• Korean Journal of Transplantation
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• v.32 no.4
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• pp.75-83
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• 2018

Background: This study was designed to analyze the clinical usefulness of mycophenolic acid trough concentration monitoring in kidney transplantation patients who were maintained with cyclosporine. Methods: The data of patients who underwent mycophenolic acid trough concentration monitoring after their first kidney transplant between November 2006 and August 2013 and were prescribed with cyclosporine, mycophenolate, and methylprednisolone were reviewed retrospectively. Cox analysis was used to analyze the risk factors for acute rejection within 1 year post-transplantation. Results: Among 90 patients, 41 (45.6%) achieved both the target levels of cyclosporine and mycophenolic acid, while three patients (3.3%) failed to achieve the target level of either cyclosporine or mycophenolic acid. Nine patients (10.0%) only achieved the mycophenolic acid target level and 37 patients (41.1%) only achieved the cyclosporine target level. While patients who achieved only the mycophenolic acid target concentration had no statistically increased risk compared to patients who achieved both target levels (hazard ratio [HR], 1.569; 95% confidence interval [CI], 0.316 to 7.778; P=0.581), patients who only achieved the cyclosporine target concentration showed an increased risk of rejection compared to the both achievement group (HR, 4.112; 95% CI, 1.583 to 10.683; P=0.004). Patients who had no achievement in the target levels showed significantly increased rejection risk compared to the patients who achieved both target levels (HR, 17.811; 95% CI, 3.072 to 103.28; P=0.001). Conclusions: Mycophenolic acid trough concentration monitoring combined with cyclosporine trough concentration monitoring is useful for avoiding acute cellular rejection if the first 1 year post-transplantation.

• Journal of the Korean Society of Safety
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• v.36 no.5
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• pp.71-78
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• 2021

There are regularly planned overhaul periods in thermal power plants, which involve the maintenance of the boiler of the power plants. However, thermal power plants workers are always exposed to risk during overhaul periods owing to the narrow space and significant dust inside the boiler. Therefore, it is essential to develop a safety monitoring system that is suitable for operating in this type of environment. In this study, we developed not only a worker three-dimensional (3D)-location monitoring system that can monitor and record the entry/exit of workers, their 3D-location, and fall accidents but also a method to secure the working environment and operation efficiency. This system comprises of a worker tag, which was equipped with an inertial measurement unit, a barometric pressure sensor, and a Bluetooth low energy (BLE), and the tags were given to each worker. In addition, the location of workers inside the boiler was measured using a pedestrian dead reckoning (PDR) method and BLE beacons. The location data of the workers tag were transmitted to the integrated database (DB) server through a gateway, and to the administrator monitoring system. The performance of the system was demonstrated inside an actual thermal power plant boiler, and the accuracy and reliability of the system were verified through a number of repeated tests. These results provide insights on designing a new system for monitoring enclosed spaces.

• Progress in Medical Physics
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• v.32 no.2
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• pp.40-49
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• 2021

Purpose: This study aimed to develop a surface-guided radiosurgery system customized for a neurosurgery clinic that could be used as an auxiliary system for improving the accuracy, monitoring the movements of patients while performing hypofractionated radiosurgery, and minimizing the geometric misses. Methods: RGB-D cameras were installed in the treatment room and a monitoring system was constructed to perform a three-dimensional (3D) scan of the body surface of the patient and to express it as a point cloud. This could be used to confirm the exact position of the body of the patient and monitor their movements during radiosurgery. The image from the system was matched with the computed tomography (CT) image, and the positional accuracy was compared and analyzed in relation to the existing system to evaluate the accuracy of the setup. Results: The user interface was configured to register the patient and display the setup image to position the setup location by matching the 3D points on the body of the patient with the CT image. The error rate for the position difference was within 1-mm distance (min, -0.21 mm; max, 0.63 mm). Compared with the existing system, the differences were found to be as follows: x=0.08 mm, y=0.13 mm, and z=0.26 mm. Conclusions: We developed a surface-guided repositioning and monitoring system that can be customized and applied in a radiation surgery environment with an existing linear accelerator. It was confirmed that this system could be easily applied for accurate patient repositioning and inter-treatment motion monitoring.

• Journal of Korean Academy of Nursing Administration
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• v.22 no.1
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• pp.91-98
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• 2016

Purpose: The aim of this study was to identify the relationship between nurses' knowledge of adverse drug reactions (ADR), attitudes, and monitoring practices and to establish an effective ADR reporting system and provide baseline data for its activation. Methods: The participants in this study were chosen by convenience sampling and included 182 nurses working at major general hospitals that operate a Regional Drug Safety Center. Data were collected from June 1 to 12, 2015 and analyzed using Cronbach's ${\alpha}$, descriptive statistics, independent t-test, one way ANOVA, Pearson correlation coefficient and stepwise regression with the SPSS program. Results: The nurses' average score for knowledge was 7.62 points, for attitude, 41.04 points and for monitoring practices, 34.22 points. ADR monitoring practices positively correlated with knowledge (r=.19, p=.011), attitude (r=.41, p<.001), drug performance competency (r=.54, p<.001), and drug education satisfaction (r=.54, p<.001). Drug performance competency, drug education satisfaction, and attitudes explained 42.0% of the ADR monitoring practices (Adj $R^2=.42$, F=43.95, p<.001). Conclusion: In order to facilitate and encourage nurses' voluntary monitoring practice of ADR, efforts must be made to create positive attitudes toward ADR, and to increase drug performance competency and drug education satisfaction.

• Geomechanics and Engineering
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• v.12 no.4
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• pp.595-609
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• 2017

Due to high in-situ stress and brittleness of rock mass, the surrounding rock masses of underground caverns are prone to appear splitting failure. In this paper, a kind of loading-unloading variable elastic modulus model has been initially proposed and developed based on energy dissipation principle, and the stress state of elements has been determined by a splitting failure criterion. Then the underground caverns of Dagangshan hydropower station is analyzed using the above model. For comparing with the monitoring results, the entire process of rock splitting failure has been achieved through monitoring the splitting failure on side walls of large-scale caverns in Dagangshan via borehole TV, micro-meter and deformation resistivity instrument. It shows that the maximum depth of splitting area in the downstream sidewall of the main power house is approximately 14 m, which is close to the numerical results, about 12.5 m based on the energy dissipation model. As monitoring result, the calculation indicates that the key point displacement of caverns decreases firstly with the distance from main powerhouse downstream side wall rising, and then increases, because this area gets close to the side wall of main transformer house and another smaller splitting zone formed here. Therefore it is concluded that the energy dissipation model can preferably present deformation and fracture zones in engineering, and be very useful for similar projects.

• Korean Journal of Veterinary Research
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• v.60 no.1
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• pp.1-7
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• 2020

We investigated the genotypes of Leptospira spp. detected in symptomatic dogs in Thailand. During April to December 2012, 6 out of 41 client-owned dogs were diagnosed with leptospirosis based on polymerase chain reaction tests. All of the infected dogs showed clinical symptoms related to leptospirosis. Direct genotyping of the causative agent of the canine leptospirosis was conducted from the archival DNA samples extracted from urine or blood of those 6 infected dogs. Sequencing of the partial 16S rRNA and lipL32 genes from all samples identified Leptospira (L.) interrogans as the infecting species. Multilocus sequence typing tests were successful for 2 out of 6 samples. The sequence type (ST) was identified as ST50 for both samples where the profile corresponded to L. interrogans species and Bataviae serogroup. The presence of this genotype of Leptospira has never been reported in Thailand. Thus, our findings showed the existence of ST50 L. interrogans serogroup Bataviae and the ability to cause leptospirosis in dogs in Thailand.

• Annals of Clinical Neurophysiology
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• v.24 no.1
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• pp.21-25
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• 2022

The newly identified frontal aslant tract (FAT) that connects the posterior Broca's area to the supplementary motor area is known to be involved in speech and language functions. We successfully intraoperatively monitored FAT using cortico-cortical evoked potentials generated by single-pulse electrical cortical stimulation in a patient with oligodendroglioma.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.492-496
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• 2002

We present the web-based remote monitoring system using distributed object technology. In order to provide the desired functionality, the system has used CORBA(Common Object Request Architecture) and Java Servlet to implement the integrated distributed object environment. It converts the existing standalone machine monitoring system into web-based machine monitoring system. It consists of applet program, CORBA server and CORBA client. The usefulness of our system will be illustrated by the application to ICM(Integrated Condition Monitoring) System developed by KIST Tribology Center.

• Journal of the Korean Society of Industry Convergence
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• v.23 no.5
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• pp.835-842
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• 2020

This paper considers a method of reproducing abnormal and fault operation for smart monitoring of thrust bearing used in wave power generation system. In order to develop smart monitoring technology, abnormal and failure data of actual equipment are required. However, it is impossible to artificially break down the actual equipment in operation due to safety and cost. To tackle this problem, a test bed that can secure data through reproduction of a faulty operating environment should be developed. Therefore, in this study, test bed that can reproduce each situation was developed and the operation result was analysis after identifying the situation to be reproduced through the failure factor analysis of the thrust bearing.

• Particle and aerosol research
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• v.14 no.4
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• pp.191-203
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• 2018

IIn this study, we have developed drying systems for reducing the error by humidity on measuring particulate matter (PM) in the ambient air with optical particle measuring instruments. Two types of drying systems were designed: drying systems using heating and dilution methods. In addition, 3 types of drying systems using a heating method were designed: Type A (1 hole), B (3 holes) and C (7 holes). After making them, the laboratory and field tests were carried out to evaluate the developed drying systems. As a result, it was shown that the PM concentrations obtained by PM monitoring devices with drying systems agree well with that of the reference devices. Therefore, it could be concluded that the drying systems can be applied to PM monitoring devices for real-time monitoring of the ambient aerosols.