• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.12
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• pp.109-120
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• 1998

An image segmentation approach based on the fuzzy worm searching and MIN-MAX clustering algorithm is proposed in this paper. This algorithm deals with fuzzy worm value and min-max node at a gross scene level, which investigates the edge information including fuzzy worm action and spatial relationship of the pixels as the parameters of its objective function. But the conventional segmentation methods for edge extraction generally need the mask information for the algebraic model, and take long run times at mask operation, whereas the proposed algorithm has single operation according to active searching of fuzzy worms. In addition, we also propose both genetic fuzzy worm searching and genetic min-max clustering using genetic algorithm to complete clustering and fuzzy searching on grey-histogram of image for the optimum solution, which can automatically determine the size of ranges and has both strong robust and speedy calculation. The simulation results showed that the proposed algorithm adaptively divided the quantized images in histogram region and performed single searching methods, significantly alleviating the increase of the computational load and the memory requirements.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.3
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• pp.115-120
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• 2017

Moving techniques is made up the physical moving status of the flow distinction modulus (FDM) and stream distinction modulus (SDM) on the shudder moving shape. Condition of the distinction modulus by the shudder moving shape is organized the dangle moving system. As to define the physical moving of special signal on the matter, we compared a shudder value of the flow distinction modulus on the flow state. The concept of stream distinction modulus is analyzed the reference of stream distinction signal and stream distinction signal by the stream state. For detecting a variation of the FDM-SDM of the maximum-minimum and average in terms of the moving shape, and shudder moving value that is a shudder value of the top variation of the $Top-{\varepsilon}$ MAX-MIN-AVG with $(-0.817){\pm}0.15$ units, that is a shudder value of the peripheral variation of the $Per-{\varepsilon}$ MAX-MIN-AVG with $(-2.53){\pm}(-0.11)$ units, that is a shudder value of the limbus variation of the $Lim-{\varepsilon}$ MAX-MIN-AVG with $(-0.29){\pm}0.03$ units, that is a shudder value of the center variation of the $Cen-{\varepsilon}$ MAX-MIN-AVG with $(-0.09){\pm}(-0.01)$ units. The dangle moving will be to assess at the capacity of the physical moving shape for the control degree of distinction modulus on the FDM-SDM that is showed the flow and stream shape by the distinction modulus system. Dangle distinction system is adjusted of a shape by the special moving and is included a shudder data of dangle moving modulus.

• YAKHAK HOEJI
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• v.37 no.3
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• pp.235-242
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• 1993

8-Fluorociprofloxacin(8-FCP) is an investigational quinolone derivative that is substituted with fluorine at the C-8 position of ciprofloxacin(CP). It was found that the in vitro activity of 8-FCP against Gram(+) bacteria was more potent that of CP, but the opposite against Gram(-) bacteria was true. However, 8-FCP showed better in vivo efficacy than CP against representative Gram(-) organisms, E. coli and K pneumoniae. In an attempt to seek for factors causing this discrepancy in the antibacterial activities, a comparative pharmacokinetic study of 8-FCP and CP was conducted in mice and rats treated either intravenously or orally at a single dose of 30 mg/kg. The pharmacokinetic parameters in mice were as follows; the mean peak serum concentrations(C$_{max}$) following i.v. and oral doses were 12.4 and 5.3 $\mu\textrm{g}$/ml for 8-FCP, and 9.5 and 2.5 $\mu\textrm{g}$/ml for CP, respectively. The terminal half-life(t$_{1/2\beta}$) was 72.9 min for 8-FCP, and 98.2 min for CP, and the oral bioavailability(F) was 89.9% for 8-FCP, and 50.5% for CP. In rats, the mean ($\pm$SD) $C_{max}$ after i.v. administration were 11.6$\pm$1.6 $\mu\textrm{g}$/ml for 8-FCP, and 10.2$\pm$1.3 $\mu\textrm{g}$/ml for CP, whereas oral administration produced $C_{max}$ of 5.9$\pm$1.8 $\mu\textrm{g}$/ml for 8-FCP and 1.1$\pm$0.9 $\mu\textrm{g}$/ml for CP, respectively. The t$_{1/2\beta}$ was 67.9$\pm$8.4 min for 8-FCP, and 76.4$\pm$7.2 min for CP. The F was 88.6$\pm$6.3% for 8-FCP, and 40.7$\pm$6.5% for CP. Marked differences were observed between the two quinolones in the $C_{max}$ and the area under the concentration-time curve obtained after oral administration in mice and rats. The extent of 8-FCP absorption in both mice and rats was approximately 2-fold higher than that of CP, suggesting that the fluorine atom attached to C-8 plays an important role in facilitating oral absorption from the gastrointestinal tract.

• Progress in Medical Physics
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• v.29 no.2
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• pp.47-52
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• 2018

To investigate the effect of low magnetic field on dose distribution in SABR plans for liver cancer, we calculated and evaluated the dose distribution to each organ with and without magnetic fields. Ten patients received a 50 Gy dose in five fractions using the $ViewRay^{(R)}$ treatment planning system. For planning target volume (PTV), the results were analyzed in the point minimum ($D_{min}$), maximum ($D_{max}$), mean dose ($D_{mean}$) and volume receiving at least 90% ($V_{90%}$), 95% ($V_{95%}$), and 100% ($V_{100%}$) of the prescription dose, respectively. For organs at risk (OARs), the duodenum and stomach were analyzed with $D_{0.5cc}$ and $D_{2cc}$, and the remained liver except for PTV was analyzed with $D_{mean}$, $D_{max}$, and $D_{min}$. Both inner and outer shells were analyzed with the point $D_{min}$, $D_{max}$, and $D_{mean}$, respectively. For PTV, the maximum change in volume due to the presence or absence of the low magnetic field showed a percentage difference of up to $0.67{\pm}0.60%$. In OAR analysis, there is no significant difference for the magnetic field. In both shell structure analyses, although there are no major changes in dose distribution, the largest value of deviation for $D_{max}$ in the outer shell is $2.12{\pm}2.67Gy$. The effect of low magnetic field on dose distribution by a Co-60 beam was not significantly observed within the body, but the dose deposition was only appreciable outside the body.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.19 no.2
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• pp.83-93
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• 2016

This study purposed to examine the water retention capacity of floor litter in deciduous forests. Water holding capacity(WHC) and interception storage capacity of Alnus hirsuta Turcz. ex Rupr., Quercus acutissima, Quercus mongolica litters were experimentally estimated. Physical characteristics of litters were also obtained to understand the relationships between water-retention capacity and litter characteristics. Experiments showed that WHC increases with specific volume of litter, varying 244.4% to 416.8% of its dry mass. Interception storage have estimated with rainfall simulation experiments. Maximum interception storage ($C_{max}$) and minimum interception storage ($C_{min}$) of litters were 220% and 138% of dry mass in Alnus hirsuta Turcz. ex Rupr., 218% and 137% in Quercus acutissima, and 240% and 156% in Quercus mongolica. Both $C_{max}$ and $C_{min}$ increased linearly with litter mass, and the values of $C_{min}$ in broadleaf litters have also linear relation to leaf area.

• YAKHAK HOEJI
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• v.36 no.3
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• pp.259-268
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• 1992

A procedure for the determination of KR-30075 and its metabolites in plasma and urine by high performance liquid chromatography is described. For the study of pharmacokinetic properties of KR-30075, a new PDE III inhibitor, the plasma concentration and urinary excretion after an oral administration of KR-30075 (4 mg/kg) in the male rat (Sprague Dawley) were determined by high performance liquid chromatography. The best extraction efficiency of KR-30075 and KR-30072 is obtained with ethyl ether adjusted to pH 4.0. Retention times of both KR-30072 and KR-30075 were within 5 min and resolution was complete at the flow rate of 1.0 ml/min. The sensitivity and specificity of this HPLC assay appears to be satisfactory for the pharmacokinetic study of KR-30075 and its metabolites. One-compartment open model with first-order absorption was applied to evaluate the pharmacokinetic parameters of KR-30075 according to Minimum AIC Estimation. $T_{max}$ was 1 hr, $C_{max}$ was $0.789{\pm}0.31\;{\mu}g/ml$ and elimination half $T_{1/2}$ was 6.31 min after oral administration of 4 mg/kg KR-30075 to male rats.

• Archives of Pharmacal Research
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• v.17 no.6
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• pp.428-433
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• 1994

The methabolism and phamacokinetics of a mixed disulfide S-(N, N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine (AC-DDTC) were studied in rats. Two metabolites of AC-DDTC following iv and po administration were indentified in plasma and liver by HPLC and GC, namely N, N-diethyldithiocarbamate (DDTC) and the methyl ester of DDTC (Me-DDTC). AC-DDTC was very unstable in vivo and could not be detected neither in plasma nor in urine. Pharmacokinetic parameters of DDTC following intravenous administration of AC-DDTC (20 mg/kg) were calculated. DDTC has a low affinity to rat tissue and the body clearance was $9.0{\pm}3.4mkl/mim/kg$. The mean residence time (MRT) was $11.5{\pm}16.3 min$. After oral administration of 20 mg/kg AC-DDTC, maximal plasma concenttion ($C_{max}$) was $3.8{\pm}0.2 nmol/ml$ and the bioavailability was 7.04%. $C_{max}$ for DDTC at a dose of 120 mg/kg. AC-DDTC was $40.1{\pm}2.2 nmol/ml$. ART was $47.1{\pm}2.8min$.at a dose of 20 mg/kg and $110.5{\pm}6.0 min$ at 120 mg/kg.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.94-96
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• 2016

본 논문에서는 기존의 백내장 추출 방법을 개선하기 위해 FCM(Fuzzy C_Means) 알고리즘을 적용하여 백내장을 추출하고 분석하는 방법을 제안한다. 제안된 방법은 애견 안구 영상에서 ROI 영역을 추출한다. 추출된 ROI 영역에서 Fuzzy Stretching 기법을 적용하여 픽셀의 상한 값과 하한 값을 조정한다. 퍼지 스트레칭 기법이 적용된 ROI 영역에 Max-Min 기반 평균 이진화 기법을 적용하여 ROI 영역을 이진화한다. 그리고 퍼지 스트레칭 기법이 적용된 ROI 영역에 FCM 알고리즘을 적용하여 양자화한 후에 양자화된 ROI 영역에서 밝기 평균 이진화 기법을 적용하여 이진화한다. 따라서 Max-Min 기반 이진화 기법을 적용하여 이진화된 ROI 영역과 밝기 평균 이진화 기법을 적용하여 이진화된 ROI 영역을 AND 연산을 적용하여 백내장의 후보 영역을 추출한다. 추출된 백내장의 후보 영역에서 침식, 팽창 기법을 적용하여 ROI 영역의 픽셀 크기를 확대 또는 축소하고 타원 형태를 가진 객체 중에서 ROI의 전체 영역의 크기가 1/5보다 적은 객체를 잡음으로 간주하여 제거한다. 잡음이 제거된 백내장의 후보 영역에서 크기가 3/5이상인 영역을 백내장 영역으로 추출한다. 제안된 방법의 성능을 분석하기 위하여 기존의 백내장 추출 방법과 제안된 백내장 추출 방법을 15개의 백내장 영상을 대상으로 실험한 결과, 제안된 방법이 기존의 백내장 추출 방법보다 백내장 추출률이 개선된 것을 확인하였다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.947-950
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• 2005

For revolving and elevating a turret of a tank, we substitute an existing oil pressure system with an electric system using a motor and applied the vector control method to this system. A switching method of an inverter for providing desired sinusoidal current to each phase of a motor, we adopted min-max pulse width modulation method which takes less computation time, rather than space vector pulse width modulation method. We designed a digital filter and applied it to the control system. Developed current controller is verified it's performance through a current control test, speed control test, frequency response and tracking a profile of speed test.

• Journal of the Korean Society for Precision Engineering
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• v.12 no.9
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• pp.156-166
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• 1995

This paper presents a bin picking method using a slit beam laser in which a robot recognizes all of the unoccluded objects from the top of jumbled objects, and picks them up one by one. Once those unoccluded objects are removed, newly developed unoccluded objects underneath are recognized and the same process is continued until the bin gets empty. To recognize unoccluded objects, a new algotithm to link edges on slices which are generated by the orthogonally mounted laser on the xy table is proposed. The edges on slices are partitioned and classified using convex and concave function with a distance parameter. The edge types on the neighborhood slices are compared, then the hamming distances among identical kinds of edges are extracted as the features of fuzzy membership function. The sugeno fuzzy integration about features is used to determine linked edges. Finally, the pick-up sequence based on MaxMin theory is determined to cause minimal disturbance to the pile. This proposed method may provide a solution to the automation of part handling in manufacturing environments such as in punch press operation or part assembly.