• Journal of Pharmaceutical Investigation
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• v.28 no.1
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• pp.43-50
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• 1998

Niosomes are vesicles formed from synthetic non-ionic surfactants, offering an alternative to chemically unstable and expensive liposomes as a drug carrier. Non-ionic surfactant and cholesterol mixture film leads to the formation of vesicular system by hydration with sonication method. The formation of niosome was ascertained by negative staining of TEM. The entrapment efficiency of niosomal suspension was gradually increased with increasing the ratio of cholesterol to surfactant. It was found that the niosome with 6 : 4 (polyoxyethylene 2-cetyl ether: cholesterol) ratio was more stable than those with other ratios. The topical application of acyclovir(ACV) in the treatment of herpes simplex virus type 1(HSV-1) skin disease has a long history. There are an increasing number of reports, however, in which topical ACV therapy is not as effective as oral administration. Lack of efficacy with topical ACV has been hypothesized to reflect the inadequate delivery of drug to the skin. We investigated the permeation of niosome containing $[^{3}H]ACV$ in hairless mouse skin using Franz diffusion cell model. Permeation coefficient(P) of aqueous ACV was $6.7{\times}10^{-4}\;(cm/hr)$ and that of ACV in niosome was $23.4{\times}10^{-4}\;(cm/hr)$, suggesting about 3.5 times increase in the transdermal permeation.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.5
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• pp.109-115
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• 2004

A 1-D system design program has been developed for the preliminary design of the turbopump system in liquid rocket engines, which use LOx and kerosene as propellants. Gasgenerator cycle and staged combustion cycle were considered as turbopump type liquid rocket engine systems. In the system analysis, mass flow balance, thrust, specific impulse, mixture ratios, turbopump power, and turbine expansion ratio of engine system were analyzed. Results show that most of the parameters agree well with real engine parameters except gasgenerator. Therefore, the l-D system design program developed in this study can be used to derive the preliminary design parameters of a turbopump with any thrust level liquid rocket engine.

• Journal of Korean Society of Rural Planning
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• v.11 no.3 s.28
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• pp.53-57
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• 2005

Up to recently building are constructed focusing on the convenience of residential condition. However, environmental-friendly materials is required for construction as people are spending more time inside buildings and causes of many problems like sick-building syndrome are known due to the noxious gases and polluted air originated from construction materials. Although loess(hwangtoh) is an environmental-friendly material, it has limitations in compressive strength far a construction material. The purpose of this study is to suggest the optimal ratio of loess(hwangtoh) mortar by tests of compressive strength comparing with standard strength of floor finishing mortar and evaluate the usability of loess(hwangtoh) mortar for floor finishing material through an impact test, a cracking test and a abrasion test. Based on the results of this study, 86% of loess(hwangtoh) and 14% of inorganic binder is suggested for the optimal mixture ratio of loess(hwangtoh) mortar. Moreover, the characteristics of loess(hwangtoh) is suitable for floor finishing material in impact, crack, abrasion.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.2
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• pp.224-230
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• 2000

In order to study the quality of uncooked-colored wine by using polished black rice(PBR) and glucoamylase, the mixture ration of PBR ws investigated. The growths of yeast and lactic acid bacteria, pH and alcohol concentration of the colored wine prepared by adding PBR in the range of 20 to 100% were higher than those of polished rice only, whereas the contents of residual sugars, total free amino acids and fusel oil of the colored wine were lower. The colored wine prepared by 20% PBR and that of over 80% PBR showed a light red color and a dark red, respectively. The optimal addition ratios of PBR evaluated by palatability of color and flavor, and sensory overall quality was 40 to 60%.

• Journal of Radiation Industry
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• v.4 no.3
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• pp.271-276
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• 2010

Epoxy resin has wide application in various industrial fields because of their good mechanical strength, superiority adhesion and low shrinkage etc. And the typical curing method for epoxy resins is thermal and press compaction. However, a curing method was used electron beam process in this study. Epoxy acrylate was fabricated from mixture of epoxy, acrylic acid, tetraphenylporphyrin (TPP) and hydroquinone monomethyl ether (MEHQ) with mole ratios. Then electron beam irradiation effect on the curing of the epoxy acrylate resin was investigated various absorption dose in nitrogen atmospheres at room temperature. The dynamic mechanical and thermal properties of the irradiated epoxy acrylate resins were characterized using dynamic mechanical analysis (DMA) and thermogravimetric analyzer (TGA). And the tensile and flexural strength were measured by an universal tensile machine (UTM).

• Korean Journal of Materials Research
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• v.29 no.10
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• pp.603-608
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• 2019

Plastic waste is becoming a problem in various countries because of the difficulty of natural decomposition. One type is PET plastic(Polyethylene Terephthalate), which is often used as a bottle for soft drink packaging, and LDPE(Low Density Polyethylene), which is also widely used as a food or beverage packaging material. The use of these two types of plastic continuously, without good recycling, will have a negative impact on the environment. Building material waste is also becoming a serious environmental problem. This study aims to provide a solution to the problem of the above plastic waste and building material waste by making them into a mixture to be used as bricks. Research is carried out by mixing both materials, namely plastic heated at a temperature of $180-220^{\circ}C$ and building material waste that had been crushed and sized to 30-40 mesh with homogeneous stirring. The ratios of PET and LDPE plastic to building material waste are 9 : 1, 8 : 2, 7 : 3, 6 : 4 and 5 : 5. After heating and printing, density, water absorption and compressive strength tests are carried out. Addition of PET and LDPE plastic can increase compressive strength, and reduce water absorption, porosity and density. A maximum compressive strength of 10.5 MPa is obtained at the ratio of 6 : 4.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2012.05a
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• pp.35-41
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• 2012

Performance of a liquid rocket thrust chamber with regenerative cooling scheme has been numerically analyzed using in-house CFD code which can predict combustion/cooling performance and provide nozzle design parameters. This paper investigates trade-offs between combustion and cooling performance with varying amount of fuel directly injected into the chamber wall to form cooling films. Also is analyzed the effect of varying mixture ratios for the peripheral injectors on combustion performance enhancement. Further efforts to verify/improve the simulation methodology including comparison with the firing test results are planned to make it a reliable tool to optimize the film cooling and other major design parameters.

• Advances in Energy Research
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• v.4 no.3
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• pp.213-221
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• 2016

The main purpose of this work is to test the validation of use of a four step reaction mechanism to simulate the laminar speed of hydrogen enriched methane flame. The laminar velocities of hydrogen-methane-air mixtures are very important in designing and predicting the progress of combustion and performance of combustion systems where hydrogen is used as fuel. In this work, laminar flame velocities of different composition of hydrogen-methane-air mixtures (from 0% to 40% hydrogen) have been calculated for variable equivalence ratios (from 0.5 to 1.5) using the flame propagation module (FSC) of the chemical kinetics software Chemkin 4.02. Our results were tested against an extended database of laminar flame speed measurements from the literature and good agreements were obtained especially for fuel lean and stoichiometric mixtures for the whole range of hydrogen blends. However, in the case of fuel rich mixtures, a slight overprediction (about 10%) is observed. Note that this overprediction decreases significantly with increasing hydrogen content. This research demonstrates that reduced chemical kinetics mechanisms can well reproduce the laminar burning velocity of methane-hydrogen-air mixtures at lean and stoichiometric mixture flame for hydrogen content in the fuel up to 40%. The use of such reduced mechanisms in complex combustion device can reduce the available computational resources and cost because the number of species is reduced.

• Biomaterials and Biomechanics in Bioengineering
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• v.2 no.2
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• pp.85-96
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• 2015

This study developed biodegradable bi-layered drug-eluting beads and investigated the in-vitro release of fluorouracil and cisplatin from the beads. To manufacture the drug-eluting beads, poly[(d,l)-lactide-co-glycolide] (PLGA) with lactide:glycolide ratios of 50:50 and 75:25 were mixed with fluorouracil or cisplatin. The mixture was compressed and sintered at $55^{\circ}C$ to form bi-layered beads. An elution method was employed to characterize the release characteristic of the pharmaceuticals over a 30-day period at $37^{\circ}C$. The influence of polymer type (i.e., 50:50 or 75:25 PLGA) and layer layout on the release characteristics was investigated. The experiment suggested that biodegradable beads released high concentrations of fluorouracil and cisplatin for more than 30 days. The 75:25 PLGA released the pharmaceuticals at a slower rate than the 50:50 PLGA. In addition, the bi-layered structure reduced the release rate of drugs from the core layer of the beads. By adopting the compression sintering technique, we will be able to manufacture biodegradable beads for long-term drug delivery of various anti-cancer pharmaceuticals.

• Steel and Composite Structures
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• v.13 no.6
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• pp.521-537
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• 2012

In this study, an experimental study is performed to understand the effect of spalling on the structural behavior of fire damaged steel reinforced high strength concrete (SRHSC) columns, and the test results of temperature distributions and the displacements at elevated temperature are analyzed. Toward this goal, three long columns are tested to investigate the effect of various test parameters on structural behavior during the fire, and twelve short columns are tested to investigate residual strength and stiffness after the fire. The test parameters are mixture ratios of polypropylene fiber (0 and 0.1 vol.%), magnitudes of applied loads (concentric loads and eccentric loads), and the time period of exposure to fire (0, 30, 60 and 90 minutes). The experimental results show that there is significant effect of loading on the structural behaviors of columns under fire. The loaded concrete columns result more explosive spalling than the unloaded columns under fire. In particular, eccentrically loaded columns are severely spalled. The temperature distributions of the concrete are not affected by the loading state if there is no spalling. However, the loading state affects the temperature distributions when there is spalling occurred. In addition, it is found that polypropylene fiber prevents spalling of both loaded and unloaded columns under fire. From these experimental findings, an equation of predicting residual load capacity of the fire damaged column is proposed.