• 환경영향평가
• /
• 제9권3호
• /
• pp.203-214
• /
• 2000

Health risk assessment is applied to streamlining LCA(Life Cycle Assessment) using Monte carlo simulation for probabilistic/stochastic exposure and risk distribution analysis caused by data variability and uncertainty. A case study was carried out to find benefits of this application. BTC(Benzene, Trichloroethylene, Carbon tetrachloride mixture alias) personal exposure cases were assumed as production worker(in workplace), manager(in office) and business man(outdoor). These cases were different from occupational retention time and exposure concentration for BTC consumption pattern. The result of cancer risk in these 3 scenario cases were estimated as $1.72E-4{\pm}1.2E+0$(production worker; case A), $9.62E-5{\pm}1.44E-5$(manger; case B), $6.90E-5{\pm}1.16E+0$(business man; case C), respectively. Portions of over acceptable risk 1.00E-4(assumed standard) were 99.85%, 38.89% and 0.61%, respectively. Estimated BTC risk was log-normal pattern, but some of distributions did not have any formal patterns. Except first impact factor(BTC emission quantity), sensitivity analysis showed that main effective factor was retention time in their occupational exposure sites. This case study is a good example to cover that LCA with probabilistic risk analysis tool can supply various significant information such as statistical distribution including personal/environmental exposure level, daily time activity pattern and individual susceptibility. Further research is needed for investigating real data of these input variables and personal exposure concentration and application of this study methodology.

• 콘크리트학회지
• /
• 제9권2호
• /
• pp.121-132
• /
• 1997

콘크리트의 열해석은 콘크리트 초기온도, 환경조건 및 시멘트의 수화 등에 의해 특징지워진다. 이러한 상호관계를 모두 고려한 프로그램을 만들어서, 콘크리트재료의 열특성과 환경조건을 감안한 콘크리트 구조물의 온도해석을 하였다. 시멘트 수화의 특성으로는 활성화에너지, 단위열량, 수화열이 있으며 이러한 인자들에 의해 콘크리트의 내부열 발생이 영향을 받는다. 본 연구에서는 활성화에너지와 수화열을 상대강도-등가재령모델에 의해 구했으며, 단위열량은 등온열량측정법에 의해 실험적으로 구하였다. 또한 콘크리트 구조물의 온도분포를 실험적으로 구하여 수치해석모델과 비교하였다. 먼저 위에서 제시된 모든 조건들에 대한 parametric 해석을 실시하여 프로그램의 신뢰성을 확보하였다. 그리고 원주형시편을 만들어서 온도분포 및 변화를 측정하여 수치해석에 의해 예측된 온도분포와 비교하였다.

• Journal of the Korean Data and Information Science Society
• /
• 제27권5호
• /
• pp.1155-1168
• /
• 2016

기상 자료의 경우 한 지역의 기후가 인접지역의 기후와 비슷한 양상을 띄고 각 지역의 확률 밀도 함수 (probability density function)가 잘 알려진 확률 모형을 따르지 않는다는 것이 알려져 있다. 본 논문에서는 이러한 특성을 고려하여 이상 기후 현상이 뚜렷히 나타나는 여름철 평균 극한 기온(extreme temperature)의 확률 밀도 함수를 추정하고자 한다. 이를 위하여 공간적 상관관계 (spatial correlation)를 고려하는 비모수 베이지안 (nonparametric Bayesian) 모형인 조건부 자기회귀 종추출 혼합모형 (mixtures of conditional autoregression species sampling model)을 이용하였다. 자료는 이스트앵글리아 대학교 (University of East Anglia)에서 제공하는 전 지구의 최대 기온과 최소 기온자료 중 우리나라에 해당하는 지역의 자료를 사용하였다.

• 한국추진공학회지
• /
• 제2권3호
• /
• pp.54-61
• /
• 1998

재생냉각방식을 사용하는 액체추진제 로켓엔진의 열 전달과정이 전산모사 되었다. 연소가스로부터 연소실 벽으로 전달되는 열 전달과정은 가스측 열 전달이라 한다. 이 열은 그을음과 연소실 금속벽을 통해 반경방향으로 전도되어 냉각제로 전달된다. 최종적으로, 이 열은 연소실 벽에 있는 통로를 따라 흐르는 냉각제에 대류전달된다. 본 연구에서는 위의 3가지 열전달량이 같은 크기임에 착안하여 냉각제측 벽 온도, 가스측 벽 온도, 열전달량을 결정한다. 냉각제 유동통로갯수 및 형상(높이, 폭), 연소실 및 노즐 외부형상(크기), 산화제 및 연료 물성치, 냉각제 물성치, 산화제/연료 혼합비, 냉각제 주입온도, 연소실 및 노즐 벽면 상에 연소시 생기는 그을음 두께가 주어지면 연소실 축방향에 따른 반경방향 온도분포 및 열 전달 량의 합리적인 수치 결과가 얻어진다.

• 한국추진공학회지
• /
• 제7권2호
• /
• pp.1-6
• /
• 2003

액체 산소와 탄화수소계 연료를 사용하는 로켓에서 삼중 충돌형(FOF, OFO) 인젝터가 흔히 사용된다. 일반적으로 FOF 형태가 OFO에 비해 낮은 성능을 보인다는 것이 알려져 있지만, 벽면 열전달에 있어서 보다 효율적인 방식이다. 한편, 산화제와 연료 분사구 직경 차가 큰 FOF 형태에서 산화제 분사구가 분리된 분리 삼중 충돌형 FOOF 인젝터(이하 FOOF 인젝터)가 제안된 바 있다. 본 연구에서는 비반응 분무 실험을 통해 FOOF 인젝터의 분무 특성을 FOF와 비교하였다. PLLIF 기법을 이용하여 산화제와 연료의 질량 분포를 측정하였고, 순간사진을 이용하여 액적의 크기를 측정하였다. 실험결과를 통해 FOOF 형태의 인젝터가 FOF에 비해 보다 안정적인 혼합 효율을 나타내며 액적 크기는 두 형태의 인젝터가 큰 차이 없이 비슷한 경향을 보임을 알 수 있었다.

• 한국환경생태학회지
• /
• 제29권2호
• /
• pp.145-161
• /
• 2015

This research was conducted in order to understand the hybridization between Quercus aliena Blume and Q. serrata Murray in Korea which show wide range of morphological variations within species and interspecific variations of diverse overlapping characteristics caused by hybridization. Morphological analysis (principal components analysis; PCA) of 116 individuals representing two species and their intermediates were performed. As a result, two species were clearly distinguished in terms of morphology, and intermediate morpho-types assumed to be hybrids between the two species were mostly located in the middle of each parent species in the plot of the principal components analysis. There was a clear distinction between two species in trichome distribution pattern which is an important diagnostic character in taxonomy of genus Quercus, whereas intermediate morpho-types showed intermediate state between two species' trichome distributions. Forty-two individuals representing two species and their intermediates were examined for leaf flavonoid constituents. Twenty-three flavonoid compounds were isolated and identified: They were glycosylated derivatives of flavonols, kaempferol, quercetin, isorhamnetin and myricetin. The flavonoid constituents of Q. aliena were five glycosylated derivatives: kaempferol 3-O-galactoside, kaempferol 3-O-glucoside, quercetin 3-O-galactoside, quercetin 3-O-glucoside, and Isorhamnetin 3-O-glucoside. The flavonoid constituents of Q. serrata had 20 diverse flavonol compounds including five flavonoid compounds found in Q. aliena. It was found that there is a clear difference in flavonoid constituents of Q. aliena and Q. serrata. Flavonoid chemistry is very useful in recognizing each species and putative hybrids. The flavonoid constituents of intermediates were a mixture of the two species' constituents and they generally showed similar characteristics to morpho-types. The hybrids between Q. aliena and Q. serrata showed morphologically and chemically diverse characteristics and it is assumed that there are frequent interspecific hybridization and introgression.

• Journal of Pharmaceutical Investigation
• /
• 제37권6호
• /
• pp.339-347
• /
• 2007

SMEDDS is mixture of oils, surfactants, and cosurfactants, which are emulsified in aqueous media under conditions of gentle agitation and digestive motility that would be encountered in the gastro-intestinal(GI) tract. The main purpose of this work is to prepare self-microemulsifying drug delivery system(SMEDDS) for oral bioavailability enhancement of a poorly water soluble drug, atorvastatin calcium. Solubility of atorvastatin calcium was determined in various vehicles. Pseudo-ternary phase diagrams were constructed to identity the efficient self-emulsification region and particle size distributions of the resultant micro emulsions were determined using a laser diffraction sizer. Optimized formulations for in vitro dissolution and bioavailability assessment were $Capryol^{(R)}$ 90(50%), Tetraglycol(16%), and $Cremophor^{(R)}$ EL(32%). The release rate of atorvastatin from SMEDDS was significantly higher than the conventional tablet ($Lipitor^{(R)}$), 2-fold. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds, such as atorvastatin calcium by the oral route.

• 공업화학
• /
• 제9권5호
• /
• pp.615-618
• /
• 1998

수성 교질법에 의한 제올라이트 합성 과정에서 활성탄을 부가함으로써 제올라이트 결정화 과정에 미치는 영향과 활성탄 기공 내에서의 제올라이트 결정의 담지현상을 조사하였다. A형 제올라이트를 합성하기 위한 몰 조성비로 조절된 알루미노 실리케이트 겔상에 5 wt % 정도의 활성탄을 첨가할 경우에는 그대로 A형 제올라이트가 생성되었으나 15 wt % 정도 첨가할 경우에는 대부분이 X형이고 일부 A형과 P형 제올라이트가 혼재된 상태로 결정화가 일어났으며, 20 wt %이상 첨가할 경우에는 순수한 X형 제올라이트가 생성되었다. 활성탄의 기공 입구와 내부에는 $1{\mu}m$ 이하의 미세한 제올라이트 결정들이 서로 엉겨붙어 있는 형태로 관찰되었으며, 기공분포 및 입도분포 결과로부터 단순히 제올라이트와 활성탄의 혼합물 형태가 아니라 활성탄 기공 내에 미세한 제올라이트 결정들이 담지되어 있는 복합 소재임을 확인하였다.

• Journal of Ginseng Research
• /
• 제46권1호
• /
• pp.115-125
• /
• 2022

Background: Ginsenosides (GS) have potential value as cosmetic additives for prevention of skin photoaging. However, their protective mechanisms against skin barrier damage and their active monomeric constituents are unknown. Methods: GS monomer types and their relative proportions were identified. A UVB-irradiated BALB/c hairless mouse model was used to assess protective effects of GS components on skin epidermal thickness and transepidermal water loss (TEWL). Skin barrier function, reflected by filaggrin (FLG), involucrin (IVL), claudin-1 (Cldn-1), and aquaporin 3 (AQP3) levels and MAPK phosphorylation patterns, were analyzed in UVB-irradiated hairless mice or HaCaT cells. Results: Total GS monomeric content detected by UPLC was 85.45% and was largely attributed to 17 main monomers that included Re (16.73%), Rd (13.36%), and Rg1 (13.38%). In hairless mice, GS ameliorated UVB-induced epidermal barrier dysfunction manifesting as increased epidermal thickness, increased TEWL, and decreased stratum corneum water content without weight change. Furthermore, GS treatment of UVB-irradiated mice restored protein expression levels and epidermal tissue distributions of FLG, IVL, Cldn-1, and AQP3, with consistent mRNA and protein expression results obtained in UVB-irradiated HaCaT cells (except for unchanging Cldn-1 expression). Mechanistically, GS inhibited JNK, p38, and ERK phosphorylation in UVB-irradiated HaCaT cells, with a mixture of Rg2, Rg3, Rk3, F2, Rd, and Rb3 providing the same protective MAPK pathway inhibition-associated upregulation of IVL and AQP3 expression as provided by intact GS treatment. Conclusion: GS protection against UVB-irradiated skin barrier damage depends on activities of six ginsenoside monomeric constituents that inhibit the MAPK signaling pathway.

• Steel and Composite Structures
• /
• 제44권4호
• /
• pp.451-471
• /
• 2022

In the present paper, the static bending and buckling responses of functionally graded carbon nanotubes-reinforced composite (FG-CNTRC) beam under various boundary conditions are investigated within the framework of higher shear deformation theory. The significant feature of the proposed theory is that it provides an accurate parabolic distribution of transverse shear stress through the thickness satisfying the traction-free boundary conditions needless of any shear correction factor. Uniform (UD) and four graded distributions of CNTs which are FG-O, FG-X, FG- and FG-V are selected here for the analysis. The effective material properties of FG-CNTRC beams are estimated according to the rule of mixture. To model the FG-CNTRC beam realistically, an efficient Hermite-Lagrangian finite element formulation is successfully developed. The accuracy and efficiency of the present model are demonstrated by comparison with published benchmark results. Moreover, comprehensive numerical results are presented and discussed in detail to investigate the effects of CNTs volume fraction, distribution patterns of CNTs, boundary conditions, and length-to-thickness ratio on the bending and buckling responses of FG-CNTRC beam. Several new referential results are also reported for the first time which will serve as a benchmark for future studies in a similar direction. It is concluded that the FG-X-CNTRC beam is the strongest beam that carries the lowest central deflection and is followed by the UD, V, Λ, and FG-O-CNTRC beam. Besides, the critical buckling load belonging to the FG-X-CNTRC beam is the highest, followed by UD and FG-O.