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Study on Tumor Control Probability and Normal Tissue Complication Probability in 3D Conformal Radiotherapy (방사선 입체조형치료에 대한 종양치유확율과 정상조직손상확율에 관한 연구)

  • 추성실
    • Progress in Medical Physics
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    • v.9 no.4
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    • pp.227-245
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    • 1998
  • A most appropriate model of 3-D conformal radiotherapy has been induced by clinical evaluation and animal study, and therapeutic gains were evaluated by numerical equation of tumor control probability(TCP) and normal tissue complication probability (NTCP). The radiation dose to the tumor and the adjacent normal organs was accurately evaluated and compared using the dose volume histogram(DVH). The TCP and NTCP was derived from the distribution of given dosage and irradiated volume, and these numbers were used as the biological index for the assessment of the treatment effects. Ten patients with liver disease have been evaluated and 3 dogs were sacrificed for this study. Based on the 3-D images of the tumor and adjacent organs, the optimum radiation dose and the projection direction which could maximize the radiation effect while minimizing the effects to the adjacent organs could be decided. 3). The most effective collimation for the normal adjacent organs was made through the beams eye view with the use of multileaf collimator. When the dose was increased from 50Gy to 70Gy, the TCP for the conventional 2-port radiation and the 5-port multidimensional therapy was 0.982 and 0.995 respectively, while the NTCP was 0.725 and 0.142 respectively, suggesting that the 3-D conformal radiotherapy might be the appropriate therapy to apply sufficient radiation dose to the tumor while minimizing the damages to the normal areas of the liver. Positive correlation was observed between the NTCP and the actual complication of the normal liver in the animal study. The present study suggest that the use of 3-D conformal radiotherapy and the application of the mathematical models of TCP and NTCP may provide the improvements in the treatment of hepatoma with enhanced results.

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Site Selection Model for Wetland Restoration and Creation for the Circulation of Water in a Newly-built Community (신도시 물순환체계 구축을 위한 습지조성 입지선정에 관한 연구)

  • Choi, Hee-Sun;Kim, Kwi-Gon
    • Journal of the Korean Institute of Landscape Architecture
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    • v.36 no.6
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    • pp.43-54
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    • 2009
  • This study attempted to develop a model for selecting sites for ecologically effective, multi-functional wetlands during the environmental and ecological planning stage, prior to land use Planning. This model was developed with an emphasis upon the creation of a water circulation system for a newly-created city, dispersing and retaining the run-off that is increased due to urbanization and securing spaces to create wetlands that can promote urban biodiversity. A series of Precesses for selecting sites for wetland restoration and creation - watershed analysis, selection of evaluation items, calculation of weights, reparation of thematic maps and synthesis - were incorporated into the model. Its potentials and limitations were examined by applying it to the recently-planned WiRae New Community Development Area, which is located in the Seoul metropolitan region. At the watershed analysis stage, the site was divided into 13 sub-catchment areas. Inflow to watersheds including the area was $3,020,765m^3$ Run-off before and after development is estimated as $1,901,969m^3$ and $1,970,735{\sim}2,039,502m^3$, respectively. The total storage capacity required in the development area amounts to $68,766{\sim}137,533m^3$. When thematic maps were overlapped during the selection stage for wetland sites, 13 sub-catchment areas were prioritized for wetland restoration and creation. The locations and areas for retaining run-off showed that various types of wetlands, including retaining wetlands (area wetlands), riverine wetlands (linear wetlands) and pond wetlands (point wetlands), can be created and that they can be systematically connected. By providing a basic framework for the water circulation system plan of an entire city, it may be used effectively in the space planning stage, such as planning an urban eco-network through integration with greet areas. In order to estimate reasonable run-off and create an adequate water circulation system however, a feedback process following land use planning is required. This study strived to promote urban changes in a positive direction while minimizing urban changes in negative forms.

Development of Two-dimensional Prompt-gamma Measurement System for Verification of Proton Dose Distribution (이차원 양성자 선량 분포 확인을 위한 즉발감마선 이차원분포 측정 장치 개발)

  • Park, Jong Hoon;Lee, Han Rim;Kim, Chan Hyeong;Kim, Sung Hun;Kim, Seonghoon;Lee, Se Byeong
    • Progress in Medical Physics
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    • v.26 no.1
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    • pp.42-51
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    • 2015
  • In proton therapy, verification of proton dose distribution is important to treat cancer precisely and to enhance patients' safety. To verify proton dose distribution, in a previous study, our team incorporated a vertically-aligned one-dimensional array detection system. We measured 2D prompt-gamma distribution moving the developed detection system in the longitudinal direction and verified similarity between 2D prompt-gamma distribution and 2D proton dose distribution. In the present, we have developed two-dimension prompt-gamma measurement system consisted of a 2D parallel-hole collimator, 2D array-type NaI(Tl) scintillators, and multi-anode PMT (MA-PMT) to measure 2D prompt-gamma distribution in real time. The developed measurement system was tested with $^{22}Na$ (0.511 and 1.275 MeV) and $^{137}Cs$ (0.662 MeV) gamma sources, and the energy resolutions of 0.511, 0.662 and 1.275 MeV were $10.9%{\pm}0.23p%$, $9.8%{\pm}0.18p%$ and $6.4%{\pm}0.24p%$, respectively. Further, the energy resolution of the high gamma energy (3.416 MeV) of double escape peak from Am-Be source was $11.4%{\pm}3.6p%$. To estimate the performance of the developed measurement system, we measured 2D prompt-gamma distribution generated by PMMA phantom irradiated with 45 MeV proton beam of 0.5 nA. As a result of comparing a EBT film result, 2D prompt-gamma distribution measured for $9{\times}10^9$ protons is similar to 2D proton dose distribution. In addition, the 45 MeV estimated beam range by profile distribution of 2D prompt gamma distribution was $17.0{\pm}0.4mm$ and was intimately related with the proton beam range of 17.4 mm.

Baseline Survey Seismic Attribute Analysis for CO2 Monitoring on the Aquistore CCS Project, Canada (캐나다 아퀴스토어 CCS 프로젝트의 이산화탄소 모니터링을 위한 Baseline 탄성파 속성분석)

  • Cheong, Snons;Kim, Byoung-Yeop;Bae, Jaeyu
    • Economic and Environmental Geology
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    • v.46 no.6
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    • pp.485-494
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    • 2013
  • $CO_2$ Monitoring, Mitigation and Verification (MMV) is the essential part in the Carbon Capture and Storage (CCS) project in order to assure the storage permanence economically and environmentally. In large-scale CCS projects in the world, the seismic time-lapse survey is a key technology for monitoring the behavior of injected $CO_2$. In this study, we developed a basic process procedure for 3-D seismic baseline data from the Aquistore project, Estevan, Canada. Major target formations of Aquistore CCS project are the Winnipeg and the Deadwood sandstone formations located between 1,800 and 1,900 ms in traveltime. The analysis of trace energy and similarity attributes of seismic data followed by spectral decomposition are carried out for the characterization of $CO_2$ injection zone. High trace energies are concentrated in the northern part of the survey area at 1,800 ms and in the southern part at 1,850 ms in traveltime. The sandstone dominant regions are well recognized with high reflectivity by the trace energy analysis. Similarity attributes show two structural discontinuities trending the NW-SE direction at the target depth. Spectral decomposition of 5, 20 and 40 Hz frequency contents discriminated the successive E-W depositional events at the center of the research area. Additional noise rejection and stratigraphic interpretation on the baseline data followed by applying appropriate imaging technique will be helpful to investigate the differences between baseline data and multi-vintage monitor data.

Study on Oxidation and Coercivity of Nd2Fe14B Compound Crystal (Nd2Fe14B 화합물 결정의 산화 및 보자력에 관한 연구)

  • Kwon, H.W.;Yu, J.H.
    • Journal of the Korean Magnetics Society
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    • v.22 no.3
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    • pp.85-90
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    • 2012
  • Oxidation of the $Nd_2Fe_{14}B$ compound crystal and its effect on the coercivity of the fine $Nd_2Fe_{14}B$ crystal particles were investigated. Oxidation kinetics of the $Nd_2Fe_{14}B$ compound crystal was investigated using an excessively grown $Nd_2Fe_{14}B$ grains in the $Nd_{15}Fe_{77}B_8$ alloy ingot. Oxidation of the $Nd_2Fe_{14}B$ compound crystal occurred by dissociation of the phase into multi-phase mixture of ${\alpha}$-Fe, $Fe_3B$, and Nd oxides. Oxidation rate of the $Nd_2Fe_{14}B$ compound crystal showed no dependence on the crystallographic direction. The oxidation reaction was modeled according to simple linear relationship. Activation energy for the oxidation of $Nd_2Fe_{14}B$ compound crystal was calculated to be approximately 26.8 kJ/mol. Fine $Nd_2Fe_{14}B$ crystal particles in near single domain size was prepared by ball milling of the HDDR-treated $Nd_{15}Fe_{77}B_8$ alloy, and these particles were used for investigating the effect of oxidation on the coercvity. The near single domain size $Nd_2Fe_{14}B$ crystal particles (${\fallingdotseq}0.3\;{\mu}m$) had high coercivity over 9 kOe. However, the coercivity was radically reduced as the temperature increased in air (<2 kOe at $200^{\circ}C$). This radical coercivity reduction was attributed to the soft magnetic phases, ${\alpha}$-Fe and $Fe_3B$, which were formed on the surface of the fine particles due to the oxidation.

Deformational Phased Structural Characteristics of the Hadong Southern Anorthosite Complex and its Surrounding Area in the Jirisan Province, Yeongnam Massif, Korea (영남육괴 지리산지구에서 하동 남부 회장암복합체와 그 주변지역의 변형단계별 구조적 특성)

  • Lee, Deok-Seon;Kang, Ji-Hoon
    • The Journal of the Petrological Society of Korea
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    • v.22 no.2
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    • pp.179-195
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    • 2013
  • The study area, which is located in the southeastern part of the Jirisan province, Yeongnam massif, Korea, is mainly composed of the Precambrian Hadong southern anorthosite complex (HSAC), the Jirisan metamorphic rock complex (JMRC) and Cretaceous sedimentary rock which unconformably covers them. Lithofacies distribution of the Precambrian constituent rocks mainly shows NS and partly NE trends. This paper researched deformational phased structural characteristics of HSAC and JMRC based on the geometric and kinematic features and the forming sequence of multi-deformed rock structures, and suggests that the geological structures of this area was formed through at least three phases of ductile deformation. The first phase ($D_1$) of deformation happened due to the large-scale top-to-the SE shearing, and formed the sheath or "A"-type fold and the regional tectonic frame of NE trend in the HSAC and JMRC. The second phase ($D_2$) of deformation, like the $D_1$ deformation, regionally occurred under the EW-directed tectonic compression, and most of the NE-trending $D_1$ tectonic frame was reoriented into NS trend by the active and passive folding, and the persistent and extensive ductile shear zone (Hadong shear zone) with no less than 2.3~1.4 km width was formed along the eastern boundary of HSAC and JMRC through the mylonitization process. The third phase ($D_3$) of deformation occurred under the NS-directed tectonic compression, and partially reoriented the pre-$D_3$ structural elements into ENE or WNW direction. It means that the distribution of Precambrian lithofacies showing NE trend locally and NS trend widely in this area is closely associated with the $D_1$ and $D_2$ deformations, respectively, and the NS-trending Hadong shear zone in the eastern part of Hadong northern anorthosite complex, which is located in the north of Deokcheon River, also extends into the HSAC with continuity.

Research Trend of Biomass-Derived Engineering Plastics (바이오매스 기반 엔지니어링 플라스틱 연구 동향)

  • Jeon, Hyeonyeol;Koo, Jun Mo;Park, Seul-A;Kim, Seon-Mi;Jegal, Jonggeon;Cha, Hyun Gil;Oh, Dongyeop X.;Hwang, Sung Yeon;Park, Jeyoung
    • Applied Chemistry for Engineering
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    • v.31 no.2
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    • pp.115-124
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    • 2020
  • Sustainable plastics can be mainly categorized into (1) biodegradable plastics decomposed into water and carbon dioxide after use, and (2) biomass-derived plastics possessing the carbon neutrality by utilizing raw materials converted from atmospheric carbon dioxide to biomass. Recently, biomass-derived engineering plastics (EP) and natural nanofiber-reinforced nanocomposites are emerging as a new direction of the industry. In addition to the eco-friendliness of natural resources, these materials are competitive over petroleum-based plastics in the high value-added plastics market. Polyesters and polycarbonates synthesized from isosorbide and 2,5-furandicarboxylic acid, which are representative biomass-derived monomers, are at the forefront of industrialization due to their higher transparency, mechanical properties, thermal stability, and gas barrier properties. Moreover, isosorbide has potential to be applied to super EP material with continuous service temperature over 150 ℃. In situ polymerization utilizing surface hydrophilicity and multi-functionality of natural nanofibers such as nanocellulose and nanochitin achieves remarkable improvements of mechanical properties with the minimal dose of nanofillers. Biomass-derived tough-plastics covered in this review are expected to replace petroleum-based plastics by satisfying the carbon neutrality required by the environment, the high functionality by the consumer, and the accessibility by the industry.

A Basic Study on the Characteristics of the Modern Garden in Incheon During the Opening Period - Focused on Rikidake's Villa - (개항기 인천 근대정원의 조영특성에 관한 기초연구 - 리키다케 별장을 중심으로 -)

  • Jin, Hye-Young;Shin, Hyun-Sil
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.38 no.3
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    • pp.83-91
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    • 2020
  • The purpose of this study is to examine the process of formation of modern gardens. Based on the analysis of the process of formation and transformation of the Jemulpo in Incheon and the details of the modern garden construction. The results are as follows; First, the formation of the Incheon Residence Site began in 1876 with the signing of the Joseon-Japan Treaty. Jemulpo used to be a desolate fishing village in the past, but after its opening in 1881, the Japanese settlement, Chinese settlement, and the general foreign settlement were formed. After that, Japan reclaimed the southern mudflats and expanded the theire settlement area, and advanced to the Joseon area(currently Sinheung-dong). In Japanese colonial era, modern Japanese urban landscapes were transplanted into the settlement area, centering on the Japanese modern gardens were distributed in the area around the center of the settlement area. Second, after examining the process of creating the garden for the Rikidake villa, Japanese Rikidake purchased a site for an orchard in Uri-tang, who was a major landowner in Incheon, to create the garden. At the time of Rikidake's residence, the garden was very large, measuring about 3,000 pyeong, and after liberation, it was acquired by Incheon City and used as Yulmok Children's Library. It was known as a rich village at the time of the opening of the port, and a garden was located at the highest point in Yulmok-dong, making it easy to see the Incheon Port area. Also, a spot located about 300 meters away from Rikidake's rice mill may have affected the location selection. Third, today's Rikidake villa has a Japanese-style house on a trapezoidal site, with a garden of about 990 square meters on the south side. Currently, it is possible to enter from the south and from Yulmok Children's Park in the north, but in the past, the main direction of the house was to view the Incheon Port, settlement area, and the Rikidake Rice Mill, so the house was located in front of the garden. The garden is a multi-faceted style with stone lanterns, tombstones, garden stones, and trees placed on each side, and is surrounded by arboreal plants such as attention, strobe pine, and maple trees, as well as royal azaleas. The view from the inside of the house was secured through shrub-oriented vegetation around the house.

Two-dimensional Velocity Measurements of Campbell Glacier in East Antarctica Using Coarse-to-fine SAR Offset Tracking Approach of KOMPSAT-5 Satellite Image (KOMPSAT-5 위성영상의 Coarse-to-fine SAR 오프셋트래킹 기법을 활용한 동남극 Campbell Glacier의 2차원 이동속도 관측)

  • Chae, Sung-Ho;Lee, Kwang-Jae;Lee, Sungu
    • Korean Journal of Remote Sensing
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    • v.37 no.6_3
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    • pp.2035-2046
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    • 2021
  • Glacier movement speed is the most basic measurement for glacial dynamics research and is a very important indicator in predicting sea level rise due to climate change. In this study, the two-dimensional velocity measurements of Campbell Glacier located in Terra Nova Bay in East Antarctica were observed through the SAR offset tracking technique. For this purpose, domestic KOMPSAT-5 SAR satellite images taken on July 9, 2021 and August 6, 2021 were acquired. The Multi-kernel SAR offset tracking proposed through previous studies is a technique to obtain the optimal result that satisfies both resolution and precision. However, since offset tracking is repeatedly performed according to the size of the kernel, intensive computational power and time are required. Therefore, in this study, we strategically proposed a coarse-to-fine offset tracking approach. Through coarse-to-fine SAR offset tracking, it is possible to obtain a result with improved observation precision (especially, about 4 times in azimuth direction) while maintaining resolution compared to general offset tracking results. Using this proposed technique, a two-dimensional velocity measurements of Campbell Glacier were generated. As a result of analyzing the two-dimensional movement velocity image, it was observed that the grounding line of Campbell Glacier exists at approximately latitude -74.56N. The flow velocity of Campbell Glacier Tongue analyzed in this study (185-237 m/yr) increased compared to that of 1988-1989 (140-240 m/yr). And compared to the flow velocity (181-268 m/yr) in 2010-2012, the movement speed near the ground line was similar, but it was confirmed that the movement speed at the end of the Campbell Glacier Tongue decreased. However, there is a possibility that this is an error that occurs because the study result of this study is an annual rate of glacier movement that occurred for 28 days. For accurate comparison, it will be necessary to expand the data in time series and accurately calculate the annual rate. Through this study, the two-dimensional velocity measurements of the glacier were observed for the first time using the KOMPSAT-5 satellite image, a domestic X-band SAR satellite. It was confirmed that the coarse-to-fine SAR offset tracking approach of the KOMPSAT-5 SAR image is very useful for observing the two-dimensional velocity of glacier movements.

A Study on History and Archetype Technology of Goli-su in Korea (한국 고리수의 역사와 원형기술의 복원 연구)

  • Kim, Young-ran
    • Korean Journal of Heritage: History & Science
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    • v.46 no.2
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    • pp.4-25
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    • 2013
  • Goli-su is the innovative special kind of the embroidery technique, which combines twining and interlacing skill with metal technology and makes the loops woven to each other with a strand. The loops floating on the space of the ground look like floating veins of sculpture and give people the feeling of the openwork. This kind of characteristic has some similarities with the lacework craft of Western Europe in texture and technique style, but it has its own features different from that of Western Europe. It mainly represents the splendid gloss with metallic materials in the Embroidered cloth, such as gold foil or wire. In the 10th century, early days of Goryo, we can see the basic Goli-su structure form of its initial period in the boy motif embroidery purse unearthed from the first level of Octagonal Nine-storied Pagoda of Woljeong-sa. In the Middle period of Joseon, there are several pieces of Goli-su embroidered relic called "Battle Flag of Goryo", which was taken by the Japanese in 1592 and is now in the Japanese temple. This piece is now converted into altar-table covers. In 18~19th century, two pairs of embroidered pillows in Joseon palace were kept intact, whose time and source are very accurate. The frame of the pillows was embroidered with Goli-su veins, and some gold foil papers were inserted into the inside. The triangle motif with silk was embroidered on the pillow. The stitch in the Needle-Looped embroidery is divided into three kinds according to comprehensive classification: 1. Goli-su ; 2. Goli-Kamgi-su ; 3. Goli-Saegim-su. From the 10th century newly establishing stage to the 13th century, Goli-su has appeared variational stitches and employed 2~3 dimensional color schemes gradually. According to the research of this thesis, we can still see this stitch in the embroidery pillow, which proves that Goli-suwas still kept in Korea in the 19th century. And in terms of the research achievement of this thesis, Archetype technology of Goli-su was restored. Han Sang-soo, Important Intangible Cultural Heritage No. 80 and Master of Embroidery already recreated the Korean relics of Goli-su in Joseon Dynasty. The Needle-Looped embriodery is the overall technological result of ancestral outstanding Metal craft, Twining and Interlacing craft, and Embroidery art. We should inherit, create, and seek the new direction in modern multi-dimensional and international industry societyon the basis of these research results. We can inherit the long history of embroidering, weaving, fiber processing, and expand the applications of other craft industries, and develop new advanced additional values of new dress material, fashion technology, ornament craft and artistic design. Thus, other crafts assist each other and broaden the expressive field to pursue more diversified formative beauty and beautify our life abundantly together.