• The Korean Journal of Physiology and Pharmacology
• /
• v.14 no.5
• /
• pp.249-256
• /
• 2010

Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were $-0.178{\pm}0.081$ (p<0.05) and $-0.088{\pm}0.022$ (p<0.05) in male (n=30), and $-0.095{\pm}0.026$ (p<0.05) and $-0.069{\pm}0.017$ (p<0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca, Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p<0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age- and gender-related SA nodal functions.

• Toxicological Research
• /
• v.21 no.3
• /
• pp.209-218
• /
• 2005

We investigated effects of recombinant human erythropoietin (rHuEPO) on profiles of mRNA transcripts in 6 male cynomolgus (M. fascicularis) monkey's spleen for 4 weeks. Six monkeys, composed of control and treatment group (Control : M1, M2, M3: Treatment : M4, M5, M6) were intravenously administered 3 times per week without or with a dose of rHuEPO 2730 IU/0.1 ml/kg. After 4 weeks rHuEPO treatment, spleen was removed for RNA isolation. Splenic gene expression was assessed using Affymetrix U133A 2.0 arrays containing 18,400 transcripts and variants, including 14,500 well-characterized human genes. Gene expression pattern was very different between individuals even in same treatment. In rHuEPO treated groups showed number of genes were up- or down-regulated (M4: 79: M5: 48; M6: 73 genes). Six genes (epidermal growth factor receptor, calgranulin A, estrogen receptor binding site associated antigen, matrix metalloproteinase 19, zinc finger and BTB domain containing 16, progestin and adipoQ receptor) were commonly expressed in rHuEPO treated group. The different individual response could be major considering factor in monkey experiment. Further study is needed to clarify the different individual response to rHuEPO in molecular level. This study will be valuable in the fundamental understanding and validation of molecular toxicology for bio-generic drugs including rHuEPO in cynomolgus monkey.

• YAKHAK HOEJI
• /
• v.51 no.3
• /
• pp.174-178
• /
• 2007

A reverse-phase high performance liquid chromatography method with electrospray ionization and detection by mass spectrometry is described for the simultaneous determination of doxifluridine and its active metabolite 5-flu-orouracil (5-FU) in monkey serum. The method has greater sensitivity and simpler process than previous published methods with good accuracy and precision. A proper liquid/liquid extraction was used to extract simultaneously doxifluridine and 5-FU which has considerable difference in the polarity. Extracts were analyzed using LC/MS/MS providing a short analysis time within 5 min. The lower limit of quantification was validated at 10.0 ng/ml of serum for both doxifluridine and 5-FU. Accuracy and precision of quality control (QC) samples for both analytes met FDA Guidance criteria of ±15% for average QC accuracy with coefficients of variation less than 15%. The method will be applicable for preclinical studies and bioequivalence studies.

• Smart Structures and Systems
• /
• v.15 no.1
• /
• pp.191-207
• /
• 2015

Proper placement of sensors plays a key role in construction and implementation of an effective structural health monitoring (SHM) system. This paper proposes a novel methodology called the distributed monkey algorithm (DMA) for the optimum design of SHM system sensor arrays. Different from the existing algorithms, the dual-structure coding method is adopted for the representation of design variables and the single large population is partitioned into subsets and each subpopulation searches the space in different directions separately, leading to quicker convergence and higher searching capability. After the personal areas of all subpopulations have been finished, the initial optimal solutions in every subpopulation are extracted and reordered into a new subpopulation, and the harmony search algorithm (HSA) is incorporated to find the final optimal solution. A computational case of a high-rise building has been implemented to demonstrate the effectiveness of the proposed method. Investigations have clearly suggested that the proposed DMA is simple in concept, few in parameters, easy in implementation, and could generate sensor configurations superior to other conventional algorithms both in terms of generating optimal solutions as well as faster convergence.

• Korean Architects
• /
• s.471
• /
• pp.10-11
• /
• 2008

• Journal of Veterinary Clinics
• /
• v.17 no.1
• /
• pp.83-87
• /
• 2000

The mortalities of the monkeys that have been raised in Everland Zoological Gardens within a designated period (1976-1999) were retrospectively analyzed based on the clinical charts and/or autopsy reports. During that period, a total of 161monkeys from 8 species were died. Noninfectious and traumatic factors, respiratory and digestive disorders account for the majority of cause of death. 62% of the death was concentrated in the winter season. The mortality of female and male was 53 and 47%, respectively. The mortality of adult monkey(62%) due to neoplasia and senile changes.

• IEIE Transactions on Smart Processing and Computing
• /
• v.3 no.6
• /
• pp.393-396
• /
• 2014

Recently, the internet of things (IoT) has become increasingly attractive in many areas to realize smart worlds. JavaScript has become prevalent for IoT programming because of its familiarity with web programmers. On the other hand, JavaScript does not allow the direct control of IoT hardware due to its language limitation. This paper proposes the IoT software platform for JavaScript programming to resolve the limitation. For proof of concept, the platform based on SpiderMonkey and Raspberry Pi was implemented.

• Korean Journal of Microbiology
• /
• v.26 no.2
• /
• pp.106-112
• /
• 1988

We have examined the structures and cellular distributions of the SV40 late RNAs present in monkey cells at late times after infection. One particular RNA species, spliced at residue 373(373-RNA), was found to be as abundant as the major late 16S RNAs. This result was unexpected since previous reports showed that the molecular ratio of the 373-spliced 19S RNA to 16S RNA is approximately 0.1 among either cytoplasmic polyadenylated or polysomal viral RNAs. Both sedimentation and electrophoretic analysis indicated that the 373-RNA was approximately 16S to 19S in size. Therefore, it was not a splicing intermediate or the product of premature termination of transcription within the late leader region. Whereas most SV40 late 16S RNA is polyadenylated and located in the cytoplasm, the majority of 373-RNA was found to lack poly A, and be located in the nucleus.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2002.11b
• /
• pp.194-194
• /
• 2002

Interferon has therapeutic potential for a wide range of infectious and proliferous disorders such as chronic hepatitis C. However, it has drawbacks such as relatively short serum half-life and rapid clearance like other therapeutic proteins. The attachment of a polyethylene glycol (PEG) moiety to interferon is considered as one of the most promising solutions for its ability to extend the plasma residence time.(omitted)

• SUVANNABHUMI
• /
• v.13 no.1
• /
• pp.89-110
• /
• 2021

The Ramayana is a very popular epic in Southeast Asia. It is the story of King Rama who must save his kidnapped wife, Sita. After Sita was abducted by the Demon King Ravana (Tosakanth) and taken to Lanka, Rama and his brother rescued her with the help of the monkey warriors, especially with the help of the Monkey King Hanuman. Along the way, the epic teaches Hindu life lessons. Today The Ramayana is told and retold through literature, theatre, orally, in movies, and is referenced in many other forms of popular culture. Nowadays, in Thailand, Ravana and Hanuman deconstruct the role of divine and become folk deities that also find their places in calendar art, advertising and stamps, etc. And in Vietnam, Ravana and Hanuman have become the two figures that can't be absent from Southern Vietnam Khmer ceremonies. In this article, our aim is to show how Ravana and Hanuman became symbols of popular culture (case studies in Thailand and Vietnam). The data provided in this article is drawn from field surveys with reliable reference resources.