• 약학회지
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• 제49권1호
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• pp.30-37
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• 2005

Xuesaitong Ruanjiaonang (XR), a soft capsule containing Panax notoginseng saponins as main ingredients, is believed to remove extravasated blood and increase cerebral blood flow by improving blood circulation, and therefore, has been used in China to treat ischemic stroke or hemiplegia caused by cerebral thrombosis. To characterize pharmacological actions of XR, the present study evaluated its effects on neuronal cell damage induced by various oxidative insults or excitotoxic amino acids in primary cultured rat cortical cells. The neuronal cell viability was not affected by XR with the exposure for 2 h at the concentrations tested in this study ($10{\sim}1000\;{\mu}g/ml$). However, significant reduction of the cell viability was observed when the cultured cells were exposed to XR at $1000\;{\mu}g/ml$ for 24 h. XR was found to concentration-dependently inhibit the oxidative neuronal damage induced by $H_{2}O_2$, xanthine/xanthine oxidase or $Fe^{2+}$/ascorbic acid. In addition, it dramatically inhibited the excitotoxic damage induced by glutamate or N-methyl-D-aspartate (NMDA). We found that the NMDA-induced neurotoxicity was inhibited more effectively and potently than the glutamate-induced toxicity. Moreover, XR was found to exert mild inhibition of lipid peroxidation induced by $Fe^{2+}$/ascorbic acid in rat brain homogenates and some 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. Taken together, these results demonstrate neuroprotective and antioxidant effects of XR, showing inhibition of oxidative and excitotoxic damage in the cultured cortical neurons, as well as inhibition of lipid peroxidation and its radical scavenging activity. Considering that excitotoxicity and oxidative stress pl ay crucial roles in neuronal cell damage during ischemia and reperfusion, these results may provide pharmacological basis for its clinical usage to treat ischemic stroke.

• Journal of Korean Neurosurgical Society
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• 제64권4호
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• pp.543-551
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• 2021

Objective : Hemorrhagic stroke (HS) and hypertensive retinopathy are known end organ damage of the brain and eye respectively, with HS having deleterious consequence to the patients. This study is to correlate between hypertensive retinopathy and HS in hypertensive disease. Methods : A control group of hypertensive patients only, and an investigated group of hypertensive HS patients. Fundoscopic examination to determine the grade of retinopathy was performed and then divided into low or high severity hypertensive retinopathy. Clinical and radiological parameter included are demography, vital signs, Glasgow coma scale (GCS) on admission, clot volume, site of clot, Intracerebral hemorrhage (ICH) score and Glasgow outcome scale (GOS). Data were correlated with the severity of hypertensive retinopathy. Results : Fifty patient in the control group and 51 patients in the investigated group were recruited. In the hypertensive HS group, 21 had low severity retinopathy (no or mild retinopathy) accounting for 41.2% and 30 patients had high severity (moderate or severe retinopathy). In the hypertensive patients 49 had low severity and one had high severity (p-value of 0.001). In HS group low severity showed better GCS score of 9-15 on admission (p-value of 0.003), clot volume less than 30 mL (p-value 0.001), and also a better 30 days mortality rate by using the ICH score (p-value 0.006), GOS score of 4 and 5 the low severity retinopathy fair better than the high severity retinopathy (p-value of 0.001), and the relative risk to develop HS in low severity and high severity retinopathy was 0.42 and 29.4, respectively. Conclusion : Hypertensive retinopathy screening could be used as an indicator in hypertensive patient, to evaluate the risk of developing hypertensive HS in the future.

• 대한중풍순환신경학회지
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• 제24권1호
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• pp.1-12
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• 2023

■Objectives This work reports the case of a patient complaining of disequilibrium due to proprioceptive disorder whose condition improved following Korean medicine treatment. ■Methods The patient was hospitalized for 15 days and treated with herbal medicine, mainly doinseunggi-tang-gami, and acupuncture, electroacupuncture, and moxibustion. Disequilibrium was clinically estimated using Korean dizziness handicap inventory(K-DHI) and the patient's subjective discomfort in this regard was also checked by numeral rating scale. The degree of improvement in blood stasis syndrome was evaluated using modified Blood Stasis Questionnaire II(modified BSQ-II) to assess the clinical effects of the treatment. ■Results After treatment, the K-DHI classification improved from severe to mild, and the patient's subjective discomfort was greatly improved from NRS 6 to NRS1. In addition, the degree of improvement in blood stasis syndrome improved from blood stasis group to blood stasis risk group compared to time of admission. ■Conclusion These results suggest that Korean medicine is effective in treating disequilibrium caused by proprioceptive disorder.

• 생약학회지
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• 제11권2호
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• pp.61-65
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• 1980

As a folkloric medicine, Siegesbeckia pubescens has been used for treatment of brain stroke and hypertension. Diterpene compound, 16,17-dihydroxy 16-${\beta}-(-)$ kaurane-19-oic acid, was isolated from the plant. Its potential antihypertensive activity was evaluated againstan animal model of hypertension, Okamoto-SHR. When diterpene compound with dose of 50mg/kg/day was orally administered, it exhibited mild antihypertensive activity comparable with propranolol administration dose of 75mg/kg/day.

• 수면정신생리
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• 제8권1호
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• pp.11-17
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• 2001

In 2000, the number of people aged 65 and over increased to 3.37 million, accounting for 7.1% of the total population of South Korea. The elderly population will increase up to 19.3% in 2030. Sleep disordered breathing (SDB) seems to increase with age. More than 50-60% of old people complain of SDB-related signs and symptoms including awakening headache, excessive daytime sleepiness, fatigue, cognitive dysfunction, memory loss, personality changes, and depression. The influence of a mild degree of SDB upon the elderly is unclear, but moderate to severe SDB is well known to be associated with many diseases including hypertension, arrhythmia, myocardial infarction, stroke, dementia, and sudden death. Therefore, physicians should pay attention to elderly patients who complain of SDB related symptoms and signs that may not be normal signs of aging. Physicians need to become more sensitive to treat SDB in the elderly.

• The Korean Journal of Physiology and Pharmacology
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• 제17권6호
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• pp.499-503
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• 2013

This study tested the hypothesis that effects of the menstrual cycle on resting blood pressure carry over to dynamic exercise. Eleven healthy females were studied during the early (EP; low estrogen, low progesterone) and late follicular (LP; high estrogen, low progesterone) menstrual phases. Stroke volume (SV), heart rate (HR), cardiac output (CO), systolic blood pressure (SBP), diastolic blood pressure (DBP), and total vascular conductance (TVC) were assessed at rest and in response to mild and moderate cycling exercise during EP and LP. During EP, compared to LP, baseline SBP ($111{\pm}1$ vs. $103{\pm}2$ mmHg), DBP ($71{\pm}2$ vs. $65{\pm}2$ mmHg) and mean arterial pressure (MAP) ($84{\pm}2$ vs. $78{\pm}1$ mmHg) were higher and TVC ($47.0{\pm}1.5$ vs. $54.9{\pm}4.2$ ml/min/mmHg) was lower (p<0.05). During exercise, absolute values of SBP (Mild: $142{\pm}4$ vs. $127{\pm}5$ mmHg; Moderate: $157{\pm}4$ vs. $144{\pm}5$ mmHg) and MAP (Mild: $100{\pm}3$ vs. $91{\pm}3$ mmHg; Moderate: $110{\pm}3$ vs. $101{\pm}3$ mmHg) were also higher, while TVC was lower (Mild: $90.9{\pm}5.1$ vs. $105.4{\pm}5.2$ ml/min/mmHg; Moderate: $105.4{\pm}5.3$ vs. $123.9{\pm}8.1$ ml/min/mmHg) during EP (p<0.05). However, exercise-induced increases in SBP, MAP and TVC at both work intensities were similar between the two menstrual phases, even though norepinephrine concentrations were higher during LP. Results indicate that blood pressure during dynamic exercise fluctuates during the menstrual cycle. It is higher during EP than LP and appears to be due to additive effects of simultaneous increases in baseline blood pressure and reductions in baseline TVC.

• 한국산학기술학회논문지
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• 제12권12호
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• pp.5684-5691
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• 2011

본 연구는 강제유도운동치료와 인지-지각 훈련을 병행하여 환측의 손 기능 변화, 일상생활 과제 수행 시 환측 상지의 사용빈도 변화, 그리고 환측 상지의 움직임의 질적 변화를 알아보고자 하였다. 연구의 대상은 Taub 등 (1999)이 제시한 조건을 만족하고 뇌졸중 발병 후 3개월이 경과하였고 NCSE 또는 MVPT 결과 경도 손상을 보이는 환자 10명을 대상으로 하였다. 중재 방법은 CIMT군은 4주 동안 낮 시간동안에는 변형된 resting arm-splint를 착용하도록 하여 건측 상지의 사용을 제한시켰고, CIMT+CPT군은 CIMT군과 같은 조건에서 인지-지각 훈련을 병행하여 실시하였다. 대조군은 변형된 resting arm-splint를 착용하지 않고 일반적인 작업치료를 받도록 하였다. 그 결과, Jebsen-Taylor Hand Function Test의 먹는 흉내 내기, 크고 가벼운 깡통 옮기기, 그리고 크고 무거운 깡통 옮기기 항목에서 CIMT+CPT군이 가장 큰 변화량을 보였으며 CIMT군도 CTL군과 비교하여 더 많은 호전을 보였다. 각 집단 간의 Motor Activity Log의 환측 상지의 사용빈도에 대한 변화량은 통계학적으로 유의한 차이를 보였다(p<.05). 집단 간의 환측 상지의 움직임의 질적 향상에 대한 변화량은 CIMT군과 CIMT+CPT군 모두 CTL군보다 통계학적으로 유의한 차이를 보였다(p<.05). 따라서 인지 지각 능력의 경도 손상을 가지고 있는 뇌졸중 환자에게 실시한 강제유도운동치료는 환측의 손 기능 향상과 일상생활 과제 수행 시 환측 상지의 사용 빈도와 움직임의 질적 향상에 효과를 보였고, 강제유도운동치료와 인지-지각 훈련을 병행하였을 때 더 큰 시너지 효과를 보였다.

• 융합정보논문지
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• 제11권2호
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• pp.229-237
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• 2021

노인과 경증 뇌질환(치매 및 뇌졸중 등) 환자들 중 일정 정도의 자력 행동 능력과 인지 능력이 있는 경우에는 운동과 인지 재활을 병행해야만 하는 경우가 많다. 그러나 기존의 재활 시스템은 대부분 운동 또는 인지 재활로 분리 또는 특화 되어 있는 경우가 많아서 두 가지 모두를 연계하는 형태에 대한 필요성이 있다고 생각된다. 본 논문에서는 ICT 기술의 하나인 CAN 통신 프로토콜을 이용하여 운동과 인지 재활을 병행할 수 있도록 하는 게임형 재활시스템을 제안하고자 한다. 이 시스템은 CAN BUS 구조를 이용하여 재활 시스템을 구성하는 각각의 개별 모듈들을 다양한 형태로 분리 및 결합 사용이 가능하도록 한다. 환자(또는 노인)의 인지 능력과 운동 능력의 정도에 따라 다양한 형태의 재활 환경을 구현할 수 있음을 보이고자 제안된 시스템의 프로토 타입을 실제로 제작하였다. 아울러 이 시스템을 이용한 몇 가지 실험을 통하여 여러 환경에 적용 가능한 운동/인지 병행 재활의 구현 가능성을 보이고 있다.

• Journal of Chest Surgery
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• 제57권2호
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• pp.184-194
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• 2024

Background: Left ventricular assist devices (LVADs) are widely employed as a therapeutic option for end-stage heart failure. We evaluated the outcomes associated with centrifugal-flow LVAD implantation, comparing 2 device models: the Heartmate 3 (HM3) and the Heartware Ventricular Assist Device (HVAD). Methods: Data were collected from patients who underwent LVAD implantation between June 1, 2015 and December 31, 2022. We analyzed overall survival, first rehospitalization, and early, late, and LVAD-related complications. Results: In total, 74 patients underwent LVAD implantation, with 42 receiving the HM3 and 32 the HVAD. A mild Interagency Registry for Mechanically Assisted Circulatory Support score was more common among HM3 than HVAD recipients (p=0.006), and patients receiving the HM3 exhibited lower rates of preoperative ventilator use (p=0.010) and extracorporeal membrane oxygenation (p=0.039). The overall early mortality rate was 5.4% (4 of 74 patients), with no significant difference between groups. Regarding early right ventricular (RV) failure, HM3 implantation was associated with a lower rate (13 of 42 [31.0%]) than HVAD implantation (18 of 32 [56.2%], p=0.051). The median rehospitalization-free period was longer for HM3 recipients (16.9 months) than HVAD recipients (5.3 months, p=0.013). Furthermore, HM3 recipients displayed a lower incidence of late hemorrhagic stroke (p=0.016). In the multivariable analysis, preoperative use of continuous renal replacement therapy (odds ratio, 22.31; p=0.002) was the only significant predictor of postoperative RV failure. Conclusion: The LVAD models (HM3 and HVAD) demonstrated comparable overall survival rates. However, the HM3 was associated with a lower risk of late hemorrhagic stroke.

• Childhood Kidney Diseases
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• 제15권1호
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• pp.14-21
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• 2011

좌심실 비대는 심부전, 허혈성 심질환, 부정맥과 같은 심혈관계 질환의 이환율 및 사망률을 높이는 강력한 위험 인자이며 고혈압으로 초래되는 가장 초기 단계의 심장 변화 이기도 하다. 소아청소년 고혈압 환자들은 분명한 심혈관계 합병증 보다는 무증상의 좌심실 비대만 볼 수 있는 경우가 대부분이나 치료하지 않는 경우 성인에서의 심혈관 합병증으로 이행될 위험이 크다. 표적장기 손상의 가장 대표적인 증거이기도 한 좌심실 비대는 소아청소년에서 고혈압 전 단계 상태에서도 나타나므로 고혈압의 진단 당시와 추후의 추적 진료 중 정기적으로 심초음파를 통한 좌심실 질량의 측정이 이루어 져야 한다. 좌심실 비대가 보인다면 적극적인 약물 치료가 또한 이루어져야 한다.