• Title/Summary/Keyword: Motor neuropathy

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Acute Motor Axonal Neuropathy Combined with Acute Disseminated Encephalomyelitis (급성 파종성 뇌척수염에 동반된 급성 운동 축삭형 신경병증)

  • Yu, Seong-Yong;Lim, Eui-Seong;Shin, Byoung-Soo;Seo, Man-Wook;Kim, Young-Hyun
    • Annals of Clinical Neurophysiology
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    • v.6 no.1
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    • pp.52-56
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    • 2004
  • Acute motor axonal neuropathy (AMAN) is a subtype of Guillain-Barre syndrome and characterized by selective involvement of motor fibers. Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease of central nervous system. The coincidence of central and peripheral nervous system involvement has been reported rarely. We described a 37-year-old male patient presented with fever and altered consciousness. The examination of cerebrospinal fluid and brain magnetic resonance imaging was compatible with acute disseminated encephalomyelitis. Several days after admissionb his mentality was improved but quadriparesis, multiple cranial neuropathies, and areflexia were detected. Electrophysiologic studies suggested axonal form of motor dominant polyneuropathy. We report a case of acute motor axonal neuropathy combined with ADEM. We consider that this case is an example of simultaneous immunologic process to the common pathogenic epitope of central nervous system and peripheral nervous system.

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Intravenous Immunoglobulin Therapy in Peripheral Neuropathy (말초신경병증에 대한 정맥내 면역글로불린 요법)

  • Kim, Nam Hee;Park, Kyung Seok
    • Annals of Clinical Neurophysiology
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    • v.8 no.1
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    • pp.6-15
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    • 2006
  • Intravenous immunoglobulin (IVIg) is the treatment of choice for many autoimmune neuropathic disorders such as Guillain-Barre syndrome (GBS), chronic inflammatory Demyelinating neuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is preferred because the adverse reactions are milder and fewer than the other immune-modulating methods such as steroid, other immunosuppressant such as azathioprine, and plasmapheresis. IVIg also has been used in other autoimmune neuromuscular disorders (inflammatory myopathy, myasthenia gravis, and Lambert-Eaton myasthenic syndrome) and has been known as safe and efficient agent in these disorders. Since IVIg would get more indications and be used more commonly, clinicians need to know the detailed mechanism of action, side effects, and practical points of IVIg.

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A Case Report of a Patient with Sensory Disturbance of the Hands and Feet Diagnosed as Hereditary Motor and Sensory Neuropathy (Charcot-Marie-Tooth Disease) Who Was Treated with Korean Medicine (유전운동감각신경병(샤르코-마리-투스병)으로 진단된 환자의 수족부 감각장애에 대한 한방 치험 1례)

  • Jeon, Gyeong-ryung;Cho, Jun-ho;Jeong, Taek-su;Lim, Bo-ra;Park, Jin-seo;Lee, Yu-jin;Jeong, Yun-kyeong
    • The Journal of Internal Korean Medicine
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    • v.39 no.5
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    • pp.1023-1031
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    • 2018
  • Objectives: The purpose of this study is to evaluate the effect of Korean medicine in a patient with sensory disturbance of the hands and feet diagnosed as hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease). Methods: A patient diagnosed with hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease) was treated with herbal medicine (Uchashinki-hwan-gami, Bosinji Granule, Ukgan-san-gami), acupuncture, moxibustion, and bee venom pharmacopuncture. Clinical improvements were evaluated using the numerical rating scale (NRS) and Toronto Clinical Neuropathy Score system (TCNSS). Results: Improvements in the total scores of NRS and TCNS were observed after Korean medicine treatments. NRS score decrease from 8 to 2, and TCNS score decreased from 10 to 7. Conclusion: Korean medicine treatment may be effective for sensory disturbance in hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease).

A Case of Strong Palm Compression-Induced Thenar Motor Neuropathy (강한 손바닥 압박 후 속발된 엄지두덩운동신경병증 1예)

  • Lee, Jeong-Gon;Jang, Il-Mi;Lee, Kyung-Bok;Roh, Hakjae;Ahn, Moo-Young
    • Annals of Clinical Neurophysiology
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    • v.14 no.1
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    • pp.41-44
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    • 2012
  • Thenar motor neuropathy (TMN) is a compressive mononeuropathy of recurrent motor branch of median nerve. It is infrequent and may have different pathogenesis. It may be a unique entity of disease or considered a variant of carpal tunnel syndrome involving the motor branch only. We report a case of TMN induced by vigorous massage that applied strong digital pressure in the region of the base of palm and thenar muscles.

Multifocal Motor Neuropathy (다초점성 운동신경병증)

  • Lee, Dong-Kuck
    • Annals of Clinical Neurophysiology
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    • v.4 no.2
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    • pp.98-107
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    • 2002
  • Multifocal motor neuropathy (MMN) is a chronic immune-mediated peripheral myelinopathy. The major clinical features include slowly progressive, painless, and asymmetric weakness, usually of distal limb muscle. Early in the course of the disease, weakness is not necessarily associated with muscle atrophy, owing to the initial primary involvement of peripheral myelin. Chronic progressive weakness is often associated with some degree of concurrent axonal loss and subsequent muscle atrophy. Sensory symptoms are usually mild or absent, and involvement of cranial and respiratory muscles is rare. The findings of multifocal motor conduction block, abnormal temporal dispersion, and focal conduction slowing at segments not at risk for common entrapment or compression injury, associated with normal sensory conduction studies along the same segments, are the hallmark electrophysiologic features of MMN. The slow progression and absence of upper motor neuron signs are the major clinical points that separate MMN from amyotrophic lateral sclerosis. The role of GM1 antibodies, found in high titers in 22~84% of MMN patients, remains uncertain. The contention that MMN is an autoimmune disorder is largely based on the often dramatic improvement in symptoms following the administration of intravenuos immunoglobulin or cyclophosphamide.

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A Case of Acute Motor Conduction Block Neuropathy Associated with Anti-GM1 Antibody (GM1 항체와 연관된 급성 운동 전도차단 신경병증 1예)

  • Park, Kang-Min;Bae, Jong-Seok;Kim, Sang-Jin;Lee, Jeong-Nyeo;Kim, Jong-Kuk
    • Annals of Clinical Neurophysiology
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    • v.9 no.2
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    • pp.89-92
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    • 2007
  • A 33-year-old women developed weakness in all limbs 3 days prior to admission. Motor examination showed decreased strength in all limbs, but sensory examination was normal. Deep tendon reflexes were areflexia. Electrophysiological examination showed conduction blocks with nearly normal conduction velocities and terminal latencies in motor nerves and normal amplitudes and velocities in sensory nerves. Her serum was positive for IgG antibodies to gangliosides GM1, GD1b, and galactocerebroside. Acute motor conduction block neuropathy may be another variant of Guillain-Barre syndrome.

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Motor and Sensory Peripheral Neuropathy in a Patient Came after Acute Carbon Monoxide Intoxication: a Case Report with Magnetic Resonance Image

  • Lee, Seungmin;Kim, Sang Yoon;Lee, Jee Young;Choi, Min Jeong
    • Investigative Magnetic Resonance Imaging
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    • v.20 no.3
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    • pp.175-180
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    • 2016
  • Carbon monoxide (CO) intoxication is a leading cause of the variable neuropsychiatric impairment. Despite of widely known central nerve system complications after CO intoxication, peripheral neuropathy due to CO poisoning is rare and has been under-recognized. We report interesting case of a 29-year-old male who suffered from motor weakness and sensory abnormalities in his lower extremity following acute CO intoxication. The patient revealed direct and indirect signs of peripheral neuropathy of the left inferior gluteal and sciatic nerve on magnetic resonance imaging.

Motor Peripheral Neuropathy Involved Bilateral Lower Extremities Following Acute Carbon Monoxide Poisoning: A Case Report (급성 일산화탄소 중독 환자에서 발생한 양하지 말초 운동신경병증 1례)

  • Choi, Jae-Hyung;Lim, Hoon
    • Journal of The Korean Society of Clinical Toxicology
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    • v.13 no.1
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    • pp.46-49
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    • 2015
  • Carbon monoxide (CO) intoxication is a leading cause of severe neuropsychological impairments. Peripheral nerve injury has rarely been reported. Following are brief statements describing the motor peripheral neuropathy involved bilateral lower extremities of a patient who recovered following acute carbon monoxide poisoning. After inhalation of smoke from a fire, a 60-year-old woman experienced bilateral leg weakness without edema or injury. Neurological examination showed diplegia and deep tendon areflexia in lower limbs. There was no sensory deficit in lower extremities, and no cognitive disturbances were detected. Creatine kinase was normal. Electroneuromyogram patterns were compatible with the diagnosis of bilateral axonal injury. Clinical course after normobaric oxygen and rehabilitation therapy was marked by complete recovery of neurological disorders. Peripheral neuropathy is an unusual complication of CO intoxication. Motor peripheral neuropathy involvement of bilateral lower extremities is exceptional. Various mechanisms have been implicated, including nerve compression secondary to rhabdomyolysis, nerve ischemia due to hypoxia, and direct nerve toxicity of carbon monoxide. Prognosis is commonly excellent without sequelae. Emergency physicians should understand the possible-neurologic presentations of CO intoxication and make a proper decision regarding treatment.

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Acute Motor Axonal Neuropathy (급성 운동축삭성 신경병증)

  • Lee, Dong-Kuck
    • Annals of Clinical Neurophysiology
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    • v.2 no.1
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    • pp.1-7
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    • 2000
  • From among the group of patients diagnosed clinically to have Guillain-Barre syndrome(GBS), subgroups with pure motor involvement have been identified. Some of such patients appear to have an axonal neuropathy by eletrophysiology. Such cases have been termed acute motor axonal neuropathy(AMAN). Many of these patients are found clinically to have normal sensation and to have electrodiagnostic patterns consistent with selective degeneration of motor axons. A serological survey showed some of individuals with AMAN had evidence of antecedent Campylobacter jejuni(CJ) infection. And AMAN has an association with the presence of anti-ganglioside antibodies. This article reviewed briefly the AMAN and their relationship to CJ infection and anti-ganglioside antibodies.

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A Case-Report of a Taeyangin Patient with Acute Motor Axonal Neuropathy Using Ogapijangchuk-tang (오가피장척탕을 사용하여 급성 운동 축색돌기 신경병증으로 진단받은 태양인 호전 1례)

  • Oh, Ji-Yeon;Kim, Won-Young;Lim, Eun-Chul
    • Journal of Sasang Constitutional Medicine
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    • v.33 no.3
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    • pp.171-180
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    • 2021
  • Objectives This case report is about a Taeyangin patient with Acute Motor Axonal Neuropathy identified as Hae-Yeok pattern using Ogapijangchuk-tang. In this study, we report the significant improvement of lower extremity weakness and pain of this patient after Sasang Constitutional medicine treatment. Methods The patient was identified as Taeyangin Hae-Yeok pattern and treated with Ogapijangchuk-tang. Guillain-Barre Syndrome disability scale was used to assess the overall function of the patient. The Numeral Rating Scale was used to assess the change of lower extremity pain. Also the change of lower extremity weakness was measured by patient's expression and graded by Manual Muscle Test. Result and Conclusion After treatment with Ogapijangchuk-tang, patient's symptoms were improved. And there was not any side effect. In conclusion, this study shows that Sasang Constitutional medicine can be effective treatment for Taeyangin patient with Acute Motor Axonal Neuropathy.