• 농촌지도와개발
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• 제11권1호
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• pp.83-93
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• 2004

This paper investigated the characteristics of population structure and the determinants of population movement in the south west area of Kyonggi-do by grouping 9 cities in 3 categories and using Panel data of $1995{\sim}2001$. The major findings of this paper were identified as follows : 1) The population structure of regions was different to the stages of urbanization. The ratio of child and elder dependency was high in the rural regions and low in the urbanized regions. It was due to the movement of economically active population of $20{\sim}40$ aged groups, from rural regions to urban regions. This means that more productive segments of the rural population leave the country to the city. In addition. The ratio of male to female was higher in $20{\sim}40$ aged groups for rural regions. This suggested that young females moved from rural regions to urban regions more than young males in the process of industrialization. 2) Based in pooling regression, income was the most significant determinant that could explain the inter-regional and intra-regional movement of population for south west area studied, The next one was educational opportunity variable. The coefficients of income and education were 0.5, 0,7 for intra-regional migration and 0.01, 0.02 for interregional migration indicating that Todaro's hypothesis could be tested well rather than Tiebout' model for this area.

• 농촌계획
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• 제20권4호
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• pp.221-232
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• 2014

초고령화된 한국 농촌에서 다양한 교육 및 직업 배경을 가진 중장년층 귀농인구의 유입은 고령화 문제에 대한 대안의 하나로 부각되고 있다. 본 연구는 농가 고령화에 대한 귀농인구의 잠재적인 기여도 측면에서 귀농인구의 지역별 유입 유출 패턴을 분석하였다. 분석에는 로그선형모형과 총합레퍼런스코딩을 사용하였고, 분석자료는 통계청의 2013년 귀농 통계이다. 분석결과에 의하면, 귀농인의 절반 정도가 수도권에서 비수도권 지역으로 이주한 인구이고, 이들을 제외하면 귀농인의 대부분은 원 거주지가 있던 도 내에서 이동하고 있다. 귀농인의 귀농 전 대비 귀농 후 지역 내 오즈비(odds ratio)는 지역별로 차이가 있으며, 귀농인의 성별과 연령에 따라서도 지역별 유입 유출패턴이 다르다. 이는 귀농인 유입의 긍정적 효과를 높이기 위해서는 지자체별 차이를 반영한 특화된 정책이 필요하다는 것을 의미한다.

• 한국인구학
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• 제11권1호
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• pp.117-130
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• 1988

Though most of East European coutries seem to hold a pronatalist policy, they approve of family planning and provide contraceptive services. One of the most popular contraceptive method has traditionally been the coitus interruptus in these countries. One of the major reasons for adopting family planning is to decrease the incidence of induced abortion has been closely related to the popular use of coitus interruptus in these countries. Most of the East European countries liberalized induce abortion legally mainly to neutralize the wide practice of illegal abortion. However, the practice of induced abortion is under the strict control of the public health authorities in these countries. Migration and redistribution of population of population are mostly under the control of the state in these socialist countries. Policies on migration and redistribution are usually carried out to achieve the general goal of socio-economic development plan of the states. Both incentive measures and control measures are mobilized to affect the internal migration and redistribution of population. With respect to public health East European countries are characterized by the socialized medicine following the Soviet model. Public health measures and medical practice are controlled by the state and highly centralized in many countries except Yugoslavia. They place much emphasis on preventive medicine, primary health care, occupatinal and industrial medicine, and health education. Private sectors in medical practice do not exist in these countries of Eastern Europe.

• 한국정보시스템학회지:정보시스템연구
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• 제30권4호
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• pp.43-69
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• 2021

Purpose Although companies occupied the network market take the advantageous position first and can be successful in securing users over a certain size, it is important to satisfy the customers' demand and prevent the outflow of users toward a new alternative SNS. What is more, there are frequent changes in the flow of users toward new SNSs. Despite these dynamic market circumstances, there is a lack of research to explain the switching behaviors of SNS users. Design/methodology/approach The objective of this study is to explain and verify a specified migration theory(Push-Pull-Mooring model) focused on SNS fatigue in the psychological point of view, as well as reviewing previous studies on functional and technical characteristics of SNSs themselves. Moreover, this study tried to highlight factors affecting users actual SNS switch rather than their switching intention. Findings According to the statistical analysis, the most influenced pull factor to switch SNS was the alternative attractiveness. On the other hand, undesired relationship burden, service innovation and important mooring factors to prevent users' SNS switch. This study has a significant contribution to the theory, which analyzed users' actual SNS switch, and examined SNS users' psychological factors(SNS fatigue), reviewing the characteristics of existing services. To secure more users and to keep them, companies providing social network service need to develop differentiated strategies by analyzing psychological characteristics of various users.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 2020년도 정기학술대회 발표논문집
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• pp.221-221
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• 2020

Curcumin, a hydrophobic polyphenol derived from turmeric, has been used a food additive and as a herbal medicine for the treatment of various diseases. In the present study, we found the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) during the wound closure. We found that the efficacy of hUCB-MSCs migration induced by CN was 1000-fold higher than that of curcumin powder. CN significantly increased the motility of hUCB-MSCs by activating c-Src, which is responsible for the phosphorylation of protein kinase C (PKC) and extracellular signal-regulated kinase (ERK). CN induced the expression levels of α-actinin-1, profilin-1 and filamentous-actin, as regulated by the phosphorylation of nuclear factor-kappa B during its promotion of cell migration. In a mouse skin excisional wound model, we found that transplantation of UCB-MSCs pre-treated with CN enhances wound closure, granulation, and re-epithelialization at mouse skin wound sites. These results indicate that CN is a functional agent that promotes the mobilization of UCB-MSCs for cutaneous wound repair.

• 대한약침학회지
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• 제26권4호
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• pp.357-365
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• 2023

Objectives: Since stroke is a serious health issue, novel therapeutic strategies are required. In a mouse model of ischemic stroke, this study analyzed the potential of electroacupuncture (EA) and tenuigenin (TE) to improve the efficacy of human mesenchymal stem cell (hMSC) transplantation. Methods: Middle cerebral artery occlusion (MCAO) with reperfusion was used to generate ischemic stroke. Forty-eight male C57BL/6 mice were randomly divided into five groups: control, MCAO-operated, MCAO-EA, MCAO-TE, or MCAO + EA + TE. Subsequently, hMSCs were transplanted into the ischemic region and EA, TE, or the combination was administered. Behavior assessments and immunohistochemistry were conducted to evaluate motor and cognitive recovery and hMSCs survival, migration, and differentiation. Results: The combined treatment of EA and TE exhibited enhanced hMSCs survival, migration and differentiation into neural cell lineages while suppressing astrocyte formation. Immunohistochemistry demonstrated increased neurogenesis through hMSCs transplantation in the ischemic brain. Immediate behavioral improvements were not significantly different between groups, but there was a gradual recovery in motor and cognitive function over time. Conclusion: These findings highlight the potential of EA and TE co-treatment as a therapeutic strategy for ischemic stroke, opening avenues for further research to optimize treatment protocols and elucidate underlying mechanisms.

• Journal of Microbiology and Biotechnology
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• 제34권3호
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• pp.589-595
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• 2024

Latilactobacillus curvatus BYB3 (BYB3) is a species of lactic acid bacteria, formerly named Lactobacillus curvatus, which is isolated from kimchi. In this study, the effect of BYB3, Lactobacillus rhamnosus GG, and Lactobacillus acidophilus GP1B strain extracts at various concentrations was examined on B16F10, a mouse melanoma cell line. Cell viability was examined via MTT assay, and the results indicated that compared to the other two probiotics, BYB3 significantly decreased the total percentages of viable cells. The effects of BYB3 on cell migration and proliferation in B16F10 cells were evaluated using wound healing mobility and proliferation assays, respectively; the results indicated that BYB3 inhibits cell migration and proliferation in a concentration-dependent manner. Using human dermal fibroblast cells to investigate BYB3 extract in vivo had no effect on skin-related cells. Nonetheless, the BYB3 extract inhibited tumor growth in a mouse model, as demonstrated by liver slices. Therefore, this suggests that using BYB3 extract to inhibit melanoma may be a novel approach.

• 지구물리와물리탐사
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• 제5권3호
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• pp.178-184
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• 2002

탄성파굴절법 탐사는 절차가 단순하고 경제적이기 때문에 대형 구조물 건설을 위한 지반조사나 지질조사에 널리 이용되고 있다. 본 연구에서는 굴절법 탐사자료에 Kirchhoff 구조보정 방법을 적용하여 다양한 모형자료의 반응을 알아보고, 이에 대한 결과를 고찰하여 굴절법 탐사 자료를 이용한 지하 경계면 영상화 기법의 적용성을 파악해보고자 하였다. 모형반응 계산에 필요한 인공주시곡선의 작성에는 Vidale(1988)이 제시한 알고리즘을 사용하였고, 모형에 따른 반응을 살펴보기 위해 2층, 3층 모형 및 불규칙한 지표면을 가지는 모형 등에 대해 다양하게 살펴보았다. 구조보정을 위한 초기 속도 모형으로는 실제 구조와 같은 모형, 토모그래피에 의한 역산 단면, 실제 구조를 평활화한 모형 등을 사용해 초기 속도 모형이 달라질 때 결과에 어떤 영향을 미치는가 살펴보았다. 각각의 모형에 본 연구에 사용된 기법을 적용해 본 결과 반사법 구조보정에 비해 초기 속도 모형에 더욱 민감하다는 것을 확인할 수 있었으며, 현장 자료에 적용되기 위해서는 적절한 초기속도모형을 결정해야 할 것임을 알 수 있었다.

• 한국수자원학회논문집
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• 제50권5호
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• pp.315-324
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• 2017

2014년 8월 25일 집중호우시 효암천 상류지역의 도심과 농경지 등에 큰 침수피해가 발생하였다. 이 지역은 고리원전 부지조성을 위해 하구부의 하천이설과 주변지역에 대한 성토 등 대규모 개발사업이 이루어진 곳이다. 본 연구에서는 이러한 개발이 홍수시 침수피해의 원인이 되었는지를 알아보기 위해 HEC-GeoRAS 모형을 이용하여 개발사업 전 후에 대한 효암천 유역의 침수심과 침수면적의 변화를 조사하였다. 분석결과, HEC-GeoRAS 모형은 농경지 등 지형변화 및 표고차가 작은 하천유역에 대해서도 홍수시 침수심과 침수면적의 변화를 비교적 정확하게 산정할 수 있는 것으로 확인되었다. 침수심은 개발사업의 영향으로 2014년 8월 집중호우시 0.99 m가 상승하였고, 100년빈도 홍수시에는 0.39 m가 상승하는 것으로 나타났다. 침수면적은 100년빈도 훙수시 침수심 1.5 m 이하에서는 감소하였으나 침수심 4.5 m 이상에서는 오히려 증가하는 것으로 나타났다. 결론적으로, 하천이설과 개발사업으로 인해 하구부의 농경지와 저지대의 자연저유기능이 상실된 것이 2014년 8월 집중호우시 홍수발생의 주된 원인이 되었으며, 하천이설에 따라 신설된 하천단면의 총 하폭은 크게 증가하였으나 실질적인 유효하폭은 오히려 축소되어 통수단면적이 감소되었던 것이 침수피해를 가중시킨 것으로 나타났다. 추후 하천이설이나 주변지역에 대한 성토 등 개발행위시에는 기존의 저유기능이 충분히 고려된 하천개수계획이 필요한 것으로 판단된다.

• Nutritional Sciences
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• 제7권3호
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• pp.144-150
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• 2004

We have investigated the effect of calcium spirulan(Ca-SP) isolated from a blue-green alga Spirulina platensis, which is a sulfated polysaccharide chelating calcium and mainly composed of rhamnose and fructose, on invasion of both B16- BL6 melanoma cells, Colon 26 carcinoma and HT-1080 fibrosarcoma cells through reconstituted basement membrane (Matrigel). Ca-SP significantly inhibited the invasion of these tumor cells through Matrigel/fibronectin-coated filters in a concentration-dependent manner. Ca-SP also inhibited the haptotactic migration of tumor cells to laminin, but it had no inhibitory effect on tumor cell migration to fibronectin-coated filters. Ca-SP prevented the adhesion of B16-BL6 cells to Matrigel- and laminin-substrates but did not affect the adhesion to fibronectin. The pretreatment of tumor cells with Ca-SP inhibited the adhesion to laminin in a concentration-dependent fashion, while the pretreatment of laminin-substrates did not. Ca-SP had no effect on the production and activation of type IV collagenase in gelatin zymography. In contraset, Ca-SP significantly inhibited degradation of heparan sulfate by purified heparanase. The experimental lung metastasis was significantly reduced by co-injection of B16-BL6 cells with Ca-SP in a dose-dependent manner. Seven intermittent ⅰ.ⅴ. injection of 100$\mu\textrm{g}$ of Ca-SP caused a marked decrease of lung tumor colonization of B16-BL6 cells in a spontaneous lung metastasis model. These results suggest that Ca-SP, a novel sulfated polysaccharide, could reduce the lung colonization of B16-BL6 melanoma cells in experimental metastasis model, by inhibiting the tumor invasion of basement membrane Matrigel, probably through the prevention of the adhesion and migration of tumor cells to laminin-substrate and of the heparanase activity.