• Spatial Information Research
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• 제17권4호
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• pp.469-481
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• 2009

늘어나는 인구로 인한 토지의 효율적 이용요구 증가, 빠르게 성장하는 건축, 토목기술의 발달로 인간의 생활 공간은 지표에서 지상, 지하로 확대되었다. 기존의 2차원 지적 시스템으로는 이러한 추세를 효과적으로 반영하지 못함을 인식하여, 3차원 지적에 대한 관심이 증가하고 있다. 이 연구에서는 소유권의 법적 안전 보장이라는 지적의 주요한 목적을 위해 한국의 현황에 적합한 3차원 지적 데이터 모델을 제시한다. 제시하는 3차원지적 데이터 모델은 3차원 지적 객체 모델과 3차원 지적 기하학적 모델로 구성되며, 데이터 구축 시 고려될 데이터 구조를 제시하였다. 3차원 지적 객체 모델은 분석된 3차원 권리와 사례 연구로부터 도출된 객체들을 기반으로 설계하였다. 3차원 지적 기하학적 모델은 국제 표준인 ISO19107 공간 스키마를 기반으로 한국의 3차원 지적에 맞게 수정되었다. 3차원 지적 데이터 구조는 점, 선, 면, 입체 요소를 기본 요소로 한다. 본 연구는 서울시의 "유비쿼터스 입체지적 기반조성" 사업의 일부분으로 수행되었으며 전체 연구의 최종 목표는 1) 토지정보의 효율적인 제공 및 관리, 2) 지상 및 지하 공간시설물에 대한 권리 설정 및 범위 표시, 3) 유비쿼터스 기반의 지적정보 서비스, 4) 도시 개발 사업 등에 대한 유비쿼터스 지적 기반의 구축, 5) 토지공간의 권리관계 규정과 이에 따른 등록 및 관리 방안 마련이다.

• The Korean Journal of Physiology and Pharmacology
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• 제27권4호
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• pp.357-364
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• 2023

Sjögren syndrome (SS) is a systemic inflammatory autoimmune disease that involves exocrine glands. Shikonin is extracted from comfrey, which is conventionally used as an anti-tumor, antibacterial, and antiviral drug in China. However, the application of Shikonin in SS remains unreported. This study aimed to verify the potential functions of Shikonin in SS progression. Firstly, non-obese diabetic mice were used as the SS mouse model, with C57BL/6 mice serving as the healthy control. It was demonstrated that the salivary gland damage and inflammation were aggravated in the SS mouse model. Shikonin improved salivary gland function decline and injury in the SS mouse model. Moreover, Shikonin reduced inflammatory cytokines and immune infiltration in the SS mouse model. Further experiments discovered that Shikonin attenuated the MAPK signaling pathway in the SS mouse model. Lastly, inhibition of the MAPK signaling pathway combined with Shikonin treatment further alleviated the symptoms of SS. In conclusion, Shikonin ameliorated salivary gland damage and inflammation in a mouse model of SS by modulating the MAPK signaling pathway. Our findings indicate that Shikonin may be a useful drug for SS treatment.

• 한국항해항만학회지
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• 제40권5호
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• pp.257-263
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• 2016

Mombasa is the principle port of Kenya, serving inland countries in Eastern and central Africa. Mombasa port has undergone a massive infrastructure upgrade and dredging works with an expectation that more vessels and large post Panamax ships will be able to enter Mombasa port. Therefore, it is vital to carry out a marine traffic risk assessment in order to quantify the degree of navigation safety needed in the Mombasa approach channel and also to evaluate the navigation risk imposed on transit traffic by local ferry traffic. In this paper, a marine traffic risk assessment is carried out using the IWRAP mk2, Environmental Stress (ES) model, and the PARK model. Risk assessment results show that Likoni area has an unacceptable stress/risk ranking at 20.7% by the ES model and 38.89% by the PARK model. The IWRAP mk2 model shows that the crossing area has the highest risk of crossing collision and the area at the entrance to the inner channel has a high risk of grounding. The conclusions derived from this study will provide the basis for proposing the most effective countermeasure to improve navigation safety in the Mombasa approach channel.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2016년도 춘계학술대회
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• pp.81-84
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• 2016

Mombasa is the principle port of Kenya, serving hinter countries in Eastern and central Africa. Mombasa port has undergone a massive infrastructure upgrade and dredging works with an expectation that more vessels and large post Panamax ships will be able to call at Mombasa port. Therefore, it is vital to carry out a marine traffic risk assessment so as to quantify the degree of navigation safety on Mombasa approach channel and also to evaluate navigation risk imposed on transit traffic by local ferry traffic. In this paper marine traffic risk assessment is carried out using IWRAP mk2, Environmental Stress model, and PARK model. Risk assessment results show that Likoni area has unacceptable stress/ risk ranking at 20.7% on ES model and 38.89% by PARK model. IWRAP mk2 model shows that crossing area has the highest risk of crossing collision and the area at the entrance to inner channel has a high risk of grounding. The conclusions derived from this study will provide the basis for proposing the most effective countermeasure so as to improve navigation safety in Mombasa approach channel.

• International Journal of Air-Conditioning and Refrigeration
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• 제11권2호
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• pp.91-103
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• 2003

The objective of this study is to analyze and evaluate the impact of the stack effect in high-rise buildings for solving the various problems resulting from it. For the evaluation of the impacts on the stack effect, computer program simulations based on the network model were performed for a typical high-rise office building. The results of the simulations show that the impact caused by the stack effect is mainly dependent on building envelope air-tightness and internal air flow resistance. Therefore the problems due to the stack effect may be solved to some extent by installing vestibules around entrance doors and doors serving elevators, and by zoning the elevators.

• 한국경영과학회지
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• 제31권3호
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• pp.81-96
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• 2006

We consider a rental company that dynamically manages Its capacity level through capacity addition and return While serving customer with its own capacity, the company expands its capacity by renting items from an outside source so that it can avoid lost opportunities of rental which occur when stock is not sufficient. If stock becomes sufficiently large enough to cope with demands, the company returns expanded capacity to the outside source. Formulating the model into a Markov decision problem, we identify an optimal capacity management Policy which states when the company should expand its capacity and when it should return expanded capacity after capacity addition. Since it is intractable to analytically find the optimal capacity management policy and the optimal size of capacity expansion, we present a numerical procedure that finds these optimal values based on the value iteration method. Numerical analysis is implemented and we observe monotonic properties of the optimal performance measures by system parameters, which are meaningful in developing effective heuristic policies.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8307-8311
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• 2016

Lung cancer is one particular type of cancer that is deadly and relatively common than any other. Treatment is with chemotherapy, radiation therapy and surgery depending on the type and stage of the disease. Focusing on drugs used for chemotherapy and their associated side effects, there is a need to design and develop new anti-lung cancer drugs with minimal side effects and improved efficacy. The pharmacophore model appears to be a very helpful tool serving in the designing and development of new lead compounds. In this paper, pharmacophore analysis of 10 novel anti-lung cancer compounds was validated for the first time. Using LigandScout the pharmacophore features were predicted and 3D pharmacophores were extracted via VMD software. A training set data was collected from literature and the proposed model was applied to the training set whereby validating and verifying similar activity as that of the most active compounds was achieved. Therefore pharmacophore develoipment could be recommended for further studies.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2001년도 춘계학술대회 논문집
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• pp.430-434
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• 2001

Virtual manufacturing system is integrated computer model that represents the precise and whole structure of manufacturing system and simulates its physical and logical behavior in operation.[1] A virtual machine is computer model that represents a CNC machine tool and one of core elements of virtual manufacturing system. In this paper, it is emphasized that a virtual machine must be web-based system for serving information to all attendants in a real machine tool without the restriction of time or location, and then in the fault diagnosis, one of important modules of a virtual machine, the methods of both using the controller signal and web-based expert system are proposed.

• 설비공학논문집
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• 제14권6호
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• pp.456-467
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• 2002

The objective of this study is to analyze and evaluate the impact of the stack effect in high-rise buildings for solving the various problems resulting from it. For the evaluation of the impact of the stack effect, computer program simulations based on the network model were performed for a typical high-rise office building. The results of the simulations show that the impact caused by the stack effect is mainly dependent on building envelope air-tightness and internal airflow resistance, so the problems due to the stack effect may be solved to some extent by installing vestibules around entrance doors and doors serving elevators, and by zoning the elevators.

• International Journal of Knowledge Content Development & Technology
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• 제12권2호
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• pp.57-75
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• 2022

Currently, it is not easy for most domestic public libraries to collect and provide reliable health information services on their own. Health information is distributed or professional, making it inconvenient for users to use. Based on the implications derived from the case study, the Library Health Information Integration Service Model was proposed as a specialized information service. The model consists of a composition shared by librarians, health and medical experts, and users, focusing on library websites that provide integrated health information integration services, and has the following features. First, it provides health and medical information on a specialized subject. Second, it provides integrated health and medical information services provided in various ways. Third, librarians and health and medical experts work together to provide information services. Fourth, users can freely use health information integration services online and offline. The model presented in this study means that libraries can play a leading role in health information integration services to increase the utilization rate of public libraries and further contribute to librarians serving as experts in health information services.