• 한국전산유체공학회지
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• 제22권1호
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• pp.15-25
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• 2017

Swirl flow is often found in proximal coronary arteries, because the aortic valves can induce swirl flows in the coronary artery due to vortex formation. In addition, the curvature and tortuosity of arterial configurations can also produce swirl flows. The present study was performed to investigate fractional flow reserve alterations in a post-stenotic distal part due to the presence of pre-stenotic swirl flow by computational fluid dynamics analysis for virtual stenotic models by quantifying fractional flow reserve(FFR). Simplified stenotic coronary models were divided into those with and without pre-stenotic swirl flow. Various degrees of virtual stenosis were grouped into three grades: mild, moderate, and severe, with degree of stenosis of 0 ~ 40%, 50 ~ 60%, and 70 ~ 90%, respectively. In this study, three-dimensional computational hemodynamic simulations were performed under hyperemic conditions in virtual stenotic coronary models by coupling with a zero-dimensional lumped parameter model. The results showed that the influence of pre-stenotic swirl inflow is dominant on FFR alteration in mild stenosis, whereas stenosis is dominant on FFR alteration in moderate/severe stenosis. The decrease in FFR caused by swirl flow is more significant in mild stenosis than moderate/severe stenosis. Biomechanical modeling is useful for clinicians to provide insight for medical intervention strategies. This hemodynamic-based parameter study could play a critical role in the development of a non-invasive imaging-based strategy-support system for percutaneous transluminal angioplasty in cases of mild/moderate stenosis.

• Journal of Pharmaceutical Investigation
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• 제36권1호
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• pp.19-22
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• 2006

The pharmacokinetics of nimodipine, following a single 16 mg/kg oral dose, was investigated in rabbits with hepatic failure induced by 0.5 mL/kg (mild), 1.0 mL/kg (moderate) and 2.0 mL/kg (severe) of carbon tetrachloride $(CCl_{4}$ : olive oil = 20 : 80, v/v). The plasma concentrations of nimodipine were determined by a high performance liquid chromatographic assay. The levels of sGOT and sGPT in rabbits with mild $(86.2{\pm}29.0\;and\;98.5{\pm}33.1\;unit/dL)$, moderate $(168.1{\pm}61.2\;and\;196.2{\pm}66.0\;unit/dL)$ and severe $(292.7{\pm}82.2\;and\;314.2{\pm}99.8\;unit/dL)$ hepatic failure were significantly increased compared to the control $(38.0{\pm}10.1\;and\;32.4{\pm}10.2\;unit/dL)$. The area under the plasma concentration-time curve (AUC) of nimodipine was significantly increased in mild $(131.7{\pm}28.1%)$, moderate $(168.8{\pm}32.8%)$ and severe $(204.6{\pm}58.3%)$ carbon tetrachloride-induced hepatic failure rabbits compared to the control (100%) rabbits. The volume of distribution $(V_{d})$ and the total body clearance $(CL_{t})$ of nimodipine were significantly decreased in all hepatic failure groups. The elimination rate constant $(K_{el})$ of nimodipine was significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. There was a correlation between sGOT (y= 1.01x+241, r=0.993) or sGPT (y=0.92x +243, r=0.997) value and the AUC of nimodipine in the rabbits with hepatic failure. These findings suggest that the hepatic metabolism of nimodipine was inhibited by carbon tetrachloride-induced hepatic failure rabbits, resulting in the decrese in $V_{d}$ and $CL_{t}$ of nimodipine in the rabbits with mild, moderate and severe hepatic failure.

• Journal of Preventive Medicine and Public Health
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• 제41권6호
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• pp.427-433
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• 2008

Objectives: This study was performed to assess the association between physical activity and the clustering of metabolic abnormalities among Korean children. The effect of substituting moderate to vigorous physical activity for the time spent in inactivity was examined as well. Methods: The study subjects were comprised of 692 (354 boys, 338 girls) 4th grade elementary school students. We used a modified form of the physical activity questionnaire that was developed in the Five-City Project. The subjects with clustering of metabolic abnormalities were defined as having two or more of the following five characteristics: waist circumference ${\geq}90\;%$, systolic or diastolic blood pressure ${\geq}90\;%$, fasting glucose ${\geq}110\;mg/dl$, triglycerides ${\geq}110\;mg/dl$ and HDL cholesterol ${\geq}40\;mg/dl$. We calculated the odds ratios to assess the effect of substituting moderate to vigorous physical activity for time spent in inactivity. Results: The risk of clustered metabolic abnormalities was inversely correlated with the increased time spent on moderate to vigorous physical activity, but the correlation was not significant. The odds ratio for clustering of metabolic abnormalities that represented the effect of substituting moderate to vigorous physical activity for 30minutes of sedentary activity was 0.87(95% Cl=0.76-1.01). Conclusions: These findings suggest that substituting moderate to vigorous physical activity for sedentary activity could decrease the risk of clustered metabolic abnormalities.

• Radiation Oncology Journal
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• 제36권4호
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• pp.325-331
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• 2018

Purpose: Soft tissue sarcoma (STS) is a rare and heterogeneous cancer with over 50 known subtypes. It is difficult to understand the role of adjuvant treatment in STS. We aimed to determine the benefits of adjuvant treatment for a rare STS subset: non-extremity STS with moderate chemosensitivity. Materials and Methods: We reviewed medical records from Pusan National University Hospital and Kosin University Gospel Hospital, which had detailed pathological reports on patients diagnosed between 2006 and 2016. The most important inclusion criterion was resection with curative intent. We grouped STS by chemosensitivity based on reported data and analyzed non-extremity STS with moderate chemosensitivity. Results: We investigated 142 patients with 20 pathological subtypes of STS. Eighty-six patients had extremity STS and 56 had non-extremity STS. Thirty-eight of 56 patients were categorized as having moderate chemosensitivity. Seventeen of 38 patients (44.7%) received adjuvant radiotherapy and 14 (36.8%) received adjuvant chemotherapy. A log-rank test showed longer disease-free survival (DFS) in the adjuvant radiotherapy group than in the group treated without adjuvant radiotherapy (not reached vs. 1.468 years, p = 0.037). Multivariate Cox proportional hazard analysis, with covariates including age, stage, resection margin, adjuvant chemotherapy, and adjuvant radiotherapy, revealed that adjuvant radiotherapy was associated with longer DFS (odds ratio = 0.369, p = 0.045). Overall survival was not correlated with adjuvant radiotherapy. Conclusion: Adjuvant radiotherapy may be associated with longer DFS in patients with non-extremity STS with moderate chemosensitivity.

• 대한물리의학회지
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• 제17권3호
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• pp.31-40
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• 2022

PURPOSE: This study was conducted to investigate the effects of postural control training using a visual blind board, on head control, trunk control, and the sitting abilities of children with moderate-to-severe cerebral palsy. METHODS: Ten children with moderate to severe cerebral palsy participated in this study. Postural control training with a visual blind board was given for 40 minutes per session, 3 times a week for 4 weeks (12 sessions). Before and after the intervention, head control, trunk control, and sitting abilities were quantified using the head control scale, Korean version-trunk control measurement scale, and the sitting part of the Korean version-gross motor function measure-88, respectively. RESULTS: Postural control with the visual blind board significantly improved the head control ability of children with moderate to severe cerebral palsy (p = .015). Their trunk control abilities also showed significant improvement after the intervention (p = .016). However, their sitting ability did not show a significant change. CONCLUSION: These results showed that postural control training using a visual blind board is effective in improving the head and trunk control abilities of children with cerebral palsy. Further studies with suitable sample sizes and control groups are needed to reach a conclusion about the use of postural control training with visual blind boards for improvement of postural control of children with moderate to severe cerebral palsy.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2000년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall 2000
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• pp.440-447
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• 2000

In order to evaluate the cost effectiveness of seismic isolation for bridges in low and moderate seismic region, a method of calculation minimum life-cycle cost of seismic-isolated bridges under specific acceleration level and soil condition is developed. Input ground motion is modeled as spectral density function compatible with response spectrum for combination of acceleration coefficient and site coefficient. Failure probability is calculated by spectrum analysis based on random vibration theories to simplify repetitive calculations in the minimization procedure. Ductility of piers and its effects on cost effectiveness are considered by stochastic linearization method. Cost function and cost effectiveness index are defined by taking into consideration the characteristics of seismic isolated bridges. Limit states for calculation of failure probability are defined on superstructure, isolator and pier, respectively. The results of example design and analysis show that seismic isolation is more cost-effective in low and moderate seismic region than in high seismic region.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2002년도 가을 학술발표회 논문집
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• pp.135-140
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• 2002

Bridge columns in strong earthquake area are to be designed and constructed so that enough ductility should be guaranteed. Therefore, large amount of transverse reinforcement is required to confine core concrete of the bridge column by design specifications. In moderate seismicity regions, however, adopting the full ductility design concept sometimes results in construction problems due to reinforcement congestion. For the moderate seismicity regions, a design based on required ductility and required transverse reinforcement might be a reasonable approach. Ductility demand design or performance-based design might be an appropriate approach especially for regions of moderate seismic risk. The procedure and application of this design approach are presented in this paper.

• 대한세포병리학회지
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• 제17권2호
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• pp.136-142
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• 2006

Villoglandular adenocarcinoma of uterine cervix has recently been described, and is characterized by good prognosis and occurrence in young women, except a small number of cases. Morphologically, it exclusively shows villoglandular growth and mild to moderate nuclear atypia, the cytologic diagnoses have been frequently missed due to interpretation error. We report here on the cytologic findings of two cases, and both cases were not diagnosed as adenocarcinoma before punch biopsy. One of these cases showed previously described characteristic features such as high cellularity and large tissue fragments with long villous fronds lined by columnar cell with mild nuclear atypia. The other showed moderate cellularity of somewhat smaller clusters without long villous structures. The clusters showed marked nuclear overlapping and the nuclei showed distinct moderate atypia with hyperchromasia and coarse chromatin pattern. The nucleoli were indistinct. Recognition of these features will be helpful to avoid underdiagnosis as a benign lesion, although diagnosis is still difficult in a portion of the cases.

• Steel and Composite Structures
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• 제14권2호
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• pp.155-171
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• 2013

This study analytically evaluated the seismic performance of wind-designed diagrid tall steel buildings in regions of moderate/low seismicity and strong winds. To this end, diagrid tall steel buildings with varying wind exposure and slenderness ratio (building height-to-width ratio) conditions were designed to satisfy the wind serviceability criteria specified in the Korean Building Code and the National Building Code of Canada. A series of seismic analyses were then performed for earthquakes having 43- and 2475- year return periods utilizing the design guidelines of tall buildings. The analyses demonstrated the good seismic performance of these wind-designed diagrid tall steel buildings, which arises because significant overstrength of the diagrid system occurs in the wind design procedure. Also, analysis showed that the elastic seismic design process of diagrid tall steel buildings might be accepted based on some wind exposures and slenderness ratios.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
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• pp.101-104
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• 2005

This study is to develop detailing guidelines based on ductility demand for reinforced concrete bridge columns in areas of low to moderate seismicity. The current seismic design criteria of the Korea Design Specifications for Highway Bridge (KDSHB 2005) adopted the seismic design concept and requirements of the AASHTO specifications. In order to obtain full ductile behavior under seismic loads, i.e. when applied seismic force is larger than design flexural strength of column section, a response modification factor (R=3 or 5) is used. In moderate seismicity regions, however, adopting the full ductility design concept sometimes results in construction problems due to reinforcement congestion. The objective of this paper is to suggest a new simplified seismic design of reinforced concrete bridge columns for moderate seismicity regions.