• 한국컴퓨터정보학회논문지
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• 제19권4호
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• pp.1-8
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• 2014

멀티코어 프로세서는 여러 개의 코어가 하나의 칩에 배치됨에 따라 전력 밀도가 상승하여 높은 발열이 발생한다. 이러한 발열 문제를 해결하기 위해서 최근까지 다양한 연구가 진행되고 있다. 마이크로프로세서의 온도 감소를 위한 기법으로는 기계적 냉각 기법, 동적 온도 관리 기법 등이 있지만 이러한 기법들은 추가적인 냉각 비용이 발생하거나 성능의 저하가 발생한다. 플로어플랜기법은 추가적인 냉각비용이 발생하지 않으며, 성능저하가 거의 발생하지 않는다는 장점을 지닌다. 본 논문에서는 멀티코어 프로세서의 특정 구성요소의 발열 문제를 해결하기 위해 코어 내부 구성요소와 L2 캐쉬의 다양한 플로어플랜을 활용하고자 한다. 실험 결과, 코어의 뜨거운 구성요소를 L2 캐쉬와 인접하게 배치할 경우 칩의 온도 감소에 매우 효과적임을 알 수 있다. 코어를 캐쉬 상단-가운데 배치하는 기본 플로어플랜과 비교하여, 코어를 중앙에 배치하고 뜨거운 구성요소를 L2 캐쉬와 인접하게 배치하는 플로어플랜의 경우에는 $8.04^{\circ}C$, 코어를 외곽에 배치하고 뜨거운 구성요소를 L2 캐쉬와 인접하게 배치하는 플로어플랜의 경우에는 $8.05^{\circ}C$의 최고온도 감소 효과를 보임을 알 수 있다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.2033-2038
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• 2003

This paper describes an integrated navigation strategy for the autonomous service robot PSR. The PSR is under development at the KIST for service tasks in indoor public environments. The PSR is a multi-functional mobile-manipulator typed agent, which works in daily life. Major advantages of proposed navigation are as follows: 1) Structured control architecture for a systematic integration of various software modules. A Petri net based configuration design enables stable control flow of a robot. 2) A range sensor based generalized scheme of navigation. Any range sensor can be selectively applied using the proposed navigation scheme. 3) No need for modification of environments. (No use of artificial landmarks.) 4) Hybrid approaches combining reactive behavior as well as deliberative planner, and local grid maps as well as global topological maps. A presented experimental result shows that the proposed navigation scheme is useful for mobile service robot in practical applications.

• 한국관개배수논문집
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• 제19권1호
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• pp.30-39
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• 2012

In recent years, there have been a lot of severe flood and drought disasters and the rural environment have been worsened due to rapid industrialization and urbanization in the river basins of Korea. To prevent such disasters and to improve environment in the era of climate change, Korean Government carried out 110 projects to heighten irrigation dam in the rural area. The study has been carried out to evaluate the heightening work of the irrigation dam for the supply of reserved water and to derive optimal scheme to allocate the water resource for irrigation, domestic demand and environmental conservation as well as to contribute for the rural development in sustainable way. The study is focused on the Seoam Irrigation Dam which has been constructed in 2005 to be connected with the new Gami Reservoir which has been constructed since 2010. In addition, it was studied the contribution effect of the reservoirs for the adjacent comprehensive rural development projects which have been executed by local government. In the study, the principles and visions of sustainable development which have been derived by International Commission on Irrigation and Drainage is applied to estimate the sustainability of the irrigation dams in line with the adjacent comprehensive rural development projects. The project is estimated that the water resource in the reservoirs shall be used integratedly in cooperation with various stakeholders not only to conserve water environment but also to increase productivity of agricultural goods and ecological tour in the rural area.

• 한국산업융합학회 논문집
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• 제22권5호
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• pp.467-473
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• 2019

In this study, approached to improve durability of the multi-functional nano-pattern fabricated on the curved lens surface using nanoimprint lithography (NIL) was proposed, and the effects of the proposed methods on functionality after wear test were examined. To improve the mechanical property of ultraviolet(UV)-curable resin, UV-NIL was conducted at the elevated temperature around $60^{\circ}C$. In addition, micro/nano hierarchical structures was fabricated on the lens surface with a durable film mold. Analysis on the worn surfaces of nano-hole pattern and hierarchical structures and measurements on the static water contact angle and critical water volume for roll-off indicated that the UV curing process with elevated temperature is effective to maintain wettability by increasing hardness of resin. Also, it was found that the micro-scale pattern is effective to protect nano-pattern from damage during wear test.

• Molecules and Cells
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• 제41권11호
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• pp.971-978
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• 2018

The stem cell factor (SCF)/c-KIT axis plays an important role in the hematopoietic differentiation of human pluripotent stem cells (hPSCs), but its regulatory mechanisms involving microRNAs (miRs) are not fully elucidated. Here, we demonstrated that supplementation with SCF increases the hematopoietic differentiation of hPSCs via the interaction with its receptor tyrosine kinase c-KIT, which is modulated by miR-221 and miR-222. c-KIT is comparably expressed in undifferentiated human embryonic and induced pluripotent stem cells. The inhibition of SCF signaling via treatment with a c-KIT antagonist (imatinib) during hPSC-derived hematopoiesis resulted in reductions in the yield and multi-lineage potential of hematopoietic progenitors. We found that the transcript levels of miR-221 and miR-222 targeting c-KIT were significantly lower in the pluripotent state than they were in terminally differentiated somatic cells. Furthermore, suppression of miR-221 and miR-222 in undifferentiated hPSC cultures induced more hematopoiesis by increasing c-KIT expression. Collectively, our data implied that the modulation of c-KIT by miRs may provide further potential strategies to expedite the generation of functional blood cells for therapeutic approaches and the study of the cellular machinery related to hematologic malignant diseases such as leukemia.

• 보건교육건강증진학회지
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• 제21권3호
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• pp.1-17
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• 2004

The purpose of this study is to evaluate the roles of expected self-control and expected self-control results in explaining adolescents' Internet addiction. In the study model, expectations of self-control and self-control results directly determine Internet addiction and Internet use time meditates the impacts of expectations of self-control and self-control results on Internet addiction. The study subjects are 1,080 middle and high school students in Busan. Stratified cluster sampling is applied by school type and school year. The response rate is 96%(l,037cases). This study develops the scales of expected self-control and expected self-control results. The scales of Internet addiction are devised by using the concept of functional dependency such as salience, withdrawal symptoms, mood modification, tolerance, relapse, and conflict. For verifying the study model, path analysis and multiple regression models are applied for identifying path significants and evaluating confounding effects of control variables, respectively. Moreover, multi partial F-test is performed for selecting the best regression model. Expected self-control is a significant determinant of Internet addiction and Internet use time that also significantly explains Internet addiction. The total effect of expected self-control towards Internet addiction is -.95. The total effect is comprised with the direct effect (-.71) and the indirect effect(-.24). In this result, the direct effect refers a curative effect since expected self-control directly reduces the level of Internet addiction, and the indirect effect refers a preventive effect because self-control can reduce time of Internet use that is a direct determinant of Internet addiction. In the test of the confounding effects of control variables, there are no confounding effects in the models of multiple regression. It implies a robustness of the study model as regards control variables. In conclusion, improving adolescents' expected self-control can control Internet addiction level. This finding implies that a health promotion program for improving expected self-control can be a cost effective method compared to other approaches.

• 대한가정학회지
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• 제31권3호
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• pp.197-212
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• 1993

The purpose of this study was to find out the physical change of the farm house and its anbang(the main room : master bed room), to identify the behavioral changes : activity and awareness of anbang, and to clarify the relationship between the physical changes of the farm house, and the behavioral changes of housing life-style in the anbang space. Bibliographical studies, cultural approaches and field survey method with questionnaire were used to collect data from 55 residents of Anwhari and Yangkyori in Pyong Teck Koon. Tables and drawings were made to analyze the data. The major findings were 1) the heating system of the ondol anbang. The most popular type is the double heating system(new pipes added to the traditional ondol). This combination ondol system brought some conviniences to the farmers. This change in structure of the ondol were of four types : Complete change in style, enlarged-completely changed style, partially changed style, enlarged-partially changed style. 2) from 1960 through 1970 lighting of the anbang changed room oil lamp to electricity. 3) the finishing material of the anbang floor changed from traditional oil paper and straw mats to vinyl flooring. 4) Traditional furniture and small decor items are gradually disappearing and are being replaced by modern items. 5) The awareness and actual use of the ondol anbang has not much changed from the multi-functional and sacred space of daily living : which are the characteristics of Korean traditional ondol anbang. The biggest consistency in the ondol anbang is the heating system of the floor, which is the characteristic of ondol culture in Korea. This system will continue regardless of time and place in Korea.

• 수산해양교육연구
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• 제17권2호
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• pp.218-227
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• 2005

Ocean resources have a very important role to meet the requirements of the people's leisure activities in a limited country, so fishing villages and fishing ports are getting more and more important as a source of supply to satisfy the demands as time goes on. There are various and far-reaching approaches to the fishing villages and fishing ports. However, studies to present the over-all direction of development policy for fishing villages and fishing ports have been short; especially the studies which have been dealing with Busan were verified to be very short relatively. As a result of survey, both officials in charge and residents in fishing villages have an enough understanding of what problems the development of fishing villages have and it's direction of development and spreading effects. In the part of the policy of developing fishing ports, officials answered that insufficient synthetic estimation was main problem in developing the fishing ports, while residents had a high recognition that local fishing ports and small scale fishing ports have had poor progress relatively. In the analysis of difference between two group about the spreading effects of developing fishing villages and fishing ports, they had affirmative opinions rather than negative ones without exemption. As mentioned above, it is a right direction to develop the existing fishing ports as well as new fishing ones to the multi-functional synthetic fishing ports. The specialized development should be made so that the special quality of coastal resources, which fishing villages have, will be made the best use of.

• Journal of Genetic Medicine
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• 제20권1호
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• pp.6-14
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• 2023

Fabry disease (FD), a rare X-linked lysosomal storage disorder, is caused by mutations in the α-galactosidase A gene gene encoding α-galactosidase A (α-Gal A). The functional deficiency of α-Gal A results in progressive accumulation of neutral glycosphingolipids, causing multi-organ damages including cardiac, renal, cerebrovascular systems. The current treatment is comprised of enzyme replacement therapy (ERT), oral pharmacological chaperone therapy and adjunctive supportive therapy. ERT has been introduced 20 years ago, changing the outcome of FD patients with proven effectiveness. However, FD patients have many unmet needs. ERT needs a life-long intravenous therapy, inefficient bio-distribution, and generation of anti-drug antibodies. Migalastat, a pharmacological chaperone, augmenting α-Gal A enzyme activity only in patients with mutations amenable to the therapy, is now available for clinical practice. Furthermore, these therapies should be initiated before the organ damage becomes irreversible. Development of novel drugs aim at improving the clinical effectiveness and convenience of therapy. Clinical trial of next generation ERT is underway. Polyethylene glycolylated enzyme has a longer half-life and potentially reduced antigenicity, compared with standard preparations with longer dosing interval. Moss-derived enzyme has a higher affinity for mannose receptors, and seems to have more efficient access to podocytes of kidney which is relatively resistant to reach by conventional ERT. Substrate reduction therapy is currently under clinical trial. Gene therapy has now been started in several clinical trials using in vivo and ex vivo technologies. Early results are emerging. Other strategic approaches at preclinical research level are stem cell-based therapy with genome editing and systemic mRNA therapy.

• The Journal of Korean Physical Therapy
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• 제22권3호
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• pp.79-85
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• 2010

Purpose: Many trials for new therapeutic approaches such as stem cell-based transplantation have been conducted to improve the repair and regeneration of injured cord tissue and to restore functions following spinal cord injury (SCI) in animals and humans. Adipose tissue-derived stromal cells (ATSCs) have multi-lineage potential to differentiate into cells with neuron-like morphology. Most studies of stem cell transplantation therapy after SCI are focused on cellular regeneration and restoration of motor function, but not on unwanted effects after transplantation such as neuropathic pain. This study was focused on whether transplantation of ATSCs could facilitate or attenuate hindpaw pain responses to heat, cold and mechanical stimulation, as well as on improvement of locomotor function in a rat with SCI. Methods: A spinal cord injury rat model was produced using an NYU impactor by dropping a 10 g rod from a height of 25 mm on to the T9 segment. Human ATSCs (hATSCs; approximately $5{\times}10^5$ cells) or DMEM were injected into the perilesional area 9 days after the SCI. After transplantation, hindpaw withdrawal responses to heat, cold and mechanical allodynia were measured over 7 weeks. Motor recovery on the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and on the inclined plane test were also evaluated. Results: The present study demonstrated that increased hindpaw withdrawal responses to cold allodynia was observed in both groups after transplantation, but the development of cold-induced allodynia in the hATSC transplantation group was significantly larger than in the control group. The difference between the two groups in locomotor functional improvement after SCI was also significant. Conclusion: Careful consideration not only of optimal functional benefits but also of unintended side effects such as neuropathic pain is necessary before stem cell transplantation therapy after SCI.