• Archives of Plastic Surgery
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• 제34권3호
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• pp.298-304
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• 2007

Purpose: This study was undertaken to investigate the osteogenic induction potential of PGA & FBS mixture on a calvarial defect in the rabbit. Methods: Twenty New zealand white rabbit, weighing from 3.5-4kg were allocated into each of the three groups. Four 8 mm sized bone defects were made on the parietal bone by drilling. In group I, the bony defects were implanted with $50{\mu}m$ thickness film containing mixture of PGA and FBS. In group II, with PGA only film, & in group III, the bony defects were left with no implants. Results were evaluated by using morphologic change, radiographic study, biochemical study and histologic examination at 1 week (group I n=7, group II n=7, group III n=14), 2 weeks (group I n=6, group II n=6, group III n=12) and 3 weeks (group I n=7, group II n=7, group III n=14) following implantation. Results: In the morphologic & radiographic study, the formation and corticalization of callus were observed earlier in group I than in groups II and III (p < 0.05). In histological examination, group I showed more abundant and faster new bone formation than in group II and III. In biochemical analysis, group I displayed more activity than in group II and III. Group I also showed more abundant osteopontin, osteocalcin than groups II and III. Conclusion: In conclusion, the results demonstrate that the mixture of PGA and FBS has an effect on osteoblastic formation in the rabbit model. It is considered that further evaluation of long term results on resorption, immunologic tissue reaction and response of applied mixture in the human model will be needed.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권2호
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• pp.108-120
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• 2004

Object : Patients with facial asymmetry accompanying mandibular prognathism have various causes and clinical features. So, it is difficult to find a satisfactory treatment method functionally and esthetically. Every traditional classification and interpretation to find etiopathogenesis and/or to establish ideal surgical modality has many limitations because it can't be applied simply to various conditions of patients with facial asymmetry accompanying mandibular prognathism. Therefore, we employ a new classification to interpret more details of the morphologic change of mandible and the spatial change of mandible and maxilla. Materials and Methods : Using panoramic X-ray films, PA cephalograms and submentovertex films of 126 patients diagnosed with facial asymmetry accompanying mandibular prognathism as resources, the following results were gathered after analyzing each characteristics through distributing the patterns according to the morphological mandibular asymmetry and mandibular and maxillary spatial asymmetry. Results : Almost frequency of morphological mandibular asymmetry was shown. In case of condyle-ramus elongation and body elongation group, it's frequency was the highest. Higher frequency of compensating vertical growth was shown on the side of over growing maxilla in case of vertical length difference between left and right condyle-ramus. On the other hand, higher frequency of no compensating vertical growth difference between left and right side was shown in case of no vertical length difference in condyle-ramus. Spatial mandibular asymmetry generally occurred when there was no morphological mandibular asymmetry. Correlation between condyle length difference and condyle-ramus length difference between left and right side was very high, but correlation between condyle length difference and body length difference, and correlation between condyle length difference and body vertical length difference was low. Conclusion : In case of patients with facial asymmetry accompanying mandibular prognathism, it is suggested that various pattern of facial asymmetry is occurred by the independent growth of each unit rather than dependent growth of other unit by major growth unit abnormality. Due to the untypical pattern and the various asymmetry occurring according to the changes of each mandibular growth unit, it is considered that an appropriate surgical method should be searched based on the accurate recognition of the each pattern for patients with facial asymmetry accompanying mandibular prognathism.

• Clinics in Shoulder and Elbow
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• 제10권1호
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• pp.99-105
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• 2007

목적: 정상인에 있어 주관절 주위 척골 신경에 대하여 초음파를 이용한 척골 신경의 형태학적인 연구 및 동적 안정성을 조사하고, 주관 증후군 환자에서 척골 신경병증에 대한 초음파 영상의 진단에 있어 기초 자료를 마련하고자 한다. 대상 및 방법: $20{\sim}30$세 사이 건강한 정상 성인 남자 25명 50예의 척골 신경에 대하여 연구를 시행하였다. 7.5 MHz 고해상도 초음파의 선상 프로브를 이용하여 주관절 주위의 척골신경을 장축 및 단축영상에서 조사하였다. 장축영상을 통해 척골 신경의 주행경로와 위치, 신경의 굵기를 파악하고, 단축 영상을 내상과 근위부 1 cm, 내상과 후방, 오스본 인대부위, 오스본 인대 원위부 1 cm에서 측정하여 주관절의 굴곡 신전시 각 네 지점에서 척골 신경의 장단경과, 동적 안정성을 측정하였다. 결과: 주관절 신전시 척골 신경의 단경은 각각 2.66 mm, 2.97 mm, 2.64 mm, 2.69 mm로 측정되었다. 한편 장경은 각각 4.61 mm, 4.56 mm, 4.36 mm, 4.37 mm로 측정되어 각 네 곳의 해부학적 지점 간에 큰 변화가 관찰되지 않았다. 한편 굴곡시 척골 신경의 단경은 각각 2.72 mm, 2.34 mm, 2.65 mm, 2.41 mm로 변경되고, 장경은 각각 4.49 mm, 5.40 mm, 4.16 mm, 4.66 mm로 측정되었다. 주관절 굴곡시 내상과 후방에서 척골신경이 의미 있는 형태의 변화가 관찰되었으며 신전 굴곡시 모두 오스본 인대 입구에서 장단경이 가장 작게 관찰되었다. 동적 안정성 측정에서 척골 신경의 아탈구는 9예, 척골 신경 탈구는 7예 관찰되었다. 결론: 주관절 척골 신경의 초음파 검사에서 척골 신경은 정상인에서도 동적 불안정성과 굴곡신전에 따른 척골 신경의 장단경의 형태 변화가 관찰되기에 초음파로 척골 신경병증 진단에 있어 참고해야 할 소견이라고 판단된다.

• 한국제4기학회지
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• 제13권1호
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• pp.67-78
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• 1999

낙동강 삼각주 말단은 하중도와 사주 그리고 간석지의 퇴적미지형으로 이루어져 있으며, 이들 미지형들은 해안선에 평행하게 바다쪽으로 향해 하중도군, 제1사주군, 제3사주군, 그리고 제4사주군의 순으로 배열되는 특징을 나타낸다. 하중도군은 을숙도-명호도-신호도로서 1916년 이전에 형성되었고, 제1사주군인 맹금머리등-대마등-진우도는 맹금머리등을 제외하면, 하중도군과 함께 1916년 이전에 출현된 사주들이다. 제2사주군인 백합등-장자도와 제3사주군인 나무싯등-새등은 각각 1970년과 1984년 이전에 형성되었으며 제4사주군인 다대등-도요등은 최근인 1990년 이후에 등장된 사주로서 현재 합성되어 있다. 이러한 사실은 삼각주 말단이 1987년 낙동강 하구둑 건설이후 빠르게 전진 발달하고 있다는 것을 의미하며, 이는 하구둑과 신호공단 및 명지주거지의 조성을 위한 하구 부근의 준설과 인공적인 수로의 변경에 따른 토사의 일시적 재퇴적현상에서 비롯된 것으로 보이며, 그 결과 연구지역의 미지형 변화는 삼각주 말단에서 일어나고 있는 낙동강의 유수와 파랑 그리고 연란류 및 조류의 에너지가 하구둑 건설 이전에 작용했던 것처럼 균형을 이룰 때까지 계속될 것으로 생각된다.

• 한국광학회지
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• 제18권5호
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• pp.367-372
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• 2007

자궁경부 상피이형성증(cervical dysplasia)은 세포핵/세포질(nuclear/cytoplasmic, N/C) 면적비의 변화를 포함하는 자궁경부 상피에서의 형태학적 변화를 일으킨다. 세포핵은 중요한 산란 원인중에 하나이기 때문에 N/C 면적비의 변화는 깊이에 따른 원형 편광장도를 반영한다. 따라서 우리는 편광 민감 광결맞음 단층촬영장치(polarization-sensitive optical coherence tomography, PS-OCT)를 이용하여 산란에 의해 발생하는 편광의 변화를 측정하였다. 자궁 경부 조직 샘플은 고등급 상피내종양(high-grade squamous intraepithelial, H-SIL)을 가진 한 명의 환자와 정상인 네 명의 환자에게서 얻어졌다. 우리는 자궁경부의 깊이에 따른 원형 편광의 유지 정도(degree of circular polarization, DOCP) 평균을 구하였고, 상피층의 깊이에서 최소 제곱 1차 선형 함수(least-square linear fit)를 사용하여 기울기를 획득하였다. 획득된 기울기를 가지고 DOCP의 변화율을 정량화 하였다. 그 결과 H-SIL에서의 DOCP의 감쇄가 정상 조직에서 보다 빠르게 나타남을 확인할 수 있었다. 이는 PS-OCT를 이용하여 산란 변화에 따른 DOCP의 변화율을 측정하는 것이 자궁경부상피 이형성증의 진단을 하는데 있어서 유용한 진단법이 될 수 있음을 의미한다.

• 대한치과교정학회지
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• 제15권1호
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• pp.123-140
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• 1985

Variation in the facial pattern and effect of the rotational jaw growth on the facial proportion were studied in serial cephalometric radiographs of 40 Korean children (25 boys, 15 girls) ranging in age from 6 to 13 years. According to Y-axis (N-S-Gn) growth change during the 7 years of period, the subject who had exhibited 'wave-like' manner of Y-axis growth change within ${\pm}\;2^{\circ}$ was classified to the Parallelwise group and the subject who had exhibited Y-axis increase more than $+2^{\circ}$ was classified to the Clockwise rotation group and the subject who had exhibited Y-axis decrease more than $-2^{\circ}$ was classified to the Counterclockwise rotation group. For the comparison of each group, a total of 22 morphologic variables were employed and the data were analyzed by means of computer morphometrics and statistical methods. On the basis of the finding of this study, the following trends were established. 1. The Parallelwise group was $75\%$, the Clockwise rotation group was $12.5\%$ and the Counter-clockwise rotation group was $12.5\%$. 2. The growth pattern of cranial base was related to the rotation of mandible. 9. Maxillary prognathism was occured in the Counterclockwise rotation group and the rotation of palatal plane was occured in the Clockwise rotation group. 4. Mandibular prognathism was occured in the Parallelwise and the Counterclockwise rotation groups, especially in the Counterclockwise rotation group. 5. The degree of maxillo-mandibular divergency was constant in the Clockwise rotation group but decreased in the Counterclockwise rotation and the Parallelwise groups, especially in the Counterclockwise group. 6. There were no differences in the size of the anterior upper facial height (N-ANS) and the posterior lower facial height ((Go-Me)-PNS) but there were differences in the size of the anterior lower facial height (ANS-Me) and the posterior upper facial height ((S-N)-PNS) between each group. 7. The growth increment and the size of the facial depth was not related to the growth pattern of the face but the growth increment and the size of the facial height was related to the growth pattern of the face. 8. Proportional change due to the facial growth rotation was concentrated in the anterior lower face. 9. The most apparent difference between each group was happened in the size of the posterior cranial base (S-Ba) and the facial length (S-Gn).

• 한방안이비인후피부과학회지
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• 제21권3호
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• pp.10-19
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• 2008

Objective : To investigate the effects of Radix Ophiopogon japonieus on atopic dermatitis, I prepared DNCB(2,4-dinitrochlorobenzen) induced atopic dermatitis NC/Nga mice and observed the mice by four ways; eye observation, the number of skin behavior times, histological changes of skin and cytokine(Total IgE, IL-4, $IFN-{\gamma}$). Methods : After prepare Radix Ophiopogon japonicus extract, DNCB induced atopic dermatitis NC/Nga mice were divided into three groups. The first is Control group which was intact group. The second is Medication group which was orally medicated Radix Ophiopogon japonicus extract one time a day for consecutive 5 days. The third group is Application group which was applied Radix Ophiopogon japonicus extract externally one time a day for consecutive 5 days. After that, the effect of Radix Ophiopogon japonicus on atopic dermatitis was observed. Statistical analysis was performed by using Kmskal-Wallis test and statistical significance was set at less than 5%. Results : 1. Radix Ophiopogon japonicus showed some in both Medication group and Application At observation of skin morphologic change, effects to prevent erythema reaction on skin group. 2. At the number of scratching behavior times, Radix Ophiopogon japonicus showed an effect to decrease scratching behavior times, but there was no statistical significance among three groups. 3. At skin tissue H-E stain, Radix Ophiopogon japonicus showed an effect to prevent skin epidermal tissue damages and also showed that it could keep the skin healthy in both Medication group and Application group. Especially in Application group, the skin of mouse showed almost normal recovery. 4. At cytokines, there was no statistical significance among three groups in IgE and IL-4. But Radix Ophiopogon japonicus showed an significant effect to suppress $IFN-{\gamma}$ in both Medication group and Application group. There was no significant difference between two groups. Conclusion : Radix Ophiopogon japonicus has some effects on atopic dermatitis in both internal medication and external application.

• 대한한방내과학회지
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• 제29권4호
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• pp.871-886
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• 2008

Objective : Gypsum fibrosum has been traditionally used in treatment of febrile diseases and recently been shown to have anti-inflammatory effect. Chronic renal failure has a serious clinical symptoms including proteinuria, azotemia, anemia, and hyperlipidemia and has characteristic histopathological changes, glomerular hypertrophy, infiltration of inflammatory cells, and crescentic sclerosis, We investigated the effects of gypsum fibrosum on renal functional and histopathological disorder in chronic renal failure rat model induced 5/6 nephrectomy. Methods : Using Sprague-Dawley rats, CRF was induced by 5/6 nephrectomy. The rats were divided into 3 groups, normal, conrol, and gypsum administered orally with gypsum fibrosum 500mg/kg/day. Body weight, 24 hr proteinuria, hematologic analysis, and histological morphologic changes were followed up after 8 weeks. The glomerular macrophage/monocyte infiltration, $TGF-{\beta}_1$, type IV collagen, and angiotensin II type1 receptor($AT_1$) were evaluated by immunohistochemistry. Resuls : In the CRF control group, functional parameters and histopathologic changes clearly indicated the development of CRF. 24 hr proteinuria significantly increased in the CRF control group over the normal group, and serum creatinine level was lower in the gypsum group than in the control group, LDL-cholesterol was significantly lower in the gypsum group than in the control group. Morphological investigations showed a variety of characteristic features of CRF, glomerular hypertrophy, increasing cellular density of glomerulus, deposition of extra-cellular matrix, fibrotic change, and glomerular sclerosis in the control group, but in the gypsum group, these features diminished significantly. In observation of renal type IV collagen and $AT_1$ expression, positive area significantly increased in the control group over the normal group, and it significantly decreased in the gypsum group compared to the control group. Conclusions : Our findings suggest that gypsum fibrosum inhibits $AT_1$ and type IV collagen expression in renal tissues and attenuates progression of glomerulosclerosis and interstitial fibrosis in chronic renal failure rats, which lead to amelioration of renal function. From these results, we suggest that gypsum fibrosum may have renoprotective effects and could be a useful remedy agent for treating chronic renal failure.

• 한국의류학회지
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• 제29권5호
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• pp.703-714
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• 2005

The purpose of this study is to acquire various methods for the fashion image coordination and to examine common features of variation of coordination methods according to the trend. It has attained by investigating Men's fashion image coordination through trend analysis in terms of its coordination features and its variety aspects. For this study, it has classified into twelve typical Men's fashion images in collecting 1,291 pieces of photographs on the subject of jackets and pants from Men's fashion collection$(1995\~2002)$. The study has examined methods and features of fashion image coordination by year according to design elements and the harmony between items. In addition, it has drawn common factors in the image coordination. The summary and conclusion are as follows. A year of 1995, it has presented as the essential code of the variation that morphologic aspects of a design in the fashion image coordination. Various designs have developed through the variation of shapes such as shoulder width, shoulder pad, jacket width and its length and so on. In the initial stage, the width of shoulder and jacket has fitted into large pattern and then adjusted elegantly to make fit the body that indicates a dissolution according to an avant-garde image. At the time that over-measurement of the shape has reduced and high quality and variation of materials has gradually become significant. Those are often used that high-quality glossy materials or other materials which are opposite to the basic code of the original fashion image materials and qualities regardless of images. On the pattern and color, in addition, have represented neat and elegant impression with moderate applications rather than quantitative abundance that have used opposite elements to the basic code f3r the change code like materials. Furthermore, before and after 1999, ' it shows that a concept of the total coordination has arisen that increased coordination methods to strengthen and affluent its images for the whole with wearing accessaries such as hats, gloves, sunglasses, mufflers, bags, belts and so on.

• 동국한의학연구소논문집
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• 제6권1호
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• pp.107-115
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• 1997

본 실험은 Triton WR-1339를 생쥐에 복강주사한 후 시간의 경과에 따른 간조직의 일반적인 형태변화와 간세포내의 콜레스테롤을 비롯한 지방입자의 분포변화를 관찰하기 위해 시행되었다. Triton 주사 후 간조직에서 나타난 일반적인 형태변화는 48시간에서 그물구조의 세포질룰 가진 간세포가 간엽 전체에서 관찰되었고, 간세포 손상으로 인해 간세포판은 사라졌다. 간조직내의 지방분포변화는 triton주사 후 48시간에 전체 간엽에서 지방입자의 과출현을 확인할 수 있었으며, 지방입자의 크기도 대조군에 비해 큰 것으로 나타났다. 간조직내의 콜레스테롤입자의 분포 변화는 triton 주사 후 48시간에 콜레스테롤입자가 간엽전체에서 과출현하는 것이 관찰되었다. 이상의 결과로 볼 때 triton 주사 후 지방대사이상에 의해 그 결과 간조직내에서 콜레스테롤를 비롯한 지방입자의 축적이 증가되는 고지혈증 병변이 유도된 것으로 사료된다.