• Tunnel and Underground Space
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• v.20 no.4
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• pp.252-259
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• 2010

In urban tunnels, namely, in case there are residents in the near distance, we normally use non-vibration and ambient vibration which are not blasting methods because it’ impossible to meet the blasting vibration regulation with only normal explosives. However, non-vibration methods not only cause increase of excavating cost, but need much time than explosives. Generally, the lower velocity explosives with 2,000 m/s VOD have been applied to ambient vibration blasting in open cut area, but difficult in tunneling in its use. However, by charging the hole together with lower velocity explosives and normal explosives, we have got the result which shows 20~30% vibration decrease compared with using only normal explosives. Therefore, I’ like to suggest the blasting method which is able to do as ambient vibration using lower velocity explosives mixed with normal explosives in urban tunnel and the area which is adjacent to security facilities within the vibration regulation.

• The Journal of Korean Medicine
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• v.40 no.4
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• pp.1-15
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• 2019

Objectives: Here, we investigated the effects of concentrated and lyophilized powders Blue honeysuckle (BH) on the PK of tamoxifen, to establish the pharmacokinetics (PK) profiles as one of essential process in new drug development. Methods: After single oral treatment of 0.4 mg/ml of tamoxifen or tamoxifen 0.4 with BH 40, 20 and 10 mg/ml, the plasma were collected at 0.5 hr before administration, 0.5, 1, 2, 3, 4, 6, 8 and 24 hr after end of single or mixed formula treatment. Plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. Tmax, Cmax, AUC, t1/2 and MRTinf were analyzed using noncompartmental PK data analyzer programs. Results: Tamoxifen and BH 40 mg/ml did not induce any significant change on the plasma tamoxifen concentrations, while significant decreases were observed in tamoxifen and BH 10 mg/ml from 2 to 8 hr as compared with tamoxifen only, respectively. Furthermore, significant increases of Tmax in tamoxifen and BH 40 mg/ml, significant decreases of Cmax in tamoxifen and BH 20 mg/ml, significant decreases of AUC0-t, AUC0-inf and MRTinf in tamoxifen and BH 10 mg/ml were demonstrated as compared with tamoxifen only. Conclusion: Taken together, tamoxifen and BH 10 mg/ml induced significant decrease of the oral bioavailability of tamoxifen, while tamoxifen and BH 40 or 20 mg/ml did not critically influenced, suggesting formulated BH concentration-independencies. It, therefore, seems to be needed that pharmacokinetic study after repeated administration should be tested to conclude the effects of BH on the pharmacokinetics of tamoxifen.

• Journal of Intelligence and Information Systems
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• v.12 no.3
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• pp.33-46
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• 2006

In order to decrease the number of handles, speed up retrieval operations, and manage products efficiently, the investment of facilities such as the installation of the storage equipment and the enlargement of the storage area may be attempted. However, the same objectives can be accomplished by utilizing the existing storage area efficiently. In many types of storage facilities, because of the limitation of storage areas, products are usually piled up, which may cause rehandles of inventories. Rehandles influence significantly the handling efficiency of warehouses. This study develops methods for minimizing rehandles of inventories to improve the operational efficiency of warehouses. A mixed storage problem is addressed for minimizing the expected number of rehandles. Optimization models are proposed and the genetic algorithm is applied to solve the problem.

• Journal of Microbiology and Biotechnology
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• v.19 no.7
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• pp.658-665
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• 2009

Quality control QC for spot-uniformity is a critical point in fabricating an oligonucleotide array, and quantification of targets is very important in array analysis. We developed two new types of QC probes as a means of confirming the quality of the uniformity of attached probes and the quantification of targets. We compared the signal intensities and fluorescent images of the QC and target-specific probes of arrays containing only target-specific probes and those containing both QC and target-specific probes. In a comparison of quality control methods, it was found that the arrays containing QC probes could check spot-uniformity or spot defects during all processes of array fabrication, including after spotting, after washing, and after hybridization. In a comparison of quantification results, the array fabricated by the method using QC probes showed linear and regular results because it was possible to normalize variations in spot size and morphology and amount of attached probe. This method could avoid errors originating in probe concentration and spot morphology because it could be normalized by QC probes. There were significant differences in the signal intensities of all mixtures (P<0.05). This result indicates that the method using QC probes is more useful than the ordinary method for quantification of mixed target. In the quantification of mixed targets, this method could determine a range for mixed targets of various amounts. Our results suggest that methods using QC probes for array fabrication are very useful to the quality control of spots in the fabrication processes of quantitative oligonucleotide arrays.

• Journal of Environmental Science International
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• v.22 no.3
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• pp.331-339
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• 2013

Efforts were made to determine the activation energy and the reaction order by adopting Kissinger and Flynn-Wall-Ozawa analysis methods. All the data were acquired from TGA thermograms for the mixed fuels with different temperature heating rates. It could be known that both the coal and the mixed fuels decomposed thermally at temperature ranges of $300{\sim}700^{\circ}C$. The temperature at the maximum reaction rate, Tp, could be determined by DTG method, which could be obtained by differentiation of TGA thermogram. Kissinger analysis showed the linear relationship with experimental data, showing the activation energy of $319.64{\pm}4$ kJ/mol. From Flynn-Wall-Ozawa analysis, it was shown that the activation energies and the reaction orders did not undergo any significant changes with both the conversions and the heating rates. It was considered from this facts that the combustion mechanism of the mixed fuels could not be affected by the extent of conversion and heating rate. In the present study, the activation energies showed different values according to the different analysis methods. The difference might be originated from the inconsistency of the mathematical data treatment method. In other words, while the activation energies obtained from the Kissinger method indicated the average values for overall reaction, that from Flynn-Wall-Ozawa method showed the average values for the each conversion around Tp.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.5D
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• pp.671-677
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• 2011

A diversity of railway network function enhancement projects such as the double tracking, electrification, and direct operation have been actively executed to improve the railway service. When the new rapid transit is provided, how many people will use it instead of other transports? How will the railway choice behavior be changed? Accordingly, in this paper, the applicability of diverted travel demand forecast methods, by Revealed Preference(RP) and Stated Preference(SP) data was reviewed for Daegu metropolitan rail rapid transit service. As the result of combining RP and SP data, including the sequential and simultaneous approach, the total travel time and travel cost parameters are of the right sign and are highly significant. The simultaneous approach is more efficient in terms of the estimation of coefficients. In particular, methods to improve validity of the Mixed RP/SP models, when RP data is used proportionally, the diverted travel demand can be easily identified by railway fare and travel time service level. Therefore, it is considered that this will practically apply even in other regions as well as Daegu metropolitan railway.

• Journal of the Korean Society of Clothing and Textiles
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• v.31 no.8
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• pp.1286-1296
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• 2007

Hanji, the korean traditional papers were mostly made from mulberry paper. But the production and demand of hanji have decreased rapidly because mulberry paper yields were insufficient and handworked hanji procedures were complicated. Recently, the researches on hanji were carried out to improve the properties of hanji. Kenaf fibers have been interested as a substitute resource of mulberry paper for hanji production. In this research, Kenai pulps were manufactured with removal methods of lignin or hemicellulose from kenaf fibers and paper mulberry pulps with traditional alkali methods. Kenaf papers, paper mulberry, and kenaf/paper mulberry mixed papers were manufactured with their pulps. The crystallinity, fiber length, color of the pulps and tensile strength, tear strength, water absorption of the papers were investigated. The results were as follow: The removal rates of lignin of chemical retted kenaf fibers with sodium chlorite reaction for 40 minutes were 70% and were higher than 40% of double retted fibers. Paper mulberry pulps has less lignin and hemicellulose than kenaf differently. The crystallinity of paper mulberry pulps were very low with 60%, but kenaf pulps were 90%. The chemical retted CR-40-1 pulps were similar with paper mulberry pulps on fiber length & fibrilation of fibers. Tensile strength of paper mulberry were higher than kenaf papers because of fibrilation of paper mulberry, but tear strength were lower. Tensile strength and tear strength were improved on kenaf/paper mulberry 30/70 mixed papers.

• The Korea Journal of Herbology
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• v.35 no.3
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• pp.33-45
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• 2020

Objective : The present study aimed to evaluate the change of the content of 7 active components in decoctions produced by various proportional pairs of Coptis chinensis Franch and Scutellaria baicalensis Georgi in 'Mixed decoction (MD)' and 'Single decoction mixture (SDM)'. Methods : The samples of MDs were prepared by decocting C. chinensis : S. baicalensis with the ratios of 10 g:10 g, 10 g:20 g, and 20 g:10 g. Those of SDMs were prepared by blending each single decoction from C. chinensis and S. Baicalensis with the ratios of 1:1, 1:2, and 2:1. The samples were evaluated by high-performance liquid chromatography with statistical analyses. Results : The analytical methods, which were optimized and validated, were reliably applied to present research. The content of all components in both MDs and SDMs at C. chinensis : S. baicalensis = 1:1 ratio were reduced compared with single herb decoction. The components from each compositional herb in MDs were proportionally increased with the ratio of original herb increased, but inversely proportional to paired herb. The contents of components in MDs were significantly lower than those in SDMs at all ratios, except for high content of baicalin at C. chinensis : S. baicalensis = 2:1. Conclusion : It was concluded that MDs and SDMs as well as the proportions of herbs could affect the contents of the components from original herbal medicines. These results provide the information for the quality control of herbal medicine combined C. chinensis with S. baicalensis.

• Journal of Environmental Science International
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• v.31 no.9
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• pp.735-741
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• 2022

Global warming affects forests and their ecology. Diversity in the forest is a buffer that reduces the damage due to global warming. Mixed forests are ecologically more valuable as versatile habitats and are effective in preventing landslides. In Korea, most forests were created by simple afforestation with trees of evergreen species. Typically, evergreen trees are shallow-rooted, and deciduous trees are deep-rooted. Mixed forest tree roots grip the soil effectively, which reduces the occurrence of landslides. Therefore, improving the distribution of tree types is essential to reduce damage due to global warming. For this improvement, the investigation of tree types of the forest is needed. However, determining the tree type distribution of forests that are spread over wide areas is labor-intensive and time-consuming. This study suggests effective methods for determining the distribution of tree types in a forest that is spread across a relatively wide area. Using normalized difference vegetation index and RGB images from unmanned aerial vehicles, each evergreen and deciduous tree, and grassland area can be distinguished. The distinguished image determines the distribution of tree type. This method is effective compared to directly determining the tree type distribution in the forest by the use of manpower. The data from these methods could be applied to plan a mixed forest or to prepare for future damage due to global warming.

• Microbiology and Biotechnology Letters
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• v.51 no.1
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• pp.43-52
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• 2023

The purpose of this study is to confirm the antioxidant, black hair, and hair growth effects of the N. jatamansi, O. basilicum, and C. sativus mixed extracts that pharmacological efficacy has been verified. Accordingly, four samples (NOC-1 to-4) produced under different extraction conditions were prepared and the results are as follows. First, all samples showed an increase in antioxidant content in a concentration-dependent manner from the results of antioxidant efficacy. In particular, NOC-4 extracted by steaming and ultrasonic methods showed the highest antioxidant effect among the four samples. As a result of analysis of the amount of melanin production in mouse melanoma cells, NOC-4 with concentration of 500 ㎍/ml showed higher melanin production compared to the control group, so the black hair efficacy was the best. Also, in the hair growth test results, it was found that the hair growth was the best at 0.94 ± 0.10 mm at experimental group orally administered with 500 mg/kg of NOC-4. In addition, as a result of cytotoxicity analysis in mouse melanoma cells, the safety of samples was demonstrated by maintaining cell viability of 95% or more at all concentrations. These results suggest that the steaming and ultrasonic extraction method increased the extraction yield of active ingredients for antioxidant, melanin, and hair generation, thereby affecting physiological activity. Based on these results, if the steaming and ultrasonic extraction methods are applied to the mixed extraction of N. jatamansi, O. basilicum, and C. sativus, it is judged that the practical potential as a natural material for black hair and hair growth agents will increase.