• Journal of Mechanical Science and Technology
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• v.18 no.6
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• pp.990-1001
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• 2004

The retention of a molten pool vessel cooled by internal vessel reflooding and/or external vessel reactor cavity flooding has been considered as one of severe accident management strategies. The present numerical study investigates the effect of both internal and external vessel mixed cooling on an internally heated molten pool. The molten pool is confined in a hemispherical vessel with reference to the thermal behavior of the vessel wall. In this study, our numerical model used a scaled-down reactor vessel of a KSNP (Korea Standard Nuclear Power) reactor design of 1000 MWe (a Pressurized Water Reactor with a large and dry containment). Well-known temperature-dependent boiling heat transfer curves are applied to the internal and external vessel cooling boundaries. Radiative heat transfer has been considered in the case of dry internal vessel boundary condition. Computational results show that the external cooling vessel boundary conditions have better effectiveness than internal vessel cooling in the retention of the melt pool vessel failure.

• Asian Journal of Atmospheric Environment
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• v.9 no.1
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• pp.91-99
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• 2015

The Multi-wavelength Raman LIDAR (MRL) system was developed to enable a better understanding of the complex properties of aerosols in the atmosphere. In this study, the microphysical, optical, and radiative properties of mixed aerosols were retrieved using the discrete aerosol observation products from the MRL. The dust mixing ratio, which is the proportion of dust particles to the total mixed, was derived using the particle depolarization ratio. It was employed in the retrieval of backscattering and extinction coefficient profiles for dust and non-dust particles. The vertical profiles of aerosol optical properties were then used as input parameters in the inversion algorithm for the retrieval of microphysical parameters including the effective radius, refractive index, and the single scattering albedo (SSA). Those products were successfully applied to an analysis of radiative flux using a radiative transfer model. The relationship between the MRL derived extinction and aerosol radiative forcing (ARF) in short-wavelength was assessed over Gwangju, Korea. The results clearly demonstrate that the MRL-derived extinction profiles are a good surrogate for use in the estimation of optical, microphysical, and radiative properties of aerosols. It is considered that the analytical results shown in this study can be used to provide a better understanding of air quality and the variation of local radiative effects due to aerosols.

• The KSFM Journal of Fluid Machinery
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• v.13 no.5
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• pp.11-16
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• 2010

The development of lifting pumps that lift minerals to a mining vessel are one of the vital parts of the commercial mining process. The purpose of this study is to investigate internal flow and its effect on the performance of a mixed flow pump in order to improve the pump's performance. Numerical analysis was performed by commercial code of ANSYS CFX-11 based on flow rate and length of flexible hose. The rated rotational speed of the impeller is 1750rpm. For taking into account the turbulence, k-$\omega$ SST model was selected to guarantee more accurate prediction of flow separation. The simulated results are in good agreement with the experimental results and showed that its efficiency and the head of the pump are related mainly to the flow rate and the length of flexible hose. A lesser flow rate caused more secondary flow through the guide vane passage. The length of flexible hose and flow rate exert much more influence on the pump's performance than the shape of the flexible hose.

• The Korean Journal of Applied Statistics
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• v.28 no.2
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• pp.241-250
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• 2015

An important scientific objective of longitudinal studies involves tracking the probability of a subject having certain health condition over the course of the study. Proper definitions and estimates of disease risk tracking have important implications in the design and analysis of long-term biomedical studies and in developing guidelines for disease prevention and intervention. We study in this paper a class of rank-tracking probabilities to describe a subject's conditional probabilities of having certain health outcomes at two different time points. Linear mixed effects models are considered to estimate the tracking probabilities and their ratios of interest. We apply our methods to an epidemiological study of childhood cardiovascular risk factors.

• Journal of Korean society of Dental Hygiene
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• v.21 no.2
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• pp.119-128
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• 2021

Objectives: The aim of this study was to investigate the effect of breastfeeding on the occurrence of early childhood caries in Korean infants and toddlers. Methods: Data on oral examinations of infants and toddlers of the National Health Insurance Service were analyzed. The study subjects were children who participated in both the first, second, and third oral examinations and the first general health examination in 2008-2017 (n=142,185). Based on the responses to the questionnaire, the subjects were classified into breastfeeding, formula feeding, and mixed feeding groups. The participants were monitored for the development of early childhood caries in three sequential oral examinations. Results: Based on the oral examination results conducted at 54-65 months old, the decayed-filled teeth index of the breastfeeding group was the highest (2.03±3.08), followed by the mixed (1.96±3.03) and the formula feeding groups (1.82±2.91). The Cox proportional hazard regression model including all the variables showed that the risk of developing dental caries was significantly lower in the formula (hazard ratio [HR], 0.85) and mixed feeding groups (HR, 0.91) than in the breastfeeding group. Conclusions: Breastfeeding children have a higher risk of early childhood caries; therefore, oral hygiene education and regular dental check-ups are necessary.

• Applied Chemistry for Engineering
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• v.9 no.7
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• pp.968-973
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• 1998

The critical micelle concentrations($CMC^*$) of the mixed surfactant systems of cationic surfactant cetylpyridinium chloride(CPC) and nonionic surfactant Triton X-100(TX-100) in aqueous solutions of salts(KCl and $Na_2CO_3$) and isomeric butanols(tert-butanol, iso-butanol and n-butanol) were determined by UV spectroscopy method. The various thermodynamic values in aqueous solutions of salts and isomeric butanols were compared with the values in pure water, calculated by means of the equation derived from the pseudo-phase separation model. Thermodynamic parameters($X_1$, $\beta$, ${\gamma}i$, $ai^M$, $C_i$ and ${\Delta}H_{mix}$) were found to have great effects of salts and isomeric butanols on the mixed micellization of CPC/TX-100 mixtures, and also in good agreements with the nonideal mixed micelle model. They showed all negative deviations from the ideal mixed micellar behavior.

• Korean Journal of Clinical Pharmacy
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• v.26 no.4
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• pp.312-317
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• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.

• Earthquakes and Structures
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• v.4 no.2
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• pp.203-217
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• 2013

In recent decades, it has been realized that increasing the lateral stiffness of structure subjected to lateral loads is not the only parameter enhancing safety or reducing damage. Factors such as ductility and damping govern the structural response due to lateral loads. Despite the significant contribution of damping in resisting lateral loads, especially at resonance, there is no accurate mathematical representation for it. The main objective of this study is to develop a damping identification procedure for linear systems based on a mixed numerical-experimental approach, assuming viscous damping. The proposed procedure has been applied to a laboratory experiment associated with a numerical model, where a hollow rectangular steel cantilever column, having three lumped masses, has been fixed on a shaking table subjected to different exciting waves. The modal damping ratio has been identified; in addition, the effect of adding filling material to the hollow specimen has been studied in relation to damping enhancement. The results have revealed that the numerically computed response based on the identified damping is in a good fitting with the measured response. Moreover, the filling material has a significant effect in increasing the modal damping.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 2002.10a
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• pp.161-164
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• 2002

This study was performed to find out the regression function to calculate the modulus of elasticity of concrete mixed by river coarse aggregate. The distribution of the group of core strength made a normal curve and the effect factor in the modulus of elasticity was 0.97 at the concrete compounded by river coarse aggregate.

• Information Systems Review
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• v.11 no.1
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• pp.197-215
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• 2009

As the ubiquitous technology has been widespread, the u-service development driven by the private sector is increasing these days. In this paper, a new development methodology of interactive u-services for a mixed-use complex in u-City is proposed. The current state-of-the-art IT, Web2.0, assumes that information must be communicated in both way, not only from service provides to users but also from users to service providers. Here the user-driven u-service will be utilized for service providers to customize user services. By this interactive u-service paradigm, the information users become the information providers so that the mixed-use complex will take advantage of massive information. Also, admitting that the mixed-use complex is limited in terms of the space size, the network effect of information and shared contents created through the interactive u-services can be maximized.