like the processor-dependent back -end which is implemented newly to build the compiler. This approach has several advantages. First, as we use GNU compiler's well-proved excellent optimization method and multi-language support capability, we can improve he efficiency and generality of the compiler. Second, as we concentrate on the high-level language as logic approving tool in processor developing process. And to support the cross-compiler, we also implement a text-level pre-linker.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.7
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• pp.2097-2107
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• 1996

The dynamic photoelastic technique had been utilized to investigate the possibillity of relieving the large local singular stresses induced at the corner of a right- angle- indenter. The indenter compressed a semi-infinite body dynamically with an impact load applied on the top of the indenter. The effects of the geometric changes of the indenter in terms of the diameter (d) and the location (1) of the stress relieving notch on the behavior of the dynamic contact stresses were investigated. The influence of stress relieving notches positioned along the edge of the semi-infinite body on the dynamic contact stresses were also studied by changing the diameter (D) and the location (L) of the notch. A multi-speak-high speed camera with twelve sparks were used to take photographs of full field dynamic isochromatic fringe patterns. The contact singular stresses were found to be released significantly by the stress relief notches both along the indenter and the edge of the semi-infinite body. The optimal position and geometry of the stress relieving notches were obtained with the aid of limited experimental results.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.7
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• pp.258-264
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• 2018

This paper presents application of a differential search (DS) meta-heuristic optimization algorithm for optimal operation of a micro grid system. The DS algorithm simulates the Brownian-like random-walk movement used by an organism to migrate. The micro grid system consists of a wind turbine, a diesel generator, a fuel cell, and a photovoltaic system. The wind turbine generator is modeled by considering the characteristics of variable output. Optimization is aimed at minimizing the cost function of the system, including fuel costs and maximizing fuel efficiency to generate electric power. The simulation was applied to a micro grid system only. This study applies the DS algorithm with excellence and efficiency in terms of coding simplicity, fast convergence speed, and accuracy in the optimal operation of micro grids based on renewable energy resources, and we compared its optimum value to other algorithms to prove its superiority.

• Journal of Korean Society for Atmospheric Environment
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• v.23 no.2
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• pp.250-260
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• 2007

It was investigated that the emission characteristics of volatile organic compounds (VOCs) from small and medium companies located on industrial complexes in Metropolitan area. The emission characteristics are intermittent sources in which VOCs emissions are highly depends on the working condition. Optimized ventilation system to improve air quality in working area for the three typical companies were installed. Adsorption characteristics of major VOCs such as MEK, IPA, and toluene emitted front the companies were investigated for design of the activated carbon vessel as a VOCs control facility in each company. Concentration of total hydrocarbon and gas amounts needed to ventilation were also used as a design parameter. Mixed adsorbent to improve adsorption characteristics of problematic solvents like IPA and the design guideline of the activated carbon vessel have been suggested.

• Journal of Korean Society for Atmospheric Environment
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• v.2 no.2
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• pp.9-18
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• 1986

For identification and apportionment of sources emitting particulate matters in environment, the multi-elemental characterization of size-density fractionated particulate matters was carried out. Eight types of samples were tested; soil, flyash released from burning of bunker-Coil, diesel oil, coal, and soft coal, urban road-way dust, urban dust fall, and airborne particulate matter. The fractions of particulate matters obtained by heavy liquid separation methos with a series of dichloromethane-bromoform were then analyzed using atomic absorption spectrophotometry for Ni, Cr, Cu, An, Fe, Al, and Mg. Each sample showed a different concentration profile as a function of density, and a number of useful conclusions concerning characterization of elemental distribution were obtained. From the density distributions of elements in soil, the maximum value was found for all elements in the density range of 2.2 $\sim 2.9g.cm^{-3}$, including the density of $SiO_2$. However, the distribution of metallic compounds with the density lower than $2.2g.cm^{-3}$ was prevalent in urban roadway dust, urban dust fall, and airborne particulate matter. And the density distribution curves of these urban dusts also have the higher distribution at the density of 2.2 - 2.9g.cm^{-3}$, including the density of wind-blown silica. This tendency generally was prevalent in the natural source elements, such as Al, Fe, Mn, and Mg. The maximum values were found in the density ranges of 1.3 $\sim 2.2g.cm^{-3}$ from the density distribution of elements in oil fired flyash. These distributions of anthropogenic source elements, such as Zn, Ni, Cu, and Cr were higher predominately than those of natural source elements. And the higher distribution was found in the density range of $2.2 \sim 2.9g.cm^{-3}$ from the density distribution of elements in coal and soft-coal fired flyash. These distributions showed similar patterns to soil. But anthropogenic source elements somewhat predominated at the density ranges of $1.3 \sim 2.2g.cm{-3} and 2.9g.cm^{-3}$ to soil. Therefore the higher distribution of anthropogenic source elements in the density ranges of $1.3 \sim 2.2g.cm^{-3} and 2.9g.cm^{-3}$ was considered as anthropogenic origin.