• Journal of Ginseng Research
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• 제46권1호
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• pp.62-70
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• 2022

Background: Maternal Toxoplasma gondii (T. gondii) infection during pregnancy has been associated with various mental illnesses in the offspring. Ginsenoside Rh2 (GRh2) is a major bioactive compound obtained from ginseng that has an anti-T. gondii effect and attenuates microglial activation through toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway. GRh2 also alleviated tumor-associated or lipopolysaccharide-induced depression. However, the effects and potential mechanisms of GRh2 on depression-like behavior in mouse offspring caused by maternal T. gondii infection during pregnancy have not been investigated. Methods: We examined GRh2 effects on the depression-like behavior in mouse offspring, caused by maternal T. gondii infection during pregnancy, by measuring depression-like behaviors and assaying parameters at the neuronal and molecular level. Results: We showed that GRh2 significantly improved behavioral measures: sucrose consumption, forced swim time and tail suspended immobility time of their offspring. These corresponded with increased tissue concentrations of 5-hydroxytryptamine and dopamine, and attenuated indoleamine 2,3-dioxygenase or enhanced tyrosine hydroxylase expression in the prefrontal cortex. GRh2 ameliorated neuronal damage in the prefrontal cortex. Molecular docking results revealed that GRh2 binds strongly to both TLR4 and high mobility group box 1 (HMGB1). Conclusion: This study demonstrated that GRh2 ameliorated the depression-like behavior in mouse offspring of maternal T. gondii infection during pregnancy by attenuating the excessive activation of microglia and neuroinflammation through the HMGB1/TLR4/NF-κB signaling pathway. It suggests that GRh2 could be considered a potential therapy in preventing and treating psychiatric disorders in the offspring mice of mothers with prenatal exposure to T. gondii infection.

• 한국환경과학회지
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• 제29권1호
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• pp.1-13
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• 2020

Recently, a heavy rainfall with high spatial variation occurred frequently in the Korean Peninsula. The meteorological event that occurred in Busan on 3 May 2016 is characterized by heavy rain in a limited area. In order to clarify the reason of large spatial variation associated with mountain height and location of low level jet, several numerical experiments were carried out using the dynamic meteorological Weather Research and Forecasting (WRF) model. In this case study, the raised topography of Mount Geumjeong increased a barrier effect and air uplifting due to topographic forcing on the windward side. As a result, wind speed reduced and precipitation increased. In contrast, on the downwind side, the wind speed was slightly faster and since the total amount of water vapor is limited, the precipitation on the downwind side reduced. Numerical experiments on shifting the location of the lower jet demonstrated that if the lower jet is close to the mountain, its core becomes higher due to the effect of friction. Additionally, the water vapor convergence around the mountain increased and eventually the precipitation also increased in the area near the mountain. Hence, the location information of the lower jet is an important factor for accurately predicting precipitation.

• 동의신경정신과학회지
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• 제15권2호
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• pp.89-101
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• 2004

Objective : The present experiments were designed to study on the immune-enhancing effect of Mountain grown ginseng, Mountain cultivated ginseng, and Panax ginseng Method : In order to compare the immune-enhancing effect of moutain grown ginseng, moutain cultivated ginseng and Panax ginseng, the study was done through the forced swimming test (FST), measurement of T helper Th1, Th2 cytokines and fatigue related factors. Result : Moutain grown ginseng and panax ginseng decreased the immobility time in the FST compared to the control. Glucose, blood urea nitrogen (BUN), creatinine, lactate dehydrogenase (LDH) and Total-protein (T-protein) in serum were investigated. The serum achieved from ginseng administered mouse showed higher BUN, T-protein than the control. moutain grown ginseng administered group showed lower LDH than the control group. moutain grown ginseng administered mouse showed higher glucose than the control. Creatinine was same in either experimental or control group. Ginseng-induced cytokine production in human T-cell line, MOLT-4 cells and mouse peritoneal macrophages were compared. Moutain cultivated ginseng (10-4 dilution) and panax ginseng (10-3 dilution) were increased the interferon $IFN-{\gamma}$ production compared with media control (about 1.6-fold P<0.05) at 48 h. Moutain grown ginseng (10-4 dilution) was increased the $IFN-{\gamma}$ and interleukin IL-4 production compared with media control (about l.4-fold for $IFN-{\gamma}$ and 1.6-fold for IL-4 P<0.05) at 48 h. Moutain grown ginseng (10-3 dilution) and moutain cultivated ginseng (10-4 dilution) were increased the turmor necrosis factor $TNF-{\alpha}$ production compared with $rIFN-{\gamma}$ treated cells (about 1.9-fold for $TNF-{\alpha}$ P<0.05), respectively. Moutain cultivated ginseng (10-3 dilution) was increased the IL-12 production compared with $rIFN-{\gamma}$ treated cell (about 1.7-fold for IL-12 P<0.05). Conclusion : These data suggest that three different three kinds of ginseng act on immune responses in different aspects.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제54권3호
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• pp.127-131
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• 2005

Big fire such as mountain fire may cause the prevention of the functions of the overhead cables and insulators, which may affect the operation of the transmission lines. In the worst case, this kind of disaster may have a huge effect on the whole industry of a country. However, the study on the effect of the mountain fire on the transmission line is very rare. Therefore, in order to understand the effect of the mountain fire on the polymeric insulator for transmission lines, the author observed the deformation of the sheds of the polymeric insulators and the change of the discs of the porcelain insulators under fire, varying the ignition time using the artificial ignition testing equipment which simulates the mountain fire, and investigated the electrical and mechanical characteristics of the insulators after the ignition test. For the test, the miniature insulators made of polymeric material and porcelain have been utilized. As the result, the following conclusions were obtained. First, the porcelain insulator was degraded in electrical characteristics when the insulator was subjected to the fire for approximately 5 minutes; whereas, the polymeric insulator was not degraded though there were some damage on its sheds. Second, after 20 minute exposure to the fire, the polymeric insulator lost a lot of parts of sheds, but the electrical characteristics was lowered by around $20\%$, but the porcelain insulators were electrically degraded by more than $80\%$.

• 대한지리학회지
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• 제38권2호
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• pp.173-183
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• 2003

본 연구에서는 시베리아 고기압의 확장시 호남 지방의 강설 분포와 강설 패턴의 지역성을 파악하기 위해 호남 지방의 15개 기상관측지점의 일강설량 및 구름 자료를 분석하였다. 호남 지방의 강설은 시베리아 고기압에 의한 것이 대부분으로 북서 계절풍에 직접적으로 노출된 서해안과 노령 산맥의 서사면은 강설이 많고, 노령 산맥의 풍하측인 남해안으로 갈수록 적어진다. 특히, 노령 산맥의 서사면 지역에서는 지형적 특색에 따라 강설 분포의 패턴이 다양하여. 해안에 위치한 군산은 강설이 많고 내륙 평야에서 강설이 감소하는 경향을 보인다 한편 내륙으로 기류가 이동하여 산지를 만나면 강제 상승하게 되어 다시 강설이 증가한다. 일반적으로 적운형 구름의 출현 빈도가 높은 지역에서 강설이 많은데, 적운형 구름은 내륙 산지, 해안, 그리고 내륙 평야 순이며, 강설 강도 또한 내륙 산지, 해안, 내륙 평야 순으로 강하다. 특히, 정읍의 경우 배후에 노령 산맥이 가까이 있고 북서 계절풍에 대해 정면으로 노출되어 강설 강도가 가장 강하게 나타난다. 따라서, 호남 지방의 강설은 해안 지역에서의 바다효과에 의한 강설과 내륙 산간 지역에서의 지형 효과에 의한 강설로 구분할 수 있다.

• Journal of Ginseng Research
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• 제48권2호
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• pp.202-210
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• 2024

Background: Panax ginseng Meyer polysaccharides exhibit various biological functions, like antagonizing galectin-3-mediated cell adhesion and migration. Galectin-8 (Gal-8), with its linker-joined N- and C-terminal carbohydrate recognition domains (CRDs), is also crucial to these biological processes, and thus plays a role in various pathological disorders. Yet the effect of ginseng-derived polysaccharides in modulating Gal-8 function has remained unclear. Methods: P. ginseng-derived pectin was chromatographically isolated and enzymatically digested to obtain a series of polysaccharides. Biolayer Interferometry (BLI) quantified their binding affinity to Gal-8, and their inhibitory effects on Gal-8 was assessed by hemagglutination, cell migration and T-cell apoptosis. Results: Our ginseng-derived pectin polysaccharides consist mostly of rhamnogalacturonan-I (RG-I) and homogalacturonan (HG). BLI shows that Gal-8 binding rests primarily in RG-I and its β-1,4-galactan side chains, with sub-micromolar K_D values. Both N- and C-terminal Gal-8 CRDs bind RG-I, with binding correlated with Gal-8-mediated function. Conclusion: P. ginseng RG-I pectin β-1,4-galactan side chains are crucial to binding Gal-8 and antagonizing its function. This study enhances our understanding of galectin-sugar interactions, information that may be used in the development of pharmaceutical agents targeting Gal-8.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2008년도 정기총회 및 학술발표대회
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• pp.719-722
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• 2008

Forest management is done to keep ecological health of forest and to enhancement of its function. Nowadays, the abnormal climate and heavy rain happen frequently. Therefore, there are opinions that the thinning slash allowed in the mountain is flowed in rivers, which can influence in flood damage. This study, we grasp moving characteristics of thinning slash through field survey and achieved basic study about the effect of thinning slash on the discharge capacity of rivers and stream structure.

• 한국식품저장유통학회지
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• 제6권1호
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• pp.48-54
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• 1999

The effect of irradiation of heat treatment either alone or in combination on the shelf-life of mixed mountain edible herb drinks (MMEHD) was investigated during storage. The MMEHD made from fresh Spuriopinella bracycarpar, Ligularia fischeri and Aster scaber was gamma -irradiated at doses of 0.1 kGy to 1 kGy. Microbial population, color change, vitamin C content, and sensory quality were evaluated during storage at 4, 25 and 35oC. Heated MMEHD induced the growth of total counts, mold and yeast as compared to the non-heated MMEHD. While some reduction in the microbial growth was observed in 1kGy-irradiated groups of both with or without heating. In both groups, L and b values decreased, but a value increased during storage. Also, heating drinks showed increased L and b values and reduced a value, compared to the non-heating drinks. Non-heated drinks showed 82% loss of vitamin C, whereas 25% loss of vitamin C was occurred in the irradiated drinks during storage at 4oC for 4days. In the meanwhile, non-irradiated heating drinks showed 99% loss of vitamin C, but irradiated heating drinks showed 58-65% reduction of vitamin C. Non-irradiated drinks without heating showed more bright color than irradiated ones, but irradiated drinks showed more enhanced brightness during storage. Also, irradiated drinks showed better falvor, sensory quality, and overall acceptability than non-irradiated drinks.

• 대한약침학회지
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• 제13권1호
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• pp.5-14
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• 2010

Objectives : This study was performed to examine the anticancer effect of mountain ginseng Pharmacopuncture(MGP) to the nude mouse of lung carcinoma induced by NCI-H460 human nonsmall lung cancer cells. Methods : Human lung cancer (NCI-H460) cells were cultured and applied to evaluate anti-tumor activity in nude mice. After confirmed tumor growth in mice, MGP was treated per 0.1ml/kg dose to intraperitoneal and intravenous injection everyday for four weeks. And checked the changes in body weights, tumor volume, mean survival time and percent, increase in life span, histo-pathological findings, organ weights, and blood chemistry levels. Results : The results of in vivo study showed that MGP may have potential as growth inhibitor of solid tumor induced NCI-H460 without marked side effects. MGP inhibited dosage-dependently the growth of NCI-H460 cell-transplanted solid tumor compared with the control group. And mean survival time of MGP treated group was prolonged comparing with control group. Generally the group of intravenous injection is more effective than intraperitoneal injection. Conclusion : These results were suggested that MGP may be a useful anticancer agent for therapy of human lung cancer. And follow study need for the certain evidence.

• 한국환경과학회지
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• 제5권6호
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• pp.713-718
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• 1996

We identified two characteristic turbulent flow cases, weakening and strengthening, which appear at the downwind side. Observations were made two times, Dec. 2-3. 1995 and Feb. 13-14. 1996 at Pusan National University site located downwind side of Kumjeong mountain. Meteorological observation system, tethersonde, was adopted to present observation. In the case of the west wind which blows perpendicular to Sanghak mountain located westward from the site, the wind speed highly increased in exponential with height. Therefore, the low level wind speed was so weak just like Taylor(1988)'s review. While the wind speed was intensified at 200-400m layer when the northwest wind blows from the continental Siberian high. We suppose 기 is because of the strong vertical convergence of flow between the surface inversion layer and the upper one, and also the horizontal convergence along the saddle and valley between the two mountains, Kumjeong and Sanghak-because of Bernoulli's effect. The inversion layer existed at surface-l00m and 500-600m level and the strong wind existed at about 200-400m layer.