• 한국융합학회논문지
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• 제13권4호
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• pp.71-78
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• 2022

파킨슨병은 임상적으로 인지 및 신경정신과 증상을 포함한 다양한 운동 및 비운동 증상으로 특징지어진다. 이러한 다양한 증상을 통합하여 임상적 하위유형(clinical subtype)으로 분류하는 것은 초기 치료 개입에 유용할 수 있다. 본 연구에서는 치매로 진단받지 않은 파킨슨병 환자의 운동, 인지, 신경정신증상과의 상관관계 패턴을 확인하고자 한다. 파킨슨병으로 진단받은 104명의 환자에게 운동 및 인지기능 검사와 신경정신증상에 대하여 종합적인 평가를 시행하였다. 인구통계학적 요인과 운동, 인지, 신경정신증상을 포함한 변수 사이의 상관관계를 확인하고 임상적 하위유형을 추출하기 위하여 요인분석을 실시하였다. 분석결과 1개의 운동관련 요인과 3개의 인지관련 요인 및 4개의 신경정신과적 요인이 추출되었다. 본 연구결과 상관관계의 특성이 파킨슨병의 질병과정에서 특징적인 동반증상 패턴을 가질 수 있음을 확인하였으며, 이를 통해 향후 하위유형을 확인하고 치료적 전략을 수립하는데 유용할 수 있을 것으로 사료된다.

• 대한한방내과학회지
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• 제42권5호
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• pp.833-845
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• 2021

Parkinson's syndrome is a degenerative brain disease that presents characteristic motor symptoms of tremor, rigidity, and gait disturbance. In addition to these motor symptoms, Parkinson's syndrome also presents non-motor symptoms (NMSs) such as sleep disturbance and cognitive decline. NMSs reduce patient's quality of life and psychosocial functioning and cause economic burden on the patient, so appropriate evaluation and treatment are required. Lewy body dementia is one of the several diseases belonging to Parkinson's syndrome. Its symptoms such as cognitive function, memory impairment, and hallucinations occur with Parkinsonism. Although drug therapy is being used with drug treatment to treat non-motor symptoms, it has limitations such as side effects, which stimulated interest in other complementary treatment methods such as oriental medicine treatment, dance, and yoga. The patient in this case complained of tremor in the right upper extremity, muscle hypertension and pain, and persistent vision, memory, and cognitive decline. The patient was diagnosed with probable Lewy body dementia. The patient was hospitalized for 4 months and received acupuncture and herbal medicines. After treatment, the patient's NMS scale scores decreased from 90 to 63, and the Unified Parkinson's Disease Rating Scale scores (summed I, II, and III) decreased from 17 points to 8 points. The Beck Depression Inventory score decreased from 22 points to 13 points. In addition, the patient's subjective evaluation revealed improvement. In this case, a patient diagnosed with probable Lewy body dementia who did not respond to the standard treatment and did not want to take medications showed improvement in not only motor symptoms but also NMSs after integrative Korean medicine treatment.

• Annals of Clinical Neurophysiology
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• 제4권2호
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• pp.98-107
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• 2002

Multifocal motor neuropathy (MMN) is a chronic immune-mediated peripheral myelinopathy. The major clinical features include slowly progressive, painless, and asymmetric weakness, usually of distal limb muscle. Early in the course of the disease, weakness is not necessarily associated with muscle atrophy, owing to the initial primary involvement of peripheral myelin. Chronic progressive weakness is often associated with some degree of concurrent axonal loss and subsequent muscle atrophy. Sensory symptoms are usually mild or absent, and involvement of cranial and respiratory muscles is rare. The findings of multifocal motor conduction block, abnormal temporal dispersion, and focal conduction slowing at segments not at risk for common entrapment or compression injury, associated with normal sensory conduction studies along the same segments, are the hallmark electrophysiologic features of MMN. The slow progression and absence of upper motor neuron signs are the major clinical points that separate MMN from amyotrophic lateral sclerosis. The role of GM1 antibodies, found in high titers in 22~84% of MMN patients, remains uncertain. The contention that MMN is an autoimmune disorder is largely based on the often dramatic improvement in symptoms following the administration of intravenuos immunoglobulin or cyclophosphamide.

• 국제물리치료학회지
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• 제10권2호
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• pp.1785-1790
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• 2019

Background: Lumbar disc herniation (LDH) causes neurological symptoms by compression of the dura mater and nerve roots. Due to the changed in proprioception inputs that can result in abnormal postural pattern, delayed reaction time, and changed in deep tendon reflex. Objective: To investigate the effects of lumbar stabilization exercises on motor neuron excitability and neurological symptoms in patients with LDH. Design: Randomized Controlled Trial (single blind) Methods: Thirty patients with LDH were recruited; they were randomly divided into the balance center stabilization resistance exercise group (n=15) and the Nordic walking group (n=15). Each group underwent their corresponding 20-minute intervention once a day, four times a week, for four weeks. Participants' motor neuron excitability and low back pain were assessed before and after the four-week intervention. Results: There were significant differences in all variables within each group (p<.05). There were significant differences between the experimental and control groups in the changes of upper motor neuron excitability and pain (p<.05), but not in the changes of lower motor neuron excitability and Korean Oswestry Disability Index. Conclusion: Lumbar stabilization exercises utilizing concurrent contraction of deep and superficial muscles improved low back function in patients with LDH by lowering upper motor neuron excitability than compared to exercises actively moving the limbs. Lumbar stabilization exercises without pain have a positive impact on improving motor neuron excitability.

• 사상체질의학회지
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• 제29권4호
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• pp.376-386
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• 2017

Objectives This case study is about a Taeeumin patient with Parkinson's disease identified as Dry-heat (Joyeol) pattern. In this study, we report significant improvement of motor and non-motor symptoms of this patient after Sasang constitutional medicine treatment. Methods The patient was identified as Taeeumin Dry-heat pattern and treated with Cheongsimyeonja-tang and acupuncture. The Unified Parkinson Disease Rating Scale(UPDRS) was used to assess the overall function of the patient. And the Global Assessment Scale (GAS) was used to assess the change of bradykinesia, tremor and dry mouth after the treatment. Results The UPDRS total score decreased from 145 points to 77 points after 5 weeks treatment. And symptoms of bradykinesia, tremor and dry mouth showed significant improvement in GAS after the treatment. Furthermore, constipation, sleep disturbance, dysuresia and anorexia were reported to be improved after treatment. Conclusions This study shows that Sasang constitutional medicine can be effective treatment for motor and non-motor symptoms caused by Parkinson's disease.

• 대한한방내과학회지
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• 제39권4호
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• pp.794-801
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• 2018

Objectives: These cases report the benefits of administration of Banhasasim-tang extracts or decoctions to patients with functional gastrointestinal disorders after motor vehicle accidents. Methods: The patients were treated with Banhasasim-tang extract or decoction three times daily. History-taking and imaging tests were used to differentiate other diseases. We evaluated the patients using the Gastrointestinal Symptom Rating Scale (GSRS), which is used to assess overall gastrointestinal symptoms. Results: Treatment with herbal medicine resulted in a decrease in the patients' complaints of symptoms. The GSRS scale showed improvement in all four cases. Conclusions: Banhasasim-tang, regardless of its form, has beneficial effects in patients with functional gastrointestinal disorders after motor vehicle accidents.

• 대한감각통합치료학회지
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• 제15권2호
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• pp.35-45
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• 2017

목적 : 본 연구는 주의력결핍과잉행동장애(Attention-Deficit/Hyperactivity Disorder; ADHD) 아동에게 사용되는 상호작용식 메트로놈(Interactive Metronome; IM) 프로토콜을 기반으로 임상에 적용 가능하도록 수정된 IM 프로그램이 ADHD 아동의 행동증상, 타이밍 및 운동기능에 미치는 효과를 알아보고자 한다. 연구방법 : 본 연구는 부산 소재의 기초정신건강증진센터 내에 있는 7-12세의 ADHD 아동 13명을 대상으로 단일 집단 사전-사후 설계(one group pretest-posttest design)를 사용하였다. 중재는 회당 30분, 주 3회, 24회기 동안 실시하였으며, 중재 전과 후의 행동증상, 타이밍 및 운동기능 변화를 비교하기 위해 부모보고형 한국어판 ADHD 평정척도, IM의 Long Form Assessment(LFA), Bruininks-Oseretsky Test of Motor Proficiency 2판(BOT-2)을 사용하였다. 결과 : 행동증상 중 과잉행동/충동성에서 유의미한 향상이 있었고, 타이밍과 손의 협응 및 신체협응에서 통계적으로 유의미한 향상이 있었다. 결론 : 임상에 적용 가능하도록 수정된 IM 프로그램이 ADHD 아동의 행동증상을 개선하고, 타이밍 및 운동기능 향상에 유의한 효과가 있다.

• The Journal of Korean Physical Therapy
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• 제31권2호
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• pp.122-128
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• 2019

Purpose: This study examined the effects of sagittal spinopelvic alignment on the clinical parameters, motor symptoms, and respiratory function in patients with mild to moderate Parkinson's disease (PD). Methods: This study was a prospective assessment of treated patients (n=28, Hoehn and Yahr (H&Y) stage 2-3) in a PD center. Twenty-eight subjects ($68.5{\pm}5.7yrs$) participated in this study. The clinical and demographic parameters, including age, sex, symptoms duration, treatment duration, and H&Y stage, were collected. Kinematic analysis was conducted in the upright standing posture with a motion capture system. A pulmonary function test (PFT) was performed in the sitting position using a spirometer. The motor symptoms were assessed on part III of the movement disorder society sponsored version of the unified Parkinson's disease rating scale (MDS-UPDRS). SPSS 18.0 was used to analyze the collected data. Results: The exceeding 12 degrees group of the lower trunk showed significantly higher on the clinical parameters than the below 12 degrees group. In addition, the exceeding 12 degrees group of the lower trunk showed a significantly lower forced expiratory volume at one second (FEV1) / forced vital capacity (FVC) (%) and 25-75% forced mid-expiratory flow (FEF) (L/s) than in the below group. On the other hand, there was no difference in the upper trunk and the cervical pelvis between the groups. Conclusion: These findings suggest that the sagittal balance in the lower trunk is related to the clinical parameters and respiratory function, but not the motor symptoms in patients with mild to moderate PD.

• 동의신경정신과학회지
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• 제18권3호
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• pp.225-236
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• 2007

Tic disorder show purposeless, repeated, unexpected, involuntary behavior and voice, can be divided into motor, vocal tic. this is about a patient who suffered from motor tic, tachycardia and other symptoms. We treated him with Sa-am acupuncture and other oriental medicine from the viewpoint of weak of kidney power. involuntary movement was estimated by doctor with Yale Global Tic Severity Scale(YGTSS). The patient's motor tic, tachycardia and other symptoms were improved and YGTSS also decresed.

• Annals of Clinical Neurophysiology
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• 제3권2호
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• pp.172-175
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• 2001

Guillain-$Barr{\acute{e}}$ syndrome(GBS) is a common demyelinating disease of the peripheral nervous system. But recently, the axonal types are also reported. Acute transverse myelitis(ATM) is also a common inflammatory disease of the spinal cord. Generally, it is difficult to identify the etiology of GBS and ATM. I guess the occurrence of the 2 diseases at once is hard to take the place. A 63-year-old woman showed an acute motor axonal GBS and a cervical-upper thoracic ATM occurring at the same time. She was treated by intravenous immunoglobulin and solumedrol therapy. Her sensory symptoms were improved rapidly but motor symptoms showed only mild improvement.