• Title/Summary/Keyword: Mixed-effect model

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Association of Leptin Polymorphism with Production, Reproduction and Plasma Glucose Level in Iranian Holstein Cows

  • Moussavi, A. Heravi;Ahouei, M.;Nassiry, M.R.;Javadmanesh, A.
    • Asian-Australasian Journal of Animal Sciences
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    • v.19 no.5
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    • pp.627-631
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    • 2006
  • The objective of this study was to evaluate the association of genetic differences in the bovine leptin gene and milk yield, reproduction, body condition score (BCS), and plasma glucose level in Iranian Holstein cows. In total, two hundred and thirty eight cows were used and genotyped for a restricted fragment length polymorphism at the leptin gene locus. Two genotypes, AA and AB, have been distinguished which have the frequencies of 0.89 and 0.11, respectively. The genotypes were distributed according to the Hardy - Weinberg equilibrium ($x^2$ = 0.733). During the first 12 wk of lactation, milk yield and composition, live weight, BCS and plasma glucose were measured in 50 cows. Data were analyzed based on a repeated measures ANOVA. During this period, milk yield and composition, live weight, BCS and plasma glucose level were similar among the genotypes. The first cumulative 60-d milk yield, 305-d milk yield, days to first breeding, days open and days from first breeding to conception using previous lactation records were also analyzed using Standard Least Square within mixed models. Fixed effects were year, season, parity and age at calving, and sire. For the reproductive traits the cumulative first 60-d milk yield was also added to the model. Animal was fitted as a random effect. A significant association was detected between the RFLP-AB genotype and 305-d milk yield (p<0.05). The first 60-d cumulative milk yield was similar for the two genotypes (p = 0.21) and tended to be higher in the heterozygous cows. The heterozygous genotypes at the above mentioned locus had a trend to better reproductive performance than the homozygous. The results demonstrate that the RFLP B-allele can yield a higher 305-d milk production with a trend to better reproductive performance.

A Strategy of Technology Transfer Based on M&A in Small & Venture Business (중소·벤처기업의 M&A를 이용한 기술이전 전략)

  • Song, Myung Kyu;Jeong, Hyesoon;Lim, Dae-Hyeon
    • Knowledge Management Research
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    • v.5 no.1
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    • pp.39-56
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    • 2004
  • Mergers and Acquisitions(M&A) have long played an important role in the growth of firm. M&A has been considered a effective strategy for Korean government to restructure industry. Previous studies provided mixed results on the synergy effect of M&A This study provides investigation on 39 mergers occurred over the sample period from 2000 to 2001. In this study, event study methodology arc used to calculate abnormal return(AR) and cumulative abnormal return(CAR) based on mean-adjusted model. The testing period of this study from date -30 through date +30, where date zero is the date of the first public announcement of the merger. The empirical results in this study can be summarized as follows. First, the return rates of KOSDAQ registered firms with M&A appears higher than that of KSE listed firms. This means that public announcement of M&A is more influential on stock price for KOSDAQ registered firms than KSE listed firms. Second, The difference between actual merging price and fair value is significant in KSE listed firms and KOSDAQ registered firms. This means that the investors take M&A of KOSDAQ registered firms as a good news. Third, the impact on the market prices of merging firms take place after the first public announcement of the merger in KSE registered firms. But the impact on the market prices take place not only merging firms but also merged firms in KOSDAQ registered firms. This result shows that the investors recognize a M&A is a strategy of technology transfer in small & venture business.

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Analysis of Facilitated Olefin Transport Through Polymer Electrolyte Membranes Containing Silver Salts (은염을 포함하는 고분자 전해질 막을 통한 올레핀 촉진수송의 해석)

  • Yong Soo Kang;Dongkyun Ko;Jong Hak Kim;Sung Taik Chung
    • Membrane Journal
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    • v.13 no.4
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    • pp.239-245
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    • 2003
  • The origin of large difference of selectivity of $C_3H_6$ over $C_3H_8$ between pure gas and mixed gas through silver polymer electrolyte membranes is investigated. Firstly, the effect of feed condition on the permeance of mixture gas ($C_3H_6/C_3H^8$) and the separation performance is examined. Upon decrease of the $C_3\;H_6$ concentration, the $C_3H_6$ permeance decreased whereas the permeance of $C_3H_8$ increased, resulting in the decrease of the selectivity of $C_3H_6/C_3H_8/.$ This result is ascribed to the $C_3H_6$-induced plasticization of membranes. Experimental results were validated by means of mathematical modeling, where pressure independent permeabilities were used.

Lactic Acid Fermentation of Chinese Yam (Dioscorea batatas Decne) Flour and Its Pharmacological Effect on Gastrointestinal Function in Rat Model

  • Shin, Kyung-Ok;Jeon, Jeong-Ryae;Lee, Ji-Seon;Kim, Jong-Yeon;Lee, Chu-Hee;Kim, Soon-Dong;Yu, Yeon-Su;Nam, Doo-Hyun
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.11 no.3
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    • pp.240-244
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    • 2006
  • To develop a health-aid preparation of Chinese yam (Dioscorea batatas Decne), lactic acid fermentation was attempted using a mixed starter comprising of Lactobacillus acidophilus, Streptococcus thermophilus, and Bifidobacterium bifidus. The anaerobic fermentation of a 5% Chinese yam flour suspension gave a uniform suspension of pH 4.35, containing $7.76{\times}10^6 CFU/mL$ lactic acid bacteria (LAB), and which was found to be acceptable to the panel from a sensory assessment. During the administration of the lactic acid fermented (LAF) Chinese yam to Sprague Dawley rats for 6 weeks, a smaller body weight gain, but greater excretion of feces were observed, implying the creation of a healthy gastrointestine on the administration of LAF Chinese yam, which was also confirmed by the gastrointestinal motility of the feed in rats fed on LAF Chinese yam. The constipation induced by loperamide was further suppressed in a rat group fed on a LAF Chinese yam diet, which was qualified from healthy gastrointestinal flora established by LAB. A serochemical analysis revealed a slight improvement in the blood glucose, neutral lipid and total cholesterol concentrations on administration of LAF Chinese yam, suggesting LAF Chinese yam could be served as a healthy-aid preparation, even for hyperglycemia or hyperlipidemia patients.

Growth and Photocurrent Properties for $CuAlSe_2$ Single Crystal Thin film ($CuAlSe_2$ 단결정 박막의 성장과 광전류 특성)

  • Hong, Kwang-Joon;Baek, Seong-Nam
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2004.11a
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    • pp.226-229
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    • 2004
  • A stoichiometric mixture of evaporating materials for $CuAlSe_2$ single crystal thin films was prepared from horizontal electric furnace. To obtain the single crystal thin films, $CuAlSe_2$ mixed crystal was deposited on thoroughly etched semi-insulating GaAs(100) substrate by the hot wall epitaxy (HWE) system. The source and substrate temperatures were $680^{\circ}C$ and $410^{\circ}C$, respectively. The crystalline structure of the single crystal thin films was investigated by the photoluminescence and double crystal X-ray diffraction (DCXD). The carrier density and mobility of $CuAlSe_2$ single crystal thin films measured with Hall effect by van der Pauw method are $9.24{\times}10^{16}\;cm^{-3}$ and $295\;cm^2/V{\cdot}s$ at 293 K, respectively. The temperature dependence of the energy band gap of the $CuAlSe_2$ obtained from the absorption spectra was well described by the Varshni's relation, $E_g(T)\;=\;2.8382\;eV\;-\;(8.68{\times}10^{-4}\;eV/K)T^2/(T+155K)$. The crystal field and the spin-orbit splitting energies for the valence band of the $CuAlSe_2$ have been estimated to be 0.2026 eV and 0.2165 eV at 10K, respectively, by means of the photocurrent spectra and the Hopfield quasicubic model. These results indicate that the splitting of the ${\Delta}so$ definitely exists in the ${\Gamma}_5$ states of the valence band of the $CuAlSe_2$. The three photocurrent peaks observed at 10K are ascribed to the $A_1-$, $B_1-$, and $C_1$-exciton peaks for n = 1.

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Effects of Calorie Restriction on Microsomal Mixed Function Oxidase System and Free Radical in Kidney of SAMP8 Mice

  • kim, Hyun-Jeong;Choi, Jin-Ho;Rhee, Soon-Jae
    • Nutritional Sciences
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    • v.7 no.4
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    • pp.189-195
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    • 2004
  • 1bis study investigated the antioxidative effect in kidney of senescence-accelerated prone SAMP8 mice with calorie restriction. 4-weeks-old SAMP8 female mice were divided into 4 groups according to the experimental feeding period: for 4, 8, 12 month, and at natural death. Each group was subdivided into 2 groups, with thirteen mice each one, as ad libitum group and as dietary restriction group (60% of ad libitum feeding amount). After feeding for a given period, the mice were sacrificed to get the following results: among the experimental groups, there wereno significant differences in xanthine oxidase (XOD) activity in their kidney tissues. The contents of cytochrome $P_{450}$ decreased in ad libitum group and dietary restriction group by age. The activity of NADPH-cytochrome $P_{450}$ reductase showed a trend similar to cytochrome $P_{450}$. Superoxide radical content increased with age. At the 4th, 8th and 12 months of the experimental period, the activity in the dietary restriction group was less than that of ad libitum group by as much as 17% 14% and 14% respectively. For hydrogen peroxide, the contents were increased in the ad libitum group with age, while no correlation between content and age was observed in the dietary restriction group. In the 8th and 12th months of the experimental period, the were in the dietary restriction group less than that of ad libitum group counterpart as much as 17% and 20o/c, respectively. For the cellular membrane stability of the kidney, no significant correlation with age was observed in either the dietary restriction group or the ad libitum group. However at the 12th month of the experiment, however, the stability in the dietary restriction group was 11 % higher than that in the ad libitum group. In conclusion, with these results obtained from the SAMP8 mouse model, we demonstrate that dietary restriction has the effects of anti-oxidation and anti-senescence in the kidney.

The Effects of Price-Framing and Message-Framing Strategies on Consumer Attitudes: Focusing on Online Travel Products (가격 프레이밍과 메시지 프레이밍 전략이 소비자 태도에 미치는 영향: 온라인 여행상품을 중심으로)

  • Kim, Mi-Kyung;Chung, Nuree;Yang, Sung-Byung
    • The Journal of Information Systems
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    • v.26 no.3
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    • pp.119-147
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    • 2017
  • Purpose In an online e-commerce environment without face-to-face contact between the seller and the buyer, the attitudes of consumers differ greatly depending on which framing strategy is applied, even in cases when the benefits of the deals represent the same value. The purpose of this study is to explore the effects of price-framing and message-framing strategies on consumer attitudes through an experimental analysis in the context of online travel product purchasing. This study suggests a research model based on prospect theory and prior literature on price-framing and message-framing strategies. Design/methodology/approach The experiment was structured as a 2 (discount price presentation: 'Won' vs. '%') ${\times}$ 2 (discount level: low vs. high) ${\times}$ 2 (time-limit message: none vs. one) mixed design. The research hypotheses were tested in a study of 200 undergraduate and graduate students assigned randomly and distributed evenly to each of the eight cells. Findings The findings indicate that consumer attitudes become more favorable when the '%' discount, higher discount rate, and time-limit message are presented. However, no significant interaction effect is found between the discount price presentation and the discount level/time-limit message. This study has a theoretical implication in that it extends the scope of research by examining the influence of framing strategies on experience goods such as online travel products. Moreover, this study can provide managers with more specific guidelines when establishing framing strategies in the context of purchasing online travel products.

Optimization of Energy Distribution in District Heating Systems (지역 냉난방 시스템의 에너지 분배 최적화)

  • Park, Tae Chang;Kim, Ui Sik;Kim, Lae-Hyun;Kim, Weon Ho;Kim, Seong Jin;Yeo, Yeong Koo
    • Korean Chemical Engineering Research
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    • v.47 no.1
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    • pp.119-126
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    • 2009
  • A district energy system plays very important role to fulfill energy demand in regional areas. This paper diagnoses the necessity of the development of an economical operation system for the efficient operation of district energy plants located in Seoul. The effect anticipated from the use of the optimal operation system is also analyzed. Production and consumption of energy are estimated for the district energy plants at Suseo, Bundang, Ilwon and Jungang located near in Seoul, Korea. The problem is formulated as a mixed integer linear programming(MILP) problem where the objective is to minimize the overall cost of the district energy system. From the results of numerical simulations we can see that the energy efficiency is improved due to the application of the optimal operation conditions provided by the proposed model.

The Wage Distribution Structure of Korean Manufacturing Industry (한국 제조업의 임금분포구조)

  • Chung, Kang-Soo;Kim, Bum-Sik;Lee, Cheol-Won
    • Journal of Labour Economics
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    • v.29 no.2
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    • pp.67-116
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    • 2006
  • This study directly analyzes the wage distributions rather than indirectly looking at a few of their moments. It also investigates wage distributions using various descriptive and semi-parametric methods. The wage distributions of Korean manufacturing industries can in general be represented by three distinct forms, underdeveloped, advanced and the medium of the two. The discrepancies in these distribution forms are explained by differences in the labor-type distributions and their weights in the composition of wage distribution forms, and further clarified through various descriptive statistics based on them. However, the descriptive statistical analysis has a limit in that it shows mixed outcomes of different categoric variables. Then, this problem is resolved by applying a semi-parametric estimation of hazard function and the marginal effect evaluations of variable changes on estimated distributions not on the function. As a result of this marginal analysis, the common features and differences of categoric variables and their intensities of effects on distributions are revealed.

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Measurement of mass Transfer Coefficients for Adsorptive Bulk Gas Separation with Velocity Variations (기체속도가 변하는 벌크기체의 흡착공정에서 물질전달계수의 측정)

  • Min, Jun-Ho;Choi, Min-Ho;Suh, Sung-Sup
    • Applied Chemistry for Engineering
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    • v.10 no.2
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    • pp.310-318
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    • 1999
  • The concentration breakthrough curves were examined to predict mass transfer coefficients of nitrogen and oxygen in adsorption column for design data of PSA process. Experimental breakthrough curves for bulk gas flow were compared with theoretical simulation results. For quantitative analysis of the adsorption, coupled Langmuir isotherm was considered and LDF model was used to describe the mass transfer effect. In the experimental and theoretical results, it was found that mass transfer coefficient was not affected by flow rate but strongly affected by pressure. As a result of this tendency, mass transfer resistance in this system was proved to belong to the macropore diffusion controlling region and the mass transfer coefficients could be expressed by exponential functions of pressure change. The mass transfer coefficients for one component, nitrogen or oxygen, were successfully applied to breakthrough curves for bulk mixed gases. The experimental curves were reasonably in consistent with the theoretical curves and the error time was less than 5 percent.

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