• 한국응용과학기술학회지
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• 제36권2호
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• pp.524-530
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• 2019

본 연구에서는 가죽 스킨층에 코팅용으로 사용할 수용성 폴리우레탄의 합성을 위해 polyrupopylene mono methyl ether (PM)를 기반으로 폴리 에테르 폴리올인 폴리 프로필렌 글리콜과 이소포론 디 이소시아네이트 (isophorone diisocyanate, IPDI)를 합성 하였다. 예비 중합체의 합성 후, 점도 상승을 억제하기 위해 $40^{\circ}C$에서 1M, 2M, 3M 및 4M으로 PM을 첨가하고 중화 반응 및 사슬연장 반응을 수행하여 폴리 우레탄 시료를 준비 하였다. 준비된 시료의 인장강도와 연신율, 접착강도를 측정한 결과로 인장강도는 PM 이 1M 일 때 2.109 kgf/mm2, 4M 에서 1.721kgf/mm2, 연신율은 PM이 1M일 때 496%, 4M 에서 522%, 접착력은 PM이 1M 일 때 1.114 kgf/cm, 4M 에서 0.99 kgf/cm 로 확인 되었다.

• 한국임상약학회지
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• 제7권2호
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• pp.51-63
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• 1997

The effect of cimetidine administration on the pharmacokinetic parameters of cyclosporine were determined in healthy voluteers. This study was performed in 10 volunteers of age ranged 22-48 years and body weight 48-62 kg. This study was performed with cross-over design. Mono cyclosporine and cyclosporine metabolites was extracted from whole blood analysed by fluororescence polarization immune assay (TDX-FLX, Abbott). After coadministration of cimetidine (300 mg) with cyclosporine (300 mg) orally, maximum concentration of mono cyclosporine was significantly increased $1221{\pm}143\;ng/ml\;to\;1562{\pm}184\;ng/ml$ (P<0.05), area under the time curve of cyclosporine (12 hr) also was significantly increased $7478{\pm}829\;ng/ml{\cdot}hr\;to\;9721{\pm}879\;ng/ml{\cdot}hr$ (P<0.05) and absolute baioavailability of cyclosporine was increased $50\pm5.6\%\;to\;57.6\pm6.1\%\;(P<0.05)$ compared to control group. The blood concentrations of cyclopsorine metabolites were significantly decrased (P<0.05) after coadministration of cimetidine. In cimetidine pretreated group, blood mono cyclosporine concentrations were increased significan시y $1220.0\pm203.00\;ng/ml\;to\;1510.0\pm204.00\;ng/ml$ compared with control group (P<0.05). In the mono cyclosporine pharmacokinetic parameter after oral administration absorption rate and maximum concentration were significantly higher in cimetidine coadministered and pretreated group than control group (P<0.05). The ratio of metabolites and mono cyclosporine concentrations was decreased significantly from $70.8\%\;in\;control\;to\;34.8\%$ in coadministration of cimetidine orally. As matter of facts these reults are considered to inhibition of cyclosporine hepatic metabolism and increasing of cyclosporine absorption rate in gastrointestinal tract because of maintaining cyclosporine stability in elevated gastric pH by cimetidine. We considered, it appeares that cimetidine increase bioavailability of cyclosporine by increasing oral absorption and by decreasing hepatic clearance. But the absorption and clearance of cyclosporine was highly variable individually, and therefore we consider that cyclosporine blood level monitoring would be essential in patients with cimetidine co-administration.

• 한국임상약학회지
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• 제24권4호
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• pp.296-303
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• 2014

Background: The first pharmacy student practice undergoing 6 year pharmacy school curriculum have begun in the hospital pharmacy, community pharmacy, pharmaceutical company and administrative office since 2013. Although most of practice sites have prepared the program of pharmacy student practice education for several years under guideline of Korean Association of Pharmacy Education, generally community pharmacies which start the pharmacy student practice education have difficulty in performing the desirable student practice program due to absent experience for it. So we reported the comparison of student practice programs between mono pharmacy and multiple pharmacies conducted by Gyeongsang National University College of Pharmacy to provide the future design information of the ideal pharmacy student practice in community pharmacy. Method: Students who practiced both multiple (multi) and mono pharmacy (mono) programs for each 5 weeks were participated the survey to evaluate the student practice programs. Results: The results of the survey on the student practice program reported that students were much more satisfied with the multiple pharmacies program than mono pharmacy program in both practical contents ($4.12{\pm}0.72$ : $3.27{\pm}1.28$; multi : mono) and satisfaction ($4.54{\pm}0.54$ : $3.54{\pm}1.3$; multi : mono) and they all gave the highest points ($5.00{\pm}0.00$) to multiple pharmacies program for recommendation because the multiple pharmacies program was significantly helpful for their experience to plan the future career. Conclusion: Mono and multiple pharmacy practice programs would be a great helpful for student's future career. However, the disadvantages of each program should be amended gradually for the unified and specialized program to be established the ideal community pharmacy student practice in Korea. The results will be affected the pharmacy practice program for students in community pharmacy and the other colleges of pharmacy to design the ideal community pharmacy practice program.

• 전기학회논문지
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• 제63권3호
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• pp.425-430
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• 2014

This paper presents a design technique to improve the power density and efficiency of a permanent magnet high-speed motor by using the mono-PM rotor. The suggested model minimized rotor diameter and stack length which have a bad influence on shafting in the high-speed operation. Conventional and suggested motors are analyzed and compared by using FEM(Finite Element Method) to verify the effectiveness. The overall performance such as torque, losses, efficiency and power density and so on are investigated in detail. The results of the analysis deduced that the suggested mono-PM rotor design is superior to the conventional one.

• Bulletin of the Korean Chemical Society
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• 제10권3호
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• pp.270-272
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• 1989

The polymeric species formed on the hydrolysis of Th(IV) from solubility experiments of $ThO_2$ in 0.1M $NaClO_4$ and $Th(OH)_4\;in\;0.5M\;NaClO_4$ were removed by ultrafiltration using 1 nm ultrafilters. The resultant equilibrium concentrations of mono-hydroxy Th(IV) species in solutions between pH 1.5 to 13 were measured by the NAA method. From these data solubility product of thorium dioxide and the stability constants of mono-hydroxy Th(Ⅳ) were determined. The values obtained were log $K_{sp}\;-\;50.76\;{\pm}\;0.08, log\;{\beta}_{1,1}\;12.42\;{\pm}\;0.02,\;log\;{\beta}_{1,2}\;22.46\;{\pm}\;0.15, log\;{\beta}_{1,3}\;34.36\;{\pm}\;0.07,\;log\;{\beta}_{1,4}\;42.58\;{\pm}\;0.08$, which are in good agreement with the values given in the literature. In addition, several dimeric species, $Th_2(OH)_2\;^{6+},\;Th_2(OH)_3\;^{5+} and\;Th_2(OH)_4\;^{4+}$ have been identified.

• 한국식품영양학회지
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• 제25권4호
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• pp.770-778
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• 2012

In this study, the effects of intake of Acer mono Max. seed oil, and Magnolia denudata seed oil on the lipid levels of mouse blood were compared to those of commercially available vegetable oils. Five ICR mice were each fed a corn oil, Acer mono Max. seed oil, and Magnolia denudata seed oil supplemented diet for a total of 8 weeks. The serum profiles of mice fed Acer mono Max. seed oil and Magnolia denudata seed oil were high in palmitic acid, oleic acid, and linoleic acid. The saturated fatty acid contents of mice fed Acer mono Max. seed oil and Magnolia denudata seed oil were 3.95% and 0.88%, whereas the unsaturated fatty acid contents were 8.71% and 4.60%, respectively. The liver and spleen weights of mice fed Acer mono Max. seed oil were higher than those fed corn oil (p<0.05). Total cholesterol level was highest in mice fed Acer mono Max. seed oil (p<0.05), whereas there were no significant changes in the cholesterol levels of mice fed Magnolia denudata seed oil and corn oil. The HDL-cholesterol levels in mice fed Acer mono Max. seed oil ($175.80{\pm}27.66mg/d{\ell}$) and in those fed Magnolia denudata seed oil ($145.20{\pm}19.10mg/d{\ell}$) were higher compared to those of mice fed corn oil (p<0.05). In conclusion, there were no significant differences in fatty acid composition between mice fed Acer mono Max. seed oil and Magnolia denudata seed oil. Future study on the antioxidant effects of seed oils should be carried out.

• Journal of the Korean Wood Science and Technology
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• 제40권6호
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• pp.378-388
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• 2012

본 연구에서는 강원도 인제지역의 가래나무의 수액 출수와 영향인자들을 분석하여 고로쇠나무 수액의 대체자원으로서 최적의 수액 출수 조건을 얻고자 출수량, 흉고직경, 시험지의 기온과 상대습도를 2008년 2월 1일~3월 31일의 기간에 측정하여 출수량과 다른 측정값들과의 상관성 분석을 수행하였고 고로쇠나무의 경우와 비교 분석하였다. 가래나무 수액의 출수는 고로쇠나무 경우와 유사한 출수 시기와 출수 기간을 가지고 있었으나 가래나무 수액 출수는 출수 기간의 초기에 집중되었다. 동일 지역의 고로쇠나무 수액의 출수량은 나무의 흉고직경이 증가할수록 증가한 것과 달리 가래나무 수액의 출수량은 흉고직경 증가에 따른 뚜렷한 증감을 관찰할 수 없었다. 수액 출수량이 높은 개체의 경우 고로쇠나무와 가래나무 모두 단위 흉고직경 당 출수량은 높은 것으로 나타났으며, 고로쇠나무의 흉고직경 당 출수량은 전체 평균 $0.9{\pm}0.1{\ell}/cm$으로 가래나무의 평균 $0.3{\pm}0.1{\ell}/cm$에 대비하여 3배에 달하였다. 수액이 많이 출수되는 날의 기온와 상대습도는 고로쇠나무와 가래나무 경우 모두 서로 유사하게 나타나 가래나무 수액 출수는 고로쇠나무의 경우와 같이 외부 기후 조건에 많이 영향받는 것으로 판단되었다. 수액출수량과 기온 및 대기 습도와의 상관 분석에서 가래나무의 경우 일중 최저 기온(P < 0.05)이, 고로쇠나무의 경우 기온차(P < 0.01)가 수액 출수량에 가장 유의적으로 영향을 미치는 것으로 나타났다. 이러한 결과를 볼 때 가래나무의 수액 출수는 고로쇠나무와 유사한 기후 조건에서 발생하나 그 수액 출수량은 고로쇠나무보다 적고 이에 영향하는 주요 인자 또한 다른 것으로 생각된다.

• 공업화학
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• 제24권6호
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• pp.605-610
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• 2013

GABA는 포유류의 신경전달물질의 분비를 억제하며, 신경안정 작용, 스트레스 해소, 우울증 완화, 불면 등에 효과가 있는 것으로 알려져 있다. 곡류식품에 존재하는 GABA 함량은 일반미 1~4 mg/100 g, 현미 4~8 mg/100 g으로 알려져 있지만, 그 함량이 낮아 자연 식품으로부터 섭취하는 양으로는 생리활성을 기대하기 어렵다. 본 연구에서는 mono sodium glutamate (MSG)발효로 얻은 GABA 코팅 쌀이 신경안정제 뿐만 아니라 수면유도제로 쓰이는 melatonin과 serotonin의 생성 촉진 효과를 알아보았다. 그 결과 melatonin의 경우 GABA (25 mg/mL) 투여군은 $3.515{\pm}0.149pg/mL$, 일반미 공급군의 경우 $2.632{\pm}0.188pg/mL$이며, GABA 코팅 쌀 공급군은 $3.578{\pm}0.158pg/mL$로 나타났다. Serotonin 함량을 측정한 결과 GABA (25 mg/mL), 일반미 공급군은 각각 $5.183{\pm}0.142ng/mL$, $4.784{\pm}0.108ng/mL$가 측정되었으며 GABA 코팅 쌀을 공급한 실험군은 $5.918{\pm}0.169ng/mL$의 serotonin이 생성되었다. GABA 코팅 쌀의 지속적인 섭취로 인해 melatonin과 serotonin은 유의적인 증가는 있었지만, 누적효과는 없었다. 기능성 식품으로 개발된 GABA 코팅 쌀을 지속적으로 섭취하면 일반미에서 섭취하여 얻을 수 있는 melatonin과 serotonin의 유도효과를 얻을 수 있고, GABA 25 mg/mL를 섭취하는 것과 비슷한 효과를 나타낼 수 있다고 사료된다.

• 한국의학물리학회지:의학물리
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• 제15권1호
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• pp.39-44
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• 2004

본 연구에서는 깊이선량률의 측정값과 단일에너지 계산값들로부터 치료용 전자선에 대한 에너지분포를 계산하였다. 최소제곱법에 기초한 수치연산을 이용하여 측정과 환산 깊이선량률의 차이가 최소가 되는 에너지분포를 결정하였다. 본 방법은 임상에 이용되는 명목에너지 6, 9, 12, 그리고 15 MeV 전자선에 대하여 적용되었다. 본 연구에서는 측정값과의 비교를 위하여 결정된 에너지분포를 입력자료로 이용한 깊이선량률의 몬테칼로 계산을 수행하였다. 계산된 깊이선량률을 측정값과 비교할 때, 모든 전자선에 대하여 표면에서 R$_{80}$ 깊이까지 측정값과 $\pm$3% 미만, 비정 근처까지 $\pm$4% 미만의 상대오차를 보였다. 본 연구는 입사 전자선의 에너지분포를 결정하기 위한 실용적 방법으로 응용될 수 있다.

• Archives of Pharmacal Research
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• 제25권5호
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• pp.709-717
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• 2002

Hypoxemia is known to induce various physiological changes which can result in alteration in drug pharmacokinetics. To examine the effect of acute moderate hypoxemia on metoclopramide (MCP) pharmacokinetics, a continuous 14-hour infusion of MCP during a normoxemic, hypoxemic and subsequent normoxemic period was conducted in eight adult sheep. Arterial blood and urine samples were collected to examine the effects on the pharmacokinetics of MCP and its deethylated metabolites. MCP and its mono- and di-deethylated metabolites were quantitated using a GC/MS method. Steady-state concentrations of MCP were achieved in each of the three periods. During hypoxemia, MCP plasma steady-state concentration increased significantly from 50.72$\pm$1.06 to 63.62$\pm$1.79 ng/mL, and later decreased to 55.83$\pm$1.15 ng/mL during the post-hypoxemic recovery period. Total body clearance ($CL_{TB}$) of MCP was significantly decreased from 274.2$\pm$48.0 L/h to 205.40$\pm$28.2 L/h during hypoxemia, and later restored to 245.8$\pm$44.2 L/h during the post-hypoxemic period. Plasma mono-deethylated MCP concentration (32.78$\pm$1.73 ng/mL) also increased, compared to the control group (21.20$\\pm$1.39 ng/mL), during hypoxemia and subsequent normoxemic period. Renal excretion of MCP and its metabolites was also decreased during hypoxemia, while urine flow was increased with a concomitant decrease in urine osmolality. Thus, the results indicate that acute moderate hypoxemia affects MCP pharmacokinetics.