• Herbal Formula Science
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• v.26 no.3
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• pp.207-221
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• 2018

Objectives : Present study investigated hepatoprotective effect of Haegan-jeon extract (HE) and tried to elucidate molecular mechanism involved. According to molecular mechanism, present study optimized herbal composition of HE (op-HE) and compared in vitro and in vivo hepatoprotective effects of op-HE to HE. Methods : For in vitro experiments, HepG2 cells were exposed to arachidonic acid (AA, $10{\mu}M$) and iron ($5{\mu}M$) for inducing oxidative stress. Cell viability, GSH contents, $H_2O_2$ production, mitochondrial membrane potential, immunoblot and reporter gene assay were performed to investigate cytoprotective effects and responsible molecular mechanisms. For in vivo experiments, hepatoprotective effect of HE and op-HE were assessed on $CCl_4-induced$ liver injury mice model. Results : HE pretreatment prevented AA+iron-mediated hepatocytes apoptosis. In addition, AA+iron-induced mitochondrial dysfunction, $H_2O_2$ production, glutathione depletion were reduced by HE pretreatment. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation, antioxidant response element (ARE)-driven reporter gene activity, and antioxidant genes expression were increased by HE. Based on reporter gene and MTT assays, we found that op-HE consisting three medicinal herbs also significantly increased transactivation of Nrf2 and reduced the AA+iron-mediated cytotoxicity. Moreover, in $CCl_4-induced$ liver injury mice model, HE-op had an ability to ameliorate $CCl_4-mediated$ increases in serum alanine transferase and aspartate aminotransferase activity, hepatic degeneration, inflammatory cell infiltration, and collagen deposition. Hepatoprotective effects of op-HE were comparable to those of HE. Conclusions : Present study suggests that op-HE as well as HE exhibit hepatoprotective effect against oxidative stress-mediated liver injury via Nrf2 activation.

• Health Policy and Management
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• v.10 no.2
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• pp.41-77
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• 2000

This study aimed at the analysis, from the perspective of rationality, of policy making process in the separation of prescribing and dispensing. This study is to identify the characteristics and problems of the policy process to introduce the new durg-prescription system, and make policy recommendations. In terms of separation of prescribing and dispensing, the development of policy making process can be divided into two periods; periods before and after the inauguration of the govemment of people. In the period before the govermment of poeple, one of the major characteristics of policy decision on the new system was the poweful influence of interset groups. At that time, the ministry lacked the problem-solving ability and commitment on the policy. Consequently, during the former period, the policy making process had been driven by interest groups. Therefore, the original purpose of the policy to secure the pulic health was lost. During the latter period, there was also the strong influence of interst groups, complexity of interest, the ministry's inability of problem solving. However, in this period, it is notable that this has drawn nation-wide attention, severl civic grouos have participated in the policy making process, and that the number and voice of these groups have remarkably increased. With regards to rationality, incrementalish model is highly sutable to explain the policy making process in the former period. But in the latter period when the new drugperscripition system became a national issue and civic groups began to participte in this matter more actively, rational model is more explanatory that incrementalism to understand the process. During the latter period, the original goal of this policy was not distored by a few interest groups thanks to the rapid development of civil movement and therebly a big influence of civic groups on the policy making. For that reson, a jigh level of rationality is found in the policy-making process of the latter period. Some suggestions to achieve the rationality in the policy making process based on the results of this study are as follows; Frist, the public's participation should be enered in the policy making process. Second, the govermment should make contiuns efforts to enhance its ability of long-term planning and policy implementation, and increase rationality of policy making process. Third, balance among interset groups should take place in the process of policy making. Forth, sound, constructive, and logical activity of interest groups is necessary to express and promote their interests.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.1 no.2
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• pp.27-65
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• 2006

This study reviews the success cases of National Research&Development Projects such as TDX and CDMA projects at the catching-up stage and FTTH technology development project at the post catching-up stage. First, we investigate why the success model of national R&D projects at the catching-up stage failed to operate properly at the post catching-up stage, and then we propose improved policies for a successful national R&D project at the post-catching up stage. From the comparison of FTTH development case at the post catching-up with TDX and CDMA cases at the catching-up stage, we observed that at the catching-up stage 1) there are high uncertainties in technology development and it is very difficult to establish technology standards, 2) it is difficult to conduct government driven R&D and to develop a market for the technology developed, 3) it is difficult to share a vision among the participants in the H&D consortium, and 4) commercialization of the technology developed from the project was carried out by SMEs and venture businesses with little marketing capabilities. Also, we discuss the national level technology development strategies and the role of the government for a successful national research and develop project at the post catching-up stage.

• Korean Journal of Agricultural and Forest Meteorology
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• v.15 no.1
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• pp.50-58
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• 2013

This study was carried out to evaluate the geospatial characteristics of blooming date migration in three major spring flowers across North and South Korea as influenced by climate change. A thermal time-based phenology model driven by daily maximum and minimum temperature was adjusted for the key parameters (i.e., reference temperature, chilling requirement, heating requirement) used for predicting blooming of forsythia, azaleas, and Japanese cherry. The model was run by the RCP 8.5 projected temperature outlook over the Korean Peninsula and produced the mean booming dates for the three climatological normal years in the future (2011-2040, 2041-2070, and 2071-2100) at a 12.5 km grid spacing. Comparison against the observed blooming date patterns in the baseline climate (1971-2000) showed that there will be a substantial acceleration in blooming dates of the three species, resulting in cherry booming in February and flowers of azaleas and forsythia found at the top of mountain Baikdu by the 2071-2100 period. Flowering dates of the three species in the near future (2011-2040) may be accelerated by 3-5 days at minimum and 10-11 days at maximum compared with that in the baseline period (1971-2000). Those values corresponding to the middle future (2041-2070) can be from a minimum of 9-11 days to a maximum of 23-24 days. Blooming date of Japanese cherry can be accelerated by 26 days on average for the far future (2071-2100). The acceleration seems more prominent at islands and coastal plain areas than over inland mountainous areas.

• Korean Journal of Agricultural and Forest Meteorology
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• v.15 no.1
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• pp.40-49
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• 2013

Current service system of the Korea Meteorological Administration (KMA) for blooming date forecasting in spring depends on regression equations derived from long term observations in both temperature and phenology at a given station. This regression based system does not allow a timely correction or update of forecasts that are highly sensitive to fluctuating weather conditions. Furthermore, the system cannot afford plant responses to climate extremes which were not observed before. Most of all, this method may not be applicable to locations other than that which the regression equations were derived from. This note suggests a way to replace the location restricted regression equations with a thermal time based phenology model to complement the KMA blooming forecast system. Necessary parameters such as reference temperature, chilling requirement and heating requirement were derived from phenology data for forsythia, azaleas and Japanese cherry at 29 KMA stations for the 1951-1980 period to optimize spring phenology prediction model for each species. Best fit models for each species were used to predict blooming dates and the results were compared with the observed dates to produce a correction grid across the whole nation. The models were driven by the KMA's daily temperature data at a 5km grid spacing and subsequently adjusted by the correction grid to produce the blooming date maps. Validation with the 1971-2012 period data showed the RMSE of 2-3 days for Japanese cherry, showing a feasibility of operational service; whereas higher RMSE values were observed with forsythia and azaleas.

• Journal of the Korean Society of Marine Environment & Safety
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• v.22 no.6
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• pp.679-687
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• 2016

In developing countries, the establishment of maritime colleges and the training of excellent merchant marine officers can greatly impact on the growth of the marine industry in a given country. The project to establish the Kenya Maritime College ('KMC') has been driven by the Kenyan government, which has been challenged by the growth of the marine industry in Korea. This study aims to the development of curriculum for the navigation science department of the KMC. To do this, firstly the Kenyan environments was surveyed. Then, IMO maritime education requirements, IMO model courses and curriculums from the navigation science departments of major maritime universities around the world were reviewed. Lastly, based on these surveys and reviews, curriculum for the navigation science department of the KMC was developed. This curriculum is comprised of an educational course that requires a total of 5 years of study, including 1 year of on-board training and a total of 200 credit hours (20 credit hours per semester). Although this curriculum has been developed to fit the environments of Kenya, it is expected to offer a point of reference for similar studies in other countries with the goal of standardizing maritime education internationally.

• Spatial Information Research
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• v.21 no.3
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• pp.45-53
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• 2013

Web GIS, based on the latest web-technology, has evolved to provide efficient and accurate spatial information to users. Furthermore, Web GIS Server has improved the performance constantly to respond user web requests and to offer spatial information service. This research aims to create a designed and implemented Web GIS Server that is named as Nodemap which uses the emergent technology, Node.js, which has been issued for an event-oriented, non-blocking I/O model framework for coding JavaScript on the server development. Basically, NodeMap is Web GIS Server that supports OGC implementation specification. It is designed to process GIS data by using DBMS, which supports spatial index and standard spatial query function. And NodeMap uses Node-Canvas module supported HTML5 canvas to render spatial information on tile map. Lastly, NodeMap uses Express module based connect module framework. NodaMap performance demonstration confirmed a possibility of applying Node.js as a (next/future) Web GIS Server development technology through the benchmarking. Having completed its quality test of NodeMap, this study has shown the compatibility and potential for Node.js as a Web GIS server development technology, and has shown the bright future of internet GIS service.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.20 no.2
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• pp.217-225
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• 2007

This paper proposes the real-time hybrid shaking table testing methods to simulate the dynamic behavior of a soil-structure interaction system with dynamic soil stiffness by using only a structure model as the physical specimen and verifies their effectiveness for experimental implementation. Experimental methodologies proposed in this paper adopt such a way that absolute accelerations measured from the superstructure and shaking table are feedback to the shaking table controller, and then the shaking table is driven by the calculated motion of the absolute acceleration (acceleration feedback method) or the absolute velocity (velocity feedback method) of foundation that is required to simulate the dynamic behavior of a whole soil-structure interaction system. The shaking table test is implemented by reflecting the dynamic soil stiffness, which are differently approximated from the theoretical one depending on the feedback methods, on the shaking table controller to calculate soil part. The effectiveness of the proposed experimental methods is verified by comparing the response measured from the test on a foundation-fixed structural model and that obtained from the experiment of a soil-interaction system under the consideration in this paper and by matching the dynamic soil stiffness reflected on the shaking table controller with that identified using the experimentally measured data.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2010.05a
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• pp.47-47
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• 2010

Over the past 20 years, constant progress in noise and vibration (NVH) engineering has enabled to constantly advance quality and comfort of operation and use of really any products - from automobiles to aircraft, to all kinds of industrial vehicles and machines - to the extend that for many products, supreme NVH performance has becomes part of its brand image in the market. At the same time, the product innovation agenda in the automotive, aircraft and really many other industries, has been extended very much in recent years by meeting ever more strict environmental regulations. Like in the automotive industry, the drive towards meeting emission and CO2 targets leads to very much accelerated adoption of new powertrain concepts (downsizing of ICE, hybrid-electrical...), and to new vehicle architectures and the application of new materials to reduce weight, which bring new challenges for not only maintaining but further improving NVH performance. This drives for innovation in NVH engineering, so as to succeed in meeting a product brand performance for NVH, while as the same time satisfying eco-constraints. Product innovation has also become increasingly dependent on the adoption of electronics and software, which drives for new solutions for NVH engineering that can be applied for NVH performance optimization of mechatronic products. Finally, relentless pressure to shorten time to market while maintaining overall product quality and reliability, mandates that the practice and solutions for NVH engineering can be optimally applied in all phases of product development. The presentation will first review the afore trends for product and process innovation, and discuss the challenges they represent for NVH engineering. Next, the presentation discusses new solutions for NVH engineering of products, so as to meet target brand values, while at the same time meeting ever more strict eco constraints, and this within a context of increasing adoption of electronics and controls to drive product innovation. NVH being very much defined by system level performance, these solutions implement the approach of "Model Based System Engineering" to increase the impact of system level analysis for NVH in all phases of product development: - At the Concept Phase, to be able to do business case analysis of new product concepts; to arrive at an optimized and robust product architecture (e.g. to hybrid powertrain lay-out, to optimize fuel economy); to enable target cascading, to subsystem and component level. - In Development Phase, to increase realism and productivity of simulation, so as to frontload virtual validation of components and subsystems and to further reduce reliance on physical testing. - During the final System Testing Phase, to enable subsystem testing by a combination of physical testing and simulation: using simulation models to simulate the final integration context when testing a subsystem, enabling to frontload subsystem testing before final system integration is possible. - To interconnect Mechanical, Electronical and Controls engineering, in all phases of development, by supporting model driven controls engineering (MIL, SIL, HIL). Finally, the presentation reviews examples of how LMS is implementing such new applications for NVH engineering with lead customers in Europe, Asia and US, with demonstrated benefits both in terms of shortening development cycles, and/or enabling a simulation based approach to reduce reliance on physical testing.

• Journal of the Korea Concrete Institute
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• v.27 no.6
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• pp.615-623
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• 2015

The previous strut-and-tie models (STMs) to evaluate the shear strength of squat shear walls with aspect ratio less than 2.0 do not consider the axial load transfer of concrete strut and individual shear transfer contribution of horizontal and vertical shear reinforcing bars in the web. To overcome the limitation of the existing models, a simple STM was established based on the crack band theory of concrete fracture mechanics. The equivalent effective width of concrete strut having a stress relief strip was determined from the neutral axis depth and effective factor of concrete strength. The shear transfer mechanism of shear reinforcement at the extended crack band zone was calculated from an internally statically indeterminate truss system. The shear transfer capacity of concrete strut and shear reinforcement was then driven using the energy equilibrium in the stress relief strip and crack band zone. The shear strength predictions of squat shear walls evaluated from the current models are in better agreement with 150 test results than those determined from STMs proposed by Siao and Hwang et al. Furthermore, the proposed STM gives consistent agreement with the observed trend of the shear strength of shear walls against different parameters.