• 대한한의진단학회지
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• 제19권3호
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• pp.151-158
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• 2015

Objectives Syndrome differentiation and treatment (辨證論治) is one of the core theories in Korean medicine and syndrome differentiation (辨證) constitutes a branch of disease diagnosis in Korean medicine. Yoon Gil-Young, one of the modern outstanding scholar of basic medical science in Korean medicine, wrote on basic theories of Korean medicine such as physiology, pathology, formula science, etc. Hereby we will analyze and discuss his works to understand his recognition of historical changes in the syndrome differentiation. Methods We conducted researches into the two works of Yoon Gil-Young's, which are "The Clinical Formula Science of Eastern Medicine (東醫臨床方劑學)" and "The theory of Four-Constitution Medicine (四象體質醫學論)". From Yoon's academic standpoint which connects the basic medical science with the clinical medicine, we analyzed his opinion about syndrome differentiation and its historical changes. Results According to Yoon's research work on syndrome differentiation and its historical changes, the development of syndrome differentiation, which goes in harmony with the history of Korean medicine, has its deep root in " Huangdi's Internal Classic (黃帝內經)" and "Treatise on Cold Damage and Miscellaneous Diseases (傷寒雜病論)". And through "Treatise on the Spleen and Stomach (脾胃論)" and the articles of warm disease (溫病論), the theory of syndrome differentiation became extended to the whole clinical diagnostic field in Korean medicine, finally including the achievements in "Treasured Mirror of Eastern Medicine (東醫寶鑑)", "Longevity and Life Preservation in Eastern Medicine (東醫壽世保元)". Conclusions Yoon Gil-Young recognized that the system of syndrome differentiation was developed in accordance with the theories from the "Treatise on Cold Damage and Miscellaneous Diseases", then the "Treatise on the Spleen and Stomach" and the articles of warm disease. The four-constitution medicine in Korea and Koho school in Japan which lays emphasis on abdominal signs also contributed to its development. Syndrome differentiation can be categorized basically into three states of intrinsic cold (本寒), intrinsic deficiency (本虛), intrinsic heat (本熱) according to the deficiency and excess in human body metabolism.

• Journal of Dairy Science and Biotechnology
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• 제33권3호
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• pp.167-170
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• 2015

The dairy industry, as part of the broader agricultural sector, is classified as a basic industry to the Korea economy. Basic industries provide income to a region by producing an output, purchasing production inputs, services and labor. An integrated, multidisciplinary approach for the next generation of dairy products with added health benefits represent the direct economic contribution. The commercialization of "nutritional" functional foods can only be successful if the consumer is confident in the scientific validity of the claims. Modern biotechnologies such as genomics, genetic expression and biomarkers of health performance suggested to whole dairy products, such as fluid milk, butter, cheese, ice cream and frozen dessert products (German, 1999). The following definition makes the point that dairy products can provide a nutritional value beyond the basic nutritional requirements: 1) The dairy industry has the opportunity to improve the health and well-being of its customers and/or to reduce their risk of disease through dairy products with added activities. 2) Functional dairy products are those that can be demonstrated to benefit target functions in the body in a way that improves the state of health and /or reduces the risk of disease. They are food products that are consumed as part of a normal diet rather than pills or supplements. 3) Dairy products based on functionality will need to link the scientific basis of such functionality to the communication of its benefit to the general public. 4) Both the efficacy and the safety of the food components with health benefits will require evidence based on the measurement of scientific biomarkers relevant to their biological responses and health end points. 5) Sound evidence from human studies based on intermediate health end points using accepted biomarkers will provide the basis for promotional messages divided into two categories-enhanced function and reduced risk of disease. 6) Success in solving key scientific and technological challenges will only be achieved by interdisciplinary research programs to exploit the scientific concepts in functional dairy science.

• Journal of Acupuncture Research
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• 제33권1호
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• pp.69-77
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• 2016

Objectives : The objective of this study is to review external approaches using acupuncture and related treatments of hyperpigmentation disorders and their classification in traditional medicine. Methods and Results : Hyperpigmentation was recorded for the first time in Treatise on the Pathogenesis and Manifestations of All Diseases published in 610 A.D. This suggests that the symptom has already been recognized as an independent disease in East Asia for more than 1,400 years. Over the course of several centuries, there has been a significant evolution in the traditional treatments for hyperpigmentation. There are many different types of therapy, including body acupuncture, intradermal acupuncture, ear acupuncture, ear acupressure, blood-letting treatment, pharmacopuncture, plum-blossom needle therapy, burning acupuncture therapy, moxibustion, and guasha. In addition, the traditional classification of hyperpigmentation has been changing shape. However, no attempts have been made to establish the academic linkage between the modern classification of hyperpigmentation disorders and the traditional one, on account of different concepts and names of the ailment. This study was designed in an attempt to identify the linkage of the categorization of the Korean Standard Classification of Disease (KCD) and the traditional classification. Conclusions : Through this literature review, we found that there has been a significant evolution in the treatment of hyperpigmentation disorders in East Asia. Traditional medical treatment for skin disease, including hyperpigmentation, is expected to be further developed with the advancement of science and technology.

• 한국컴퓨터정보학회논문지
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• 제11권6호
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• pp.107-111
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• 2006

IT산업 발전에 따라 일상생활은 점차 편리해지고 있으며 이와 비례하여 환경오염의 확산과 각종 질병들에 대한 위험도 점차 높아지고 있다. 인간의 생명을 위협하는 위험한 질병 중에는 사전에 예방하지 않으면 돌이킬 수 없는 사태로 확산되기도 하지만 바쁜 현대인들에게는 자신의 건강상태를 사전에 파악하고 관리하기 힘든 실정이다. 이에 유비쿼터스 환경에 접어든 IT기술을 바탕으로 의료진단 및 예방 시스템을 구축하여 사용자들이 센서를 통해 컴퓨터를 직접 이용하지 않더라도 자신의 건강상태를 유지 관리할 필요가 있다. 그러므로 본 논문에서는 이와 같이 유비궈터스 환경으로 변화해가는 기술적 변화를 바탕으로 의료 진단 및 예방이 가능한 시스템 구축을 위한 모델로서 뇌혈관 질환에 대한 모델을 제시하고자 한다. 또한, 이를 통해 향후 구축하고자 하는 u-헬스 케어 의료진단 시스템 구축 모델에 활용하고자 하며, 본 모델을 통해 의료정보를 활용한 산업 발전과 인류의 편이성 증대 및 건강상태의 주기적 검사를 통해 향상된 복지문화를 유도할 수 있을 것이다.

• KSBB Journal
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• 제29권1호
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• pp.36-41
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• 2014

Skin disease is one of the most common diseases and its incidence is increasing dramatically in modern society. Specially, many attempts have been made to treat chronic skin inflammation diseases, such as psoriasis and atopic dermatitis, but effective therapies for the immune cell-mediated skin diseases, including psoriasis and atopic dermatitis have not been developed. Until recently, several drug candidates which were claimed to be effective for skin diseases have been reported, but most of them are not used to treat chronic skin disease. Especially, Psoriasis is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells and various immune-related cytokines. Formation of new blood vessels starts with early psoriatic changes and disappears with disease clearance. Several angiogenic mediators are up-regulated in psoriasis development. Contact- and mediator-dependent factors derived from keratinocytes, mast cells and immune cells may contribute to the strong blood vessel formation of psoriasis. New technologies and experimental models provide new insights into the role of angiogenesis in psoriasis pathogenesis. TMP and its derivatives themselves effectively inhibited in vitro cell migration, tube formation, and the expression of angiogenic factors. However, TMP and its derivatives induced side effects including hemolysis and local side effects. Therefore, in an attempt to reduce the toxicity and the undesirable side effects of TMP and derivatives, a liposomal formulation was prepared and tested for its effectiveness. TMP and derivatives liposomes retained the effectiveness of TMP in vitro while side effects were reduced. These results support the conclusion that TMP effectively inhibits in vitro angiogenesis, with the possibility that use as a psoriasis relief agent.

• 한국전자통신학회논문지
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• 제15권4호
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• pp.785-790
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• 2020

4차 산업혁명과 더불어 의료정보에 관한 관심과 연구가 활발히 이루어지고 있다. 그중 근거리 저 전력 무선통신을 활용한 기술들이 모바일 기기와 연계 적용되면서 의료기관에서도 그 활용도가 점차 높아짐에 따라 기술의 발전과 변화에 맞춰 의료 환경에서도 IT 기술을 이용해 양질의 서비스를 받고자 하는 고객의 요구가 점점 증대되고 있다. 또한, 스마트 장비에 익숙하고 시간의 가치를 중요하게 생각하는 현대인의 경우 신속한 서비스를 통해 자신의 시간을 낭비하지 않기를 기대한다. 더불어 최근 코로나바이러스 감염증-19(Coronavirus Disease 2019;COVID-19)를 비롯한 각종 전염병이 유행함에 따라 언택트(비대면)에 대한 관심이 증가하고 있어 전염병에 대한 예비조치로 사회적 거리가 필요한 실정이다. 이러한 이유로 본 연구에서는 근거리 저전력 무선통신을 이용하여 환자에게 신속한 서비스를 제공하고 의료기관 종사자와 방문자들에게 더욱 안전하고 편안한 환경을 제공할 수 있도록 언택트 기반의 의료접수 시스템을 연구하였다.

• 대한상부위장관⦁헬리코박터학회지
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• 제18권3호
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• pp.150-156
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• 2018

Precision medicine stands for 4Ps - precise, preventive, participatory, and personal; in which "precision" is important because the current modern medicine starts from "trial and error," and "one does not fit all". Current targeted therapies for cancer have changed treatment approaches and led the precision medicine; however, clinical use of liquid biopsy, using blood or other liquid specimens to characterize circulating tumor cells (CTC) or tumor genes instead of biopsies of tumor tissues, still awaits availability of more information regarding non-invasive cancer detection and characterization, prediction of treatment response, monitoring the disease course and relapse possibilities, identification of mechanisms of drug resistance, and newer pathogenesis. In this review, we will introduce the basic concept of CTC, circulating cell free DNA, and exosomes and their possible application for gastric cancer relevant with Helicobacter pylori infection.

• Genomics & Informatics
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• 제17권1호
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• pp.7.1-7.10
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• 2019

Cysticercosis, a parasitic disease caused by Taenia solium metacestode (TsM), has a major global public health impact in terms of disability-adjusted life years. The parasite preferentially infects subcutaneous tissue, but may invade the central nervous system, resulting in neurocysticercosis (NC). NC is an important neglected tropical disease and an emerging disease in industrialized countries due to immigration from endemic areas. The prevalence of taeniasis in Korea declined from 0.3%-12.7% during the 1970s to below 0.02% since the 2000s. A survey conducted from 1993 to 2006 revealed that the percentage of tested samples with high levels of specific anti-TsM antibody declined from 8.3% to 2.2%, suggesting the continuing occurrence of NC in Korea. Modern imaging modalities have substantially improved the diagnostic accuracy of NC, and recent advances in the molecular biochemical characterization of the TsM cyst fluid proteome also significantly strengthened NC serodiagnosis. Two glycoproteins of 150 and 120 kDa that induce strong antibody responses against sera from patients with active-stage NC have been elucidated. The 150 kDa protein showed hydrophobic-ligand binding activities and might be critically involved in the acquisition of host-derived lipid molecules. Fasciclin and endophilin B1, both of which play roles in the homeostatic functions of TsM, showed fairly high antibody responses against calcified NC cases. NC is now controllable and manageable. Further studies should focus on controlling late-onset intractable seizures and serological diagnosis of NC patients infected with few worms. This article briefly overviews diagnostic approaches and discusses current issues relating to NC serodiagnosis.

• 한국융합학회논문지
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• 제12권5호
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• pp.101-108
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• 2021

현대인들은 일상생활과 함께 운동 부족에 시달리고 있으며 이에 따라 발의 족부질환도 증가하는 추세이다. 이에 따라 양말 디자인도 다양화되고 있으며, 그중 족부질환의 예방과 완화에 도움을 주는 발가락 양말의 개발도 활발하게 진행되고 있다. 이에 본 연구는 발가락 양말 디자인에 대한 연구를 진행하였으며, 이론적 배경을 통해 발가락 양말 디자인에 대한 개념을 정리하였다. 또한 사례 조사 및 선행연구를 통해 사용성 평가에 활용할 Task를 수립하였다. 실증연구를 통해 사용성 평가를 진행한 결과 일반 양말 디자인 대비 발가락 양말 디자인의 만족도가 낮음을 알 수 있었고 사용성 측면에서는 발가락 양말 디자인의 사용성의 만족도가 높은 것을 알 수 있었다. 이에 따라 발가락 양말 디자인의 개선점을 도출하였으며, 첫째 발가락 양말 사이의 히든 파티션을 보완하고, 색상의 유사 배색과 색상의 다원화를 통해 발가락 양말 디자인을 개선할 수 있을 것으로 기대한다.

• 한국전자통신학회논문지
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• 제18권3호
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• pp.545-554
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• 2023

현대 산업에서 위성항법시스템(Global Navigation Satellite System : GNSS)은 PNT 정보(측위(P : Positioning), 항법(N : Navigation), 시각동기(T : Timing))가 항상 제공되어야 하고, 그 정보를 기반으로 정밀한 위치추정이 요구되는 다양한 분야에 활용되고 있다. 특히, 2019년부터 시작된 COVID-19 펜데믹 상황에 대한 감염 예방 및 확산 방지를 위해 정밀한 위성항법시스템 기술과 이를 보조하는 다양한 기술들이 사용되어 왔고, 전 세계의 적극적인 방역과 감염 확산 억제 노력으로 엔데믹 상황으로의 전환을 앞두고 있다. 질병, E-health 분야는 감염병의 추적 및 감시와 더불어 원격 의료 서비스 제공을 위해 이용자의 위치정보가 반드시 필요한데, 위성항법시스템이 정확한 위치정보 제공에 주도적인 역할을 하고 있다. 본 논문은 이러한 위성항법시스템 기술이 질병 및 E-health 분야에 활용된 최신 연구 동향에 대해 조사한 결과를 제시하고 그 결과를 분석한다.