• Journal of the Korean Institute of Navigation
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• v.25 no.1
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• pp.45-52
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• 2001

The purpose of this study is the optimum modification of dynamic characteristics of stiffened plate structure. In the method of the optimization, finite element method(FEM), sensitivity analysis and optimum structural modification method are used. To begin with, using FEM, the dynamic characteristics of stiffened plate structure is analyzed. Next, rate of change of dynamic characteristics by the change of design variable is calculated using the sensitivity analysis. Then, amount of change of design variable is calculated using this sensitivity value and optimum structural modification method. The change of natural frequency is made to be an objective function. Thickness of plate and cross section moment become a design variable. It is shown that the results are effective in the optimum modification for dynamic characteristics of the stiffened plate structure.

• Macromolecular Research
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• v.10 no.5
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• pp.291-295
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• 2002

Atomic force microscopy(AFM) was used to study the polyethylene(PE) surfaces grafted and immobilized with acrylic acid by Ar plasma treatment. The topographical images and parameters including RMS roughness and Rp-v value provided an appropriate means to characterize the surfaces. The plasma grafting and immobilization method were a useful tool for the preparation of surfaces with carboxyl group. However, the plasma immobilization method turned out to have a limitation to use as a means of preparation of PE surface with specific functionalities, due to ablation effect during the Ar plasma treatment process.

• Textile Coloration and Finishing
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• v.9 no.2
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• pp.50-56
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• 1997

Poly(ethylene terephthalate) (PET) has been etched by sputtering in the presence of argon gas and the resulting surface modifications investigated via weight loss, time of water permeation, half value period, scanning electron microscope(SEM) and color difference measurements. According to increasing sputter etching time, weight loss increased, the time of water permeation and half value period of the sputter etched PET fabrics decreased. Color depth of fabrics increased by increasing sputter etching time. We investigated the fabric surface modification by SEM. Many microcraters on the fabric surface formed by the sputter etching resulted in increase of surface area of the fabric and wettability.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2007.05a
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• pp.185-231
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• 2007

• BMB Reports
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• v.53 no.5
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• pp.266-271
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• 2020

Breast cancer encompasses a major portion of human cancers and must be carefully monitored for appropriate diagnoses and treatments. Among the many types of breast cancers, triple negative breast cancer (TNBC) has the worst prognosis and the least cases reported. To gain a better understanding and a more decisive precursor for TNBC, two major histone modifications, an activating modification H3K4me3 and a repressive modification H3K27me3, were analyzed using data from normal breast cell lines against TNBC cell lines. The combination of these two histone markers on the gene promoter regions showed a great correlation with gene expression. A list of signature genes was defined as active (highly enriched H3K4me3), including NOVA1, NAT8L, and MMP16, and repressive genes (highly enriched H3K27me3), IRX2 and ADRB2, according to the distribution of these histone modifications on the promoter regions. To further enhance the investigation, potential candidates were also compared with other types of breast cancer to identify signs specific to TNBC. RNA-seq data was implemented to confirm and verify gene regulation governed by the histone modifications. Combinations of the biomarkers based on H3K4me3 and H3K27me3 showed the diagnostic value AUC 93.28% with P-value of 1.16e-226. The results of this study suggest that histone modification analysis of opposing histone modifications may be valuable toward developing biomarkers and targets for TNBC.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.26 no.3
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• pp.299-305
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• 2017

Gate-lifting devices in small- to mid-sized sluice gates mostly employ the mechanical roller rack pinion (RRP) system. This RRP system, which consists of a rack-bar and a pinion, transforms a rotation motion into a linear one. The rack-bar has a series of roller trains that mesh with the pinion. In this study, we adopt an exact involute-trochoid tooth profile of the pinion to obtain a higher contact fatigue strength using the profile modification coefficient. Further, we determine the contact forces and investigate Hertz contact stresses to predict the pitting life of the pinion according to varying the shape design parameters. The results indicate that the design fatigue life of an RRP system for sluice gate can be achieved only when the design value of the profile modification coefficient reaches or exceeds a certain level.

• Journal of Korea Foundry Society
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• v.24 no.3
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• pp.145-152
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• 2004

The eutectic Si in Al-8.5wt.%Si alloy was changed from large flake to fine lemellar(or fibrous) shape when the Sc amount in the Al-Si alloy reaches 0.2wt.%. The optimum amount of Sc for the best modification effect was 0.8wt.% and slight decrease of modification effect occurred over this value. The study on the distribution of the modifiers(Sr, Na, and Sc) and the measurement of the surface tension of the Al-8.5wt.%Si alloy melt added with Sr, Na, and Sc modifier, respectively, reveals that Sc modifies the eutectic Si by the decrease of surface tension, while Sr and Na modify the eutectic Si mainly by impurity induced twinning mechanism.

• Journal of Microbiology
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• v.34 no.3
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• pp.270-273
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• 1996

Micrococcus luteus purine nucleoside phosphorylase (PNP) has been purified and characterized. The physical and kinetic properties have been described previously. Chemical modification of the enzyme was attempted to gain insight on the active site. The enzyme was inactivated in a time-dependent manner by the arginine- specific modifying reagent phenylglyoxal. There was a linear relationship between the observed rate of inactivation and the phenylglyoxal concentration. At 30 $^{\circ}C$ the bimolecular rate constant for the modification was 0.015 $min^{-1}mM^{-1}$ in 50 mM $NaHCO_3$ buffer, pH 7.5. The plot of logk versus log phenylglyoxal concentration was a strainght line with a slope value of 0.9, indicating that modification of one arginine residue was needed to inactivate the enzyme. Preincubation with saturated solutions of substrates protected the enzyme from inhibition of phenylglyoxal, indicating that reactions with phenylglyoxal were directed at arginyl residues essential for the catalytic functioning of the enzyme.

• 한국기계연구소 소보
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• s.20
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• pp.71-78
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• 1990

This investigation was undertaken to establish the technologies of grain refinement and modification, and to characterize material properties, essential for high quality aluminum alloy castings. Grain refinement seldom changed DAS and eutectic Si size, but largely decrease grain size. The variations of grain size induced by grain refinement had a great influence on the elongation without changes in the tensile strength or yield strength. The optimum Ti level lies between 0.1% and 0.16% to achieve the best possible mechanical properties. DAS and grain size were little affected, but eutectic Si size was greatly refined by modification. The variation of eutectic Si size had a great effect on the elongation, impact value, fracture toughness and fatigue crack propagation rate without changes in the tensile strength or yield strength. The Sr content of 0.015% is optimum to modification.

• Journal of Korean Society of Water and Wastewater
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• v.22 no.1
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• pp.113-120
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• 2008

A large majority of clearwell must be modified with maintaining the present baffles since they were underground built with the material like concrete. Therefore it is unreasonable to apply the previous research in clearwell modification which is studied with the assumption that distance between baffles is constant. In this study, internal short-circuiting estimation method (ISEM), which has the advantage of being applied at any condition, is applied to evaluate modification of A clearwell and modify B and C clerwell which have unusual characteristics. After analyzing the hydraulic efficiency at current state, modifications, where baffles, intra basins and diffuser walls are additionally installed, are considered and evaluate using ISEM. And the effect of intra basin and diffuser wall on $T_{10}/T$ is estimated and application feasibility of ISEM is evaluated. The improvement of intra basins is almost same with that of baffles. Also, short-circuiting in effluent zone can be reduced with the same level of channel zone if intra basin is added in effluent zone. However, effect range is restricted to the next channel zone. Diffuser wall can obtain the lower ISI than minimum ISI of cases where baffles and intra basins are installed. Therefore, additional improvement of $T_{10}/T$ value can be expected after $T_{10}/T$ value converges maximum only using baffles