• 통합자연과학논문집
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• 제16권2호
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• pp.47-51
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• 2023

Ras small GTPases are involved in regulating various cellular signaling pathways including cell migration, proliferation, and differentiation. Ras GTPase subfamily is comprised of 15 proteins; 11 Ras, 3 Rap, and one Rheb related protein. Some Ras proteins, such as RasC and RasG, have been identified for their major functions, but there are proteins whose functions have not been studied yet, such as RasU and RasX. Here, we investigated the roles of RasU in cell motility and development. RasU shows the highest homology with RasX. To investigate the functions of RasU, rasU null cells were used to observe the phenotype. Cells lacking RasU were larger and more spread than wild-type cells. These results indicate that RasU plays a negative role in cell spreading. In addition, we investigated the roles of RasU in cell motility and development of Dictyostelium cells and found that rasU null cells exhibited decreased random migration speed and delayed developmental process. These results suggest that RasU plays an important role in cell motility and development.

• 대한한의학방제학회지
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• 제31권4호
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• pp.245-252
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• 2023

Objectives : The purpose of this study was to explore the compounds, targets and related diseases of garlic by the approaches of network pharmacology and bioinformatics in traditional chinese medicine. Methods : We investigated components and their target molecules of garlic using SymMap and TCMSP and they were compared with analysis platform. Results : 56 potential compounds were identified in garlic, 26 of which contained target information, and it was found that these 26 compounds and 154 targets interact with each other through a combination of 243 compounds. In addition, Apigenin was linked to the most targeted gene (78) in 26 compounds, followed by Kaempferol (61 genes), Nicotic Acid (14 genes), Geraniol (11 genes), Eee (10 genes), and Sobrol A (9 genes). Among 56 potential compounds, three compounds (Kaempferol, Dipterocarpol, and N-Methyl cytisine) corresponded to the active compound by screening criterion Absorption, Distribution, Metabolism, Excretion (ADME). In addition, 12 compounds in 56 potential compounds were associated with gastrointestinal (GI) motility disorder. Among them, Kaempferol was a compound that met the ADME parameters and the rest were potential compounds that did not meet. Also, Kaempferol was closely related to GI motility disorder, indicating that this Kaempferol could be a candidate for potential medical efficacy. Conclusions : It shows the relationship between the compound of garlic, an herbal supplement, and the biological process associated with GI motility disorder. These results are thought to help develop strategies for treating GI motility disorders.

• Archives of Plastic Surgery
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• 제42권3호
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• pp.346-350
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• 2015

Brown syndrome is known as limited elevation of the affected eye during adduction. It is caused by a disorder of the superior oblique tendon, which makes it difficult for the eyeball to look upward, especially during adduction. It is classified into congenital true sheath Brown syndrome and acquired simulated Brown syndrome. Acquired simulated Brown syndrome can be caused by trauma, infection, or inflammatory conditions. The surgical restoration of blowout fractures can also lead to limitations of ocular motility, including Brown syndrome. We report on three patients with acquired simulated Brown syndrome, who complained of diplopia and limitation of ocular motility after operations to treat blowout fractures.

• 대한두개안면성형외과학회지
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• 제13권2호
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• pp.130-134
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• 2012

Purpose: Brown syndrome is motility disorder of the eyeball which shows limited elevation in adduction and occurs very rarely after eye surgery. The authors have experienced a case of strabismus-like Brown syndrome combined with blepharoptosis and report this case with the review of literatures. Methods: A 28-year-old female suffered from hypotropia in the primary gaze and severe blepharoptosis with diplopia of the right eye after upper blepharoplasty. Rotation showed an inability to elevate the adducted right eye. She underwent extraocular muscle surgery about the 7 mm tucking of the right superior rectus muscle and 6 mm recession of right inferior rectus muscle. Intraoperatively, injury of the superior rectus muscle and foreign body were observed. Seven months after the extraocular surgery, the patient underwent frontalis muscle transfer on the right upper eyelid for the correction of blepharoptosis. Results: Postoperatively, the patient was orthophoric in the primary gaze, and she had improvements in the correction of blepharoptosis and eyeball movement. Conclusion: Repeated eyelid surgeries increase the risk of ocular motility disorder. Careful approach is essential for the proper treatment and successful outcome in secondary surgeries.

• Journal of Interdisciplinary Genomics
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• 제4권1호
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• pp.11-14
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• 2022

Primary ciliary dyskinesia (PCD) is a genetic disorder that affects approximately 1 in 15,000-30,000 people, with the majority of patients inheriting the disorder via autosomal recessive inheritance. PCD is characterized by abnormal ciliary ultrastructure and/or function, which results in impaired mucociliary clearance and recurrent respiratory infections. Despite the presence of symptoms from birth, many patients with PCD remain undiagnosed until adulthood. Many advances in the diagnosis of PCD have occurred in recent years, including nasal nitric oxide assays, ciliary motility tests, and genetic sequencing. Early diagnosis and symptom management may reduce morbidity and mortality from PCD improving the patient's quality of life.

• Advances in pediatric surgery
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• 제8권1호
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• pp.54-61
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• 2002

Hirschsprung's disease (HD) is usually diagnosed in the newborn period and early infancy. The common presentation of HD in newborns consists of a history of delayed passage of meconium within the first 48 hours of life. The differential diagnosis in newborns is one of the clinical challenges of this disorder. A number of medical conditions which cause functional obstruction of the intestines are easily excluded. Neonates with meconium ileus, meconium plug syndrome, distal ileal atresia and low imperforate anus often present in a manner similar to those with HD in the first few days of life. Abdominal radiographs may help to diagnose complete obstruction such as intestinal atresia. Microcolon on contrast enema can be shown in cases with total colonic aganglionosis, ileal atresia or meconium ileus. Suction rectal biopsy or frozen section biopsy at operation is essential for differential diagnosis in such cases. HD is also considered in any child who has a history of constipation regardless of age. Older children with functional constipation may have symptoms that resemble those of HD and contrast enema is usually diagnostic. However, children with other motility disorders generally referred to as chronic idiopathic intestinal pseudoobstruction present with very similar symptoms and radiographic findings. These disorders are classified according to their histologic characteristics.; visceral myopathy, visceral neuropathy, intestinal neuronal dysplasia (IND), hypoganglionosis, immature ganglia, internal sphincter achalasia. Therefore, the workup for motility disorders should include rectal biopsy not only to confirm the presence of ganglion cells but also evaluate the other pathologic conditions.

• 대한기관식도과학회지
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• 제1권1호
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• pp.146-150
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• 1995

Esophageal manometry and Bernstein acid perfusion test were performed in 39 patients with globus sensation and 30 controls without experiencing a lump sensation in the throat. Globus patients also underwent physical examination, paranasal sinus x-ray, laryngoscopy and esophagogram. Nine of 39 patients were excluded from the study because local reasons for a lump sensation in the throat were found. Globus group showed significant elevation in upper esophageal sphinter pressure(P=0.0001) and six patients(20%) had evidence of nonspecific esophageal motility disorders, which suggested that hypertonicity of the upper esophageal sphinter and esophageal motility disorders could be the cause of globus syndrome.

• Journal of Chest Surgery
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• 제25권10호
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• pp.1098-1101
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• 1992

Esophageal achalasia is a disease with characteristic disorder of esophageal motility. Also, this disorder is known to be predisposing factor of malignancy. Although the incidence of esophageal cancer in patients with achalasia varies widely, the incidence hed been reported from l% to 29% in many articles. It is known that delay in management of achalasia is believed to increase the risk of malignant degeneration. We experience a case with esophageal cancer complicating longstanding esophageal achalasia.

• 대한한방소아과학회지
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• 제23권3호
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• pp.89-108
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• 2009

Objectives The purpose of this study is to report the clinical effects of oriental medical treatment on developmental disorder induced by traumatic brain injuries. Methods The patients were treated with herb medicine, acupunctures, moxibustions, and negative pressures, and then evaluated by manual muscle tests, gross motor function measurements, sequenced language scales for infants. Results The patient's manual muscle power, motility, cognition, speech were significantly improved after six weeks of oriental medical treatment. Conclusions This study showed that oriental medical treatments were effective on developmental disorder induced by traumatic brain injuries. However, further clinical studies were needed.

• 대한방사선기술학회지:방사선기술과학
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• 제27권4호
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• pp.11-16
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• 2004

식도의 운동장애에 대한 분류는 새로 기술되는 질환도 있고, 분류가 바뀌는 경우도 있으며 제외되는 경우도 있어 아직 확립이 되지 않고 계속 진행 중인 상태이다. 방사선학적으로 일차연동운동은 없으며 식도의 하부 끝은 특징적으로 새 부리모양(Smooth, Tapered, Beak-like appearance)을 보인다. 대부분의 식도운동장애는 평활근 부위에서 발생되며 여러 질환에 의해 식도의 정상 연동이 감소되거나 소실되고(Hypomotility), 비정상적으로 증가되는 경우(Hypermotility)도 있다. 적절한 방사선학적 검사와 진단을 위하여 식도의 해부학과 생리학을 이해하는 것이 중요하다. 또 방사선학적 진단 시에는 환자의 증상이나 Manometry 소견을 참고해야 한다. 하부식도괄약근의 기능은 정상일 수 있으며 음식이 내려갈 때 완전히 열린다. Sperandio M 등은 diffuse esophageal spasm의 대부분이 평활근으로 되어 있는 distal esophagus에서 일어나기 때문에 diffuse 대신 distal로 바꾸어 DES로 표현해야 한다고 주장하고 있다. 식도 운동 장애의 진단에 있어 바륨 검사의 유용성은 Ott 등에 의하면 Achalasia 95%, DES 71%, NEMD 46%로 Overall sensitivity는 56%이지만 방사선 검사로 진단하지 못하는 Nutcracker esophagus나 Nonspecific disorder를 제외하면 89%의 sensitivity를 보인다. Videofluoroscopy를 이용하고 5번 swallows를 시켰을 때의 진단율은 평균 90%이었다. 결론적으로 식도 운동 검사에서 식도 바륨 검사는 쉽게 할 수 있는 일차적인 검사이며, 식도의 해부학과 생리학에 대한 지식을 갖고, 정지 영상뿐만 아니라 Videofluoroscopy를 이용하여 검사하면 정확한 진단을 할 수 있으리라 생각한다. 더욱 발전했는데 그는 Fast T2 weighted turbo spin echo 기술을 이용하여 영상을 좀더 세밀하게 얻을 수 있게 되었다. 지금까지의 앙와위에서의 검사로 진단에 한계가 있었던 Intussusception 등의 질환을 Open MR 등의 방법으로 극복할 수 있다면 장래에는 방사선학적 배변조영술을 대체할 수 있는 검사법으로 발전할 수 있을 것으로 생각된다., 신장, 고환, 흉선에서는 각 군간에 별다른 차이가 없었으나, 간의 경우 방사선 처리군과 방사선 처리전 추출물 투여군에서 분자량 90, 53, 32 kDa 크기의 단백질이 감소하였고, 방사선 처리군에서는 감소하였으나 추출물 투여군에서는 감소되지 않은 단백질도 관찰되었다. 따라서 본 실험을 통해 생쥐에 방사선을 처리했을 경우 저령의 열수추출물을 투여한 생쥐 군이 투여하지 않은 군에 비해 생존율이나 내장 장기무게의 감소에 있어서 생존율은 20% 증가하였고 비장의 무게는 44.4%, 고환의 무게는 66.6%, 그리고 흉선의 무게는 66.6% 증가한 방호효과를 나타내는 것을 확인할 수 있었다.경이 증가($0.32\;mm{\sim}0.91\;mm$)함을 알 수 있었으며, 그 차이를 분산분석(ANOVA)을 통해 비교한 결과 하부경추로 갈수록 유의한 차이가 있는 것으로 나타났다(P<0.001). IV. 결 론 : 우리나라 성인에 있어서 추간공을 관찰하기 위한 전 후 사방향촬영각도는 상부 경추의 경우 전 후사방향 $50^{\circ}$에서, 하부 경추의 경우 $55^{\circ}$에서 추간공을 가장 크게 관찰할 수 있었다. 따라서 향후 경추의 퇴행성 질환을 진단하는데 본 연구의 촬영법이 유용할 것으로 사료된다.서 기존 조청의 특성을 변화시키지 않는 제품을 제조할 수 있을 것으로 보인다.mic acid의 생성량(生成量)은 0.78 mole이다.한 경우도 비교적