• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.10 no.5
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• pp.619-629
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• 1998

An experimental work was conducted to investigate a feasibility of simultaneous measurement of gas-liquid two-phase flowrates with double orifice plates using air and water. The tests were carried out under the atmospheric pressure and at the ambient temperature using two different tube sizes. Qualities of an air-water flow in the present study have values less than 0.1 and thus the mixed flow showed bubbly, plug, slug flow regimes. The probability density function (PDF) and the power spectral density function (PSDF) of the instantaneous pressure drop traces for the flow regimes were obtained. It is found that some distinctive features exist in the distribution of these functions, depending upon the two-phase flow pattern. The time-averaged value of the instantaneous pressure drop increases with increasing gas and liquid flowrates, showing a single-valued function for the total mass flowrate and the quality. It is also found that the two-phase discharge coefficient exhibits a consistent trend for variation of dimensionless parameters such as the superficial velocity ratio and the gas Reynolds number. The results indicate that simultaneous measurement of two-phase flowrate may be possible based upon a statistical analysis of the instantaneous pressure drop curves monitored using double orifice plates.

• Korean Institute of Interior Design Journal
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• v.15 no.6 s.59
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• pp.188-195
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• 2006

The development of a general hospital has a close connection with the trend of the society in general and it flows to the ways that satisfies the demanded value of the time. Therefore, various internal changes have occurred since a hospital has built. The changes is appearing through the time not only in the quantitative changes, but also in functional changes and correlations between each department. This study focused on these changes, and observed the St. Mary's Hospital - one of the major hospitals - which is constructed in 1980's. And then, it was divided into the D/T, O.P.D and ward as function that focused on the time of hospital's establishment (1980), the present (2006), and new hospital (2009) to observe the changing aspect of the function and department. As a result, according as age passes, this study shows function of each department is mixed. Among the D/T, O.P.D and ward, mixing functions of O.P.D is most notable. The mixing function brings changes in hospital's arrangement type. In the past, verticality style hospital was evaded, but recently verticality style hospital is appearing. Through this study, it is expected to forecast the new aspects of hospital and apply it to the new project.

• Interdisciplinary Bio Central
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• v.4 no.3
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• pp.9.1-9.7
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• 2012

Filamentous phages have been in the limelight as a new type of nanomaterial. In this study, genetically and chemically modified fd phage was used to generate a biomimetic phage self-assembly product. Positively charged fd phage (p8-SSG) was engineered by conjugating 3-aminopropyltriethoxysilane (APTES) to hydroxyl groups of two serine amino acid residues introduced at the N-terminus of major coat protein, p8. In particular, formation of a phage network was controlled by changing mixed ratios between wild type fd phage and APTES conjugated fd-SSG phage. Assembled phages showed unique bundle and network like structures. The bacteriophage based self-assembly approach illustrated in this study might contribute to the design of three dimensional microporous structures. In this work, we demonstrated that the positively charged APTES conjugated fd-SSG phages can assemble into microstructures when they are exposed to negatively charged wild-type fd phages through electrostatic interaction. In summary, since we can control the phage self-assembly process in order to obtain bundle or network like structures and since they can be functionalized by means of chemical or genetic modifications, bacteriophages are good candidates for use as bio-compatible scaffolds. Such new type of phage-based artificial 3D architectures can be applied in tuning of cellular structures and functions for tissue engineering studies.

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.319-329
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• 2003

Ursolic acid (UA) and oleanolic acid (OA) are pentacyclic triterpenoids which are widely distributed in plants, and their derivatives are aglycones of many naturally occurring saponins. It is known that pentacyclic acids may possibly enhance the mechanical barrier functions of cell membranes in plants. Recently, it has been reported that OA and UA have interesting biological activities on skin, such as anti-inflammatory and anti-wrinkle activities. Since triterpenoids are extremely insoluble and their solubility problem limits skin-care application, OA and UA were encapsulated in liposomes via micelle-to-vesicle transition to overcome poorly soluble property and enhance biological efficacy. Optimal molar ratio of OA to lecithin was found to exist for producing liposomes of small hydrodynamic size and liposomal suspensions without recrystallized precipitation of OA. From electron micrograph and dynamic light scattering studies, reconstituted OA-containing liposomes without severe mechanical treatment showed small hydrodynamic size about 150 nm. Wide-angle X-ray diffraction coupled with dynamic light scattering revealed that optimal amount of OA in liposome was 25.4 mole %. In biological evaluation, OA-containing liposome significantly increased filaggrin and transglutaminase as markers of keratinocyte differentiation in epidermal layer of hairless mouse, whereas ursolic acid-containing liposome did not show noticeable increase of filaggrin and transglutaminase compared to empty liposome. It is concluded that nano-scaled liposomes containing triterpenoids were spontaneously prepared by vesicular transition from mixed micelle and liposomal triterpenoids can enhance skin absorption of triterpenoid and biological efficacy.

• International Journal of Aeronautical and Space Sciences
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• v.18 no.3
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• pp.403-413
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• 2017

Dual-point aerodynamic design optimization is conducted for DLR-F6 wing-body-nacelle-pylon configuration adopting an efficient surface mesh movement method for complex junction geometries. A three-dimensional unstructured Euler solver and its discrete adjoint code are utilized for flow and sensitivity analysis, respectively. Considered design conditions are a low-lift condition and a cruise condition in a transonic regime. Design objective is to minimize drag and reduce shock strength at both flow conditions. Shape deformation is made by variation of the section shapes of inboard wing and pylon, nacelle vertical location and nacelle pitch angle. Hicks-Henne shape functions are employed for deformation of the section shapes of wing and pylon. By the design optimization, drag coefficients were remarkably reduced at both design conditions retaining specified lift coefficient and satisfying other constraints. Two-point design results show mixed features of the one-point design results at low-lift condition and cruise conditions.

• Journal of Satellite, Information and Communications
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• v.9 no.4
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• pp.26-31
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• 2014

In this paper, we present performance analysis of video smoke detection based on BPN-Network that is using multi-smoke feature, and Neural Network. Conventional smoke detection method consist of simple or mixed functions using color, temporal, spatial characteristics. However, most of all, they don't consider the early fire conditions. In this paper, we analysis the smoke color and motion characteristics, and revised distinguish the candidate smoke region. Smoke diffusion, transparency and shape features are used for detection stage. Then it apply the BPN-Network (Back-Propagation Neural Network). The simulation results showed 91.31% accuracy and 2.62% of false detection rate.

• Journal of Korean Institute of Industrial Engineers
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• v.25 no.4
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• pp.500-509
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• 1999

In this paper, we consider an optimal routing problem when point-to-point and point-to-multipoint connection traffics are offered in an ATM network. We propose a mathematical model for cost-minimizing configuration of a logical network for a given ATM-based BISDN. Our model is essentially identical to the previous one proposed by Kim(Kim, 1996) which finds a virtual-path configuration where the relevant gains obtainable from the ATM technology such as the statistical multiplexing gain and the switching/control cost-saving gain are optimally traded-off. Unlike the Kim's model, however, ours explicitly considers the VP's QoS(Quality of Service) for more efficient utilization of bandwidth. The problem is a large-scale, nonlinear, and mixed-integer problem. The proposed algorithm is based on the local linearization of equivalent-capacity functions and the relaxation of link capacity constraints. As a result, the problem can be decomposed into moderate-sized shortest path problems, Steiner arborescence problems, and LPs. This fact renders our algorithm a lot faster than the previous nonlinear programming algorithm while the solution quality is maintained, hence application to large-scale network problems.

• Structural Engineering and Mechanics
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• v.47 no.1
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• pp.45-58
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• 2013

In structural reliability analysis, the response surface method is a powerful method to evaluate the probability of failure. However, the location of experimental points used to form a response surface function must be selected in a judicious way. It is necessary for the highly nonlinear limit state functions to consider the design point and the nonlinear trend of the limit state, because both of them influence the probability of failure. In this paper, in order to approximate the actual limit state more accurately, experimental points are selected close to the design point and the actual limit state, and consider the nonlinear trend of the limit state. Linear, quadratic and cubic polynomials without mixed terms are utilized to approximate the actual limit state. The direct Monte Carlo simulation on the approximated limit state is carried out to determine the probability of failure. Four examples are given to demonstrate the efficiency and the accuracy of the proposed method for both numerical and implicit limit states.

• Bulletin of the Korean Chemical Society
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• v.6 no.4
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• pp.186-191
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• 1985

The effect of pressure and temperature on the stabilities of the charge transfer complexes of hexamethyl benzene with iodine in n-hexane has been investigated by UV-spectrophotometric measurements. In this experiment the absorption spectra of mixed solutions of hexamethyl benzene and iodine in n-hexane were measured at 25, 40 and $60^{\circ}C$ under 1,200, 600, 1200 and 1600 bar. The equilibrium constant of the complex formation was increased with pressure while being decreased with temperature raising. Changes of volume, enthalpy, free energy and entropy for the formation of the complexes were obtained from the equilibrium constants. The red shift at higher pressure, the blue shift at higher temperature and the relation between pressure and oscillator strength were discussed by means of thermodynamic functions. In comparison with the results in the previous studies, it can be seen that the pressure dependence of oscillator strength has a extremum behavior in durene as the variation of ${\Delta}H$ or ${\Delta}S$ with the number of methyl groups of polymethyl benzene near atmospheric pressure in the previous study. The shift or deformation of the potential in the ground state and in the excited state of the complexes formed between polymethyl benzene and iodine was considered from the correlation between the differences of the electron transfer energies and the differences of free energies of the complex formation for the pressure variation.

• BMB Reports
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• v.55 no.3
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• pp.154-159
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• 2022

Protein S-glutathionylation is a reversible post-translational modification on cysteine residues forming a mixed disulfide with glutathione. S-glutathionylation, not only protects proteins from oxidation but also regulates the functions of proteins involved in various cellular signaling pathways. In this study, we developed a method for the detection of S-glutathionylated proteins (ProSSG) using eosin-glutathione (E-GSH) and mouse glutaredoxin 1 (mGrx1). ProSSG was efficiently and specifically labeled with E-GSH to form ProSSG-E via thiol-disulfide exchange. ProSSG-E was readily luminescent allowing the detection of ProSSG with semi-quantitative determination. In addition, a deglutathionylation enzyme mGrx1 specifically released E-GSH from ProSSG-E, which increased fluorescence allowing a sensitive determination of ProSSG levels. Application of the method to the adipocyte differentiation of 3T3-L1 cells showed specific detection of ProSSG and its increase upon differentiation induction, which was consistent with the result obtained by conventional immunoblot analysis, but with greater specificity and sensitivity.