• Clinical and Experimental Pediatrics
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• 제58권3호
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• pp.96-101
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• 2015

Purpose: Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. Methods: We enrolled 91 children with AD and 32 control subjects without history or symptoms of allergic diseases. Blood was drawn to evaluate complete blood cell count, total eosinophil count (TEC), and total IgE, specific IgE to common allergens, 25(OH)D, and IL-31 levels. Serum 25(OH)D and IL-31 levels were measured using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. The scoring atopic dermatitis (SCORAD) index was used to evaluate the severity of AD. Results: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group. Children with atopic sensitization showed significantly lower 25(OH)D levels than nonatopic children. However, serum IL-31 levels were not related to AD group, SCORAD index, or 25(OH)D levels. The SCORAD index was inversely correlated with serum 25(OH)D level and positively correlated with TECs and total IgE levels. Children with moderate and severe AD had significantly higher TECs than children with mild AD. Conclusion: Vitamin D is related to the severity of AD independently of IL-31.

• Annals of Occupational and Environmental Medicine
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• 제34권
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• pp.40.1-40.9
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• 2022

Background: According to the occupational accident status analysis in 2020, of 1,180 occupational deaths, 463 were caused by cardiovascular disease (CVD). Workers should be assessed for CVD risk at regular intervals to prevent work-related CVD in accordance with the rules on occupational safety and health standards. However, no previous study has addressed risk and mortality. Therefore, this longitudinal study was conducted to evaluate the relationship between 10-year cardiovascular risk of the general health checkup and mortality. Methods: The study included 545,859 participants who visited Kangbuk Samsung Total Healthcare Centers from January 1, 2002, to December 31, 2017. We performed 10-year cardiovascular risk assessment for the participants and the risk was divided into 4 groups (low, moderate, high, and very high). The study used death data from the Korea National Statistical Office for survival status as an outcome variable by December 31, 2019, and the cause of death based on the International Classification of Diseases, 10^th Revision (ICD-10) was identified. Statistical analysis was performed using Cox proportional hazards regression analysis, and the sum of the periods from the first visit to the date of death or December 31, 2019, was used as a time scale. We also performed a stratified analysis for age at baseline and sex. Results: During 5,253,627.9 person-years, 4,738 overall deaths and 654 cardiovascular deaths occurred. When the low-risk group was set as a reference, in the multivariable-adjusted model, the hazard ratios (HRs) (95% confidence interval [CI]) for overall mortality were 3.36 (2.87-3.95) in the moderate-risk group, 11.08 (9.27-13.25) in the high-risk group, and 21.20 (17.42-25.79) in the very-high-risk group, all of which were statistically significant. In cardiovascular deaths, the difference according to the risk classification was more pronounced. The HRs (95% CI) were 8.57 (4.95-14.83), 38.95 (21.77-69.69), and 78.81 (42.62-145.71) in each group. As a result of a subgroup analysis by age and sex, the HRs of all-cause mortality and cardiovascular mortality tended to be higher in the high-risk group. Conclusions: This large-scale longitudinal study confirmed that the risk of death increases with the 10-year cardiovascular risk of general health checkup.

• Bulletin of the Korean Chemical Society
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• 제33권9호
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• pp.2890-2896
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• 2012

A simple regioselective synthesis of cinnoline derivatives was achieved by a one-pot three component synthetic methodology. New substituted 7,8-dihydrocinnolin-5(6H)-ones are prepared via one-pot three component reaction of arylglyoxals with 1,3-cyclohexanedione and dimedone in the presence of hydrazine hydrate in moderate to good yields.

• Journal of Dairy Science and Biotechnology
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• 제23권2호
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• pp.99-106
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• 2005

Chronic diseases such as cancer, cardiovascular diseases, are the leading cause of death and disability in Korea since 1970 due to lifestyle change introduced by urbanization & industrialization. The type of cancer and cardiovascular diseases changes as lifestyle becomes westernized. These diseases account for 4 of every 10 deaths and affect the quality of lift of Koreans. Although chronic diseases are among the most common and costly healthy problems, they are also preventable. Adopting healthy behaviors such as quitting smoking, being physically active, eating right with moderate alcohol drinking, and maintaining healthy weight can prevent or control the effect of these diseases.

• Korea-Australia Rheology Journal
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• 제21권2호
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• pp.103-108
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• 2009

Hemorheological properties are easily modified by glucose-induced oxidation and glycation. Carnosine, a naturally occurring dipeptide ($\beta$-alanyl-LFull-size image-histidine), has been recently proposed to act as an antioxidant as well as a free-radical scavenger. In the present study, we investigate its protective and rejuvenating effects in erythrocytes that are exposed to glucose-rich plasma. Erythrocytes that were incubated in glucose solutions were treated with different concentrations of carnosine and for different incubation times. Their hemorheological alterations were examined. The results reveal that the presence of carnosine effectively prevented these rheological alterations in a concentration-dependent manner in glucose-rich media. It is proposed that moderate concentrations of carnosine might be further explored as potential therapeutic agents for pathologies that involve hemorheological modification.

• 대한가정학회지
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• 제33권5호
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• pp.89.2-98
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• 1995

This study examined whether specific coping strategies for the university entrance examination stress are related to high school seniors' depression and whether these strategies moderate the relationship between additional life event stress and depression. A sample of 358 high school seniors reported their level of additional life event stress, coping strategies they were using to handle examination stress, and their levels of depression. Problem-focused coping strategies and affective-regulation coping strategies were found to be related to reduction in depression. And, coping with examination stress was found to be related to depression independent of the level of additional life event stress.

• 접착 및 계면
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• 제7권4호
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• pp.45-52
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• 2006

Five low molar ratio urea-formaldehyde (LUF) resins were synthesized in this study. The effects of molar ratio, free formaldehyde content, and catalysts on the curing characteristics of LUF resins were studied by measuring its free formaldehyde content, pH value change after catalysts added, curing rate, and pot life, observing its cured appearance, and analyzing its thermal behavior. The results indicate that: 1) The LUF resin with lower molar ratio than 1.0 can still cure; 2) Free formaldehyde content is not the main factor in affecting curing rate of LUF resin; 3) Compared with ammonium chloride as a traditional catalyst, persulfate salts markedly accelerate the curing rate of LUF resin, and result in the different appearance; 4) the addition of sodium chloride to catalysts can accelerate the curing rate of LUF resin, but the effect is moderate.

• 영어어문교육
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• 제17권1호
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• pp.165-190
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• 2011

This research investigates listening strategies and the relationship between the employment of strategy and listening proficiency of Korean EFL middle school students. One hundred and four middle school students (N = 104) participated in this study and their strategy use was assessed through a questionnaire adapted from Oxford's (1990) SILL and O'Malley and Chamot (1990). To measure listening proficiency, the English Listening Ability Test designed by 15 city and provincial offices of education in Korea was used. The results show that students employed a moderate use of strategies; compensation strategies were used most frequently and metacognitive strategies were used the least frequently. Significant differences were found in the use of implicit strategy among different listening proficiency groups, but not in their use of behavioral strategy. Furthermore, there were significant differences in the use of implicit memory, cognitive and compensation strategies among groups of students with different listening proficiencies, but not in their use of metacognitive strategy. The results from multiple regression analysis indicate that implicit strategy use could play an important role in listening comprehension. The findings suggest the need for additional research to explore the effect of listening strategy training for English language learners.

• ETRI Journal
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• 제35권6호
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• pp.1160-1163
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• 2013

Herein, we propose a novel method to create multidirectional and multilevel pointing input using only a hardware keyboard. The relative position vectors among pressed keys are calculated into an input vector. The pointing performance of this method is evaluated based on the ISO 9241-9 recommendations. We find that the performance of the method is sufficient to create moderate pointing input, as the measurement of the throughput is close to that of a touchpad, as measured in past studies also using the ISO 9241-9 recommendations.

• Fibers and Polymers
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• 제3권3호
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• pp.85-90
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• 2002

Five temporarily solubilized reactive disperse dyes were synthesized and characterized. They were applied to polyester/cotton blend fabric using one-bath dyeing method without dispersing agent. The dye that has azonaphthalene chro-mophore seemed to not only be exhausted on polyester but also react with cotton. But other dyes were selectively dyed on polyester and showed limited uptake on cotton. Good levelling as well as moderate to good colour fastness was obtained with the dyes on P/C blend fabric.