• Title/Summary/Keyword: Mixed Methods

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Quantitative Mass Spectrometric Analysis of Mixed Self-Assembled Monolayers for Biochips

  • Son, Jin Gyeong;Shon, Hyun Kyong;Hong, Daewha;Choi, Changrok;Han, Sang Woo;Choi, Insung S.;Lee, Tae Geol
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.275-275
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    • 2013
  • Formation and characterization of self-assembled monolayers (SAMs) on various surfaces are the essential basis for many other applications, including molecular switches, biosensors, microfluidics, and fundamental studies in surfaces and interfaces. To improve the performance at these applications, it is a key to control the quantity of each molecule in various mixed SAMs on the surface. In this study, using mixed SAM of carbamate-based hydroquinone (HQ)-PhBr and11-mercaptoundecanol, the quantitative mass spectrometric method of mixed SAM was developed based on comparison study with XPS and FT-IR methods. In addition, our method was applied to another mixed SAM of biotinylated PEG alkane thiol and 11-mercaptoundecanol for verification purpose. Time-of-flight secondary mass spectrometry (ToF-SIMS) analysis was performed to identify and quantify each molecule of mixed SAM along with principal component analysis (PCA). Since there is no matrix effect in the X-ray photoelectron spectroscopy (XPS) and Fourier transform-infrared (FT-IR) techniques, we compared ToF-SIMS results with XPS and FT-IR results. Because PCA results from ToF-SIMS analysis are well matched with XPS and FT-IR results from both mixed SAMs, we are expecting that our method will be useful to identify and quantify each molecule in various mixed SAMs.

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Breast Conserving Therapy and Quality of Life in Thai Females: a Mixed Methods Study

  • Peerawong, Thanarpan;Phenwan, Tharin;Supanitwatthana, Sojirat;Mahattanobon, Somrit;Kongkamol, Chanon
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.6
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    • pp.2917-2921
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    • 2016
  • Background: To explore factors that influence quality of life (QOL) in patients receiving breast conserving therapy (BCT). Materials and Methods: In this sequential mixed methods study, 118 women from Songklanagarind Hospital were included. We used participants' characteristics, Body Image Scale (BIS), and Functional Assessment of Cancer Therapy with the Breast Cancer Subscale (FACT-B) for analysis. The BIS transformed into presence of body image disturbance (BID). Factors that influenced QOL were determined by stepwise multiple linear regression. Forty-one participants were selected for qualitative analysis. Our female researcher performed the semi-structured interviews with questions based on the symbolic interaction theory. Final codes were analysed using thematic analysis along with investigator triangulation methods. Results: Ninety percent had early stage breast cancer with post-completed BCT, for an average of 2.7 years. The median BIS score and FACT-B score were 2 (IQR=10) and 130 (IQR=39). In the regression analysis, an age of more than 50 years and BID were significant factors. As for the value of conserved breasts, two themes emerged: a conserved breast is an essential part of a participant's life and also the representation of her womanhood; the importance of a breast is related to age. Conclusions: Body image influenced QOL in post BCT participants. The conserved breasts also lead to positive and better impact on their body image as an essential part of their life.

Comparions of Removal Performances of Divalent Heavy Metals by Natural and Pretreated Zeolites (천연 및 전처리 제올라이트에 의한 2가 중금속 이온 제거능의 비교.검토)

  • 감상규;김덕수;이민규
    • Journal of Environmental Science International
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    • v.8 no.3
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    • pp.399-409
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    • 1999
  • The three domestic natural zeolites(Yong dong-ri (Y), Daesin-ri (D), Seogdong-ri (S)) harvested in Kyeongju-shi and Pohang-shi, Kyungsangbug-Do, were pretreatd with each of the NaOH, $Ca(OH)_2$ and NaOH following HCl solutions, and the removal performances of divalent haevy metals(Cu, Mn, Pb, and Sr) for natural and pretreated zeolites were investigated and compared in the single and mixed solutions. The natural zeolite-heavy metal system attained the final equilibrium plateau within 20 min, irrespective of initial heavy metal concentration. The heavy metal uptakes increased with increasing initial heavy metal concentration and pH. The heavy metal uptakes for natural zeolites decreased in the following sequences : D>Y>S among the natural zeolites; Pb>Cu>Sr>Mn among the heavy metals. The pretreated zeolites showed higher heavy metal removal performances than natural zeolites and decreased in the order of NaOH, NaOH following HCl, $Ca(OH)_2$ treatment among the pretreatment methods. The heavy metal ion exchange capacity by natural and pretreated zeolites was described either by Freundlich equation or Langmuir equation, but it followed the former better than the latter. The heavy metal uptakes for natural zeolites decreased in the mixed solution, in comparing with those in the single solution and especially, the manganese uptake decreased greatly in the mixed solution. The pretreated zeolites showed the improved removal performances of heavy metals in the mixed solution than in the single solution and the heavy metal uptakes by those in the mixed solution showed the same trends in the single solution among the chemical treatment methods and heavy metals.

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Second order Temporal Finite Element Methods in Linear Elasticity through the Mixed Convolved Action Principle (혼합 합성 변분이론에 근거한 선형탄성시스템의 이차 시간 유한요소해석법)

  • Kim, Jinkyu
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.27 no.3
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    • pp.173-182
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    • 2014
  • The mixed convolved action principle provides a new rigorous weak variational formalism for a broad range of initial boundary value problems in mathematical physics and mechanics in terms of mixed formulation, convolution, and fractional calculus. In this paper, its potential in the development of numerical methods for transient problems in various dynamical systems when adopting temporally second order approximation is investigated. For this, the classical single-degree-of-freedom linear elastic dynamical systems are primarily considered to investigate computational characteristics of the developed algorithms. For the undamped system, all the developed algorithms are symplectic with respect to the time step. For the damped system, they are shown to be accurate with good convergence characteristics.

Child Care Curricula According to Teacher's Teaching Method Types (보육교사의 교수 신념 유형에 따른 보육과정 운영)

  • Kwon, Yeon-Hee;Choi, Mock-Wha;Rha, Jong-Hay
    • Korean Journal of Human Ecology
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    • v.20 no.2
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    • pp.353-364
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    • 2011
  • The purpose of this study was to examine different child care curricula according to teacher's teaching method types. The subjects of the study were three hundred and fifty-six teachers, who were divided into four groups according to their teaching method: mixed method(type A), child oriented method(type B), teacher oriented method(type C), and beliefless method(type D). The data on the duration of free play and outdoor play time, activities frequently practiced in class, and outside one the playground were collected. The dimensions of child care programs were measured using Moore(1994)'s "The Early Childhood Dimensions of Education Rating Scale". The results of this study were as follows: first, teachers who used child oriented teaching methods gave more free play time than teachers using teacher oriented or mixed teaching methods. Second, teachers using teacher oriented methods showed the closeness and teachers using child oriented methods showed the openness in child care programs. Last, the activities teachers thought were the most important differed according to the teachers' methods even though in actual practice, there was no difference shown.

Comparison of the Ingredient Quantities, and Antioxidant and Anti-inflammatory Activities of Hwangryunhaedok Decoction Pharmacopuncture by Preparation Type

  • Lee, Jin Ho;Kim, Min Jeong;Lee, Jae Woong;Kim, Me Riong;Lee, In Hee;Kim, Eun Jee
    • Journal of Acupuncture Research
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    • v.31 no.4
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    • pp.45-55
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    • 2014
  • Objectives : The main aim of this study was to assess the comparative efficiency of two preparation types of Hwangryunhaedok decoction(HRHD-D) using distilled and mixed extraction by measuring the index components and indicators of antioxidant and anti-inflammatory effects. Methods : The antioxidant activity was assessed by comparing distilled and mixed extractions of HRHD-D using an ELISA reader. The anti-inflammatory effect was determined by measuring NO amounts in RAW 264.7 cells. The contents were analyzed with high performance liquid chromatography-diode array detector(HPLC-DAD). Results : The electron donating ability of mixed and distilled extractions obtained with 500 ppm DPPH(1,1-diphenyl-2-picrylhydrazyl assay) solution were 57.8 % and 4.2 %, respectively. The total phenolic content of mixed extraction was 6.9 times that of distilled extraction and total flavonoid content was 51.5 times higher. The anti-inflammatory effect was assessed by NO measurement, and was found to increase significantly dependent on concentration in all mixed extract concentrations(25, 50, 100, 200, $400{\mu}g/mL$), but the difference in distilled extraction by concentration was only significant at 200 and $400{\mu}g/mL$. The HPLC analysis results of mixed extract of HRHD-D showed detection of all four main active constituents of HRHD-D. However, they were not detected in the distilled extract of HRHD-D. Conclusions : Mixed extraction with distillation added to decoction of HRHD-D showed better efficacy in antioxidant and anti-inflammatory effects, and ingredient quantities compared to distilled extraction. Further stability and clinical efficacy studies for standardization of mixed extractions are required.

Multiple Densities of the Chronic Subdural Hematoma in CT Scans

  • Park, Hye-Ran;Lee, Kyeong-Seok;Shim, Jae-Jun;Yoon, Seok-Mann;Bae, Hack-Gun;Doh, Jae-Won
    • Journal of Korean Neurosurgical Society
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    • v.54 no.1
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    • pp.38-41
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    • 2013
  • Objective : Density of the chronic subdural hematoma (cSDH) is variable. It often appears to be mixed density. Multiple densities of cSDH may result from multiple episodes of trauma. We investigated the frequency of mixed density and the causes of head injuries representing each density. Methods : We could collect 242 cases of chronic SDH. The cSDHs were classified into four groups; hypodensity, homogeneous isodensity, layered type, and mixed type on the basis of CT scans. Results : The density of cSDH was isodense in 115 patients, hypodense in 31 patients, mixed in 79 cases, and layered in 17 cases. The cSDH was on the left side in 115 patients, on the right side in 70 patients, and bilateral in 40 patients. The history of trauma was identifiable in 122 patients. The etiology could be identified in 67.7% of the hypodense hematomas, while it was obscure in 59.5% of the mixed hematomas. Conclusion : Mixed density of cSDH results from multiple episodes of trauma, usually in the aged. It is hard to remember all the trivial traumas for the patients with the mixed density cSDHs. Although there were membranes within the mixed density hematomas, burr-holes were usually enough to drain the hematomas.

A Study on the Characteristic of Energy Consumption in the Super High-rise Mixed-use Housing (초고층 주상복합 아파트의 에너지 소비특성에 관한 연구)

  • Lee, Byunghee;Lee, Jaehyuk;Je, Heaseong;Kang, Dongho
    • KIEAE Journal
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    • v.10 no.5
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    • pp.63-69
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    • 2010
  • Recently, by the increase of demand on Super High-rise mixed-use housing and it's advanced quality, the interest on it has been raised socially. In accordance with it, the matter of resident's health and energy efficiency has been controversial in terms of living in super high-rise housing. This study started from the idea that it is necessary to have an objective data which that has many residents in narrow space with high density. The purpose of this study are as follows; Firstly, with the quantitative data analysis on energy, it will confirm the objective information on the unclear negative idea of super high-rise mixed-use housing. Secondly, it will establish the fundamental data on the energy of super high-rise mixed-use housing by examining the characteristic of energy consumption of the complex which was built more than 5 years ago. There are 4 methods of this study. Firstly, it follows the steps of theoretical view, and defines concept to study on the characteristic of super high-rise mixed-use housing. Secondly, referring to the previous study, it provides better understanding on th stream of this research and the limit as well to guide the direction in terms of energy consumption. Thirdly, it evaluates the characteristic of monthly consumption by researching the use of electricity energy and heating energy of super high-rise mixed-use housing. The major conclusions of this study are as follows; Firstly, the heating use of apartment complex is same, which is not influenced by the type of the building. Secondly, the electricity use of super high-rise mixed-use housing is from 1,2 to 1.5 as high as the normal apartment.