• Journal of Chest Surgery
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• 제46권6호
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• pp.402-412
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• 2013

Background: Moderate and severe hypothermia with cardiopulmonary bypass during aortic surgery can cause some complications such as endothelial cell dysfunction or coagulation disorders. This study found out the difference of vascular reactivity by phenylephrine in moderate and severe hypothermia. Methods: Preserved aortic endothelium by excised rat thoracic aorta was sectioned, and then down the temperature rapidly to $25^{\circ}C$ by 15 minutes at $38^{\circ}C$ and then the vascular tension was measured. The vascular tension was also measured in rewarming at $25^{\circ}C$ for temperatures up to $38^{\circ}C$. To investigate the mechanism of the changes in vascular tension on hypothermia, NG-nitro-L-arginine methyl esther (L-NAME) and indomethacin administered 30 minutes before the phenylephrine administration. And to find out the hypothermic effect can persist after rewarming, endothelium intact vessel and endothelium denuded vessel exposed to hypothermia. The bradykinin dose-response curve was obtained for ascertainment whether endothelium-dependent hyperpolarization factor involves decreasing the phenylnephrine vascular reactivity on hypothermia. Results: Fifteen minutes of the moderate hypothermia blocked the maximum contractile response of phenylephrine about 95%. The vasorelaxation induced by hypothermia was significantly reduced with L-NAME and indomethacin administration together. There was a significant decreasing in phenylephrine susceptibility and maximum contractility after 2 hours rewarming from moderate and severe hypothermia in the endothelium intact vessel compared with contrast group. Conclusion: The vasoplegic syndrome after cardiac surgery might be caused by hypothermia when considering the vascular reactivity to phenylephrine was decreased in the endothelium-dependent mechanism.

• 동의신경정신과학회지
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• 제3권1호
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• pp.91-106
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• 1992

The effectiveness, the safety and the usefulness of HPS-A(An Jung San with Chyag Yag Kam Cho Tang), herbal digestive, was examined on 32 patients complained digestive symptoms. This medicine was administered 1 package per 1 time 3 times per 1 day, during 2 weeks. From the examination of the improvemnt and the safety mainly by subjective symptoms, the usefulness was gained. The results were as follows ; 1. In the improvement rate of susbjective symptoms, high rate symptoms was gastric distension, anorexia, heart burn, gastric discomport, dyspepsia, acrid eructation, indigestion, nausea. 2. The improvment over moderate effective was 85.7% after 1 week 96.4% after 2 weeks. The 4 cases breaked medicine during experimental period were all over moderate offectiveness. 3. There weren't any cases complaind particular problem about safety except for 1 case complained mild pushing up of heat. There weren't also any side effect of medicine on common blood count, blood chemistry and urinalysis. 4. In the dicision of usefulness, 19cases(59.4%) were usefulnesss, 12cases(37.5%) were moderate usefulness, 1 case was uselessness(3.1%). So the cases over moderate usefulness were 31 and rate was 96.9%. 5. The usefulness rates according to physical features were all over 95.5% in sturdiness, middle feature and infirmity. So the rates were no relations with the features. 6. The usefulness rates over moderate usefulness according to total seriousness were all over 90% in high, middle, and mild cases. So the rates were no relations with the seriousness. Totally HPS-A was a medicine that was highly effective, safe and useful to patients complained various digestive symptomes.

• Journal of Chest Surgery
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• 제19권2호
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• pp.225-231
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• 1986

Pericardial adhesions following open heart surgery pose a special problems, increasing the risk of cardiac reoperation because of the danger of damaging the heart, coronary artery and veins, or grafts and also the fibrous tissue may obliterate the pericardial space and eventually constrict the heart. This study was undertaken to evaluate the effect of intrapericardial urokinase and dextran 40 on the formation of pericardial adhesions in an animal model. latrogenic traumas on the pericardium were surgically induced in 30 rabbits, simulating injuries possible during actual surgery. In all rabbits, blood [1 ml] was obtained from an ear vessel and injected into the pericardium. Control group of ten rabbits did not receive any further medication, urokinase group of ten received 15, 000-20, 000 IU of urokinase, and remained ten received 1 ml of 10% dextran 40. All rabbits were sacrificed at 4 weeks. At autopsy, the development of adhesions were graded as none [Grade I], minimal [Grade II], moderate [Grade III], and severe [Grade IV]. Histological studies of the parietal pericardium and epicardium were performed. The results were as follows: 1. Group 1[Control group] showed minimal adhesion in 40%, moderate in 50%, and severe in 10% of the group. Sharp dissections were necessary in 60% of adhesions. 2. Group II [Dextran group] showed no adhesions in 20%, minimal in 60%, and moderate in 20% of the group. 3. Group III [Urokinase group] showed no adhesions in 40%, minimal in 40%, and moderate in 20% of the group. Considering in this group, the adhesion activity was significantly suppressed [60% adhesions] compared to the control group [100% adhesions] [P < 0.05]. 4. Histological findings revealed mild serosal fibrosis in none adherent group, loose fibrous connections between two layers of pericardium in minimal adhesion group, tight fibrous connections in moderate adhesion group, and marked fibrous thickening and close attachment of two surfaces were noted in severe adhesion group. These data have revealed the decreased incidence of pericardial adhesions with urokinase and dextran 40.

• 한국체육학회지인문사회과학편
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• 제58권4호
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• pp.447-459
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• 2019

이 연구는 비활동 여성 30명을 대상으로 중강도 지속 운동(moderate-intensity continuous exercise; MICE)과 고강도 인터벌 운동(high-intensity interval exercise; HIIE) 시 감정적 반응과 신경전달물질의 차이를 규명하기 위해 실시되었다. 두 집단 모두 설계된 일회성 트레드밀 운동을 실시하였고, 동일한 운동을 1주일 간격으로 총 3회 반복 실시하였다. MICE는 환기역치(VT) 50% 수준에서 5분간 준비운동 후 90%VT 수준에서 25분간 지속운동을 실시하였고 다시 50%VT 수준에서 5분간 정리운동을 실시하였다. HIIE는 115%VT 수준에서 2분간 6회 반복하였고, 중간의 운동성 회복은 85%VT 수준에서 2분간 4회 반복하였다. 통계분석결과 MICE는 첫 번째 실험에서 운동 중 감정반응과 운동 후 즐거움에 대해 긍정적으로 나타났지만 세 번째 실험에서는 부정적으로 나타났다. 반대로 HIIE는 첫 번째 실험에서 운동 중 감정반응과 운동후 즐거움에 대해 부정적으로 나타났지만 세 번째 실험에서는 긍정적으로 나타났다. 신경전달물질의 경우 3번의 실험에서 두 집단 모두 운동전에 비해 운동 10분 후 유의하게 증가한 것으로 나타났다. 종합해볼 때 비활동 여성에게 HIIE 운동이 운동순응을 높이는 전략이 될 수 있다고 판단된다.

• Food Science and Biotechnology
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• 제15권5호
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• pp.817-819
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• 2006

8-Quinolinol and other quinolinol derivatives were evaluated with regard to their growth-inhibitory effects against intestinal bacteria, using the paper disk-agar diffusion method. The observed growth responses varied according to the chemicals and dosages used, as well as the bacterial species tested. 8-Quinolinol showed a significant inhibitory effect against Clostridium difficile, C. perfringens, and Escherichia coli, at 5, 2, 1, and 0.5 mg/disk, and also exhibited a very strong inhibitory effect at 0.25 mg/disk. At low concentrations, 8-quinolinol had strong inhibitory effects against C. perfringens at 0.1 and 0.05 mg/disk; 8-quinolinol also manifested a moderate inhibitory effect against C. perfringens at 0.025 mg/disk. Furthermore, 8-quinolinol revealed moderate and weak growth inhibition against C. difficile and E. coli at concentrations of 0.1 and 0.05 mg/disk, respectively, but 2-quinolinol, 4-quinolinol, and 6-quinolinol evidenced no growth inhibition against B. bifidum, B. longum, C. difficile, C. perfringens, E. coli, or L. casei. The inhibitory effects of 8-quinolinol against C. difficile, C. perfringens, and E. coli lead to its consideration as a possible therapeutic modality for the treatment of diseases associated with harmful intestinal bacteria.

• 대한간호학회지
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• 제32권2호
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• pp.265-276
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• 2002

This study was to identify the trends and contents of imagery interventions and to evaluate the effects of imagery interventions by using meta-analysis. Method: The materials used for this study were 15 imagery intervention studies carried out from Jan. 1995 to Dec. 2001. The studies were analyzed and evaluated in different categories: 1) types of dependent variables 2) types of imagery 3) interval of imagery 4) total duration of imagery 5) sample characteristics 6) intervention method. Result: 1) Behavioral imagery was more prevalent than dynamic imagery. There were wide variations in duration, and interval of interventions. Imagery intervention had moderate effects on psychological variables (state of anxiety, depression & and stress etc.) and had moderate to large effects on physiological variable(pulse rate, cortisol etc.). Behavioral imagery had larger effects than dynamic imagery. Imagery applied to the public had larger effect on decreasing the state of anxiety and stress than applied to the patients. But imagery applied to the patients had a larger effect on decreasing depression than applied to the public. The imagery intervention method by using the individual approach had greater effect than group approach method. Conclusion: These results of this study will be used to guide the development of imagery interventions to nursing practice. Also, various types of imagery interventions need to be developed based on the characteristics of nursing practice.

• 디지털융복합연구
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• 제8권3호
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• pp.115-127
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• 2010

본 연구는 현재 사이버 대학에서 제공하고 있는 강의서비스 품질이 학습자의 학습동기에 따라 학습 만족에 어떠한 영향을 미치고 있는지를 연구하였다. 강의서버스 품질은 기존의 서비스 품질 측정요인으로 사용되고 있는 SERVQUAL(유형성, 신뢰성, 반응성, 확신성, 공감성) 바탕으로 강의서비스 품질을 측정하였다. 분석결과 강의서비스 품질와 유형성, 확신성, 신뢰성, 공감성은 학습만족에 지지되었고 반응성은 기각되었다. 학습동기가 학습만족에 조절변수로서의 할 것이라는 가설을 검정하기 위하여 3단계 계층회귀분석을 실시하였다. 강의서비스 품질의 각 구성요인과 학습동기가 상호작용할 때 전반적 만족에 유의한 영향을 주고 있다는 3단계 모델의 설명력이 높게 나타남으로써 전체적으로 학습동기의 상호 작용 효과는 입증되었다.

• 대한간호학회지
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• 제42권6호
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• pp.833-842
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• 2012

Purpose: The purpose of this study was to evaluate the effectiveness of spiritual intervention studies by examining biological, psychological, and spiritual outcomes. Methods: From electronic databases 2522 studies were retrieved, of which 21 studies met the inclusion criteria. These studies had 1411 participants. Two authors independently extracted data from the selected studies and assessed the methodological quality. The data were analyzed using the RevMan 5.1 program of the Cochrane library. Results: Overall effect size of spiritual intervention on spiritual and psychological (depression and anxiety) outcomes were moderate (d= -0.65 to d= -0.76, p<.001). The effects on biological outcomes (pain and functional status) ranged from -0.51 to -0.39, respectively. No publication bias was detected as evaluated by a funnel plot. Spiritual intervention had a moderate effect on psychological and spiritual outcomes and a smaller effect on biological outcomes. Conclusion: The results of this study suggest that spiritual intervention can relieve depression and anxiety. Further randomized controlled trials studies are needed to evaluate the effects of spiritual intervention on biological outcomes.

• 지역사회간호학회지
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• 제28권4호
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• pp.440-449
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• 2017

Purpose: This study was conducted to identify the moderate effect of social support on the relationship between death anxiety and depressive symptoms among poor older women in rural areas. Methods: This was a secondary analysis of the data from 209 women who were participated in the intervention study to evaluate the effectiveness of depression prevention program. Data were collected between April and September 2012. The data were analyzed using moderate multiple regressions. Results: Among these poor older women, depressive symptoms were associated with death anxiety and social support. Self-esteem support had a moderating effect on the relationship between death anxiety and depressive symptoms. Conclusion: The results indicate that the self-esteem support was effective in decreasing depressive symptoms and death anxiety in poor older women. In order to reduce their depression and make positive changes in their lives, self-esteem improvement programs are needed.

• 대한수의학회지
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• 제53권4호
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• pp.231-237
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• 2013

This study aimed to assess the attraction effect against Lycorma delicatula and antioxidant activity of hexane, chloroform, butanol and water fraction obtained from Ailanthus altissima methanol extract. The attraction effect of chloroform fraction showed the highest activity (47%) as compared to that of other fractions. In the DPPH radical scavenging activity, methanol and butanol fraction showed higher antioxidant activity than other solvent fractions. From the above results, the potential chloroform fraction was further performed by local irritation test in New Zealand white rabbits. In eye irritation test, chloroform fraction showed moderate irritant at high concentration 0.5 g/site/mL, but there was no eye irritation at low concentration (0.05 g/site/mL). In accordance with the Draize evaluation of skin irritation, the primary irritation index was calculated to 3.3 and 0.68 at high (0.5 g/site/mL) and low concentration (0.05 g/site/mL) causing moderate and mild irritation, respectively. On the basis of this study, Ailanthus altissima chloroform fraction could be safely considered to be a candidate of attractant against Lycorma delicatula.