• Advances in Traditional Medicine
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• 제8권1호
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• pp.73-80
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• 2008

The objective of the present study was to assess the antipsychotic and antidiarrhoeal activities of ethanolic extract of roots of Rubia cordifolia in mice and rats. The antipsychotic activity of ethanolic extract of roots of Rubia cordifolia (ERC) was evaluated by observing its effect on amphetamineinduced stereotyped behavior in mice. Effect of ERC was also studied on motor coordination and locomotion in mice. The antidiarrhoeal activity was evaluated using castor oil-induced diarrhoea and excretion of sodium and potassium ions in the intestinal secretion in rats and gastrointestinal transit in mice. The ERC inhibited amphetamine-induced stereotyped behaviour, diminished locomotion and impaired motor coordination. ERC inhibited castor oil-induced diarrhoea, decreased both sodium and potassium excretion in the intestine and decreased gastrointestinal transit. Thus the present study confirms the anti-diarrhoeal activity of Rubia cordifolia. Further studies are necessary to evaluate the potential of Rubia cordifolia as an antipsychotic.

• The Journal of Korean Physical Therapy
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• 제28권1호
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• pp.8-13
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• 2016

Purpose: The purpose of the present current study was to examine control of upper limb multi-joint movements with differential coordination stability. To achieve the goals of the study, torque analyses were utilized to answer questions about how torque components were differed among various elbow-wrist coordination patterns. Methods: Eight self-reported right-handed college students (3 males and 5 females, mean age=20.6 yr) were volunteered. The task required participants to rhythmically coordinate the flexion-extension motions of their elbow and wrist with coordination relationship of $0^{\circ}$, $90^{\circ}$, and $180^{\circ}$relative phases between the two joints. Mean relative phase and phase stability (standard deviation of relative phase) were computed to for analysisze of overall coordination performance. To determine the figure out characteristics of torque components in elbow and wrist joints, impulse values of muscle torque (MT) and interactive torque (IT) and MT as a percentage of cycle duration (MT-PCD) were analyzed. Results: Torque results showed that the proximal elbow joint generated motions with mainly muscle efforts regardless of coordination patterns, while the distal wrist joint adjusted the coordination patterns by changing amount of MT. Impulse analyses showed that the least stable $90^{\circ}$ pattern was performed by utilizing a similar coordination strategy of the most stable $0^{\circ}$ pattern. Conclusion: The present current study suggests that the roles of distal and proximal joints differ in order to achieve various multi-joint coordination movements. This study provides information for use in gives an idea to development of rehabilitation or training programs for to persons with an impaired upper limb motor ability.

• The Korean Journal of Pain
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• 제32권2호
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• pp.79-86
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• 2019

Background: The use of aroma oils dates back to at least 3000 B.C., where it was applied to mummify corpses and treat the wounds of soldiers. Since the 1920s, the term "aromatherapy" has been used for fragrance therapy with essential oils. The purpose of this study was to determine whether the essential oil of Eucalyptus (EOE) affects pain pathways in various pain conditions and motor coordination. Methods: Mice were subjected to inhalation or intraperitoneal injection of EOE, and its analgesic effects were assessed by conducting formalin, thermal plantar, and acetic acid tests; the effects of EOE on motor coordination were evaluated using a rotarod test. To determine the analgesic mechanism, 5'-guanidinonaltrindole (${\kappa}$-opioid antagonist, 0.3 mg/kg), naltrindole (${\delta}$-opioid antagonist, 5 mg/kg), glibenclamide (${\delta}$-opioid antagonist, 2 mg/kg), and naloxone (${\mu}$-opioid antagonist, 4, 8, 12 mg/kg) were injected intraperitoneally. Results: EOE showed an analgesic effect against visceral pain caused by acetic acid (EOE, 45 mg/kg); however, no analgesic effect was observed against thermal nociceptive pain. Moreover, it was demonstrated that EOE did not have an effect on motor coordination. In addition, an anti-inflammatory effect was observed during the formalin test. Conclusions: EOE, which is associated with the ${\mu}$-opioid pain pathway, showed potential effects against somatic, inflammatory, and visceral pain and could be a potential therapeutic agent for pain.

• 운동영양학회지
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• 제16권2호
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• pp.73-84
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• 2012

Thyroid hormones are important for the development of the brain including the cerebellum. In the present study, we investigated the effect of treadmill exercise on the survival of Purkinje neurons and the activation of astrocytes in the cerebellar vermis of hypothyroidism-induced rat pups. On the day of perinatal 14, pregnant rats were divided into two groups (n = 5 in each group): the pregnant control group and the pregnantmethimazole (MMI)-treated group. For the induction of hypothyroidism in the rat pups, MMI was added to the drinking water (0.02% wt/vol), from the day of perinatal 14 to postnatal 49. After delivery, male rat pups born from the pregnant control group were assigned to the control group. Male rat pups born from the MMI-treated group were divided into the hypothyroidism-induction group, the hypothyroidism-induction with treadmill exercise group, and the hypothyroidism-induction with thyroxine (T4) treatment group (n = 10 in each group). The rat pups in the exercise group were forced to run on a treadmill for 30 min once a day for 4 weeks, starting on postnatal day 22. In the hypothyroidism-induced rat pups, motor coordination was reduced and Purkinje cell death and reactive astrocytes in the cerebellar vermis were increased. Treadmill exercise enhanced motor coordination, increased the survival of Purkinje neurons, down-regulated reactive astrocytes, and enhanced brain-derived neurotrophic factor (BDNF) and receptor tyrosine kinase B (TrkB) expressions in the hypothyroidism-induced rat pups. These results suggest that treadmill exercise has beneficial effects in terms of protecting against thyroid dysfunction by increasing T3 and T4 and the related protein, BDNF, as well as TrkB, inhibition on astrocyte activation and the reduction of Purkinje cell loss regarding the cerebellum in hypothyroidism rat pups.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제9권2호
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• pp.165-173
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• 1998

본 연구에서는 아스퍼거장애와 비전형 자폐장애 아동의 인지기능과 시각-운동 협응능력을 비교하였다. 아스퍼거장애(13명)와 비전형 자폐장애(14명) 환아 27명의 인지기능과 시각-운동 협응능력을 알아보기 위해 K-WISC와 BGT 수행결과를 비교하였다. 아스퍼거장애는 비전형 자폐장애보다 전체 지능이 유의미하게 더 높았다. 아스퍼거장애는 언어성 지능과 동작성 지능이 차이를 보이지 않은 반면, 비전형 자폐장애는 동작성 지능이 언어성 지능에 비해 유의미하게 더 높았다. 아스퍼거장애는 비전형 자폐장애에 비해 상식과 이해 소검사에서 더 우수한 수행을 보였고, 토막짜기에서는 더 낮은 점수를 받았다. 또한 비전형 자폐장애와 비교할 때, 아스퍼거장애는 시각-운동 협응에 더 어려움이 있는 것으로 나타났다. 아스퍼거 장애는 언어 및 학습능력이, 비전형 자폐장애는 시공간 기능 및 시각-운동 협응능력이 상대적으로 우수하였다. 이러한 결과는 K-WISC와 BGT가 이 두 장애를 구분하는데 유용한 평가도구가 될 수 있음을 시사해주었다.

• 대한감각통합치료학회지
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• 제9권1호
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• pp.21-31
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• 2011

목적 : 학령전기 아동의 글씨 쓰기 명료도 및 속도와 지각-운동 기술의 상관관계를 확인하고, 글씨 쓰기에 가장 영향을 주는 요인을 알아보고자 하였다. 연구방법 : 덴버 발달 선별 검사를 통하여 정상 발달로 선별된 23명의 학령 전기 아동(평균 연령=68.61개월, SD=2.04)을 대상으로 글씨 쓰기 명료도 및 속도 측정을 위하여 한글 자모 쓰기 검사지를 사용하여 자음과 모음을 쓰도록 하였다. 시지각과 시각-운동 통합 수행 능력 측정을 위하여 시지각 발달 검사를 사용하였고, 소운동 협응 수행 능력 측정을 위하여 Grooved pegboard test를 사용하였다. 결과 : 글씨 쓰기 명료도와 전반적인 시지각, 비운동성 시지각, 시각-운동 통합, 우세손 소동작 협응의 상관관계는 없었으며, 글씨 쓰기의 속도는 전반적 시지각과 우세손 소동작 협응 항목에서 유의한 상관관계를 보였다. 회귀 분석 결과 글씨 쓰기 속도에 가장 큰 영향을 주는 요인은 전반적 시지각 항목이었다. 결론 : 만 5~6세 학령 전기 아동의 전반적 시지각 능력의 발달을 향상시키기 위한 중재를 제공하는 것이 글씨 쓰기의 속도 능력을 향상 시킬 수 있다는 것을 알 수 있다.

• 대한정형도수물리치료학회지
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• 제26권2호
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• pp.45-53
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• 2020

Purpose: The purpose of this study was conducted to investigate the effects of kinesio taping and coordination exercise on the myofascial pain syndrome and shoulder function. Methods: The patients with myofascial pain syndrome were participated in this study and divided randomly 2 groups. Control group (n=22) was taken only physical therapy program. Experimental group (n=22) was taken physical therapy with Kinesio taping and coordination exercise. The Kinesio taping in experimental group applied on levator scapulae and supraspinatus. The coordination exercise performed in supine position and sitting position on 15 times during 10 seconds each positions. We measured the pain degree using visual analog scale (VAS), pain rating score (PRS), pressure pain threshold (PPT), myofascial pain subjects symptoms index and shoulder motor function using constant shoulder assessment scale; CSA before and after experiment. Results: The significant test of CSA, myofascial pain subjects symptoms index, VAS, PRS according to applying the Kinesio taping and coordination exercise between groups used ANCOVA. In the result following analysis, there was significance on VAS (F=13.071, p=.031), PRS (F=12.130, p=.014), PPT (F=7.378, p=.016), CSA (F=5.302, p=.026) between control group and experimental group. Conclusion: Then, Kinesio taping and coordination exercise has benefit on the VAS, PRS, PPT, CSA in patients with myofascial pain syndrome. So, it may suggest that Kinesio taping combined with coordination exercise will be helpful of the pain and shoulder function improvement the patients with myofascial pain syndrome.

• International journal of advanced smart convergence
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• 제12권2호
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• pp.167-172
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• 2023

In this study, the absolute and relative strength of six upper extremity resistance exercises were measured by classifying resistance exercise experts and non-experts. As a result, the skilled group showed higher absolute and relative muscle strength than the unskilled group in the 6 upper extremity resistance exercises. These results are judged to be the hypertrophy of fast-twith muscles, the mobilization of motor units, and the increase in the speed of nerve conduction while the skilled person consistently performs resistance exercise. Experts use intermuscular coordination efficiently to stably perform the load according to the movement and exercise intensity performed during exercise, whereas the inexperienced person uses relatively large muscle groups rather than efficiently using intermuscular coordination. It is considered that exercise motion and load were performed by mobilizing. In addition, as a result of comparing the absolute and relative muscle strength between the 6 types of upper limb resistance exercises, there was a difference between the 6 types of upper limb resistance exercises in the two groups. It can be judged that greater muscle strength and endurance were created through liver coordination.

• The Journal of Korean Physical Therapy
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• 제31권4호
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• pp.212-215
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• 2019

Purpose: This study examined whether there is a difference in motor learning through short-term repetitive movement practice in stroke survivors with a unilateral brain injury compared to normal elderly participants. Methods: Twenty-six subjects who were divided into a stroke group (n=13) or sex-aged matched normal elder group (n=13) participated in this study. To evaluate the effects of motor learning, the participants conducted a tracking task for visuomotor coordination. The accuracy index was calculated for each trial. Both groups received repetitive tracking task training of metacarpophalangeal joint for 50 trials. The stroke group performed a tracking task in the upper extremity insi-lesional to the damaged hemisphere, and the normal elder group performed the upper extremity matched for the same side. Results: Two-way repetitive ANOVA revealed a significant difference in the interactions ($time{\times}group$) and time effects. These results indicated that the motor skill improved in both the stroke and normal elder group with a tracking task. On the other hand, the stroke group showed lesser motor learning skill than the normal elder group, in comparison with the amount of motor learning improvement. Conclusion: These results provide novel evidence that stroke survivors with unilateral brain damage might have difficulty in performing ipsilateral movement as well as in motor learning with the ipsilateral upper limb, compared to normal elderly participants.

• 대한감각통합치료학회지
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• 제7권2호
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• pp.23-35
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• 2009

목적: 본 연구의 목적은 발달장애 아동에게 그룹 감각통합치료를 적용하여 아동의 운동기능 및 사회성 증진에 어떠한 영향을 미치는지 알아보고자 한다. 연구방법: 대전 S 아동연구소 감각통합치료실을 이용하는 아동 중, 발달장애 및 정신지체로 진단받은 아동 10명을 대상으로 하였다. 실험군은 그룹 감각통합치료에 참여하는 아동 5명, 대조군은 개별 감각 통합치료에 참여하는 아동 5명으로 주 1회 90분, 20주 동안 적용하였다. 아동의 운동기능 및 사회성 증진 정도를 측정하기 위한 사전 사후 검사로 운동적합성 검사(Bruininks-Oseretsky test of Motor Proficiency 2), 한국판 적응행동검사(Korean-Scales of Independent Behavior-Revised) 그리고 사회성숙도 검사(Social Maturity Scale)를 사용하였다. 결과: 그룹 감각통합치료 적용 전 후 실험군 대부분의 아동이 손/상지협응(Manual coordination)과 신체협응(Body coordination), 사회성 전반적 영역에서 기능향상을 보였지만, 통계적으로 유의미하지 않았다. 그러나 그룹 감각통합치료 프로그램 전 후 운동기능 및 사회성 향상의 차이는 실험군 아동이 대조군 아동보다 더 크게 나타났으며, 특히 손/상지협응(Manual coordination), 손기민성(Manual dexterity) 하위항목, 사회성숙도 검사의 사회연령, 사회지수에서 통계적으로 유의미하게 나타났다. 결론: 본 연구결과를 통하여 그룹 감각통합치료 프로그램이 발달장애 아동의 운동기능 및 사회성 기능증진에 효과가 있음을 알 수 있었다. 추후 보다 다양한 장애 유형의 아동을 대상으로 그룹 감각통합치료 프로그램을 적용하여 그 효과를 증명하는 연구가 진행되어야 할 것이다.