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http://dx.doi.org/10.15207/JKCS.2022.13.04.071

Correlation of motor and non-motor symptoms in Parkinson's disease: a factor-analytic convergence study  

Gang, Miyeong (Department of Occupational Therapy, Woosong University)
Publication Information
Journal of the Korea Convergence Society / v.13, no.4, 2022 , pp. 71-78 More about this Journal
Abstract
Parkinson's disease (PD) is clinically characterized by a variety of motor and non-motor symptoms, including cognitive and neuropsychiatric symptoms. Integrating a large variety of symptoms into a small number of clinical subtypes could be valuable for appropriate and early therapeutic intervention. As a first step toward this aim, this study attempted to identify correlation patterns among motor, cognitive and neuropsychiatric symptoms in PD without dementia. One hundred four non-demented patients with PD underwent a comprehensive motor, neuropsychological, and neuropsychiatric assessments. Factor analysis was performed to identify correlation patterns among demographic, motor, cognitive and neuropsychiatric variables. The eight factors were extracted: 1 motor-related, 3 cognitive-related and 4 neuropsychiatric factors. We indentified that characteristics of correlation can have associated symptom pattern in the disease process of Parkinson's disease. The current results suggest that a broad range of motor and non-motor symptoms in PD may be reducible to a small number of clinical parameters, which may be useful for identifying clinical subtypes of PD for individual patients.
Keywords
Parkinson's disease; Motor symptoms; Cognitive symtpoms; Neuropsychiatric symptoms; Factor analysis; Convergence;
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